4dph - Revision history

OCA at 13:44, 8 November 2023

2023-11-08T13:44:22Z

←Older revision		Revision as of 13:44, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dph]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_VS/1 Plasmodium falciparum VS/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DPH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dph]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_VS/1 Plasmodium falciparum VS/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DPH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=P65:2,4-DIAMINO-6-METHYL-5-[3-(2,4,5-TRICHLOROPHENOXY)PROPYLOXY]PYRIMIDINE'>P65</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.38Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=P65:2,4-DIAMINO-6-METHYL-5-[3-(2,4,5-TRICHLOROPHENOXY)PROPYLOXY]PYRIMIDINE'>P65</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dph OCA], [https://pdbe.org/4dph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dph RCSB], [https://www.ebi.ac.uk/pdbsum/4dph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dph ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dph OCA], [https://pdbe.org/4dph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dph RCSB], [https://www.ebi.ac.uk/pdbsum/4dph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dph ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]	+	[https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:33, 21 September 2022

2022-09-21T08:33:13Z

←Older revision		Revision as of 08:33, 21 September 2022
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	==Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH==		==Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH==
-	<StructureSection load='4dph' size='340' side='right' caption='[[4dph]], [[Resolution\|resolution]] 2.38Å' scene=''>	+	<StructureSection load='4dph' size='340' side='right'caption='[[4dph]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dph]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plasmodium_falciparum_vs~~/1 Plasmodium falciparum vs/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DPH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dph]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_VS/1 Plasmodium falciparum VS/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DPH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=P65:2,4-DIAMINO-6-METHYL-5-[3-(2,4,5-TRICHLOROPHENOXY)PROPYLOXY]PYRIMIDINE'>P65</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=P65:2,4-DIAMINO-6-METHYL-5-[3-(2,4,5-TRICHLOROPHENOXY)PROPYLOXY]PYRIMIDINE'>P65</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j3k\|1j3k]], [[2jsu\|2jsu]], [[3qg2\|3qg2]], [[4dp3\|4dp3]], [[4dpd\|4dpd]], [[4ddr\|4ddr]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dph OCA], [https://pdbe.org/4dph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dph RCSB], [https://www.ebi.ac.uk/pdbsum/4dph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dph ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=478864 Plasmodium falciparum VS/1])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dph OCA], [~~http~~://pdbe.org/4dph PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dph RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dph PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dph ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]	+	[[https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Plasmodium falciparum vs/1]]	+	[[Category: Large Structures]]
-	[[Category: Arwon, U]]	+	[[Category: Plasmodium falciparum VS/1]]
-	[[Category: Bongard, E]]	+	[[Category: Arwon U]]
-	[[Category: Charman~~, S A~~]]	+	[[Category: Bongard E]]
-	[[Category: Charman~~, W N~~]]	+	[[Category: Charman SA]]
-	[[Category: Chitnumsub, P]]	+	[[Category: Charman WN]]
-	[[Category: Fantauzzi, P]]	+	[[Category: Chitnumsub P]]
-	[[Category: Kamchonwongpaisan, S]]	+	[[Category: Fantauzzi P]]
-	[[Category: Matthews, D]]	+	[[Category: Kamchonwongpaisan S]]
-	[[Category: McLennan~~, D N~~]]	+	[[Category: Matthews D]]
-	[[Category: Tarnchompoo, B]]	+	[[Category: McLennan DN]]
-	[[Category: Taweechai, S]]	+	[[Category: Tarnchompoo B]]
-	[[Category: Thongphanchang, C]]	+	[[Category: Taweechai S]]
-	[[Category: Vanichtanakul, J]]	+	[[Category: Thongphanchang C]]
-	[[Category: Vilaivan, T]]	+	[[Category: Vanichtanakul J]]
-	[[Category: Vivas, L]]	+	[[Category: Vilaivan T]]
-	[[Category: White~~, K L~~]]	+	[[Category: Vivas L]]
-	[[Category: Yuthavong, Y]]	+	[[Category: White KL]]
-	[[Category: Yuvaniyama, J]]	+	[[Category: Yuthavong Y]]
-	~~[[Category: Antifolate]]~~	+	[[Category: Yuvaniyama J]]
-	~~[[Category: Nadph binding]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Plasmodium falciparum]]~~	+
-	~~[[Category: Reductase]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 02:54, 11 December 2016

2016-12-11T02:54:31Z

←Older revision		Revision as of 02:54, 11 December 2016
Line 1:		Line 1:
		+
	==Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH==		==Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH==
	<StructureSection load='4dph' size='340' side='right' caption='[[4dph]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='4dph' size='340' side='right' caption='[[4dph]], [[Resolution\|resolution]] 2.38Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j3k\|1j3k]], [[2jsu\|2jsu]], [[3qg2\|3qg2]], [[4dp3\|4dp3]], [[4dpd\|4dpd]], [[4ddr\|4ddr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j3k\|1j3k]], [[2jsu\|2jsu]], [[3qg2\|3qg2]], [[4dp3\|4dp3]], [[4dpd\|4dpd]], [[4ddr\|4ddr]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=478864 Plasmodium falciparum VS/1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=478864 Plasmodium falciparum VS/1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dph RCSB], [http://www.ebi.ac.uk/pdbsum/4dph PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dph OCA], [http://pdbe.org/4dph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dph RCSB], [http://www.ebi.ac.uk/pdbsum/4dph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dph ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4dph" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:04, 9 December 2014

