4d38 - Revision history

OCA at 07:45, 14 September 2022

2022-09-14T07:45:14Z

←Older revision		Revision as of 07:45, 14 September 2022
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	<StructureSection load='4d38' size='340' side='right'caption='[[4d38]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4d38' size='340' side='right'caption='[[4d38]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d38]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D38 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d38]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D38 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=L5Z:(1R,2R)-2-(3-FLUOROBENZYL)-N-{2-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]ETHYL}CYCLOPROPANAMINE'>L5Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=L5Z:(1R,2R)-2-(3-FLUOROBENZYL)-N-{2-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]ETHYL}CYCLOPROPANAMINE'>L5Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d38 OCA], [https://pdbe.org/4d38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d38 RCSB], [https://www.ebi.ac.uk/pdbsum/4d38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d38 ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d2y\|4d2y]], [[4d2z\|4d2z]], [[4d30\|4d30]], [[4d31\|4d31]], [[4d32\|4d32]], [[4d33\|4d33]], [[4d34\|4d34]], [[4d35\|4d35]], [[4d36\|4d36]], [[4d37\|4d37]], [[4d39\|4d39]], [[4d3a\|4d3a]], [[4d3b\|4d3b]], [[4v3u\|4v3u]], [[4v3v\|4v3v]], [[4v3w\|4v3w]], [[4v3x\|4v3x]], [[4v3y\|4v3y]], [[4v3z\|4v3z]]</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d38 OCA], [~~http~~://pdbe.org/4d38 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d38 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d38 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d38 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.	+	[[https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]	+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, H]]	+	[[Category: Li H]]
-	[[Category: Poulos~~, T L]]~~	+	[[Category: Poulos TL]]
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Nitric oxide synthase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 09:53, 20 March 2019

2019-03-20T09:53:29Z

←Older revision		Revision as of 09:53, 20 March 2019
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	==Structure of bovine endothelial nitric oxide synthase heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}cyclopropanamine==		==Structure of bovine endothelial nitric oxide synthase heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}cyclopropanamine==
-	<StructureSection load='4d38' size='340' side='right' caption='[[4d38]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4d38' size='340' side='right'caption='[[4d38]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d38]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d38]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D38 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=L5Z:(1R,2R)-2-(3-FLUOROBENZYL)-N-{2-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]ETHYL}CYCLOPROPANAMINE'>L5Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=L5Z:(1R,2R)-2-(3-FLUOROBENZYL)-N-{2-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]ETHYL}CYCLOPROPANAMINE'>L5Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4d38" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4d38" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 20:04, 15 December 2016

2016-12-15T20:04:59Z

←Older revision		Revision as of 20:04, 15 December 2016
Line 1:		Line 1:
		+
	==Structure of bovine endothelial nitric oxide synthase heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}cyclopropanamine==		==Structure of bovine endothelial nitric oxide synthase heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}cyclopropanamine==
	<StructureSection load='4d38' size='340' side='right' caption='[[4d38]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4d38' size='340' side='right' caption='[[4d38]], [[Resolution\|resolution]] 2.30Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d2y\|4d2y]], [[4d2z\|4d2z]], [[4d30\|4d30]], [[4d31\|4d31]], [[4d32\|4d32]], [[4d33\|4d33]], [[4d34\|4d34]], [[4d35\|4d35]], [[4d36\|4d36]], [[4d37\|4d37]], [[4d39\|4d39]], [[4d3a\|4d3a]], [[4d3b\|4d3b]], [[4v3u\|4v3u]], [[4v3v\|4v3v]], [[4v3w\|4v3w]], [[4v3x\|4v3x]], [[4v3y\|4v3y]], [[4v3z\|4v3z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d2y\|4d2y]], [[4d2z\|4d2z]], [[4d30\|4d30]], [[4d31\|4d31]], [[4d32\|4d32]], [[4d33\|4d33]], [[4d34\|4d34]], [[4d35\|4d35]], [[4d36\|4d36]], [[4d37\|4d37]], [[4d39\|4d39]], [[4d3a\|4d3a]], [[4d3b\|4d3b]], [[4v3u\|4v3u]], [[4v3v\|4v3v]], [[4v3w\|4v3w]], [[4v3x\|4v3x]], [[4v3y\|4v3y]], [[4v3z\|4v3z]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d38 RCSB], [http://www.ebi.ac.uk/pdbsum/4d38 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d38 OCA], [http://pdbe.org/4d38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d38 RCSB], [http://www.ebi.ac.uk/pdbsum/4d38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d38 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d38" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:56, 24 December 2014

