4dfb - Revision history

OCA at 14:06, 13 March 2024

2024-03-13T14:06:29Z

←Older revision		Revision as of 14:06, 13 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dfb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dfb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfb OCA], [https://pdbe.org/4dfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dfb RCSB], [https://www.ebi.ac.uk/pdbsum/4dfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfb OCA], [https://pdbe.org/4dfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dfb RCSB], [https://www.ebi.ac.uk/pdbsum/4dfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]]	+	[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Kinase-mediated resistance to antibiotics is a significant clinical challenge. These enzymes share a common protein fold characteristic of Ser/Thr/Tyr protein kinases. We screened 14 antibiotic resistance kinases against 80 chemically diverse protein kinase inhibitors to map resistance kinase chemical space. The screens identified molecules with both broad and narrow inhibition profiles, proving that protein kinase inhibitors offer privileged chemical matter with the potential to block antibiotic resistance. One example is the flavonol quercetin, which inhibited a number of resistance kinases in vitro and in vivo. This activity was rationalized by determination of the crystal structure of the aminoglycoside kinase APH(2'')-IVa in complex with quercetin and its antibiotic substrate kanamycin. Our data demonstrate that protein kinase inhibitors offer chemical scaffolds that can block antibiotic resistance, providing leads for co-drug design.	+
-		+
-	A small molecule discrimination map of the antibiotic resistance kinome.,Shakya T, Stogios PJ, Waglechner N, Evdokimova E, Ejim L, Blanchard JE, McArthur AG, Savchenko A, Wright GD Chem Biol. 2011 Dec 23;18(12):1591-601. PMID:22195561<ref>PMID:22195561</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4dfb" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]		*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:15, 21 September 2022

2022-09-21T08:15:36Z

←Older revision		Revision as of 08:15, 21 September 2022
Line 1:		Line 1:

	==Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin==		==Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin==
-	<StructureSection load='4dfb' size='340' side='right' caption='[[4dfb]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4dfb' size='340' side='right'caption='[[4dfb]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dfb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus~~ casseliflavus~~" vaughan et al. 1979~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DFB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dfb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfb OCA], [https://pdbe.org/4dfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dfb RCSB], [https://www.ebi.ac.uk/pdbsum/4dfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfb ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dbx\|4dbx]], [[4de4\|4de4]], [[4dfu\|4dfu]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2")-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfb OCA], [~~http~~://pdbe.org/4dfb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dfb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dfb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphotransferase\|Phosphotransferase]]	+	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptococcus~~ casseliflavus ~~vaughan et al. 1979~~]]	+	[[Category: Enterococcus casseliflavus]]
-	[[Category: Anderson~~, W F~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Structural genomic~~]]	+	[[Category: Anderson WF]]
-	[[Category: Egorova, E]]	+	[[Category: Di leo R]]
-	[[Category: Evdokimova, E]]	+	[[Category: Egorova E]]
-	[[Category: Li, H]]	+	[[Category: Evdokimova E]]
-	[[Category: Minasov, G]]	+	[[Category: Li H]]
-	[[Category: Osipiuk, J]]	+	[[Category: Minasov G]]
-	[[Category: Savchenko, A]]	+	[[Category: Osipiuk J]]
-	[[Category: Stogios~~, P J]]~~	+	[[Category: Savchenko A]]
-	~~[[Category: Leo, R Di]]~~	+	[[Category: Stogios PJ]]
-	~~[[Category: Aminoglycoside phosphotransferase]]~~	+
-	~~[[Category: Aminoglycoside]]~~	+
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Eukaryotic protein kinase-like fold]]~~	+
-	~~[[Category: Kanamycin]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-antibiotic complex~~]]	+

OCA at 02:46, 11 December 2016

2016-12-11T02:46:41Z

←Older revision		Revision as of 02:46, 11 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin==		==Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin==
	<StructureSection load='4dfb' size='340' side='right' caption='[[4dfb]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4dfb' size='340' side='right' caption='[[4dfb]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dfb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_casseliflavus Enterococcus casseliflavus] and [http://en~~.~~wikipedia~~.~~org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DFB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dfb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus casseliflavus" vaughan et al. 1979]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dbx\|4dbx]], [[4de4\|4de4]], [[4dfu\|4dfu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dbx\|4dbx]], [[4de4\|4de4]], [[4dfu\|4dfu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2")-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 ~~Enterococcus~~ casseliflavus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2")-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dfb RCSB], [http://www.ebi.ac.uk/pdbsum/4dfb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfb OCA], [http://pdbe.org/4dfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dfb RCSB], [http://www.ebi.ac.uk/pdbsum/4dfb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4dfb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterococcus~~ casseliflavus]]	+	[[Category: Streptococcus casseliflavus vaughan et al. 1979]]
-	~~[[Category: Streptomyces kanamyceticus~~]]	+
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 17:33, 9 December 2014

