4dc1 - Revision history

OCA at 10:44, 1 March 2024

2024-03-01T10:44:23Z

←Older revision		Revision as of 10:44, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dc1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DC1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dc1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DC1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.82Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc1 OCA], [https://pdbe.org/4dc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dc1 RCSB], [https://www.ebi.ac.uk/pdbsum/4dc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dc1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc1 OCA], [https://pdbe.org/4dc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dc1 RCSB], [https://www.ebi.ac.uk/pdbsum/4dc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dc1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACT3_STRCO ACT3_STRCO]]	+	[https://www.uniprot.org/uniprot/ACT3_STRCO ACT3_STRCO]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	In the actinorhodin type II polyketide synthase, the first polyketide modification is a regiospecific C9-carbonyl reduction, catalyzed by the ketoreductase (actKR). Our previous studies identified the actKR 94-PGG-96 motif as a determinant of stereospecificity. The molecular basis for reduction regiospecificity is, however, not well understood. In this study, we examined the activities of 20 actKR mutants through a combination of kinetic studies, PKS reconstitution, and structural analyses. Residues have been identified that are necessary for substrate interaction, and these observations have suggested a structural model for this reaction. Polyketides dock at the KR surface and are steered into the enzyme pocket where C7-C12 cyclization is mediated by the KR before C9-ketoreduction can occur. These molecular features can potentially serve as engineering targets for the biosynthesis of novel, reduced polyketides.	+
-		+
-	The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.,Javidpour P, Bruegger J, Srithahan S, Korman TP, Crump MP, Crosby J, Burkart MD, Tsai SC Chem Biol. 2013 Oct 24;20(10):1225-34. doi: 10.1016/j.chembiol.2013.07.016. Epub , 2013 Sep 12. PMID:24035284<ref>PMID:24035284</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4dc1" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:10, 21 September 2022

2022-09-21T08:10:54Z

←Older revision		Revision as of 08:10, 21 September 2022
Line 1:		Line 1:

	==Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH==		==Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH==
-	<StructureSection load='4dc1' size='340' side='right' caption='[[4dc1]], [[Resolution\|resolution]] 2.82Å' scene=''>	+	<StructureSection load='4dc1' size='340' side='right'caption='[[4dc1]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dc1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces~~ coelicolor~~" (muller 1908) lieske 1921~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dc1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DC1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dbz\|4dbz]], [[4dc0\|4dc0]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc1 OCA], [https://pdbe.org/4dc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dc1 RCSB], [https://www.ebi.ac.uk/pdbsum/4dc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dc1 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actIII, SCBAC28G1.12c, SCO5086 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc1 OCA], [~~http~~://pdbe.org/4dc1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dc1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dc1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dc1 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/ACT3_STRCO ACT3_STRCO]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Javidpour, P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Tsai, S C~~]]	+	[[Category: Streptomyces coelicolor]]
-	[[Category: ~~Ketoreductase~~]]	+	[[Category: Javidpour P]]
-	[[Category: ~~Oxidoreductase]]~~	+	[[Category: Tsai S-C]]
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Short~~-~~chain dehydrogenase/reductase~~]]	+

OCA at 10:23, 5 August 2016

2016-08-05T10:23:09Z

←Older revision		Revision as of 10:23, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH==		==Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH==
	<StructureSection load='4dc1' size='340' side='right' caption='[[4dc1]], [[Resolution\|resolution]] 2.82Å' scene=''>		<StructureSection load='4dc1' size='340' side='right' caption='[[4dc1]], [[Resolution\|resolution]] 2.82Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dbz\|4dbz]], [[4dc0\|4dc0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dbz\|4dbz]], [[4dc0\|4dc0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actIII, SCBAC28G1.12c, SCO5086 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actIII, SCBAC28G1.12c, SCO5086 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dc1 RCSB], [http://www.ebi.ac.uk/pdbsum/4dc1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc1 OCA], [http://pdbe.org/4dc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dc1 RCSB], [http://www.ebi.ac.uk/pdbsum/4dc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dc1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4dc1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:54, 21 December 2014

2014-12-21T18:54:43Z

←Older revision		Revision as of 18:54, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4dc1\| PDB=4dc1 \| SCENE= }}~~	+	==Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH==
-	===Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH===	+	<StructureSection load='4dc1' size='340' side='right' caption='[[4dc1]], [[Resolution\|resolution]] 2.82Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24035284}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4dc1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DC1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dbz\|4dbz]], [[4dc0\|4dc0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">actIII, SCBAC28G1.12c, SCO5086 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dc1 RCSB], [http://www.ebi.ac.uk/pdbsum/4dc1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the actinorhodin type II polyketide synthase, the first polyketide modification is a regiospecific C9-carbonyl reduction, catalyzed by the ketoreductase (actKR). Our previous studies identified the actKR 94-PGG-96 motif as a determinant of stereospecificity. The molecular basis for reduction regiospecificity is, however, not well understood. In this study, we examined the activities of 20 actKR mutants through a combination of kinetic studies, PKS reconstitution, and structural analyses. Residues have been identified that are necessary for substrate interaction, and these observations have suggested a structural model for this reaction. Polyketides dock at the KR surface and are steered into the enzyme pocket where C7-C12 cyclization is mediated by the KR before C9-ketoreduction can occur. These molecular features can potentially serve as engineering targets for the biosynthesis of novel, reduced polyketides.

