4caw - Revision history

OCA at 11:10, 9 May 2024

2024-05-09T11:10:38Z

←Older revision		Revision as of 11:10, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CAW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CAW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [https://pdbe.org/4caw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [https://www.ebi.ac.uk/pdbsum/4caw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4caw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [https://pdbe.org/4caw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [https://www.ebi.ac.uk/pdbsum/4caw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4caw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.	+	[https://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Treatment of filamentous fungal infections relies on a limited repertoire of antifungal agents. Compounds possessing novel modes of action are urgently required. N-myristoylation is a ubiquitous modification of eukaryotic proteins. The enzyme N-myristoyltransferase (NMT) has been considered a potential therapeutic target in protozoa and yeasts. Here, we show that the filamentous fungal pathogen Aspergillus fumigatus possesses an active NMT enzyme that is essential for survival. Surprisingly, partial repression of the gene revealed downstream effects of N-myristoylation on cell wall morphology. Screening a library of inhibitors led to the discovery of a pyrazole sulphonamide compound that inhibits the enzyme and is fungicidal under partially repressive nmt conditions. Together with a crystallographic complex showing the inhibitor binding in the peptide substrate pocket, we provide evidence of NMT being a potential drug target in A. fumigatus.
		+
		+	N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.,Fang W, Robinson DA, Raimi OG, Blair DE, Harrison JR, Lockhart DE, Torrie LS, Ruda GF, Wyatt PG, Gilbert IH, van Aalten DM ACS Chem Biol. 2015 Jun 19;10(6):1425-34. doi: 10.1021/cb5008647. Epub 2015 Feb, 27. PMID:25706802<ref>PMID:25706802</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4caw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:35, 7 September 2022

2022-09-07T17:35:26Z

←Older revision		Revision as of 17:35, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4caw' size='340' side='right'caption='[[4caw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4caw' size='340' side='right'caption='[[4caw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aspfm Aspfm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CAW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cav\|4cav]], [[4cax\|4cax]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [https://pdbe.org/4caw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [https://www.ebi.ac.uk/pdbsum/4caw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4caw ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [~~http~~://pdbe.org/4caw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4caw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4caw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.	+	[[https://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Treatment of filamentous fungal infections relies on a limited repertoire of antifungal agents. Compounds possessing novel modes of action are urgently required. N-myristoylation is a ubiquitous modification of eukaryotic proteins. The enzyme N-myristoyltransferase (NMT) has been considered a potential therapeutic target in protozoa and yeasts. Here, we show that the filamentous fungal pathogen Aspergillus fumigatus possesses an active NMT enzyme that is essential for survival. Surprisingly, partial repression of the gene revealed downstream effects of N-myristoylation on cell wall morphology. Screening a library of inhibitors led to the discovery of a pyrazole sulphonamide compound that inhibits the enzyme and is fungicidal under partially repressive nmt conditions. Together with a crystallographic complex showing the inhibitor binding in the peptide substrate pocket, we provide evidence of NMT being a potential drug target in A. fumigatus.	+
-		+
-	N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.,Fang W, Robinson DA, Raimi OG, Blair DE, Harrison JR, Lockhart DE, Torrie LS, Ruda GF, Wyatt PG, Gilbert IH, van Aalten DM ACS Chem Biol. 2015 Jun 19;10(6):1425-34. doi: 10.1021/cb5008647. Epub 2015 Feb, 27. PMID:25706802<ref>PMID:25706802</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4caw" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspfm]]~~	+	[[Category: Aspergillus fumigatus]]
-	~~[[Category: Glycylpeptide N-tetradecanoyltransferase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Aalten, D M.F Van]]~~	+	[[Category: Blair DE]]
-	[[Category: Blair~~, D E~~]]	+	[[Category: Fang W]]
-	[[Category: Fang, W]]	+	[[Category: Gilbert IH]]
-	[[Category: Gilbert~~, I H~~]]	+	[[Category: Harrison J]]
-	[[Category: Harrison, J]]	+	[[Category: Lockhart DEA]]
-	[[Category: Lockhart~~, D E.A~~]]	+	[[Category: Raimi OG]]
-	[[Category: Raimi~~, O G~~]]	+	[[Category: Robinson DA]]
-	[[Category: Robinson~~, D A~~]]	+	[[Category: Ruda GF]]
-	[[Category: Ruda~~, G F~~]]	+	[[Category: Torrie LS]]
-	[[Category: Torrie~~, L S~~]]	+	[[Category: Van Aalten DMF]]
-	[[Category: ~~Wyatt, P G~~]]	+	[[Category: Wyatt PG]]
-	[[Category: ~~Drug discovery]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:37, 20 March 2019

2019-03-20T09:37:07Z

←Older revision		Revision as of 09:37, 20 March 2019
Line 1:		Line 1:

	==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand==		==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand==
-	<StructureSection load='4caw' size='340' side='right' caption='[[4caw]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4caw' size='340' side='right'caption='[[4caw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfm Aspfm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CAW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cav\|4cav]], [[4cax\|4cax]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cav\|4cav]], [[4cax\|4cax]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [http://pdbe.org/4caw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [http://www.ebi.ac.uk/pdbsum/4caw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [http://pdbe.org/4caw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [http://www.ebi.ac.uk/pdbsum/4caw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4caw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aspfm]]
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Aalten, D M.F Van]]		[[Category: Aalten, D M.F Van]]
	[[Category: Blair, D E]]		[[Category: Blair, D E]]

OCA at 17:04, 10 May 2016

2016-05-10T17:04:12Z

←Older revision		Revision as of 17:04, 10 May 2016
Line 1:		Line 1:
		+
	==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand==		==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand==
	<StructureSection load='4caw' size='340' side='right' caption='[[4caw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4caw' size='340' side='right' caption='[[4caw]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cav\|4cav]], [[4cax\|4cax]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cav\|4cav]], [[4cax\|4cax]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [http://www.ebi.ac.uk/pdbsum/4caw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [http://pdbe.org/4caw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [http://www.ebi.ac.uk/pdbsum/4caw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.		[[http://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Treatment of filamentous fungal infections relies on a limited repertoire of antifungal agents. Compounds possessing novel modes of action are urgently required. N-myristoylation is a ubiquitous modification of eukaryotic proteins. The enzyme N-myristoyltransferase (NMT) has been considered a potential therapeutic target in protozoa and yeasts. Here, we show that the filamentous fungal pathogen Aspergillus fumigatus possesses an active NMT enzyme that is essential for survival. Surprisingly, partial repression of the gene revealed downstream effects of N-myristoylation on cell wall morphology. Screening a library of inhibitors led to the discovery of a pyrazole sulphonamide compound that inhibits the enzyme and is fungicidal under partially repressive nmt conditions. Together with a crystallographic complex showing the inhibitor binding in the peptide substrate pocket, we provide evidence of NMT being a potential drug target in A. fumigatus.
		+
		+	N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.,Fang W, Robinson DA, Raimi OG, Blair DE, Harrison JR, Lockhart DE, Torrie LS, Ruda GF, Wyatt PG, Gilbert IH, van Aalten DM ACS Chem Biol. 2015 Jun 19;10(6):1425-34. doi: 10.1021/cb5008647. Epub 2015 Feb, 27. PMID:25706802<ref>PMID:25706802</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4caw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:28, 25 December 2014

2014-12-25T14:28:18Z

←Older revision		Revision as of 14:28, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [http://www.ebi.ac.uk/pdbsum/4caw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [http://www.ebi.ac.uk/pdbsum/4caw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:50, 21 December 2014

2014-12-21T09:50:00Z

←Older revision		Revision as of 09:50, 21 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand==
-		+	<StructureSection load='4caw' size='340' side='right' caption='[[4caw]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~The entry~~ 4caw is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CAW FirstGlance]. <br>
-	~~Authors~~: ~~Robinson~~, D.A., ~~Fang~~, W., ~~Raimi~~, O.G., Blair, D.E., Harrison, J~~., Ruda, G.F.,~~ Lockhart, D.E.A., Torrie, L.S., Wyatt, P.G~~., Gilbert, I.H., Van Aalten, D.M.F.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cav\|4cav]], [[4cax\|4cax]]</td></tr>
-	~~Description~~: ~~Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [http://www.ebi.ac.uk/pdbsum/4caw PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Aalten, D M.F Van]]
		+	[[Category: Blair, D E]]
		+	[[Category: Fang, W]]
		+	[[Category: Gilbert, I H]]
		+	[[Category: Harrison, J]]
		+	[[Category: Lockhart, D E.A]]
		+	[[Category: Raimi, O G]]
		+	[[Category: Robinson, D A]]
		+	[[Category: Ruda, G F]]
		+	[[Category: Torrie, L S]]
		+	[[Category: Wyatt, P G]]
		+	[[Category: Drug discovery]]
		+	[[Category: Transferase]]

OCA: Protected "4caw" [edit=sysop:move=sysop]

2013-10-16T07:09:51Z

Protected "4caw" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:09, 16 October 2013

OCA: New page: '''Unreleased structure''' The entry 4caw is ON HOLD Authors: Robinson, D.A., Fang, W., Raimi, O.G., Blair, D.E., Harrison, J., Ruda, G.F., Lockhart, D.E.A., Torrie, L.S., Wyatt, P.G., ...

2013-10-16T07:09:50Z

New page: '''Unreleased structure''' The entry 4caw is ON HOLD Authors: Robinson, D.A., Fang, W., Raimi, O.G., Blair, D.E., Harrison, J., Ruda, G.F., Lockhart, D.E.A., Torrie, L.S., Wyatt, P.G., ...

New page

'''Unreleased structure'''

The entry 4caw is ON HOLD

Authors: Robinson, D.A., Fang, W., Raimi, O.G., Blair, D.E., Harrison, J., Ruda, G.F., Lockhart, D.E.A., Torrie, L.S., Wyatt, P.G., Gilbert, I.H., Van Aalten, D.M.F.

Description: Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand