4cwp - Revision history

OCA at 11:15, 9 May 2024

2024-05-09T11:15:31Z

←Older revision		Revision as of 11:15, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [https://pdbe.org/4cwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [https://www.ebi.ac.uk/pdbsum/4cwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [https://pdbe.org/4cwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [https://www.ebi.ac.uk/pdbsum/4cwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:36, 14 September 2022

2022-09-14T07:36:25Z

←Older revision		Revision as of 07:36, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4cwp' size='340' side='right'caption='[[4cwp]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4cwp' size='340' side='right'caption='[[4cwp]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CWP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cwf\|4cwf]], [[4cwn\|4cwn]], [[4cwo\|4cwo]], [[4cwq\|4cwq]], [[4cwr\|4cwr]], [[4cws\|4cws]], [[4cwt\|4cwt]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [https://pdbe.org/4cwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [https://www.ebi.ac.uk/pdbsum/4cwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwp ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [~~http~~://pdbe.org/4cwp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cwp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwp ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amboldi, N]]	+	[[Category: Amboldi N]]
-	[[Category: Brasca, G]]	+	[[Category: Brasca G]]
-	[[Category: Caronni, D]]	+	[[Category: Caronni D]]
-	[[Category: Casale, E]]	+	[[Category: Casale E]]
-	[[Category: Casuscelli, F]]	+	[[Category: Casuscelli F]]
-	[[Category: Colombo, N]]	+	[[Category: Colombo N]]
-	[[Category: Dalvit, C]]	+	[[Category: Dalvit C]]
-	[[Category: Felder~~, E R~~]]	+	[[Category: Felder ER]]
-	[[Category: Fogliatto, G]]	+	[[Category: Fogliatto G]]
-	[[Category: Isacchi, A]]	+	[[Category: Isacchi A]]
-	[[Category: Mantegani, S]]	+	[[Category: Mantegani S]]
-	[[Category: Polucci, P]]	+	[[Category: Polucci P]]
-	[[Category: Riceputi, L]]	+	[[Category: Riceputi L]]
-	[[Category: Sola, F]]	+	[[Category: Sola F]]
-	[[Category: Visco, C]]	+	[[Category: Visco C]]
-	[[Category: Zuccotto, F]]	+	[[Category: Zuccotto F]]
-	~~[[Category: Chaperone~~]]	+

OCA at 18:11, 14 August 2019

2019-08-14T18:11:20Z

←Older revision		Revision as of 18:11, 14 August 2019
Line 1:		Line 1:

	==Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor==		==Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor==
-	<StructureSection load='4cwp' size='340' side='right' caption='[[4cwp]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4cwp' size='340' side='right'caption='[[4cwp]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWP FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4cwp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cwp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Amboldi, N]]		[[Category: Amboldi, N]]
	[[Category: Brasca, G]]		[[Category: Brasca, G]]

OCA at 12:33, 6 November 2017

2017-11-06T12:33:34Z

←Older revision		Revision as of 12:33, 6 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4cwp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cwp" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:28, 5 August 2016

2016-08-05T11:28:17Z

←Older revision		Revision as of 11:28, 5 August 2016
Line 1:		Line 1:
		+
	==Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor==		==Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor==
	<StructureSection load='4cwp' size='340' side='right' caption='[[4cwp]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4cwp' size='340' side='right' caption='[[4cwp]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cwf\|4cwf]], [[4cwn\|4cwn]], [[4cwo\|4cwo]], [[4cwq\|4cwq]], [[4cwr\|4cwr]], [[4cws\|4cws]], [[4cwt\|4cwt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cwf\|4cwf]], [[4cwn\|4cwn]], [[4cwo\|4cwo]], [[4cwq\|4cwq]], [[4cwr\|4cwr]], [[4cws\|4cws]], [[4cwt\|4cwt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [http://www.ebi.ac.uk/pdbsum/4cwp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [http://pdbe.org/4cwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [http://www.ebi.ac.uk/pdbsum/4cwp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cwp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:26, 25 December 2014

