4dny - Revision history

OCA at 10:52, 1 March 2024

2024-03-01T10:52:44Z

←Older revision		Revision as of 10:52, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DNY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DNY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.61Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dny OCA], [https://pdbe.org/4dny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dny RCSB], [https://www.ebi.ac.uk/pdbsum/4dny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dny ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dny OCA], [https://pdbe.org/4dny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dny RCSB], [https://www.ebi.ac.uk/pdbsum/4dny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dny ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/STCE_ECO57 STCE_ECO57]] Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as a mucinase, allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly, in the colon, StcE cleaves the glycoproteins that protect the intestinal epithelial surface, allowing EHEC to come into close contact with host cell membranes. Secondly, it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes.<ref>PMID:15731026</ref> <ref>PMID:12123444</ref> <ref>PMID:15096536</ref> <ref>PMID:16788173</ref>	+	[https://www.uniprot.org/uniprot/STCE_ECO57 STCE_ECO57] Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as a mucinase, allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly, in the colon, StcE cleaves the glycoproteins that protect the intestinal epithelial surface, allowing EHEC to come into close contact with host cell membranes. Secondly, it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes.<ref>PMID:15731026</ref> <ref>PMID:12123444</ref> <ref>PMID:15096536</ref> <ref>PMID:16788173</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Mucin glycoproteins with large numbers of O-linked glycosylations comprise the mucosal barrier lining the mammalian gastrointestinal tract from mouth to gut. A critical biological function of mucins is to protect the underlying epithelium from infection. Enterohemorrhagic Escherichia coli (EHEC), the mediator of severe food- and water-borne disease, can breach this barrier and adhere to intestinal cells. StcE, a approximately 100 kDa metalloprotease secreted by EHEC, plays a pivotal role in remodeling the mucosal lining during infection. To obtain mechanistic insight into its function, we have determined the structure of StcE. Our data reveal a dynamic, multidomain architecture featuring an unusually large substrate-binding cleft and a prominent polarized surface charge distribution highly suggestive of an electrostatic role in substrate targeting. The observation of key conserved motifs in the active site allows us to propose the structural basis for the specific recognition of alpha-O-glycan-containing substrates. Complementary biochemical analysis provides further insight into its distinct substrate specificity and binding stoichiometry.	+
-		+
-	Structural insight into the bacterial mucinase StcE essential to adhesion and immune evasion during enterohemorrhagic E. coli infection.,Yu AC, Worrall LJ, Strynadka NC Structure. 2012 Apr 4;20(4):707-17. Epub 2012 Apr 3. PMID:22483117<ref>PMID:22483117</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4dny" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:31, 21 September 2022

2022-09-21T08:31:23Z

←Older revision		Revision as of 08:31, 21 September 2022
Line 1:		Line 1:

	==Crystal structure of enterohemorrhagic E. coli StcE(132-251)==		==Crystal structure of enterohemorrhagic E. coli StcE(132-251)==
-	<StructureSection load='4dny' size='340' side='right' caption='[[4dny]], [[Resolution\|resolution]] 1.61Å' scene=''>	+	<StructureSection load='4dny' size='340' side='right'caption='[[4dny]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dny]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Eco57 Eco57~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DNY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ujz\|3ujz]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dny OCA], [https://pdbe.org/4dny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dny RCSB], [https://www.ebi.ac.uk/pdbsum/4dny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dny ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">stcE, tagA, L7031, ECO57PM83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dny OCA], [~~http~~://pdbe.org/4dny PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dny RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dny PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dny ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/STCE_ECO57 STCE_ECO57]] Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as a mucinase, allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly, in the colon, StcE cleaves the glycoproteins that protect the intestinal epithelial surface, allowing EHEC to come into close contact with host cell membranes. Secondly, it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes.<ref>PMID:15731026</ref> <ref>PMID:12123444</ref> <ref>PMID:15096536</ref> <ref>PMID:16788173</ref>	+	[[https://www.uniprot.org/uniprot/STCE_ECO57 STCE_ECO57]] Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as a mucinase, allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly, in the colon, StcE cleaves the glycoproteins that protect the intestinal epithelial surface, allowing EHEC to come into close contact with host cell membranes. Secondly, it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes.<ref>PMID:15731026</ref> <ref>PMID:12123444</ref> <ref>PMID:15096536</ref> <ref>PMID:16788173</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Eco57]]~~	+	[[Category: Escherichia coli O157:H7]]
-	~~[[Category~~: ~~Strynadka, N C.J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Yu, A C.Y~~]]	+	[[Category: Strynadka NCJ]]
-	[[Category: ~~Bacterial zinc metalloprotease~~]]	+	[[Category: Yu ACY]]
-	[[Category: ~~Hydrolase]]~~	+
-	~~[[Category: Metzincin]]~~	+
-	~~[[Category: O-linked glycoprotein~~]]	+

