4cvn - Revision history

OCA at 11:15, 9 May 2024

2024-05-09T11:15:18Z

←Older revision		Revision as of 11:15, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CVN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CVN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.121Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [https://pdbe.org/4cvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [https://www.ebi.ac.uk/pdbsum/4cvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cvn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [https://pdbe.org/4cvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [https://www.ebi.ac.uk/pdbsum/4cvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cvn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KAD6_PYRAB KAD6_PYRAB]] Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates (By similarity).	+	[https://www.uniprot.org/uniprot/KAD6_PYRAB KAD6_PYRAB] Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:34, 14 September 2022

2022-09-14T07:34:42Z

←Older revision		Revision as of 07:34, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4cvn' size='340' side='right'caption='[[4cvn]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='4cvn' size='340' side='right'caption='[[4cvn]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pyrab Pyrab~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CVN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cw7\|4cw7]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [https://pdbe.org/4cvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [https://www.ebi.ac.uk/pdbsum/4cvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cvn ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [~~http~~://pdbe.org/4cvn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cvn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cvn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KAD6_PYRAB KAD6_PYRAB]] Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates ~~(By similarity). [[http://www.uniprot.org/uniprot/RS11_PYRAB RS11_PYRAB]] Located on the platform of the 30S subunit~~ (By similarity).	+	[[https://www.uniprot.org/uniprot/KAD6_PYRAB KAD6_PYRAB]] Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adenylate kinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pyrab~~]]	+	[[Category: Pyrococcus abyssi GE5]]
-	[[Category: Bareille, J]]	+	[[Category: Bareille J]]
-	[[Category: Blaud, M]]	+	[[Category: Blaud M]]
-	[[Category: Chardon, F]]	+	[[Category: Chardon F]]
-	[[Category: Charenton, C]]	+	[[Category: Charenton C]]
-	[[Category: Delbos, L]]	+	[[Category: Delbos L]]
-	[[Category: Deschamps, P]]	+	[[Category: Deschamps P]]
-	[[Category: Jombart, J]]	+	[[Category: Jombart J]]
-	[[Category: Lebaron, S]]	+	[[Category: Lebaron S]]
-	[[Category: Leulliot, N]]	+	[[Category: Leulliot N]]
-	[[Category: Loch, J]]	+	[[Category: Loch J]]
-	[[Category: Rety, S]]	+	[[Category: Rety S]]
-	[[Category: Robert-Paganin, J]]	+	[[Category: Robert-Paganin J]]
-	[[Category: Tollervey, D]]	+	[[Category: Tollervey D]]
-	[[Category: Zhang, E]]	+	[[Category: Zhang E]]
-	~~[[Category: Ribosome biogenesis]]~~	+
-	~~[[Category: Rnp assembly]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:24, 20 March 2019

2019-03-20T09:24:42Z

←Older revision		Revision as of 09:24, 20 March 2019
Line 1:		Line 1:

	==Structure of the Fap7-Rps14 complex==		==Structure of the Fap7-Rps14 complex==
-	<StructureSection load='4cvn' size='340' side='right' caption='[[4cvn]], [[Resolution\|resolution]] 2.12Å' scene=''>	+	<StructureSection load='4cvn' size='340' side='right'caption='[[4cvn]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrab Pyrab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cw7\|4cw7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cw7\|4cw7]]</td></tr>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Adenylate kinase]]		[[Category: Adenylate kinase]]
		+	[[Category: Large Structures]]
		+	[[Category: Pyrab]]
	[[Category: Bareille, J]]		[[Category: Bareille, J]]
	[[Category: Blaud, M]]		[[Category: Blaud, M]]

OCA at 09:04, 4 August 2016

2016-08-04T09:04:59Z

←Older revision		Revision as of 09:04, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of the Fap7-Rps14 complex==		==Structure of the Fap7-Rps14 complex==
	<StructureSection load='4cvn' size='340' side='right' caption='[[4cvn]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='4cvn' size='340' side='right' caption='[[4cvn]], [[Resolution\|resolution]] 2.12Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cw7\|4cw7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cw7\|4cw7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [http://www.ebi.ac.uk/pdbsum/4cvn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [http://pdbe.org/4cvn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [http://www.ebi.ac.uk/pdbsum/4cvn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cvn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cvn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosomal protein S11\|Ribosomal protein S11]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:00, 24 December 2014

2014-12-24T08:00:58Z

←Older revision		Revision as of 08:00, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cw7\|4cw7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cw7\|4cw7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [http://www.ebi.ac.uk/pdbsum/4cvn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [http://www.ebi.ac.uk/pdbsum/4cvn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAD6_PYRAB KAD6_PYRAB]] Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates (By similarity). [[http://www.uniprot.org/uniprot/RS11_PYRAB RS11_PYRAB]] Located on the platform of the 30S subunit (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis.,Loc'h J, Blaud M, Rety S, Lebaron S, Deschamps P, Bareille J, Jombart J, Robert-Paganin J, Delbos L, Chardon F, Zhang E, Charenton C, Tollervey D, Leulliot N PLoS Biol. 2014 May 13;12(5):e1001860. doi: 10.1371/journal.pbio.1001860., eCollection 2014 May. PMID:24823650<ref>PMID:24823650</ref>		RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis.,Loc'h J, Blaud M, Rety S, Lebaron S, Deschamps P, Bareille J, Jombart J, Robert-Paganin J, Delbos L, Chardon F, Zhang E, Charenton C, Tollervey D, Leulliot N PLoS Biol. 2014 May 13;12(5):e1001860. doi: 10.1371/journal.pbio.1001860., eCollection 2014 May. PMID:24823650<ref>PMID:24823650</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Adenylate kinase]]		[[Category: Adenylate kinase]]
-	[[Category: Bareille, J.]]	+	[[Category: Bareille, J]]
-	[[Category: Blaud, M.]]	+	[[Category: Blaud, M]]
-	[[Category: Chardon, F.]]	+	[[Category: Chardon, F]]
-	[[Category: Charenton, C.]]	+	[[Category: Charenton, C]]
-	[[Category: Delbos, L.]]	+	[[Category: Delbos, L]]
-	[[Category: Deschamps, P.]]	+	[[Category: Deschamps, P]]
-	[[Category: Jombart, J.]]	+	[[Category: Jombart, J]]
-	[[Category: Lebaron, S.]]	+	[[Category: Lebaron, S]]
-	[[Category: Leulliot, N.]]	+	[[Category: Leulliot, N]]
-	[[Category: Loch, J.]]	+	[[Category: Loch, J]]
-	[[Category: Rety, S.]]	+	[[Category: Rety, S]]
-	[[Category: Robert-Paganin, J.]]	+	[[Category: Robert-Paganin, J]]
-	[[Category: Tollervey, D.]]	+	[[Category: Tollervey, D]]
-	[[Category: Zhang, E.]]	+	[[Category: Zhang, E]]
	[[Category: Ribosome biogenesis]]		[[Category: Ribosome biogenesis]]
	[[Category: Rnp assembly]]		[[Category: Rnp assembly]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:35, 28 May 2014

2014-05-28T09:35:01Z

←Older revision		Revision as of 09:35, 28 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of the Fap7-Rps14 complex==
		+	<StructureSection load='4cvn' size='340' side='right' caption='[[4cvn]], [[Resolution\|resolution]] 2.12Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cvn]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cw7\|4cw7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cvn RCSB], [http://www.ebi.ac.uk/pdbsum/4cvn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	During biogenesis of the 40S and 60S ribosomal subunits, the pre-40S particles are exported to the cytoplasm prior to final cleavage of the 20S pre-rRNA to mature 18S rRNA. Amongst the factors involved in this maturation step, Fap7 is unusual, as it both interacts with ribosomal protein Rps14 and harbors adenylate kinase activity, a function not usually associated with ribonucleoprotein assembly. Human hFap7 also regulates Cajal body assembly and cell cycle progression via the p53-MDM2 pathway. This work presents the functional and structural characterization of the Fap7-Rps14 complex. We report that Fap7 association blocks the RNA binding surface of Rps14 and, conversely, Rps14 binding inhibits adenylate kinase activity of Fap7. In addition, the affinity of Fap7 for Rps14 is higher with bound ADP, whereas ATP hydrolysis dissociates the complex. These results suggest that Fap7 chaperones Rps14 assembly into pre-40S particles via RNA mimicry in an ATP-dependent manner. Incorporation of Rps14 by Fap7 leads to a structural rearrangement of the platform domain necessary for the pre-rRNA to acquire a cleavage competent conformation.

-	~~The entry 4cvn is ON HOLD~~	+	RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis.,Loc'h J, Blaud M, Rety S, Lebaron S, Deschamps P, Bareille J, Jombart J, Robert-Paganin J, Delbos L, Chardon F, Zhang E, Charenton C, Tollervey D, Leulliot N PLoS Biol. 2014 May 13;12(5):e1001860. doi: 10.1371/journal.pbio.1001860., eCollection 2014 May. PMID:24823650<ref>PMID:24823650</ref>

-	~~Authors~~: ~~Loch~~, J., Blaud, M., ~~Rety, S~~., ~~Lebaron, S~~., Deschamps, P.~~, Bareille~~, J., ~~Jombart~~, J., Robert-Paganin, J., ~~Delbos, L~~.~~, Chardon, F.,~~ Zhang, E.~~, Charenton, C., Tollervey, D., Leulliot, N.~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of the Fap7-Rps14 complex~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adenylate kinase]]
		+	[[Category: Bareille, J.]]
		+	[[Category: Blaud, M.]]
		+	[[Category: Chardon, F.]]
		+	[[Category: Charenton, C.]]
		+	[[Category: Delbos, L.]]
		+	[[Category: Deschamps, P.]]
		+	[[Category: Jombart, J.]]
		+	[[Category: Lebaron, S.]]
		+	[[Category: Leulliot, N.]]
		+	[[Category: Loch, J.]]
		+	[[Category: Rety, S.]]
		+	[[Category: Robert-Paganin, J.]]
		+	[[Category: Tollervey, D.]]
		+	[[Category: Zhang, E.]]
		+	[[Category: Ribosome biogenesis]]
		+	[[Category: Rnp assembly]]
		+	[[Category: Transferase]]

OCA at 05:36, 9 April 2014

2014-04-09T05:36:32Z

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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cvn is ON HOLD ~~until sometime in the future~~	+	The entry 4cvn is ON HOLD

	Authors: Loch, J., Blaud, M., Rety, S., Lebaron, S., Deschamps, P., Bareille, J., Jombart, J., Robert-Paganin, J., Delbos, L., Chardon, F., Zhang, E., Charenton, C., Tollervey, D., Leulliot, N.		Authors: Loch, J., Blaud, M., Rety, S., Lebaron, S., Deschamps, P., Bareille, J., Jombart, J., Robert-Paganin, J., Delbos, L., Chardon, F., Zhang, E., Charenton, C., Tollervey, D., Leulliot, N.

	Description: Structure of the Fap7-Rps14 complex		Description: Structure of the Fap7-Rps14 complex

OCA: Protected "4cvn" [edit=sysop:move=sysop]

2014-04-02T08:13:38Z

Protected "4cvn" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:13, 2 April 2014

OCA: New page: '''Unreleased structure''' The entry 4cvn is ON HOLD until sometime in the future Authors: Loch, J., Blaud, M., Rety, S., Lebaron, S., Deschamps, P., Bareille, J., Jombart, J., Robert-P...

2014-04-02T08:13:37Z

New page: '''Unreleased structure''' The entry 4cvn is ON HOLD until sometime in the future Authors: Loch, J., Blaud, M., Rety, S., Lebaron, S., Deschamps, P., Bareille, J., Jombart, J., Robert-P...

New page

'''Unreleased structure'''

The entry 4cvn is ON HOLD until sometime in the future

Authors: Loch, J., Blaud, M., Rety, S., Lebaron, S., Deschamps, P., Bareille, J., Jombart, J., Robert-Paganin, J., Delbos, L., Chardon, F., Zhang, E., Charenton, C., Tollervey, D., Leulliot, N.

Description: Structure of the Fap7-Rps14 complex