2014-12-25T18:26:42Z

←Older revision		Revision as of 18:26, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cwf\|4cwf]], [[4cwn\|4cwn]], [[4cwo\|4cwo]], [[4cwq\|4cwq]], [[4cwr\|4cwr]], [[4cws\|4cws]], [[4cwt\|4cwt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cwf\|4cwf]], [[4cwn\|4cwn]], [[4cwo\|4cwo]], [[4cwq\|4cwq]], [[4cwr\|4cwr]], [[4cws\|4cws]], [[4cwt\|4cwt]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [http://www.ebi.ac.uk/pdbsum/4cwp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [http://www.ebi.ac.uk/pdbsum/4cwp PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Amboldi, N.]]	+	[[Category: Amboldi, N]]
-	[[Category: Brasca, G.]]	+	[[Category: Brasca, G]]
-	[[Category: Caronni, D.]]	+	[[Category: Caronni, D]]
-	[[Category: Casale, E.]]	+	[[Category: Casale, E]]
-	[[Category: Casuscelli, F.]]	+	[[Category: Casuscelli, F]]
-	[[Category: Colombo, N.]]	+	[[Category: Colombo, N]]
-	[[Category: Dalvit, C.]]	+	[[Category: Dalvit, C]]
-	[[Category: Felder, E R.]]	+	[[Category: Felder, E R]]
-	[[Category: Fogliatto, G.]]	+	[[Category: Fogliatto, G]]
-	[[Category: Isacchi, A.]]	+	[[Category: Isacchi, A]]
-	[[Category: Mantegani, S.]]	+	[[Category: Mantegani, S]]
-	[[Category: Polucci, P.]]	+	[[Category: Polucci, P]]
-	[[Category: Riceputi, L.]]	+	[[Category: Riceputi, L]]
-	[[Category: Sola, F.]]	+	[[Category: Sola, F]]
-	[[Category: Visco, C.]]	+	[[Category: Visco, C]]
-	[[Category: Zuccotto, F.]]	+	[[Category: Zuccotto, F]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 07:19, 9 July 2014

2014-07-09T07:19:19Z

←Older revision		Revision as of 07:19, 9 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor==
		+	<StructureSection load='4cwp' size='340' side='right' caption='[[4cwp]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TV2:5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>TV2</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cwf\|4cwf]], [[4cwn\|4cwn]], [[4cwo\|4cwo]], [[4cwq\|4cwq]], [[4cwr\|4cwr]], [[4cws\|4cws]], [[4cwt\|4cwt]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwp RCSB], [http://www.ebi.ac.uk/pdbsum/4cwp PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the last decade the heat shock protein 90 (Hsp90) has emerged as a major therapeutic target and many efforts have been dedicated to the discovery of Hsp90 inhibitors as new potent anticancer agents. Here we report the identification of a novel class of Hsp90 inhibitors by means of a biophysical FAXS-NMR based screening of a library of fragments. The use of X-ray structure information combined with modeling studies enabled the fragment evolution of the initial triazoloquinazoline hit to a class of compounds with nanomolar potency and drug-like properties suited for further lead optimization.

-	~~The entry 4cwp is ON HOLD until Paper Publication~~	+	Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.,Casale E, Amboldi N, Brasca MG, Caronni D, Colombo N, Dalvit C, Felder ER, Fogliatto G, Galvani A, Isacchi A, Polucci P, Riceputi L, Sola F, Visco C, Zuccotto F, Casuscelli F Bioorg Med Chem. 2014 Jun 14. pii: S0968-0896(14)00415-5. doi:, 10.1016/j.bmc.2014.05.056. PMID:24980703<ref>PMID:24980703</ref>

-	~~Authors: Casale~~, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F.~~, Casuscelli, F.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Amboldi, N.]]
		+	[[Category: Brasca, G.]]
		+	[[Category: Caronni, D.]]
		+	[[Category: Casale, E.]]
		+	[[Category: Casuscelli, F.]]
		+	[[Category: Colombo, N.]]
		+	[[Category: Dalvit, C.]]
		+	[[Category: Felder, E R.]]
		+	[[Category: Fogliatto, G.]]
		+	[[Category: Isacchi, A.]]
		+	[[Category: Mantegani, S.]]
		+	[[Category: Polucci, P.]]
		+	[[Category: Riceputi, L.]]
		+	[[Category: Sola, F.]]
		+	[[Category: Visco, C.]]
		+	[[Category: Zuccotto, F.]]
		+	[[Category: Chaperone]]

OCA at 07:05, 23 April 2014

2014-04-23T07:05:01Z

←Older revision		Revision as of 07:05, 23 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cwp is ON HOLD	+	The entry 4cwp is ON HOLD until Paper Publication

	Authors: Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.		Authors: Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.

	Description: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor		Description: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor

OCA at 08:45, 16 April 2014

2014-04-16T08:45:41Z

←Older revision		Revision as of 08:45, 16 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cwp is ON HOLD ~~until sometime in the future~~	+	The entry 4cwp is ON HOLD

	Authors: Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.		Authors: Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.

	Description: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor		Description: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor

OCA: Protected "4cwp" [edit=sysop:move=sysop]

2014-04-09T05:37:30Z

Protected "4cwp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 9 April 2014