OCA at 18:34, 5 August 2016

2016-08-05T18:34:38Z

←Older revision		Revision as of 18:34, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of enterohemorrhagic E. coli StcE(132-251)==		==Crystal structure of enterohemorrhagic E. coli StcE(132-251)==
	<StructureSection load='4dny' size='340' side='right' caption='[[4dny]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='4dny' size='340' side='right' caption='[[4dny]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DNY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ujz\|3ujz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ujz\|3ujz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">stcE, tagA, L7031, ECO57PM83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562 Escherichia coli~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">stcE, tagA, L7031, ECO57PM83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dny RCSB], [http://www.ebi.ac.uk/pdbsum/4dny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dny OCA], [http://pdbe.org/4dny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dny RCSB], [http://www.ebi.ac.uk/pdbsum/4dny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dny ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4dny" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Eco57]]
	[[Category: Strynadka, N C.J]]		[[Category: Strynadka, N C.J]]
	[[Category: Yu, A C.Y]]		[[Category: Yu, A C.Y]]

OCA at 04:51, 25 December 2014

2014-12-25T04:51:47Z

←Older revision		Revision as of 04:51, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4dny.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of enterohemorrhagic E. coli StcE(132-251)==
		+	<StructureSection load='4dny' size='340' side='right' caption='[[4dny]], [[Resolution\|resolution]] 1.61Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4dny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DNY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ujz\|3ujz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">stcE, tagA, L7031, ECO57PM83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dny RCSB], [http://www.ebi.ac.uk/pdbsum/4dny PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STCE_ECO57 STCE_ECO57]] Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as a mucinase, allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly, in the colon, StcE cleaves the glycoproteins that protect the intestinal epithelial surface, allowing EHEC to come into close contact with host cell membranes. Secondly, it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes.<ref>PMID:15731026</ref> <ref>PMID:12123444</ref> <ref>PMID:15096536</ref> <ref>PMID:16788173</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mucin glycoproteins with large numbers of O-linked glycosylations comprise the mucosal barrier lining the mammalian gastrointestinal tract from mouth to gut. A critical biological function of mucins is to protect the underlying epithelium from infection. Enterohemorrhagic Escherichia coli (EHEC), the mediator of severe food- and water-borne disease, can breach this barrier and adhere to intestinal cells. StcE, a approximately 100 kDa metalloprotease secreted by EHEC, plays a pivotal role in remodeling the mucosal lining during infection. To obtain mechanistic insight into its function, we have determined the structure of StcE. Our data reveal a dynamic, multidomain architecture featuring an unusually large substrate-binding cleft and a prominent polarized surface charge distribution highly suggestive of an electrostatic role in substrate targeting. The observation of key conserved motifs in the active site allows us to propose the structural basis for the specific recognition of alpha-O-glycan-containing substrates. Complementary biochemical analysis provides further insight into its distinct substrate specificity and binding stoichiometry.

-	~~<!--~~	+	Structural insight into the bacterial mucinase StcE essential to adhesion and immune evasion during enterohemorrhagic E. coli infection.,Yu AC, Worrall LJ, Strynadka NC Structure. 2012 Apr 4;20(4):707-17. Epub 2012 Apr 3. PMID:22483117<ref>PMID:22483117</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4dny"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_4dny\| PDB=4dny \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~enterohemorrhagic E. coli StcE(132-251)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22483117}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22483117 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22483117}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4dny]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022483117<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Strynadka, N C.J.]]	+	[[Category: Strynadka, N C.J]]
-	[[Category: Yu, A C.Y.]]	+	[[Category: Yu, A C.Y]]
	[[Category: Bacterial zinc metalloprotease]]		[[Category: Bacterial zinc metalloprotease]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Metzincin]]		[[Category: Metzincin]]
	[[Category: O-linked glycoprotein]]		[[Category: O-linked glycoprotein]]

OCA at 09:09, 16 May 2012

2012-05-16T09:09:44Z

←Older revision		Revision as of 09:09, 16 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4dny.jpg\|left\|200px]]

-	The ~~entry 4dny~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4dny", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4dny\| PDB=4dny \| SCENE= }}

-	~~Authors: Yu, A.C.Y., Strynadka, N.C.J~~.	+	===Crystal structure of enterohemorrhagic E. coli StcE(132-251)===

-	~~Description~~: Structure of a ~~bacterial protease 2~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22483117}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22483117 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22483117}}
		+
		+	==About this Structure==
		+	[[4dny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022483117</ref><references group="xtra"/>
		+	[[Category: Escherichia coli]]
		+	[[Category: Strynadka, N C.J.]]
		+	[[Category: Yu, A C.Y.]]
		+	[[Category: Bacterial zinc metalloprotease]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metzincin]]
		+	[[Category: O-linked glycoprotein]]

OCA at 06:36, 11 April 2012

2012-04-11T06:36:30Z

←Older revision		Revision as of 06:36, 11 April 2012
Line 5:		Line 5:
	Authors: Yu, A.C.Y., Strynadka, N.C.J.		Authors: Yu, A.C.Y., Strynadka, N.C.J.

-	Description: Structure of a ~~Bacterial Protease~~ 2	+	Description: Structure of a bacterial protease 2

OCA at 06:11, 14 March 2012

2012-03-14T06:11:07Z

←Older revision		Revision as of 06:11, 14 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dny is ON HOLD	+	The entry 4dny is ON HOLD until Paper Publication

	Authors: Yu, A.C.Y., Strynadka, N.C.J.		Authors: Yu, A.C.Y., Strynadka, N.C.J.

	Description: Structure of a Bacterial Protease 2		Description: Structure of a Bacterial Protease 2

OCA at 07:30, 22 February 2012

2012-02-22T07:30:31Z

←Older revision		Revision as of 07:30, 22 February 2012
Line 3:		Line 3:
	The entry 4dny is ON HOLD		The entry 4dny is ON HOLD

-	Authors: Yu, A.C.Y, Strynadka, N.C.J	+	Authors: Yu, A.C.Y., Strynadka, N.C.J.

	Description: Structure of a Bacterial Protease 2		Description: Structure of a Bacterial Protease 2

OCA: Protected "4dny" [edit=sysop:move=sysop]

2012-02-15T06:26:06Z

Protected "4dny" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:26, 15 February 2012

OCA: New page: '''Unreleased structure''' The entry 4dny is ON HOLD Authors: Yu, A.C.Y, Strynadka, N.C.J Description: Structure of a Bacterial Protease 2

2012-02-15T06:26:05Z

New page: '''Unreleased structure''' The entry 4dny is ON HOLD Authors: Yu, A.C.Y, Strynadka, N.C.J Description: Structure of a Bacterial Protease 2

New page

'''Unreleased structure'''

The entry 4dny is ON HOLD

Authors: Yu, A.C.Y, Strynadka, N.C.J

Description: Structure of a Bacterial Protease 2