4cud - Revision history

OCA at 12:16, 20 December 2023

2023-12-20T12:16:31Z

←Older revision		Revision as of 12:16, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CUD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [https://pdbe.org/4cud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [https://www.ebi.ac.uk/pdbsum/4cud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cud ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [https://pdbe.org/4cud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [https://www.ebi.ac.uk/pdbsum/4cud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cud ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:[https://omim.org/entry/109730 109730]]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.<ref>PMID:16025100</ref>	+	[https://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN] Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:[https://omim.org/entry/109730 109730]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.<ref>PMID:16025100</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity).	+	[https://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:33, 14 September 2022

2022-09-14T07:33:32Z

←Older revision		Revision as of 07:33, 14 September 2022
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	<StructureSection load='4cud' size='340' side='right'caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4cud' size='340' side='right'caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CUD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cue\|4cue]], [[4cuf\|4cuf]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [https://pdbe.org/4cud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [https://www.ebi.ac.uk/pdbsum/4cud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cud ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [~~http~~://pdbe.org/4cud PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cud PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cud ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:[~~http~~://omim.org/entry/109730 109730]]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.<ref>PMID:16025100</ref>	+	[[https://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:[https://omim.org/entry/109730 109730]]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.<ref>PMID:16025100</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity).	+	[[https://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chillakuri, C]]	+	[[Category: Chillakuri C]]
-	[[Category: Haltiwanger~~, R S~~]]	+	[[Category: Haltiwanger RS]]
-	[[Category: Handford~~, P A~~]]	+	[[Category: Handford PA]]
-	[[Category: Lea~~, S M~~]]	+	[[Category: Lea SM]]
-	[[Category: Sheppard, D]]	+	[[Category: Sheppard D]]
-	[[Category: Takeuchi, H]]	+	[[Category: Takeuchi H]]
-	[[Category: Taylor, P]]	+	[[Category: Taylor P]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Ank repeat]]~~	+
-	~~[[Category: Developmental]]~~	+
-	~~[[Category: Differentiation]]~~	+
-	~~[[Category: Egf]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Extracellular]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Jagged]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Notch signaling pathway]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Protein]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Regulation]]~~	+
-	~~[[Category: Signalling]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 10:00, 5 February 2020

2020-02-05T10:00:54Z

←Older revision		Revision as of 10:00, 5 February 2020
Line 1:		Line 1:

	==Human Notch1 EGF domains 11-13 mutant fucosylated at T466==		==Human Notch1 EGF domains 11-13 mutant fucosylated at T466==
-	<StructureSection load='4cud' size='340' side='right' caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4cud' size='340' side='right'caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CUD FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chillakuri, C]]		[[Category: Chillakuri, C]]
	[[Category: Haltiwanger, R S]]		[[Category: Haltiwanger, R S]]

OCA at 06:35, 7 February 2018

2018-02-07T06:35:25Z

←Older revision		Revision as of 06:35, 7 February 2018
Line 3:		Line 3:
	<StructureSection load='4cud' size='340' side='right' caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4cud' size='340' side='right' caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CUD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cue\|4cue]], [[4cuf\|4cuf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cue\|4cue]], [[4cuf\|4cuf]]</td></tr>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chillakuri, C]]		[[Category: Chillakuri, C]]
-	[[Category: Haltiwanger, R]]	+	[[Category: Haltiwanger, R S]]
-	[[Category: Handford, P]]	+	[[Category: Handford, P A]]
-	[[Category: Lea, S]]	+	[[Category: Lea, S M]]
	[[Category: Sheppard, D]]		[[Category: Sheppard, D]]
	[[Category: Takeuchi, H]]		[[Category: Takeuchi, H]]

OCA at 10:37, 11 August 2016

2016-08-11T10:37:29Z

←Older revision		Revision as of 10:37, 11 August 2016
Line 1:		Line 1:
		+
	==Human Notch1 EGF domains 11-13 mutant fucosylated at T466==		==Human Notch1 EGF domains 11-13 mutant fucosylated at T466==
	<StructureSection load='4cud' size='340' side='right' caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4cud' size='340' side='right' caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cue\|4cue]], [[4cuf\|4cuf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cue\|4cue]], [[4cuf\|4cuf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [http://www.ebi.ac.uk/pdbsum/4cud PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [http://pdbe.org/4cud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [http://www.ebi.ac.uk/pdbsum/4cud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cud ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cud" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:31, 4 January 2015

2015-01-04T14:31:00Z

←Older revision		Revision as of 14:31, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CUD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cue\|4cue]], [[4cuf\|4cuf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cue\|4cue]], [[4cuf\|4cuf]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [http://www.ebi.ac.uk/pdbsum/4cud PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [http://www.ebi.ac.uk/pdbsum/4cud PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:[http://omim.org/entry/109730 109730]]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.<ref>PMID:16025100</ref>		[[http://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:[http://omim.org/entry/109730 109730]]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.<ref>PMID:16025100</ref>
Line 17:		Line 17:
	Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.,Taylor P, Takeuchi H, Sheppard D, Chillakuri C, Lea SM, Haltiwanger RS, Handford PA Proc Natl Acad Sci U S A. 2014 May 6. PMID:24803430<ref>PMID:24803430</ref>		Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.,Taylor P, Takeuchi H, Sheppard D, Chillakuri C, Lea SM, Haltiwanger RS, Handford PA Proc Natl Acad Sci U S A. 2014 May 6. PMID:24803430<ref>PMID:24803430</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chillakuri, C.]]	+	[[Category: Chillakuri, C]]
-	[[Category: Haltiwanger, R.]]	+	[[Category: Haltiwanger, R]]
-	[[Category: Handford, P.]]	+	[[Category: Handford, P]]
-	[[Category: Lea, S.]]	+	[[Category: Lea, S]]
-	[[Category: Sheppard, D.]]	+	[[Category: Sheppard, D]]
-	[[Category: Takeuchi, H.]]	+	[[Category: Takeuchi, H]]
-	[[Category: Taylor, P.]]	+	[[Category: Taylor, P]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]