2014-12-09T17:33:37Z

←Older revision		Revision as of 17:33, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4dfb.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin==
		+	<StructureSection load='4dfb' size='340' side='right' caption='[[4dfb]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4dfb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DFB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dbx\|4dbx]], [[4de4\|4de4]], [[4dfu\|4dfu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2")-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 Enterococcus casseliflavus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dfb RCSB], [http://www.ebi.ac.uk/pdbsum/4dfb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kinase-mediated resistance to antibiotics is a significant clinical challenge. These enzymes share a common protein fold characteristic of Ser/Thr/Tyr protein kinases. We screened 14 antibiotic resistance kinases against 80 chemically diverse protein kinase inhibitors to map resistance kinase chemical space. The screens identified molecules with both broad and narrow inhibition profiles, proving that protein kinase inhibitors offer privileged chemical matter with the potential to block antibiotic resistance. One example is the flavonol quercetin, which inhibited a number of resistance kinases in vitro and in vivo. This activity was rationalized by determination of the crystal structure of the aminoglycoside kinase APH(2'')-IVa in complex with quercetin and its antibiotic substrate kanamycin. Our data demonstrate that protein kinase inhibitors offer chemical scaffolds that can block antibiotic resistance, providing leads for co-drug design.

-	~~{{STRUCTURE_4dfb\| PDB=4dfb \| SCENE= }}~~	+	A small molecule discrimination map of the antibiotic resistance kinome.,Shakya T, Stogios PJ, Waglechner N, Evdokimova E, Ejim L, Blanchard JE, McArthur AG, Savchenko A, Wright GD Chem Biol. 2011 Dec 23;18(12):1591-601. PMID:22195561<ref>PMID:22195561</ref>

-	~~===Crystal structure of aminoglycoside phosphotransferase aph(2")-id~~/~~aph(2")-iva in complex with kanamycin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22195561}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4dfb]] is~~ a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase\|Phosphotransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022195561<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterococcus casseliflavus]]		[[Category: Enterococcus casseliflavus]]
	[[Category: Streptomyces kanamyceticus]]		[[Category: Streptomyces kanamyceticus]]
-	[[Category: Anderson, W F.]]	+	[[Category: Anderson, W F]]
-	[[Category: ~~CSGID, Center for~~ Structural ~~Genomics of Infectious Diseases.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Egorova, E.]]	+	[[Category: Egorova, E]]
-	[[Category: Evdokimova, E.]]	+	[[Category: Evdokimova, E]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Minasov, G.]]	+	[[Category: Minasov, G]]
-	[[Category: Osipiuk, J.]]	+	[[Category: Osipiuk, J]]
-	[[Category: Savchenko, A.]]	+	[[Category: Savchenko, A]]
-	[[Category: Stogios, P J.]]	+	[[Category: Stogios, P J]]
-	[[Category: Leo, R Di.]]	+	[[Category: Leo, R Di]]
	[[Category: Aminoglycoside phosphotransferase]]		[[Category: Aminoglycoside phosphotransferase]]
	[[Category: Aminoglycoside]]		[[Category: Aminoglycoside]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
-	[[Category: Center for structural genomics of infectious disease]]
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: Eukaryotic protein kinase-like fold]]		[[Category: Eukaryotic protein kinase-like fold]]
	[[Category: Kanamycin]]		[[Category: Kanamycin]]
	[[Category: Kinase]]		[[Category: Kinase]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-antibiotic complex]]		[[Category: Transferase-antibiotic complex]]

OCA at 12:11, 20 October 2012

2012-10-20T12:11:53Z

←Older revision		Revision as of 12:11, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[4dfb]] is a 2 chain structure ~~of [[Phosphotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA].	+	[[4dfb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:022195561</ref><references group="xtra"/>		<ref group="xtra">PMID:022195561</ref><references group="xtra"/>
		+	[[Category: Enterococcus casseliflavus]]
	[[Category: Streptomyces kanamyceticus]]		[[Category: Streptomyces kanamyceticus]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA at 06:14, 10 October 2012

2012-10-10T06:14:48Z

←Older revision		Revision as of 06:14, 10 October 2012
Line 5:		Line 5:
	===Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin===		===Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin===

		+	{{ABSTRACT_PUBMED_22195561}}

	==About this Structure==		==About this Structure==
-	[[4dfb]] is a 2 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_casseliflavus Enterococcus casseliflavus~~] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA].	+	[[4dfb]] is a 2 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA].

