4er4 - Revision history

OCA at 09:13, 15 November 2023

2023-11-15T09:13:38Z

←Older revision		Revision as of 09:13, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='4er4' size='340' side='right'caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4er4' size='340' side='right'caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4er4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Crypa Crypa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ER4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4er4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER4 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=LAV:N~~-[~~(2S)-~~2~~-AMINO-4-METHYLPENTYL]-L-VALINE'>LAV</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number~~ [~~http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30 3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30] </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LAV:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-VALINE'>LAV</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4er4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er4 OCA], [~~http~~://pdbe.org/4er4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4er4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4er4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4er4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er4 OCA], [https://pdbe.org/4er4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er4 RCSB], [https://www.ebi.ac.uk/pdbsum/4er4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CARP_CRYPA CARP_CRYPA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	==See Also==		==See Also==
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
		+	*[[Proteinase 3D structures\|Proteinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Crypa]]~~	+	[[Category: Cryphonectria parasitica]]
-	~~[[Category: Hydrolase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blundell~~, T L~~]]	+	[[Category: Blundell TL]]
-	[[Category: Foundling~~, S I~~]]	+	[[Category: Foundling SI]]
-	[[Category: Szelke, M]]	+	[[Category: Szelke M]]
-	[[Category: Watson~~, F E]]~~	+	[[Category: Watson FE]]
-	~~[[Category: Acid proteinase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 09:42, 5 February 2020

2020-02-05T09:42:10Z

←Older revision		Revision as of 09:42, 5 February 2020
Line 1:		Line 1:

	==HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES==		==HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES==
-	<StructureSection load='4er4' size='340' side='right' caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4er4' size='340' side='right'caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4er4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crypa Crypa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4er4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crypa Crypa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER4 FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/4er4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/4er4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 4er4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4er4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pepsin\|Pepsin]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	[[Category: Crypa]]		[[Category: Crypa]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
		+	[[Category: Large Structures]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]
	[[Category: Foundling, S I]]		[[Category: Foundling, S I]]

OCA at 07:19, 29 November 2017

2017-11-29T07:19:35Z

←Older revision		Revision as of 07:19, 29 November 2017
Line 1:		Line 1:
		+
	==HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES==		==HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES==
	<StructureSection load='4er4' size='340' side='right' caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4er4' size='340' side='right' caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAV:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-VALINE'>LAV</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAV:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-VALINE'>LAV</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30 3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30 3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er4 OCA], [http://pdbe.org/4er4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4er4 RCSB], [http://www.ebi.ac.uk/pdbsum/4er4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er4 OCA], [http://pdbe.org/4er4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4er4 RCSB], [http://www.ebi.ac.uk/pdbsum/4er4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4er4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 4er4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4er4" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Pepsin\|Pepsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:10, 7 February 2016

2016-02-07T11:10:10Z

←Older revision		Revision as of 11:10, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='4er4' size='340' side='right' caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4er4' size='340' side='right' caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4er4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cryphonectria_parasitica Cryphonectria parasitica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4er4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crypa Crypa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER4 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAV:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-VALINE'>LAV</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAV:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-VALINE'>LAV</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30 3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30 3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4er4 RCSB], [http://www.ebi.ac.uk/pdbsum/4er4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er4 OCA], [http://pdbe.org/4er4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4er4 RCSB], [http://www.ebi.ac.uk/pdbsum/4er4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4er4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4er4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cryphonectria parasitica~~]]	+	[[Category: Crypa]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]

OCA at 15:31, 9 December 2014

2014-12-09T15:31:00Z

←Older revision		Revision as of 15:31, 9 December 2014
Line 1:		Line 1:
-	[[~~Image~~:4er4.~~png\|left~~\|200px]]	+	==HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES==
		+	<StructureSection load='4er4' size='340' side='right' caption='[[4er4]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4er4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER4 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAV:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-VALINE'>LAV</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30 3.4.21.103, 3.4.23.18, 3.4.23.19, 3.4.23.20, 3.4.23.21, 3.4.23.22, 3.4.23.23, 3.4.23.24, 3.4.23.25, 3.4.23.26, 3.4.23.28 and 3.4.23.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4er4 RCSB], [http://www.ebi.ac.uk/pdbsum/4er4 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/4er4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibitors of the conversion of angiotensinogen to the vasoconstrictor angiotensin II have considerable value as antihypertensive agents. For example, captopril and enalapril are clinically useful as inhibitors of angiotensin-converting enzyme. This has encouraged intense activity in the development of inhibitors of kidney renin, which is a very specific aspartic proteinase catalysing the first and rate limiting step in the conversion of angiotensinogen to angiotensin II. The most effective inhibitors such as H-142 and L-363,564 have used non-hydrolysable analogues of the proposed transition state, and partial sequences of angiotensinogen (Table 1). H-142 is effective in lowering blood pressure in humans but has no significant effect on other aspartic proteinases such as pepsin in the human body (Table 1). At present there are no crystal structures available for human or mouse renins although three-dimensional models demonstrate close structural similarity to other spartic proteinases. We have therefore determined by X-ray analysis the three-dimensional structures of H-142 and L-363,564 complexed with the aspartic proteinase endothiapepsin, which binds these inhibitors with affinities not greatly different from those measured against human renin (Table 1). The structures of these complexes and of that between endothiapepsin and the general aspartic proteinase inhibitor, H-256 (Table 1) define the common hydrogen bonding schemes that allow subtle differences in side-chain orientations and in the positions of the transition state analogues with respect to the active-site aspartates.