-	~~==About this Structure==~~	+	The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.,Javidpour P, Bruegger J, Srithahan S, Korman TP, Crump MP, Crosby J, Burkart MD, Tsai SC Chem Biol. 2013 Oct 24;20(10):1225-34. doi: 10.1016/j.chembiol.2013.07.016. Epub , 2013 Sep 12. PMID:24035284<ref>PMID:24035284</ref>
-	~~[[4dc1]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"actinomyces_coelicolor"_~~(~~muller_1908~~)~~_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4DC1 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024035284</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Javidpour, P.]]	+	== References ==
-	[[Category: Tsai, S C.]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Javidpour, P]]
		+	[[Category: Tsai, S C]]
	[[Category: Ketoreductase]]		[[Category: Ketoreductase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
	[[Category: Short-chain dehydrogenase/reductase]]		[[Category: Short-chain dehydrogenase/reductase]]

OCA at 08:53, 27 November 2013

2013-11-27T08:53:40Z

←Older revision		Revision as of 08:53, 27 November 2013
Line 1:		Line 1:
-	[[Image:4dc1.jpg\|left\|200px]]
-
	{{STRUCTURE_4dc1\| PDB=4dc1 \| SCENE= }}		{{STRUCTURE_4dc1\| PDB=4dc1 \| SCENE= }}
-
	===Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH===		===Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH===
		+	{{ABSTRACT_PUBMED_24035284}}

		+	==About this Structure==
		+	[[4dc1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC1 OCA].

-	==~~About this Structure~~==	+	==Reference==
-	~~[[4dc1]] is a 2 chain structure with sequence from [http~~://~~en.wikipedia.org~~/~~wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC1 OCA].~~	+	<ref group="xtra">PMID:024035284</ref><references group="xtra"/><references/>
-	~~[[Category: Streptomyces coelicolor]]~~	+
	[[Category: Javidpour, P.]]		[[Category: Javidpour, P.]]
	[[Category: Tsai, S C.]]		[[Category: Tsai, S C.]]

OCA at 09:09, 16 January 2013

2013-01-16T09:09:18Z

←Older revision		Revision as of 09:09, 16 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4dc1.jpg\|left\|200px]]

-	~~The entry~~ 4dc1 ~~is ON HOLD~~ ~~until Jan 16 2014~~	+	{{STRUCTURE_4dc1\| PDB=4dc1 \| SCENE= }}

-	~~Authors: Javidpour, P., Tsai, S.-C.~~	+	===Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH===

-	~~Description: Crystal~~ Structure ~~of Y202F Actinorhodin Polyketide Ketoreductase~~ with ~~NADPH~~	+
		+	==About this Structure==
		+	[[4dc1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DC1 OCA].
		+	[[Category: Streptomyces coelicolor]]
		+	[[Category: Javidpour, P.]]
		+	[[Category: Tsai, S C.]]
		+	[[Category: Ketoreductase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Short-chain dehydrogenase/reductase]]

OCA at 07:40, 9 January 2013

2013-01-09T07:40:27Z

←Older revision		Revision as of 07:40, 9 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dc1 is ON HOLD until Jan 09 2014	+	The entry 4dc1 is ON HOLD until Jan 16 2014

	Authors: Javidpour, P., Tsai, S.-C.		Authors: Javidpour, P., Tsai, S.-C.

	Description: Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH		Description: Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH

OCA at 13:54, 28 November 2012

2012-11-28T13:54:12Z

←Older revision		Revision as of 13:54, 28 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dc1 is ON HOLD until ~~Paper Publication~~	+	The entry 4dc1 is ON HOLD until Jan 09 2014

	Authors: Javidpour, P., Tsai, S.-C.		Authors: Javidpour, P., Tsai, S.-C.

	Description: Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH		Description: Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH

OCA at 06:59, 1 February 2012

2012-02-01T06:59:55Z

←Older revision		Revision as of 06:59, 1 February 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dc1 is ON HOLD	+	The entry 4dc1 is ON HOLD until Paper Publication

	Authors: Javidpour, P., Tsai, S.-C.		Authors: Javidpour, P., Tsai, S.-C.

	Description: Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH		Description: Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH

OCA: Protected "4dc1" [edit=sysop:move=sysop]

2012-01-25T06:11:07Z

Protected "4dc1" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:11, 25 January 2012