2014-12-09T17:04:03Z

←Older revision		Revision as of 17:04, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4dph.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH==
		+	<StructureSection load='4dph' size='340' side='right' caption='[[4dph]], [[Resolution\|resolution]] 2.38Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4dph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_vs/1 Plasmodium falciparum vs/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DPH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=P65:2,4-DIAMINO-6-METHYL-5-[3-(2,4,5-TRICHLOROPHENOXY)PROPYLOXY]PYRIMIDINE'>P65</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j3k\|1j3k]], [[2jsu\|2jsu]], [[3qg2\|3qg2]], [[4dp3\|4dp3]], [[4dpd\|4dpd]], [[4ddr\|4ddr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=478864 Plasmodium falciparum VS/1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dph RCSB], [http://www.ebi.ac.uk/pdbsum/4dph PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malarial dihydrofolate reductase (DHFR) is the target of antifolate antimalarial drugs such as pyrimethamine and cycloguanil, the clinical efficacy of which have been compromised by resistance arising through mutations at various sites on the enzyme. Here, we describe the use of cocrystal structures with inhibitors and substrates, along with efficacy and pharmacokinetic profiling for the design, characterization, and preclinical development of a selective, highly efficacious, and orally available antimalarial drug candidate that potently inhibits both wild-type and clinically relevant mutated forms of Plasmodium falciparum (Pf) DHFR. Important structural characteristics of P218 include pyrimidine side-chain flexibility and a carboxylate group that makes charge-mediated hydrogen bonds with conserved Arg122 (PfDHFR-TS amino acid numbering). An analogous interaction of P218 with human DHFR is disfavored because of three species-dependent amino acid substitutions in the vicinity of the conserved Arg. Thus, P218 binds to the active site of PfDHFR in a substantially different fashion from the human enzyme, which is the basis for its high selectivity. Unlike pyrimethamine, P218 binds both wild-type and mutant PfDHFR in a slow-on/slow-off tight-binding mode, which prolongs the target residence time. P218, when bound to PfDHFR-TS, resides almost entirely within the envelope mapped out by the dihydrofolate substrate, which may make it less susceptible to resistance mutations. The high in vivo efficacy in a SCID mouse model of P. falciparum malaria, good oral bioavailability, favorable enzyme selectivity, and good safety characteristics of P218 make it a potential candidate for further development.

-	~~{{STRUCTURE_4dph\| PDB=4dph \| SCENE= }}~~	+	Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.,Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E, Thongphanchang C, Taweechai S, Vanichtanankul J, Rattanajak R, Arwon U, Fantauzzi P, Yuvaniyama J, Charman WN, Matthews D Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. doi:, 10.1073/pnas.1204556109. Epub 2012 Oct 3. PMID:23035243<ref>PMID:23035243</ref>

-	~~===Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-		+	==See Also==
-	==~~About this Structure~~==	+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
-	[[~~4dph~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Plasmodium_falciparum_vs/1 Plasmodium falciparum vs/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPH OCA].~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Plasmodium falciparum vs/1]]		[[Category: Plasmodium falciparum vs/1]]
-	[[Category: Arwon, U.]]	+	[[Category: Arwon, U]]
-	[[Category: Bongard, E.]]	+	[[Category: Bongard, E]]
-	[[Category: Charman, S A.]]	+	[[Category: Charman, S A]]
-	[[Category: Charman, W N.]]	+	[[Category: Charman, W N]]
-	[[Category: Chitnumsub, P.]]	+	[[Category: Chitnumsub, P]]
-	[[Category: Fantauzzi, P.]]	+	[[Category: Fantauzzi, P]]
-	[[Category: Kamchonwongpaisan, S.]]	+	[[Category: Kamchonwongpaisan, S]]
-	[[Category: Matthews, D.]]	+	[[Category: Matthews, D]]
-	[[Category: McLennan, D N.]]	+	[[Category: McLennan, D N]]
-	[[Category: Tarnchompoo, B.]]	+	[[Category: Tarnchompoo, B]]
-	[[Category: Taweechai, S.]]	+	[[Category: Taweechai, S]]
-	[[Category: Thongphanchang, C.]]	+	[[Category: Thongphanchang, C]]
-	[[Category: Vanichtanakul, J.]]	+	[[Category: Vanichtanakul, J]]
-	[[Category: Vilaivan, T.]]	+	[[Category: Vilaivan, T]]
-	[[Category: Vivas, L.]]	+	[[Category: Vivas, L]]
-	[[Category: White, K L.]]	+	[[Category: White, K L]]
-	[[Category: Yuthavong, Y.]]	+	[[Category: Yuthavong, Y]]
-	[[Category: Yuvaniyama, J.]]	+	[[Category: Yuvaniyama, J]]
	[[Category: Antifolate]]		[[Category: Antifolate]]
	[[Category: Nadph binding]]		[[Category: Nadph binding]]

