4eow - Revision history

OCA at 12:14, 6 March 2024

2024-03-06T12:14:36Z

←Older revision		Revision as of 12:14, 6 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [https://pdbe.org/4eow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [https://www.ebi.ac.uk/pdbsum/4eow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eow ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.97Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [https://pdbe.org/4eow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [https://www.ebi.ac.uk/pdbsum/4eow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eow ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.	+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]]	+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Polyclonal autoantibodies against human granulocyte macrophage- colony stimulating factor (hGM-CSF) are a hallmark of pulmonary alveolar proteinosis (PAP) affection and several other reported autoimmune diseases. MB007 is a high affinity anti-human GM-CSF autoantibody isolated from a patient suffering from PAP which shows only modest neutralization of GM-CSF bioactivity. We describe the first crystal structure of a cytokine directed human IgG1lambda autoantibody binding fragment (Fab) at 1.9 A resolution. Its CDR3-H substantially differs from all previously reported VH7 germline IgG1 structures. We derive a reliable model of the antigen:autoantibody complex by using NMR chemical shift perturbation data in combination with computational methods. Superposition of the modeled complex structure with the human GM-CSF/GM-CSF ternary receptor complex reveals only little overlap between receptor and Fab when bound to GM-CSF. Our model provides a structural basis for understanding the mode-of-action of the MB007 autoantibody.	+
-		+
-	Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications.,Blech M, Seeliger D, Kistler B, Bauer MM, Hafner M, Horer S, Zeeb M, Nar H, Park JE Biochem J. 2012 Jul 27. PMID:22839360<ref>PMID:22839360</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4eow" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:21, 28 September 2022

2022-09-28T07:21:12Z

←Older revision		Revision as of 07:21, 28 September 2022
Line 3:		Line 3:
	<StructureSection load='4eow' size='340' side='right'caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4eow' size='340' side='right'caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EOW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [~~http~~://pdbe.org/4eow PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eow PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eow ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [https://pdbe.org/4eow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [https://www.ebi.ac.uk/pdbsum/4eow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eow ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blech, M]]	+	[[Category: Blech M]]
-	~~[[Category: Alpha-helical stretch in cdr3-h]]~~	+
-	~~[[Category: Autoantibody causing pap]]~~	+
-	~~[[Category: Gm-csf]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunsystem]]~~	+
-	~~[[Category: Protein-docking~~]]	+

OCA at 17:45, 14 August 2019

2019-08-14T17:45:57Z

←Older revision		Revision as of 17:45, 14 August 2019
Line 1:		Line 1:

	==Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007==		==Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007==
-	<StructureSection load='4eow' size='340' side='right' caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>	+	<StructureSection load='4eow' size='340' side='right'caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOW FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Blech, M]]		[[Category: Blech, M]]
	[[Category: Alpha-helical stretch in cdr3-h]]		[[Category: Alpha-helical stretch in cdr3-h]]

OCA at 08:17, 3 August 2017

2017-08-03T08:17:33Z

←Older revision		Revision as of 08:17, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='4eow' size='340' side='right' caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4eow' size='340' side='right' caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOW FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [http://pdbe.org/4eow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [http://www.ebi.ac.uk/pdbsum/4eow PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eow ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [http://pdbe.org/4eow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [http://www.ebi.ac.uk/pdbsum/4eow PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eow ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Homo sapiens]]
	[[Category: Blech, M]]		[[Category: Blech, M]]
	[[Category: Alpha-helical stretch in cdr3-h]]		[[Category: Alpha-helical stretch in cdr3-h]]

OCA at 15:48, 5 August 2016

2016-08-05T15:48:32Z

←Older revision		Revision as of 15:48, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007==		==Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007==
	<StructureSection load='4eow' size='340' side='right' caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4eow' size='340' side='right' caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [http://www.ebi.ac.uk/pdbsum/4eow PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [http://pdbe.org/4eow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [http://www.ebi.ac.uk/pdbsum/4eow PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eow ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4eow" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:49, 21 December 2014

