4esq - Revision history

OCA at 04:12, 7 October 2022

2022-10-07T04:12:54Z

←Older revision		Revision as of 04:12, 7 October 2022
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	==Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis==		==Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis==
-	<StructureSection load='4esq' size='340' side='right' caption='[[4esq]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4esq' size='340' side='right'caption='[[4esq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4esq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ESQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4esq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pknH, Rv1266c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esq OCA], [https://pdbe.org/4esq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esq RCSB], [https://www.ebi.ac.uk/pdbsum/4esq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4esq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esq OCA], [~~http~~://pdbe.org/4esq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4esq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4esq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4esq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PKNH_MYCTU PKNH_MYCTU] May regulate bacterial growth in response to external signals to facilitate adaptation to the host environment. In vitro, phosphorylates several substrates such as EmbR, DevR (DosR), DacB1 and Rv0681.<ref>PMID:14690440</ref> <ref>PMID:15043876</ref> <ref>PMID:16077122</ref> <ref>PMID:16585755</ref> <ref>PMID:16817899</ref> <ref>PMID:17286964</ref> <ref>PMID:20630871</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4esq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4esq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Myctu~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Alber, T~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: ~~Cavazos, A~~]]	+	[[Category: Alber T]]
-	[[Category: ~~Prigozhin, D M~~]]	+	[[Category: Cavazos A]]
-	[[Category: ~~Membrane]]~~	+	[[Category: Prigozhin DM]]
-	~~[[Category: Receptor kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:08, 15 November 2017

2017-11-15T08:08:24Z

←Older revision		Revision as of 08:08, 15 November 2017
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	</div>		</div>
	<div class="pdbe-citations 4esq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4esq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:48, 11 December 2016

2016-12-11T02:48:56Z

←Older revision		Revision as of 02:48, 11 December 2016
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		+
	==Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis==		==Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis==
	<StructureSection load='4esq' size='340' side='right' caption='[[4esq]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4esq' size='340' side='right' caption='[[4esq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4esq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ESQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4esq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ESQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pknH, Rv1266c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 ~~Mycobacterium tuberculosis H37Rv~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pknH, Rv1266c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4esq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4esq RCSB], [http://www.ebi.ac.uk/pdbsum/4esq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4esq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esq OCA], [http://pdbe.org/4esq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4esq RCSB], [http://www.ebi.ac.uk/pdbsum/4esq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4esq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4esq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis h37rv~~]]	+	[[Category: Myctu]]
	[[Category: Alber, T]]		[[Category: Alber, T]]
	[[Category: Cavazos, A]]		[[Category: Cavazos, A]]

OCA at 17:38, 9 December 2014

2014-12-09T17:38:37Z

←Older revision		Revision as of 17:38, 9 December 2014
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-	[[~~Image:~~4esq.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis==
		+	<StructureSection load='4esq' size='340' side='right' caption='[[4esq]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4esq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ESQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pknH, Rv1266c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4esq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4esq RCSB], [http://www.ebi.ac.uk/pdbsum/4esq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Since their discovery over 20years ago, eukaryotic-like transmembrane receptor Ser/Thr protein kinases (STPKs) have been shown to play critical roles in the virulence, growth, persistence, and reactivation of many bacteria. Information regarding the signals transmitted by these proteins, however, remains scarce. To enhance understanding of the basis for STPK receptor signaling, we determined the 1.7-A-resolution crystal structure of the extracellular sensor domain of the Mycobacterium tuberculosis receptor STPK, PknH (Rv1266c). The PknH sensor domain adopts an unanticipated fold containing two intramolecular disulfide bonds and a large hydrophobic and polar cleft. The residues lining the cleft and those surrounding the disulfide bonds are conserved. These results suggest that PknH binds a small-molecule ligand that signals by changing the location or quaternary structure of the kinase domain.

