4dz5 - Revision history

OCA at 14:48, 14 March 2024

2024-03-14T14:48:18Z

←Older revision		Revision as of 14:48, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DZ5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [https://pdbe.org/4dz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4dz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dz5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [https://pdbe.org/4dz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4dz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.	+	[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

	==See Also==		==See Also==
-	*[[Prostaglandin F synthase\|Prostaglandin F synthase]]	+	*[[Prostaglandin F synthase 3D structures\|Prostaglandin F synthase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:44, 21 September 2022

2022-09-21T08:44:38Z

←Older revision		Revision as of 08:44, 21 September 2022
Line 1:		Line 1:

	==W227F active site mutant of AKR1C3==		==W227F active site mutant of AKR1C3==
-	<StructureSection load='4dz5' size='340' side='right' caption='[[4dz5]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4dz5' size='340' side='right'caption='[[4dz5]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DZ5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [https://pdbe.org/4dz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4dz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dz5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [~~http~~://pdbe.org/4dz5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dz5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dz5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.	+	[[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

	==See Also==		==See Also==
Line 15:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Flanagan, J U~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Squire, C J~~]]	+	[[Category: Flanagan JU]]
-	[[Category: ~~Yosaatmadja, Y~~]]	+	[[Category: Squire CJ]]
-	[[Category: ~~Oxidoreductase]]~~	+	[[Category: Yosaatmadja Y]]
-	~~[[Category: Tim barrel~~]]	+

OCA at 23:54, 4 August 2016

2016-08-04T23:54:02Z

←Older revision		Revision as of 23:54, 4 August 2016
Line 1:		Line 1:
		+
	==W227F active site mutant of AKR1C3==		==W227F active site mutant of AKR1C3==
	<StructureSection load='4dz5' size='340' side='right' caption='[[4dz5]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4dz5' size='340' side='right' caption='[[4dz5]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DZ5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4dz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [http://pdbe.org/4dz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4dz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Flanagan, J U]]		[[Category: Flanagan, J U]]
	[[Category: Squire, C J]]		[[Category: Squire, C J]]

OCA at 20:55, 24 December 2014

2014-12-24T20:55:19Z

←Older revision		Revision as of 20:55, 24 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4dz5.~~jpg~~\|~~left~~\|~~200px~~]]	+	==W227F active site mutant of AKR1C3==
		+	<StructureSection load='4dz5' size='340' side='right' caption='[[4dz5]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4dz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DZ5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4dz5 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

-	~~{{STRUCTURE_4dz5\| PDB~~=~~4dz5 \| SCENE= }}~~	+	==See Also==
-		+	*[[Prostaglandin F synthase\|Prostaglandin F synthase]]
-	~~===W227F active site mutant of AKR1C3~~===	+	__TOC__
-		+	</StructureSection>
-		+
-	~~==About this Structure==~~	+
-	[[~~4dz5~~]] ~~is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA].~~	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Flanagan, J U.]]	+	[[Category: Flanagan, J U]]
-	[[Category: Squire, C J.]]	+	[[Category: Squire, C J]]
-	[[Category: Yosaatmadja, Y.]]	+	[[Category: Yosaatmadja, Y]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 14:24, 6 March 2013

2013-03-06T14:24:24Z

←Older revision		Revision as of 14:24, 6 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4dz5.jpg\|left\|200px]]

-	~~The entry~~ 4dz5 ~~is ON HOLD~~ ~~until Mar 01 2014~~	+	{{STRUCTURE_4dz5\| PDB=4dz5 \| SCENE= }}

-	~~Authors: Squire, C.J., Yosaatmadja, Y., Flanagan, J.U.~~	+	===W227F active site mutant of AKR1C3===

-	~~Description~~: ~~W227F active site mutant of AKR1C3~~	+
		+	==About this Structure==
		+	[[4dz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DZ5 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Flanagan, J U.]]
		+	[[Category: Squire, C J.]]
		+	[[Category: Yosaatmadja, Y.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tim barrel]]

OCA at 09:55, 13 February 2013

2013-02-13T09:55:35Z

←Older revision		Revision as of 09:55, 13 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dz5 is ON HOLD until ~~Paper Publication~~	+	The entry 4dz5 is ON HOLD until Mar 01 2014

	Authors: Squire, C.J., Yosaatmadja, Y., Flanagan, J.U.		Authors: Squire, C.J., Yosaatmadja, Y., Flanagan, J.U.

	Description: W227F active site mutant of AKR1C3		Description: W227F active site mutant of AKR1C3

OCA at 06:13, 14 March 2012

2012-03-14T06:13:45Z

←Older revision		Revision as of 06:13, 14 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dz5 is ON HOLD	+	The entry 4dz5 is ON HOLD until Paper Publication

	Authors: Squire, C.J., Yosaatmadja, Y., Flanagan, J.U.		Authors: Squire, C.J., Yosaatmadja, Y., Flanagan, J.U.

	Description: W227F active site mutant of AKR1C3		Description: W227F active site mutant of AKR1C3

OCA: Protected "4dz5" [edit=sysop:move=sysop]

2012-03-08T05:30:34Z

Protected "4dz5" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:30, 8 March 2012

OCA: New page: '''Unreleased structure''' The entry 4dz5 is ON HOLD Authors: Squire, C.J., Yosaatmadja, Y., Flanagan, J.U. Description: W227F active site mutant of AKR1C3

2012-03-08T05:30:32Z

New page: '''Unreleased structure''' The entry 4dz5 is ON HOLD Authors: Squire, C.J., Yosaatmadja, Y., Flanagan, J.U. Description: W227F active site mutant of AKR1C3

New page

'''Unreleased structure'''

The entry 4dz5 is ON HOLD

Authors: Squire, C.J., Yosaatmadja, Y., Flanagan, J.U.

Description: W227F active site mutant of AKR1C3