OCA at 09:06, 21 May 2014

2014-05-21T09:06:32Z

←Older revision		Revision as of 09:06, 21 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Human Notch1 EGF domains 11-13 mutant fucosylated at T466==
		+	<StructureSection load='4cud' size='340' side='right' caption='[[4cud]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cud]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CUD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cue\|4cue]], [[4cuf\|4cuf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cud RCSB], [http://www.ebi.ac.uk/pdbsum/4cud PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:[http://omim.org/entry/109730 109730]]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.<ref>PMID:16025100</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Notch signaling pathway is essential for many aspects of development, cell fate determination, and tissue homeostasis. Notch signaling can be modulated by posttranslational modifications to the Notch receptor, which are known to alter both ligand binding and receptor activation. We have modified the ligand-binding region (EGF domains 11-13) of human Notch1 (hN1) with O-fucose and O-glucose glycans and shown by flow cytometry and surface plasmon resonance that the Fringe-catalyzed addition of GlcNAc to the O-fucose at T466 in EGF12 substantially increases binding to Jagged1 and Delta-like 1 (DLL1) ligands. We have subsequently determined the crystal structures of EGF domains 11-13 of hN1 modified with either the O-fucose monosaccharide or the GlcNAc-fucose disaccharide at T466 of EGF12 and observed no change in backbone structure for each variant. Collectively, these data demonstrate a role for GlcNAc in modulating the ligand-binding site in hN1 EGF12, resulting in an increased affinity of this region for ligands Jagged1 and DLL1. We propose that this finding explains the Fringe-catalyzed enhancement of Notch-Delta signaling observed in flies and humans, but suggest that the inhibitory effect of Fringe on Jagged/Serrate mediated signaling involves other regions of Notch.

-	~~The entry 4cud is ON HOLD~~	+	Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.,Taylor P, Takeuchi H, Sheppard D, Chillakuri C, Lea SM, Haltiwanger RS, Handford PA Proc Natl Acad Sci U S A. 2014 May 6. PMID:24803430<ref>PMID:24803430</ref>

-	~~Authors: Taylor~~, P.~~, Takeuchi, H~~.~~, Sheppard, D~~., Chillakuri, C., Lea, S., ~~Haltiwanger~~, R.~~, Handford~~, P.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Human Notch1 EGF domains 11~~-~~13 mutant fucosylated at T466~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chillakuri, C.]]
		+	[[Category: Haltiwanger, R.]]
		+	[[Category: Handford, P.]]
		+	[[Category: Lea, S.]]
		+	[[Category: Sheppard, D.]]
		+	[[Category: Takeuchi, H.]]
		+	[[Category: Taylor, P.]]
		+	[[Category: Activator]]
		+	[[Category: Ank repeat]]
		+	[[Category: Developmental]]
		+	[[Category: Differentiation]]
		+	[[Category: Egf]]
		+	[[Category: Egf-like domain]]
		+	[[Category: Extracellular]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Jagged]]
		+	[[Category: Membrane]]
		+	[[Category: Metal-binding]]
		+	[[Category: Notch signaling pathway]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphorylation]]
		+	[[Category: Protein]]
		+	[[Category: Receptor]]
		+	[[Category: Regulation]]
		+	[[Category: Signalling]]
		+	[[Category: Transcription]]
		+	[[Category: Transmembrane]]

OCA at 07:21, 7 May 2014

2014-05-07T07:21:33Z

←Older revision		Revision as of 07:21, 7 May 2014
Line 5:		Line 5:
	Authors: Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S., Haltiwanger, R., Handford, P.		Authors: Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S., Haltiwanger, R., Handford, P.

-	Description: Human ~~Notch-1 EGFS~~ 11-13 ~~Fucose~~	+	Description: Human Notch1 EGF domains 11-13 mutant fucosylated at T466

OCA: Protected "4cud" [edit=sysop:move=sysop]

2014-03-26T08:28:45Z

Protected "4cud" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:28, 26 March 2014

OCA: New page: '''Unreleased structure''' The entry 4cud is ON HOLD Authors: Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S., Haltiwanger, R., Handford, P. Description: Human Notch-1 ...

2014-03-26T08:28:44Z

New page: '''Unreleased structure''' The entry 4cud is ON HOLD Authors: Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S., Haltiwanger, R., Handford, P. Description: Human Notch-1 ...

New page

'''Unreleased structure'''

The entry 4cud is ON HOLD

Authors: Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S., Haltiwanger, R., Handford, P.

Description: Human Notch-1 EGFS 11-13 Fucose