2014-12-21T10:49:27Z

←Older revision		Revision as of 10:49, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4eow\| PDB=4eow \| SCENE= }}~~	+	==Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007==
-	===Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007===	+	<StructureSection load='4eow' size='340' side='right' caption='[[4eow]], [[Resolution\|resolution]] 1.97Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22839360}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4eow]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOW FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eow RCSB], [http://www.ebi.ac.uk/pdbsum/4eow PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polyclonal autoantibodies against human granulocyte macrophage- colony stimulating factor (hGM-CSF) are a hallmark of pulmonary alveolar proteinosis (PAP) affection and several other reported autoimmune diseases. MB007 is a high affinity anti-human GM-CSF autoantibody isolated from a patient suffering from PAP which shows only modest neutralization of GM-CSF bioactivity. We describe the first crystal structure of a cytokine directed human IgG1lambda autoantibody binding fragment (Fab) at 1.9 A resolution. Its CDR3-H substantially differs from all previously reported VH7 germline IgG1 structures. We derive a reliable model of the antigen:autoantibody complex by using NMR chemical shift perturbation data in combination with computational methods. Superposition of the modeled complex structure with the human GM-CSF/GM-CSF ternary receptor complex reveals only little overlap between receptor and Fab when bound to GM-CSF. Our model provides a structural basis for understanding the mode-of-action of the MB007 autoantibody.

-	~~==About this Structure==~~	+	Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications.,Blech M, Seeliger D, Kistler B, Bauer MM, Hafner M, Horer S, Zeeb M, Nar H, Park JE Biochem J. 2012 Jul 27. PMID:22839360<ref>PMID:22839360</ref>
-	~~[[4eow]] is a 2 chain~~ structure with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:022839360</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blech, M.]]	+	[[Category: Blech, M]]
	[[Category: Alpha-helical stretch in cdr3-h]]		[[Category: Alpha-helical stretch in cdr3-h]]
	[[Category: Autoantibody causing pap]]		[[Category: Autoantibody causing pap]]

OCA at 01:04, 25 March 2013

2013-03-25T01:04:36Z

←Older revision		Revision as of 01:04, 25 March 2013
Line 1:		Line 1:
-	[[Image:4eow.png\|left\|200px]]
-
	{{STRUCTURE_4eow\| PDB=4eow \| SCENE= }}		{{STRUCTURE_4eow\| PDB=4eow \| SCENE= }}
-
	===Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007===		===Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007===
-
	{{ABSTRACT_PUBMED_22839360}}		{{ABSTRACT_PUBMED_22839360}}

Line 11:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022839360</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022839360</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blech, M.]]		[[Category: Blech, M.]]

OCA at 20:55, 26 September 2012

2012-09-26T20:55:54Z

←Older revision		Revision as of 20:55, 26 September 2012
Line 1:		Line 1:
-	[[Image:4eow.~~jpg~~\|left\|200px]]	+	[[Image:4eow.png\|left\|200px]]

	{{STRUCTURE_4eow\| PDB=4eow \| SCENE= }}		{{STRUCTURE_4eow\| PDB=4eow \| SCENE= }}

OCA at 05:56, 22 August 2012

2012-08-22T05:56:45Z

←Older revision		Revision as of 05:56, 22 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4eow.jpg\|left\|200px]]

-	~~The entry~~ 4eow ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4eow\| PDB=4eow \| SCENE= }}

-	~~Authors: Blech, M.~~	+	===Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007===

-	~~Description: Crystal structure of~~ a ~~disease~~-~~associated anti~~-~~human GM~~-~~CSF autoantibody MB007~~	+	{{ABSTRACT_PUBMED_22839360}}
		+
		+	==About this Structure==
		+	[[4eow]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022839360</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Blech, M.]]
		+	[[Category: Alpha-helical stretch in cdr3-h]]
		+	[[Category: Autoantibody causing pap]]
		+	[[Category: Gm-csf]]
		+	[[Category: Immune system]]
		+	[[Category: Immunsystem]]
		+	[[Category: Protein-docking]]

OCA at 05:38, 23 May 2012

2012-05-23T05:38:23Z

←Older revision		Revision as of 05:38, 23 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4eow is ON HOLD	+	The entry 4eow is ON HOLD until Paper Publication

	Authors: Blech, M.		Authors: Blech, M.

	Description: Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007		Description: Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007