-	~~{{STRUCTURE_4er4\| PDB=4er4 \| SCENE= }}~~	+	High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.,Foundling SI, Cooper J, Watson FE, Cleasby A, Pearl LH, Sibanda BL, Hemmings A, Wood SP, Blundell TL, Valler MJ, et al. Nature. 1987 May 28-Jun 3;327(6120):349-52. PMID:3295561<ref>PMID:3295561</ref>

-	~~===HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_3295561}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4er4]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA].~~	+

	==See Also==		==See Also==
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:003295561<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cryphonectria parasitica]]		[[Category: Cryphonectria parasitica]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Blundell, T L.]]	+	[[Category: Blundell, T L]]
-	[[Category: Foundling, S I.]]	+	[[Category: Foundling, S I]]
-	[[Category: Szelke, M.]]	+	[[Category: Szelke, M]]
-	[[Category: Watson, F E.]]	+	[[Category: Watson, F E]]
	[[Category: Acid proteinase]]		[[Category: Acid proteinase]]
-	[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 06:27, 20 October 2012

2012-10-20T06:27:28Z

←Older revision		Revision as of 06:27, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[4er4]] is a 2 chain structure ~~of [[Pepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA].	+	[[4er4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA].

	==See Also==		==See Also==

OCA at 13:14, 25 July 2012

2012-07-25T13:14:32Z

←Older revision		Revision as of 13:14, 25 July 2012
Line 1:		Line 1:
	[[Image:4er4.png\|left\|200px]]		[[Image:4er4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4er4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4er4\| PDB=4er4 \| SCENE= }}		{{STRUCTURE_4er4\| PDB=4er4 \| SCENE= }}

	===HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES===		===HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_3295561}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 3295561 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_3295561}}		{{ABSTRACT_PUBMED_3295561}}

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	==See Also==		==See Also==
-	*[[Pepsin]]	+	*[[Pepsin\|Pepsin]]

	==Reference==		==Reference==

OCA: Protected "4er4" [edit=sysop:move=sysop]

2012-02-29T07:20:44Z

Protected "4er4" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 29 February 2012

OCA at 07:20, 29 February 2012

2012-02-29T07:20:42Z

←Older revision		Revision as of 07:20, 29 February 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:4er4.png\|left\|200px]]		[[Image:4er4.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~4ER4~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA].	+	[[4er4]] is a 2 chain structure of [[Pepsin]] with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA].
		+
		+	==See Also==
		+	*[[Pepsin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~3295561~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:003295561</ref><references group="xtra"/>
	[[Category: Cryphonectria parasitica]]		[[Category: Cryphonectria parasitica]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 30:		Line 32:
	[[Category: Szelke, M.]]		[[Category: Szelke, M.]]
	[[Category: Watson, F E.]]		[[Category: Watson, F E.]]
-		+	[[Category: Acid proteinase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 13~~:~~24:18 2009''~~	+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 11:24, 16 February 2009

2009-02-16T11:24:21Z

←Older revision		Revision as of 11:24, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	4ER4 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA].	+	4ER4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER4 OCA].

	==Reference==		==Reference==
-	High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes., Foundling SI, Cooper J, Watson FE, Cleasby A, Pearl LH, Sibanda BL, Hemmings A, Wood SP, Blundell TL, Valler MJ, et al., Nature. 1987 May 28-Jun 3;327(6120):349-52. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/3295561 3295561]~~	+	<ref group="xtra">PMID:3295561</ref><references group="xtra"/>
	[[Category: Cryphonectria parasitica]]		[[Category: Cryphonectria parasitica]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Single protein]]
	[[Category: Blundell, T L.]]		[[Category: Blundell, T L.]]
	[[Category: Foundling, S I.]]		[[Category: Foundling, S I.]]
Line 32:		Line 31:
	[[Category: Watson, F E.]]		[[Category: Watson, F E.]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3~~ 13:35:~~58 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:24:18 2009''