2014-12-24T10:56:18Z

←Older revision		Revision as of 10:56, 24 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of bovine endothelial nitric oxide synthase heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}cyclopropanamine==
		+	<StructureSection load='4d38' size='340' side='right' caption='[[4d38]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4d38]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D38 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=L5Z:(1R,2R)-2-(3-FLUOROBENZYL)-N-{2-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]ETHYL}CYCLOPROPANAMINE'>L5Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d2y\|4d2y]], [[4d2z\|4d2z]], [[4d30\|4d30]], [[4d31\|4d31]], [[4d32\|4d32]], [[4d33\|4d33]], [[4d34\|4d34]], [[4d35\|4d35]], [[4d36\|4d36]], [[4d37\|4d37]], [[4d39\|4d39]], [[4d3a\|4d3a]], [[4d3b\|4d3b]], [[4v3u\|4v3u]], [[4v3v\|4v3v]], [[4v3w\|4v3w]], [[4v3x\|4v3x]], [[4v3y\|4v3y]], [[4v3z\|4v3z]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d38 RCSB], [http://www.ebi.ac.uk/pdbsum/4d38 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Selective inhibition of neuronal nitric oxide synthase (nNOS) is an important therapeutic approach to target neurodegenerative disorders. However, the majority of the nNOS inhibitors developed are arginine mimetics and, therefore, suffer from poor bioavailability. We designed a novel strategy to combine a more pharmacokinetically favorable 2-imidazolylpyrimidine head with promising structural components from previous inhibitors. In conjunction with extensive structure-activity studies, several highly potent and selective inhibitors of nNOS were discovered. X-ray crystallographic analysis reveals that these type II inhibitors utilize the same hydrophobic pocket to gain strong inhibitory potency (13), as well as high isoform selectivity. Interestingly, select compounds from this series (9) showed good permeability and low efflux in a Caco-2 assay, suggesting potential oral bioavailability, and exhibited minimal off-target binding to 50 central nervous system receptors. Furthermore, even with heme-coordinating groups in the molecule, modifying other pharmacophoric fragments minimized undesirable inhibition of cytochrome P450s from human liver microsomes.

-	~~The entry 4d38 is ON HOLD until Paper Publication~~	+	Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-permeable Inhibitors of Neuronal Nitric Oxide Synthase.,Mukherjee P, Li H, Sevrioukova IF, Chreifi G, Martasek P, Roman LJ, Poulos TL, Silverman RB J Med Chem. 2014 Dec 9. PMID:25489882<ref>PMID:25489882</ref>

-	~~Authors~~: Li, H., Poulos, T.L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of bovine endothelial nitric~~ oxide synthase ~~heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-~~[~~2-(1H-imidazol-1-yl)pyrimidin-4-yl~~]~~ethyl}cyclopropanamine~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Li, H]]
		+	[[Category: Poulos, T L]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Nitric oxide synthase]]
		+	[[Category: Oxidoreductase]]

OCA at 07:18, 5 November 2014

2014-11-05T07:18:52Z

←Older revision		Revision as of 07:18, 5 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4d38 is ON HOLD	+	The entry 4d38 is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

-	Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)ethyl~~-(S,R)-2-(3-fluorobenzyl)cyclopropan-1-amine~~	+	Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}cyclopropanamine

OCA: Protected "4d38" [edit=sysop:move=sysop]

2014-10-29T09:45:57Z

Protected "4d38" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:45, 29 October 2014

OCA: New page: '''Unreleased structure''' The entry 4d38 is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-2-(2...

2014-10-29T09:45:56Z

New page: '''Unreleased structure''' The entry 4d38 is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-2-(2...

New page

'''Unreleased structure'''

The entry 4d38 is ON HOLD

Authors: Li, H., Poulos, T.L.

Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)ethyl-(S,R)-2-(3-fluorobenzyl)cyclopropan-1-amine