	==See Also==		==See Also==
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase\|Phosphotransferase]]
-	~~[[Category~~: ~~Enterococcus casseliflavus]]~~	+
		+	==Reference==
		+	<ref group="xtra">PMID:022195561</ref><references group="xtra"/>
	[[Category: Streptomyces kanamyceticus]]		[[Category: Streptomyces kanamyceticus]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA at 07:55, 26 July 2012

2012-07-26T07:55:22Z

←Older revision		Revision as of 07:55, 26 July 2012
Line 1:		Line 1:
-	[[Image:4dfb.~~jpg~~\|left\|200px]]	+	[[Image:4dfb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4dfb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4dfb\| PDB=4dfb \| SCENE= }}		{{STRUCTURE_4dfb\| PDB=4dfb \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4dfb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA].	+	[[4dfb]] is a 2 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA].
		+
		+	==See Also==
		+	*[[Phosphotransferase\|Phosphotransferase]]
	[[Category: Enterococcus casseliflavus]]		[[Category: Enterococcus casseliflavus]]
	[[Category: Streptomyces kanamyceticus]]		[[Category: Streptomyces kanamyceticus]]

OCA at 06:25, 8 February 2012

2012-02-08T06:25:11Z

←Older revision		Revision as of 06:25, 8 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4dfb.jpg\|left\|200px]]

-	The ~~entry 4dfb~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4dfb", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4dfb\| PDB=4dfb \| SCENE= }}

-	~~Authors: Stogios, P.J., Minasov, G., Osipiuk, J., Evdokimova, E., Egorova, E., Di leo, R., Li, H., Savchenko, A., Anderson, W.F., Center for Structural Genomics~~ of ~~Infectious Diseases~~ (~~CSGID~~)	+	===Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin===

-	~~Description~~: ~~Crystal~~ structure ~~of aminoglycoside phosphotransferase aph(2")~~-id/~~aph(2")~~-~~iva in~~ complex ~~with kanamycin~~	+
		+	==About this Structure==
		+	[[4dfb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus] and [http://en.wikipedia.org/wiki/Streptomyces_kanamyceticus Streptomyces kanamyceticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r81 3r81]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFB OCA].
		+	[[Category: Enterococcus casseliflavus]]
		+	[[Category: Streptomyces kanamyceticus]]
		+	[[Category: Anderson, W F.]]
		+	[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
		+	[[Category: Egorova, E.]]
		+	[[Category: Evdokimova, E.]]
		+	[[Category: Li, H.]]
		+	[[Category: Minasov, G.]]
		+	[[Category: Osipiuk, J.]]
		+	[[Category: Savchenko, A.]]
		+	[[Category: Stogios, P J.]]
		+	[[Category: Leo, R Di.]]
		+	[[Category: Aminoglycoside phosphotransferase]]
		+	[[Category: Aminoglycoside]]
		+	[[Category: Antibiotic]]
		+	[[Category: Center for structural genomics of infectious disease]]
		+	[[Category: Csgid]]
		+	[[Category: Eukaryotic protein kinase-like fold]]
		+	[[Category: Kanamycin]]
		+	[[Category: Kinase]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-antibiotic complex]]

OCA: Protected "4dfb" [edit=sysop:move=sysop]

2012-02-01T07:02:24Z

Protected "4dfb" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:02, 1 February 2012

OCA: New page: '''Unreleased structure''' The entry 4dfb is ON HOLD Authors: Stogios, P.J., Minasov, G., Osipiuk, J., Evdokimova, E., Egorova, E., Di leo, R., Li, H., Savchenko, A., Anderson, W.F., Ce...

2012-02-01T07:02:23Z

New page: '''Unreleased structure''' The entry 4dfb is ON HOLD Authors: Stogios, P.J., Minasov, G., Osipiuk, J., Evdokimova, E., Egorova, E., Di leo, R., Li, H., Savchenko, A., Anderson, W.F., Ce...

New page

'''Unreleased structure'''

The entry 4dfb is ON HOLD

Authors: Stogios, P.J., Minasov, G., Osipiuk, J., Evdokimova, E., Egorova, E., Di leo, R., Li, H., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

Description: Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin