4d4p - Revision history

OCA at 11:17, 9 May 2024

2024-05-09T11:17:43Z

←Older revision		Revision as of 11:17, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D4P FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D4P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.999Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4p OCA], [https://pdbe.org/4d4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d4p RCSB], [https://www.ebi.ac.uk/pdbsum/4d4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4p OCA], [https://pdbe.org/4d4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d4p RCSB], [https://www.ebi.ac.uk/pdbsum/4d4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DPH3_YEAST DPH3_YEAST]] Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Required for conferring sensitivity to K.lactis zymocin.<ref>PMID:15485916</ref> [[https://www.uniprot.org/uniprot/ATS1_YEAST ATS1_YEAST]] May participate in regulatory interactions between microtubules and the cell cycle.	+	[https://www.uniprot.org/uniprot/DPH3_YEAST DPH3_YEAST] Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Required for conferring sensitivity to K.lactis zymocin.<ref>PMID:15485916</ref> [https://www.uniprot.org/uniprot/ATS1_YEAST ATS1_YEAST] May participate in regulatory interactions between microtubules and the cell cycle.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:47, 14 September 2022

2022-09-14T07:47:22Z

←Older revision		Revision as of 07:47, 14 September 2022
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	<StructureSection load='4d4p' size='340' side='right'caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4d4p' size='340' side='right'caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D4P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D4P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4q\|4d4q]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4p OCA], [https://pdbe.org/4d4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d4p RCSB], [https://www.ebi.ac.uk/pdbsum/4d4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4p ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4p OCA], [~~http~~://pdbe.org/4d4p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d4p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d4p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4p ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATS1_YEAST ATS1_YEAST]] May participate in regulatory interactions between microtubules and the cell cycle.	+	[[https://www.uniprot.org/uniprot/DPH3_YEAST DPH3_YEAST]] Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Required for conferring sensitivity to K.lactis zymocin.<ref>PMID:15485916</ref> [[https://www.uniprot.org/uniprot/ATS1_YEAST ATS1_YEAST]] May participate in regulatory interactions between microtubules and the cell cycle.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Glatt, S~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Mueller, C W~~]]	+	[[Category: Glatt S]]
-	[[Category: ~~Diphthamide modification]]~~	+	[[Category: Mueller CW]]
-	~~[[Category: Elongator]]~~	+
-	~~[[Category: Kti11]]~~	+
-	~~[[Category: Kti13]]~~	+
-	~~[[Category: Translation]]~~	+
-	~~[[Category: Trna modification~~]]	+

OCA at 16:33, 28 August 2019

2019-08-28T16:33:36Z

←Older revision		Revision as of 16:33, 28 August 2019
Line 1:		Line 1:

	==Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65==		==Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65==
-	<StructureSection load='4d4p' size='340' side='right' caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4d4p' size='340' side='right'caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4P FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4P FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Glatt, S]]		[[Category: Glatt, S]]
	[[Category: Mueller, C W]]		[[Category: Mueller, C W]]

OCA at 22:24, 15 November 2017

2017-11-15T22:24:07Z

←Older revision		Revision as of 22:24, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4d4p' size='340' side='right' caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4d4p' size='340' side='right' caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4q\|4d4q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4q\|4d4q]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
	[[Category: Glatt, S]]		[[Category: Glatt, S]]
	[[Category: Mueller, C W]]		[[Category: Mueller, C W]]

OCA at 13:38, 11 August 2016

2016-08-11T13:38:29Z

←Older revision		Revision as of 13:38, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65==		==Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65==
	<StructureSection load='4d4p' size='340' side='right' caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4d4p' size='340' side='right' caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4q\|4d4q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4q\|4d4q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d4p RCSB], [http://www.ebi.ac.uk/pdbsum/4d4p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4p OCA], [http://pdbe.org/4d4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d4p RCSB], [http://www.ebi.ac.uk/pdbsum/4d4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d4p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:33, 14 January 2015