-	~~{{STRUCTURE_4esq\| PDB=4esq \| SCENE= }}~~	+	Structure of the Sensor Domain of Mycobacterium tuberculosis PknH Receptor Kinase Reveals a Conserved Binding Cleft.,Cavazos A, Prigozhin DM, Alber T J Mol Biol. 2012 Jun 20. PMID:22727744<ref>PMID:22727744</ref>

-	~~===Crystal structure~~ of the ~~extracellular domain~~ of ~~PknH from Mycobacterium tuberculosis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22727744}}~~	+	==See Also==
-		+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4esq]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA~~].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:022727744<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
-	[[Category: Alber, T.]]	+	[[Category: Alber, T]]
-	[[Category: Cavazos, A.]]	+	[[Category: Cavazos, A]]
-	[[Category: Prigozhin, D M.]]	+	[[Category: Prigozhin, D M]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Receptor kinase]]		[[Category: Receptor kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:57, 2 January 2013

2013-01-02T07:57:38Z

←Older revision		Revision as of 07:57, 2 January 2013
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-	[[Image:4esq.~~jpg~~\|left\|200px]]	+	[[Image:4esq.png\|left\|200px]]

	{{STRUCTURE_4esq\| PDB=4esq \| SCENE= }}		{{STRUCTURE_4esq\| PDB=4esq \| SCENE= }}
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	==About this Structure==		==About this Structure==
-	[[4esq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis~~ Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA].	+	[[4esq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:022727744</ref><references group="xtra"/>		<ref group="xtra">PMID:022727744</ref><references group="xtra"/>
-	[[Category: Mycobacterium tuberculosis]]	+	[[Category: Mycobacterium tuberculosis h37rv]]
	[[Category: Alber, T.]]		[[Category: Alber, T.]]
	[[Category: Cavazos, A.]]		[[Category: Cavazos, A.]]

OCA at 05:22, 18 July 2012

2012-07-18T05:22:25Z

←Older revision		Revision as of 05:22, 18 July 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4esq.jpg\|left\|200px]]

-	~~The entry~~ 4esq ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4esq\| PDB=4esq \| SCENE= }}

-	~~Authors: Cavazos, A., Prigozhin, D.M., Alber, T.~~	+	===Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis===

-	~~Description: Crystal~~ structure ~~of the extracellular domain of PknH~~ from Mycobacterium tuberculosis	+	{{ABSTRACT_PUBMED_22727744}}
		+
		+	==About this Structure==
		+	[[4esq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022727744</ref><references group="xtra"/>
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Alber, T.]]
		+	[[Category: Cavazos, A.]]
		+	[[Category: Prigozhin, D M.]]
		+	[[Category: Membrane]]
		+	[[Category: Receptor kinase]]
		+	[[Category: Transferase]]

OCA at 05:38, 23 May 2012

2012-05-23T05:38:54Z

←Older revision		Revision as of 05:38, 23 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4esq is ON HOLD	+	The entry 4esq is ON HOLD until Paper Publication

	Authors: Cavazos, A., Prigozhin, D.M., Alber, T.		Authors: Cavazos, A., Prigozhin, D.M., Alber, T.

	Description: Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis		Description: Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis

OCA: Protected "4esq" [edit=sysop:move=sysop]

2012-05-02T18:58:17Z

Protected "4esq" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:58, 2 May 2012

OCA: New page: '''Unreleased structure''' The entry 4esq is ON HOLD Authors: Cavazos, A., Prigozhin, D.M., Alber, T. Description: Crystal structure of the extracellular domain of PknH from Mycobacter...

2012-05-02T18:58:16Z

New page: '''Unreleased structure''' The entry 4esq is ON HOLD Authors: Cavazos, A., Prigozhin, D.M., Alber, T. Description: Crystal structure of the extracellular domain of PknH from Mycobacter...

New page

'''Unreleased structure'''

The entry 4esq is ON HOLD

Authors: Cavazos, A., Prigozhin, D.M., Alber, T.

Description: Crystal structure of the extracellular domain of PknH from Mycobacterium tuberculosis