4clx - Revision history

OCA at 11:13, 9 May 2024

2024-05-09T11:13:09Z

←Older revision		Revision as of 11:13, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4clx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4clx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CLX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q0K:2-AMINO-5-(P-TOLYL)-3H-PYRROLO[2,3-D]PYRIMIDIN-4(7H)-ONE'>Q0K</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q0K:2-AMINO-5-(P-TOLYL)-3H-PYRROLO[2,3-D]PYRIMIDIN-4(7H)-ONE'>Q0K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4clx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4clx OCA], [https://pdbe.org/4clx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4clx RCSB], [https://www.ebi.ac.uk/pdbsum/4clx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4clx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4clx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4clx OCA], [https://pdbe.org/4clx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4clx RCSB], [https://www.ebi.ac.uk/pdbsum/4clx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4clx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]]	+	[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:21, 14 September 2022

2022-09-14T07:21:05Z

←Older revision		Revision as of 07:21, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4clx' size='340' side='right'caption='[[4clx]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4clx' size='340' side='right'caption='[[4clx]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4clx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trybb Trybb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4clx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CLX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q0K:2-AMINO-5-(P-TOLYL)-3H-PYRROLO[2,3-D]PYRIMIDIN-4(7H)-ONE'>Q0K</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q0K:2-AMINO-5-(P-TOLYL)-3H-PYRROLO[2,3-D]PYRIMIDIN-4(7H)-ONE'>Q0K</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm7\|4cm7]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4clx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4clx OCA], [https://pdbe.org/4clx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4clx RCSB], [https://www.ebi.ac.uk/pdbsum/4clx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4clx ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4clx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4clx OCA], [~~http~~://pdbe.org/4clx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4clx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4clx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4clx ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pteridine reductase]]~~	+	[[Category: Trypanosoma brucei brucei]]
-	~~[[Category: Trybb~~]]	+	[[Category: Barrack KL]]
-	[[Category: Barrack~~, K L~~]]	+	[[Category: Hunter WN]]
-	[[Category: Hunter~~, W N]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Short-chain dehydrogenase/reductase~~]]	+

OCA at 09:02, 20 March 2019

2019-03-20T09:02:40Z

←Older revision		Revision as of 09:02, 20 March 2019
Line 1:		Line 1:

	==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==		==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==
-	<StructureSection load='4clx' size='340' side='right' caption='[[4clx]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4clx' size='340' side='right'caption='[[4clx]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4clx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4clx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CLX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q0K:2-AMINO-5-(P-TOLYL)-3H-PYRROLO[2,3-D]PYRIMIDIN-4(7H)-ONE'>Q0K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q0K:2-AMINO-5-(P-TOLYL)-3H-PYRROLO[2,3-D]PYRIMIDIN-4(7H)-ONE'>Q0K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm7\|4cm7]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm7\|4cm7]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pteridine reductase]]		[[Category: Pteridine reductase]]
		+	[[Category: Trybb]]
	[[Category: Barrack, K L]]		[[Category: Barrack, K L]]
	[[Category: Hunter, W N]]		[[Category: Hunter, W N]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Short-chain dehydrogenase/reductase]]		[[Category: Short-chain dehydrogenase/reductase]]

OCA at 07:24, 11 August 2016

2016-08-11T07:24:05Z

←Older revision		Revision as of 07:24, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==		==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==
	<StructureSection load='4clx' size='340' side='right' caption='[[4clx]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4clx' size='340' side='right' caption='[[4clx]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm7\|4cm7]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm7\|4cm7]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4clx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4clx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4clx RCSB], [http://www.ebi.ac.uk/pdbsum/4clx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4clx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4clx OCA], [http://pdbe.org/4clx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4clx RCSB], [http://www.ebi.ac.uk/pdbsum/4clx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4clx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4clx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pteridine reductase\|Pteridine reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:45, 21 January 2015

2015-01-21T16:45:41Z

←Older revision		Revision as of 16:45, 21 January 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==
		+	<StructureSection load='4clx' size='340' side='right' caption='[[4clx]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4clx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CLX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q0K:2-AMINO-5-(P-TOLYL)-3H-PYRROLO[2,3-D]PYRIMIDIN-4(7H)-ONE'>Q0K</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm7\|4cm7]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4clx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4clx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4clx RCSB], [http://www.ebi.ac.uk/pdbsum/4clx PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The treatment of Human African trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important; pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp., has been identified as a candidate target, and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from Trypanosoma brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. Eight compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus, although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development.

-	~~The entry 4clx is ON HOLD until Paper Publication~~	+	Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.,Khalaf AI, Huggan JK, Suckling CJ, Gibson CL, Stewart K, Giordani F, Barrett MP, Wong PE, Barrack KL, Hunter WN J Med Chem. 2014 Aug 14;57(15):6479-94. doi: 10.1021/jm500483b. Epub 2014 Jul 29. PMID:25007262<ref>PMID:25007262</ref>

-	~~Authors: Barrack~~, K.L.~~, Hunter, W.N~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of pteridine~~ reductase ~~1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Hunter, W.N]]	+	__TOC__
-	[[Category: ~~Barrack, K.L~~]]	+	</StructureSection>
		+	[[Category: Pteridine reductase]]
		+	[[Category: Barrack, K L]]
		+	[[Category: Hunter, W N]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Short-chain dehydrogenase/reductase]]

OCA at 13:22, 24 December 2014

2014-12-24T13:22:52Z

←Older revision		Revision as of 13:22, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor		Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
		+	[[Category: Unreleased Structures]]
		+	[[Category: Hunter, W.N]]
		+	[[Category: Barrack, K.L]]

OCA at 06:44, 29 January 2014

2014-01-29T06:44:50Z

←Older revision		Revision as of 06:44, 29 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4clx is ON HOLD	+	The entry 4clx is ON HOLD until Paper Publication

	Authors: Barrack, K.L., Hunter, W.N.		Authors: Barrack, K.L., Hunter, W.N.

	Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor		Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor

OCA: Protected "4clx" [edit=sysop:move=sysop]

2014-01-22T06:39:56Z

Protected "4clx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:39, 22 January 2014

OCA: New page: '''Unreleased structure''' The entry 4clx is ON HOLD Authors: Barrack, K.L., Hunter, W.N. Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in tern...

2014-01-22T06:39:56Z

New page: '''Unreleased structure''' The entry 4clx is ON HOLD Authors: Barrack, K.L., Hunter, W.N. Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in tern...

New page

'''Unreleased structure'''

The entry 4clx is ON HOLD

Authors: Barrack, K.L., Hunter, W.N.

Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor