4cfg - Revision history

OCA at 17:42, 7 September 2022

2022-09-07T17:42:54Z

←Older revision		Revision as of 17:42, 7 September 2022
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	<StructureSection load='4cfg' size='340' side='right'caption='[[4cfg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4cfg' size='340' side='right'caption='[[4cfg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CFG FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [~~http~~://pdbe.org/4cfg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cfg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cfg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [https://pdbe.org/4cfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [https://www.ebi.ac.uk/pdbsum/4cfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cfg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN]] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref>	+	[[https://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN]] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref>

	==See Also==		==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: James, L]]	+	[[Category: James L]]
-	~~[[Category: Ligase~~]]	+

OCA at 08:51, 20 March 2019

2019-03-20T08:51:55Z

←Older revision		Revision as of 08:51, 20 March 2019
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	==Structure of the TRIM25 coiled-coil==		==Structure of the TRIM25 coiled-coil==
-	<StructureSection load='4cfg' size='340' side='right' caption='[[4cfg]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4cfg' size='340' side='right'caption='[[4cfg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CFG FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://pdbe.org/4cfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cfg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://pdbe.org/4cfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cfg ProSAT]</span></td></tr>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN]] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref>		[[http://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN]] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: James, L]]		[[Category: James, L]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 07:23, 4 August 2016

2016-08-04T07:23:40Z

←Older revision		Revision as of 07:23, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of the TRIM25 coiled-coil==		==Structure of the TRIM25 coiled-coil==
	<StructureSection load='4cfg' size='340' side='right' caption='[[4cfg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4cfg' size='340' side='right' caption='[[4cfg]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CFG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CFG FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://pdbe.org/4cfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cfg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:49, 24 December 2014

2014-12-24T06:49:31Z

←Older revision		Revision as of 06:49, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN]] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: James, L]]		[[Category: James, L]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 16:17, 10 December 2014

2014-12-10T16:17:28Z

←Older revision		Revision as of 16:17, 10 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the TRIM25 coiled-coil==
-		+	<StructureSection load='4cfg' size='340' side='right' caption='[[4cfg]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~The entry~~ 4cfg is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CFG FirstGlance]. <br>
-	~~Authors~~: ~~James~~, L.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum]</span></td></tr>
-	~~Description~~:	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: James, L]]
		+	[[Category: Ligase]]

OCA at 09:43, 29 October 2014

2014-10-29T09:43:51Z

←Older revision		Revision as of 09:43, 29 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cfg is ON HOLD	+	The entry 4cfg is ON HOLD until Paper Publication

	Authors: James, L.		Authors: James, L.

-	Description: ~~TBC~~	+	Description:

OCA: Protected "4cfg" [edit=sysop:move=sysop]

2013-11-27T09:19:42Z

Protected "4cfg" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:19, 27 November 2013

OCA: New page: '''Unreleased structure''' The entry 4cfg is ON HOLD Authors: James, L. Description: TBC

2013-11-27T09:19:40Z

New page: '''Unreleased structure''' The entry 4cfg is ON HOLD Authors: James, L. Description: TBC

New page

'''Unreleased structure'''

The entry 4cfg is ON HOLD

Authors: James, L.

Description: TBC