OCA at 06:48, 14 November 2012

2012-11-14T06:48:03Z

←Older revision		Revision as of 06:48, 14 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4dph.jpg\|left\|200px]]

-	~~The entry~~ 4dph ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4dph\| PDB=4dph \| SCENE= }}

-	Authors: Yuthavong, Y., Vilaivan, T., Kamchonwongpaisan, K., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Chitnumsub, P., Tarnchompoo, B., Thongphanchang, C., Taweechai, S., Vanichtanakul, J., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D.	+	===Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH===

-	~~Description~~: ~~Quadruple mutant (N51I+C59R+S108N+I164L)~~ Plasmodium falciparum ~~dihydrofolate reductase~~-~~thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH~~	+
		+	==About this Structure==
		+	[[4dph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_vs/1 Plasmodium falciparum vs/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPH OCA].
		+	[[Category: Plasmodium falciparum vs/1]]
		+	[[Category: Arwon, U.]]
		+	[[Category: Bongard, E.]]
		+	[[Category: Charman, S A.]]
		+	[[Category: Charman, W N.]]
		+	[[Category: Chitnumsub, P.]]
		+	[[Category: Fantauzzi, P.]]
		+	[[Category: Kamchonwongpaisan, S.]]
		+	[[Category: Matthews, D.]]
		+	[[Category: McLennan, D N.]]
		+	[[Category: Tarnchompoo, B.]]
		+	[[Category: Taweechai, S.]]
		+	[[Category: Thongphanchang, C.]]
		+	[[Category: Vanichtanakul, J.]]
		+	[[Category: Vilaivan, T.]]
		+	[[Category: Vivas, L.]]
		+	[[Category: White, K L.]]
		+	[[Category: Yuthavong, Y.]]
		+	[[Category: Yuvaniyama, J.]]
		+	[[Category: Antifolate]]
		+	[[Category: Nadph binding]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Reductase]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Transferase]]

OCA at 06:36, 11 April 2012

2012-04-11T06:36:45Z

←Older revision		Revision as of 06:36, 11 April 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dph is ON HOLD	+	The entry 4dph is ON HOLD until Paper Publication

	Authors: Yuthavong, Y., Vilaivan, T., Kamchonwongpaisan, K., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Chitnumsub, P., Tarnchompoo, B., Thongphanchang, C., Taweechai, S., Vanichtanakul, J., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D.		Authors: Yuthavong, Y., Vilaivan, T., Kamchonwongpaisan, K., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Chitnumsub, P., Tarnchompoo, B., Thongphanchang, C., Taweechai, S., Vanichtanakul, J., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D.

	Description: Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH		Description: Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH

OCA at 06:11, 14 March 2012

2012-03-14T06:11:29Z

←Older revision		Revision as of 06:11, 14 March 2012
Line 3:		Line 3:
	The entry 4dph is ON HOLD		The entry 4dph is ON HOLD

-	Authors: Yuthavong, Y., Vilaivan, T., Kamchonwongpaisan, K., Charman, S. A., McLennan, D. N., White, K. L., Vivas, L., Bongard, E., Chitnumsub, P., Tarnchompoo, B., Thongphanchang, C., Taweechai, S., Vanichtanakul, J., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W. N., Matthews, D.	+	Authors: Yuthavong, Y., Vilaivan, T., Kamchonwongpaisan, K., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Chitnumsub, P., Tarnchompoo, B., Thongphanchang, C., Taweechai, S., Vanichtanakul, J., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D.

-	Description: ~~QUADRUPLE MUTANT~~ (N51I+C59R+S108N+I164L) ~~PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE~~-~~THYMIDYLATE SYNTHASE~~ (PfDHFR-TS) ~~COMPLEXED WITH~~ P65 and NADPH	+	Description: Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH

OCA: Protected "4dph" [edit=sysop:move=sysop]

2012-02-22T07:32:05Z

Protected "4dph" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:32, 22 February 2012

OCA: New page: '''Unreleased structure''' The entry 4dph is ON HOLD Authors: Yuthavong, Y., Vilaivan, T., Kamchonwongpaisan, K., Charman, S. A., McLennan, D. N., White, K. L., Vivas, L., Bongard, E., ...

2012-02-22T07:32:04Z

New page: '''Unreleased structure''' The entry 4dph is ON HOLD Authors: Yuthavong, Y., Vilaivan, T., Kamchonwongpaisan, K., Charman, S. A., McLennan, D. N., White, K. L., Vivas, L., Bongard, E., ...

New page

'''Unreleased structure'''

The entry 4dph is ON HOLD

Authors: Yuthavong, Y., Vilaivan, T., Kamchonwongpaisan, K., Charman, S. A., McLennan, D. N., White, K. L., Vivas, L., Bongard, E., Chitnumsub, P., Tarnchompoo, B., Thongphanchang, C., Taweechai, S., Vanichtanakul, J., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W. N., Matthews, D.

Description: QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS) COMPLEXED WITH P65 and NADPH