2015-01-14T13:33:35Z

←Older revision		Revision as of 13:33, 14 January 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65==
		+	<StructureSection load='4d4p' size='340' side='right' caption='[[4d4p]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4d4p]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4P FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4q\|4d4q]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d4p RCSB], [http://www.ebi.ac.uk/pdbsum/4d4p PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATS1_YEAST ATS1_YEAST]] May participate in regulatory interactions between microtubules and the cell cycle.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The small, highly conserved Kti11 alias Dph3 protein encoded by the Kluyveromyces lactis killer toxin insensitive gene KTI11/DPH3 is involved in the diphthamide modification of eukaryotic elongation factor 2 and, together with Kti13, in Elongator-dependent tRNA wobble base modifications, thereby affecting the speed and accuracy of protein biosynthesis through two distinct mechanisms. We have solved the crystal structures of Saccharomyces cerevisiae Kti13 and the Kti11/Kti13 heterodimer at 2.4 and 2.9 A resolution, respectively, and validated interacting residues through mutational analysis in vitro and in vivo. We show that metal coordination by Kti11 and its heterodimerization with Kti13 are essential for both translational control mechanisms. Our structural and functional analyses identify Kti13 as an additional component of the diphthamide modification pathway and provide insight into the molecular mechanisms that allow the Kti11/Kti13 heterodimer to coregulate two consecutive steps in ribosomal protein synthesis.

-	~~The entry 4d4p is ON HOLD until Paper Publication~~	+	Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2.,Glatt S, Zabel R, Vonkova I, Kumar A, Netz DJ, Pierik AJ, Rybin V, Lill R, Gavin AC, Balbach J, Breunig KD, Muller CW Structure. 2015 Jan 6;23(1):149-60. doi: 10.1016/j.str.2014.11.008. Epub 2014 Dec, 24. PMID:25543256<ref>PMID:25543256</ref>

-	~~Authors: Glatt~~, S.~~, Mueller, C.W~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	~~[[Category: Mueller, C.W]]~~	+	__TOC__
		+	</StructureSection>
	[[Category: Glatt, S]]		[[Category: Glatt, S]]
		+	[[Category: Mueller, C W]]
		+	[[Category: Diphthamide modification]]
		+	[[Category: Elongator]]
		+	[[Category: Kti11]]
		+	[[Category: Kti13]]
		+	[[Category: Translation]]
		+	[[Category: Trna modification]]

OCA at 13:48, 24 December 2014

2014-12-24T13:48:06Z

←Older revision		Revision as of 13:48, 24 December 2014
Line 6:		Line 6:

	Description: Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65		Description: Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65
		+	[[Category: Unreleased Structures]]
		+	[[Category: Mueller, C.W]]
		+	[[Category: Glatt, S]]

OCA at 11:06, 19 November 2014

2014-11-19T11:06:20Z

←Older revision		Revision as of 11:06, 19 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4d4p is ON HOLD until ~~sometime in the future~~	+	The entry 4d4p is ON HOLD until Paper Publication

	Authors: Glatt, S., Mueller, C.W.		Authors: Glatt, S., Mueller, C.W.

-	Description: Crystal Structure the Kti11 Kti13 heterodimer Spacegroup P65	+	Description: Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65

OCA: Protected "4d4p" [edit=sysop:move=sysop]

2014-11-05T07:20:37Z

Protected "4d4p" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 5 November 2014

OCA: New page: '''Unreleased structure''' The entry 4d4p is ON HOLD until sometime in the future Authors: Glatt, S., Mueller, C.W. Description: Crystal Structure the Kti11 Kti13 heterodimer Spacegrou...

2014-11-05T07:20:35Z

New page: '''Unreleased structure''' The entry 4d4p is ON HOLD until sometime in the future Authors: Glatt, S., Mueller, C.W. Description: Crystal Structure the Kti11 Kti13 heterodimer Spacegrou...

New page

'''Unreleased structure'''

The entry 4d4p is ON HOLD until sometime in the future

Authors: Glatt, S., Mueller, C.W.

Description: Crystal Structure the Kti11 Kti13 heterodimer Spacegroup P65