4cng - Revision history

OCA at 12:13, 20 December 2023

2023-12-20T12:13:12Z

←Older revision		Revision as of 12:13, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CNG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CNG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [https://pdbe.org/4cng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [https://www.ebi.ac.uk/pdbsum/4cng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cng ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [https://pdbe.org/4cng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [https://www.ebi.ac.uk/pdbsum/4cng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cng ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRMJ_SULAC TRMJ_SULAC]] Catalyzes the formation of 2'O-methylated cytidine (Cm32) at position 32 in tRNA. Is specific for cytidine.<ref>PMID:24951554</ref>	+	[https://www.uniprot.org/uniprot/TRMJ_SULAC TRMJ_SULAC] Catalyzes the formation of 2'O-methylated cytidine (Cm32) at position 32 in tRNA. Is specific for cytidine.<ref>PMID:24951554</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:23, 14 September 2022

2022-09-14T07:23:26Z

←Older revision		Revision as of 07:23, 14 September 2022
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	<StructureSection load='4cng' size='340' side='right'caption='[[4cng]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4cng' size='340' side='right'caption='[[4cng]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_33909 Atcc 33909~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CNG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CNG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnd\|4cnd]], [[4cne\|4cne]], [[4cnf\|4cnf]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [https://pdbe.org/4cng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [https://www.ebi.ac.uk/pdbsum/4cng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cng ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytidine(32)/uridine(32)-2'-O)-methyltransferase tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.200 2.1.1.200] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [~~http~~://pdbe.org/4cng PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cng PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cng ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TRMJ_SULAC TRMJ_SULAC]] Catalyzes the formation of 2'O-methylated cytidine (Cm32) at position 32 in tRNA. Is specific for cytidine.<ref>PMID:24951554</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[TRNA methyltransferase\|TRNA methyltransferase]]	+	*[[TRNA methyltransferase 3D structures\|TRNA methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 33909]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Droogmans, L~~]]	+	[[Category: Sulfolobus acidocaldarius]]
-	[[Category: ~~Laer, B Van~~]]	+	[[Category: Droogmans L]]
-	[[Category: Roovers, M]]	+	[[Category: Roovers M]]
-	[[Category: Somme, J]]	+	[[Category: Somme J]]
-	[[Category: Steyaert, J]]	+	[[Category: Steyaert J]]
-	[[Category: ~~Versees, W~~]]	+	[[Category: Van Laer B]]
-	[[Category: ~~Spout]]~~	+	[[Category: Versees W]]
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Trna 2'-o-methyltransferase~~]]	+

OCA at 09:33, 20 March 2019

2019-03-20T09:33:17Z

←Older revision		Revision as of 09:33, 20 March 2019
Line 1:		Line 1:

	==Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adenosyl-L-Homocysteine==		==Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adenosyl-L-Homocysteine==
-	<StructureSection load='4cng' size='340' side='right' caption='[[4cng]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='4cng' size='340' side='right'caption='[[4cng]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CNG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33909 Atcc 33909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CNG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnd\|4cnd]], [[4cne\|4cne]], [[4cnf\|4cnf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnd\|4cnd]], [[4cne\|4cne]], [[4cnf\|4cnf]]</td></tr>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4cng" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cng" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TRNA methyltransferase\|TRNA methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 33909]]
		+	[[Category: Large Structures]]
	[[Category: Droogmans, L]]		[[Category: Droogmans, L]]
	[[Category: Laer, B Van]]		[[Category: Laer, B Van]]

OCA at 21:06, 11 August 2016

2016-08-11T21:06:53Z

←Older revision		Revision as of 21:06, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adenosyl-L-Homocysteine==		==Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adenosyl-L-Homocysteine==
	<StructureSection load='4cng' size='340' side='right' caption='[[4cng]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4cng' size='340' side='right' caption='[[4cng]], [[Resolution\|resolution]] 1.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnd\|4cnd]], [[4cne\|4cne]], [[4cnf\|4cnf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnd\|4cnd]], [[4cne\|4cne]], [[4cnf\|4cnf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytidine(32)/uridine(32)-2'-O)-methyltransferase tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.200 2.1.1.200] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytidine(32)/uridine(32)-2'-O)-methyltransferase tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.200 2.1.1.200] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [http://www.ebi.ac.uk/pdbsum/4cng PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [http://pdbe.org/4cng PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [http://www.ebi.ac.uk/pdbsum/4cng PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cng ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cng" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:56, 5 January 2015

2015-01-05T12:56:50Z

←Older revision		Revision as of 12:56, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CNG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CNG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnd\|4cnd]], [[4cne\|4cne]], [[4cnf\|4cnf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnd\|4cnd]], [[4cne\|4cne]], [[4cnf\|4cnf]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytidine(32)/uridine(32)-2'-O)-methyltransferase tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.200 2.1.1.200] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytidine(32)/uridine(32)-2'-O)-methyltransferase tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.200 2.1.1.200] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [http://www.ebi.ac.uk/pdbsum/4cng PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [http://www.ebi.ac.uk/pdbsum/4cng PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Droogmans, L.]]	+	[[Category: Droogmans, L]]
-	[[Category: Laer, B Van.]]	+	[[Category: Laer, B Van]]
-	[[Category: Roovers, M.]]	+	[[Category: Roovers, M]]
-	[[Category: Somme, J.]]	+	[[Category: Somme, J]]
-	[[Category: Steyaert, J.]]	+	[[Category: Steyaert, J]]
-	[[Category: Versees, W.]]	+	[[Category: Versees, W]]
	[[Category: Spout]]		[[Category: Spout]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Trna 2'-o-methyltransferase]]		[[Category: Trna 2'-o-methyltransferase]]

OCA at 08:31, 2 July 2014

2014-07-02T08:31:17Z

←Older revision		Revision as of 08:31, 2 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adenosyl-L-Homocysteine==
		+	<StructureSection load='4cng' size='340' side='right' caption='[[4cng]], [[Resolution\|resolution]] 1.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cng]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CNG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnd\|4cnd]], [[4cne\|4cne]], [[4cnf\|4cnf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytidine(32)/uridine(32)-2'-O)-methyltransferase tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.200 2.1.1.200] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cng RCSB], [http://www.ebi.ac.uk/pdbsum/4cng PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 2'-O-methylation of the nucleoside at position 32 of tRNA is found in organisms belonging to the three domains of life. Unrelated enzymes catalyzing this modification in Bacteria (TrmJ) and Eukarya (Trm7) have already been identified, but until now, no information is available for the archaeal enzyme. In this work we have identified the methyltransferase of the archaeon Sulfolobus acidocaldarius responsible for the 2'-O-methylation at position 32. This enzyme is a homolog of the bacterial TrmJ. Remarkably, both enzymes have different specificities for the nature of the nucleoside at position 32. While the four canonical nucleosides are substrates of the Escherichia coli enzyme, the archaeal TrmJ can only methylate the ribose of a cytidine. Moreover, the two enzymes recognize their tRNA substrates in a different way. We have solved the crystal structure of the catalytic domain of both enzymes to gain better understanding of these differences at a molecular level.

-	~~The entry 4cng is ON HOLD until Paper Publication~~	+	Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.,Somme J, Van Laer B, Roovers M, Steyaert J, Versees W, Droogmans L RNA. 2014 Jun 20. PMID:24951554<ref>PMID:24951554</ref>

-	~~Authors: Van Laer~~, B., ~~Somme, J~~., Roovers, M., Steyaert, J.~~, Droogmans, L.,~~ Versees, W.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S~~-~~adenosyl-L~~-~~Homocysteine~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Droogmans, L.]]
		+	[[Category: Laer, B Van.]]
		+	[[Category: Roovers, M.]]
		+	[[Category: Somme, J.]]
		+	[[Category: Steyaert, J.]]
		+	[[Category: Versees, W.]]
		+	[[Category: Spout]]
		+	[[Category: Transferase]]
		+	[[Category: Trna 2'-o-methyltransferase]]

OCA at 09:48, 5 February 2014

2014-02-05T09:48:15Z

←Older revision		Revision as of 09:48, 5 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cng is ON HOLD	+	The entry 4cng is ON HOLD until Paper Publication

	Authors: Van Laer, B., Somme, J., Roovers, M., Steyaert, J., Droogmans, L., Versees, W.		Authors: Van Laer, B., Somme, J., Roovers, M., Steyaert, J., Droogmans, L., Versees, W.

-	Description: Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-~~adensosylhomocysteine~~	+	Description: Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adenosyl-L-Homocysteine

OCA: Protected "4cng" [edit=sysop:move=sysop]

2014-01-29T06:46:52Z

Protected "4cng" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:46, 29 January 2014

OCA: New page: '''Unreleased structure''' The entry 4cng is ON HOLD Authors: Van Laer, B., Somme, J., Roovers, M., Steyaert, J., Droogmans, L., Versees, W. Description: Crystal structure of Sulfolobu...

2014-01-29T06:46:51Z

New page: '''Unreleased structure''' The entry 4cng is ON HOLD Authors: Van Laer, B., Somme, J., Roovers, M., Steyaert, J., Droogmans, L., Versees, W. Description: Crystal structure of Sulfolobu...

New page

'''Unreleased structure'''

The entry 4cng is ON HOLD

Authors: Van Laer, B., Somme, J., Roovers, M., Steyaert, J., Droogmans, L., Versees, W.

Description: Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adensosylhomocysteine