4cri - Revision history

OCA at 12:15, 20 December 2023

2023-12-20T12:15:22Z

←Older revision		Revision as of 12:15, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [https://pdbe.org/4cri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [https://www.ebi.ac.uk/pdbsum/4cri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [https://pdbe.org/4cri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [https://www.ebi.ac.uk/pdbsum/4cri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.	+	[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>	+	[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:29, 14 September 2022

2022-09-14T07:29:28Z

←Older revision		Revision as of 07:29, 14 September 2022
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	<StructureSection load='4cri' size='340' side='right'caption='[[4cri]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4cri' size='340' side='right'caption='[[4cri]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CRI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [~~http~~://pdbe.org/4cri PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cri PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [https://pdbe.org/4cri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [https://www.ebi.ac.uk/pdbsum/4cri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.	+	[[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>	+	[[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4cri" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cri" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Carr, S]]	+	[[Category: Carr S]]
-	[[Category: Crawley, L]]	+	[[Category: Crawley L]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Fedorov O]]
-	[[Category: Fedorov, O]]	+	[[Category: Gileadi C]]
-	[[Category: Gileadi, C]]	+	[[Category: Johansson C]]
-	[[Category: Johansson, C]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: La Thangue NB]]
-	[[Category: ~~Oppermann, U~~]]	+	[[Category: Oppermann U]]
-	[[Category: ~~Thangue, N B.La~~]]	+	[[Category: Vollmar M]]
-	[[Category: Vollmar, M]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Peptide binding protein]]~~	+
-	~~[[Category: Tumour suppressor prb~~]]	+

OCA at 08:46, 20 March 2019

2019-03-20T08:46:00Z

←Older revision		Revision as of 08:46, 20 March 2019
Line 1:		Line 1:

	==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==		==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==
-	<StructureSection load='4cri' size='340' side='right' caption='[[4cri]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='4cri' size='340' side='right'caption='[[4cri]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://pdbe.org/4cri PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://pdbe.org/4cri PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4cri" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cri" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 15:03, 11 August 2016

2016-08-11T15:03:04Z

←Older revision		Revision as of 15:03, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==		==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==
	<StructureSection load='4cri' size='340' side='right' caption='[[4cri]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4cri' size='340' side='right' caption='[[4cri]], [[Resolution\|resolution]] 2.35Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://pdbe.org/4cri PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cri ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cri" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:11, 5 January 2015

2015-01-05T14:11:31Z

←Older revision		Revision as of 14:11, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.		[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Carr, S.]]	+	[[Category: Carr, S]]
-	[[Category: Crawley, L.]]	+	[[Category: Crawley, L]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Fedorov, O.]]	+	[[Category: Fedorov, O]]
-	[[Category: Gileadi, C.]]	+	[[Category: Gileadi, C]]
-	[[Category: Johansson, C.]]	+	[[Category: Johansson, C]]
-	[[Category: Krojer, T.]]	+	[[Category: Krojer, T]]
-	[[Category: Oppermann, U.]]	+	[[Category: Oppermann, U]]
-	[[Category: Thangue, N B.La.]]	+	[[Category: Thangue, N B.La]]
-	[[Category: Vollmar, M~~.]]~~	+	[[Category: Vollmar, M]]
-	~~[[Category: 53bp1~~]]	+
	[[Category: Peptide binding protein]]		[[Category: Peptide binding protein]]
	[[Category: Tumour suppressor prb]]		[[Category: Tumour suppressor prb]]

OCA at 02:23, 7 August 2014

2014-08-07T02:23:29Z

←Older revision		Revision as of 02:23, 7 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide==
		+	<StructureSection load='4cri' size='340' side='right' caption='[[4cri]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cri]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cri OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cri RCSB], [http://www.ebi.ac.uk/pdbsum/4cri PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphorylated growth-suppressing state. We show here that methyl K810 is read by the tandem tudor domain containing tumor protein p53 binding protein 1 (53BP1). Structural elucidation of 53BP1 in complex with a methylated K810 pRb peptide emphasized the role of the 53BP1 tandem tudor domain in recognition of the methylated lysine and surrounding residues. Significantly, binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor target genes and allows pRb activity to be effectively integrated with the DNA damage response. Our results widen the repertoire of cellular targets for 53BP1 and suggest a previously unidentified role for 53BP1 in regulating pRb tumor suppressor activity.

-	~~The entry 4cri is ON HOLD until Paper Publication~~	+	Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.,Carr SM, Munro S, Zalmas LP, Fedorov O, Johansson C, Krojer T, Sagum CA, Bedford MT, Oppermann U, La Thangue NB Proc Natl Acad Sci U S A. 2014 Jul 21. pii: 201403737. PMID:25049398<ref>PMID:25049398</ref>

-	~~Authors: Krojer~~, T.~~, Johansson, C~~.~~, Fedorov, O~~.~~, Tallant~~, C., ~~Canning, P~~., ~~Kopec, J~~., Crawley, L.~~, Vollmar, M., von~~ Delft, F.~~, Arrowsmith, C.H.,~~ Edwards, A., ~~Bountra~~, C., Oppermann, U.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Carr, S.]]
		+	[[Category: Crawley, L.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A.]]
		+	[[Category: Fedorov, O.]]
		+	[[Category: Gileadi, C.]]
		+	[[Category: Johansson, C.]]
		+	[[Category: Krojer, T.]]
		+	[[Category: Oppermann, U.]]
		+	[[Category: Thangue, N B.La.]]
		+	[[Category: Vollmar, M.]]
		+	[[Category: 53bp1]]
		+	[[Category: Peptide binding protein]]
		+	[[Category: Tumour suppressor prb]]

OCA at 08:26, 26 March 2014

2014-03-26T08:26:34Z

←Older revision		Revision as of 08:26, 26 March 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cri is ON HOLD	+	The entry 4cri is ON HOLD until Paper Publication

-	Authors: Krojer, T., Johansson, C., Fedorov, O., Arrowsmith, C.H., Edwards, A., Bountra, C.	+	Authors: Krojer, T., Johansson, C., Fedorov, O., Tallant, C., Canning, P., Kopec, J., Crawley, L., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Oppermann, U.

	Description: Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide		Description: Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide

OCA: Protected "4cri" [edit=sysop:move=sysop]

2014-03-12T11:48:07Z

Protected "4cri" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:48, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 4cri is ON HOLD Authors: Krojer, T., Johansson, C., Fedorov, O., Arrowsmith, C.H., Edwards, A., Bountra, C. Description: Crystal Structure of 53BP1...

2014-03-12T11:48:05Z

New page: '''Unreleased structure''' The entry 4cri is ON HOLD Authors: Krojer, T., Johansson, C., Fedorov, O., Arrowsmith, C.H., Edwards, A., Bountra, C. Description: Crystal Structure of 53BP1...

New page

'''Unreleased structure'''

The entry 4cri is ON HOLD

Authors: Krojer, T., Johansson, C., Fedorov, O., Arrowsmith, C.H., Edwards, A., Bountra, C.

Description: Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide