4eva - Revision history

OCA at 11:06, 1 March 2024

2024-03-01T11:06:17Z

←Older revision		Revision as of 11:06, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4eva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EVA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4eva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EVA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=URE:UREA'>URE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.003Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eva OCA], [https://pdbe.org/4eva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eva RCSB], [https://www.ebi.ac.uk/pdbsum/4eva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eva ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eva OCA], [https://pdbe.org/4eva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eva RCSB], [https://www.ebi.ac.uk/pdbsum/4eva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eva ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:18, 7 October 2022

2022-10-07T04:18:20Z

←Older revision		Revision as of 04:18, 7 October 2022
Line 1:		Line 1:

	==Crystal Structure of Mouse Catenin beta-59 in 5.6M urea==		==Crystal Structure of Mouse Catenin beta-59 in 5.6M urea==
-	<StructureSection load='4eva' size='340' side='right' caption='[[4eva]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4eva' size='340' side='right'caption='[[4eva]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4eva]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4eva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EVA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=URE:UREA'>URE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bct\|3bct]], [[4ev8\|4ev8]], [[4ev9\|4ev9]], [[4evt\|4evt]], [[4evp\|4evp]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eva OCA], [https://pdbe.org/4eva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eva RCSB], [https://www.ebi.ac.uk/pdbsum/4eva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eva ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ctnnb1, Catnb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4eva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eva OCA], [~~http~~://pdbe.org/4eva PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4eva RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4eva PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4eva ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE]] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).	+	[https://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).

	==See Also==		==See Also==
-	*[[Catenin\|Catenin]]	+	*[[Catenin 3D structures\|Catenin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Wang, C~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Zhang, G Y~~]]	+	[[Category: Wang C]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Zhang GY]]
-	~~[[Category: Mouse beta catenin]]~~	+
-	~~[[Category: Urea~~]]	+

OCA at 03:36, 5 August 2016

2016-08-05T03:36:09Z

←Older revision		Revision as of 03:36, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Mouse Catenin beta-59 in 5.6M urea==		==Crystal Structure of Mouse Catenin beta-59 in 5.6M urea==
	<StructureSection load='4eva' size='340' side='right' caption='[[4eva]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4eva' size='340' side='right' caption='[[4eva]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4eva]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4eva]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EVA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=URE:UREA'>URE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bct\|3bct]], [[4ev8\|4ev8]], [[4ev9\|4ev9]], [[4evt\|4evt]], [[4evp\|4evp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bct\|3bct]], [[4ev8\|4ev8]], [[4ev9\|4ev9]], [[4evt\|4evt]], [[4evp\|4evp]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ctnnb1, Catnb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ctnnb1, Catnb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eva RCSB], [http://www.ebi.ac.uk/pdbsum/4eva PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eva OCA], [http://pdbe.org/4eva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eva RCSB], [http://www.ebi.ac.uk/pdbsum/4eva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eva ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Wang, C]]		[[Category: Wang, C]]
	[[Category: Zhang, G Y]]		[[Category: Zhang, G Y]]

OCA at 15:32, 25 December 2014

2014-12-25T15:32:15Z

←Older revision		Revision as of 15:32, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4eva\| PDB=4eva \| SCENE= }}~~	+	==Crystal Structure of Mouse Catenin beta-59 in 5.6M urea==
-	===Crystal Structure of Mouse Catenin beta-59 in 5.6M urea===	+	<StructureSection load='4eva' size='340' side='right' caption='[[4eva]], [[Resolution\|resolution]] 2.00Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4eva]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EVA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bct\|3bct]], [[4ev8\|4ev8]], [[4ev9\|4ev9]], [[4evt\|4evt]], [[4evp\|4evp]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ctnnb1, Catnb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eva RCSB], [http://www.ebi.ac.uk/pdbsum/4eva PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE]] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).		[[http://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE]] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4eva~~]] ~~is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA].~~	+	*[[Catenin\|Catenin]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Wang, C.]]	+	[[Category: Wang, C]]
-	[[Category: Zhang, G Y.]]	+	[[Category: Zhang, G Y]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Mouse beta catenin]]		[[Category: Mouse beta catenin]]
	[[Category: Urea]]		[[Category: Urea]]

OCA at 07:47, 2 May 2013

2013-05-02T07:47:48Z

←Older revision		Revision as of 07:47, 2 May 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4eva\| PDB=4eva \| SCENE= }}
		+	===Crystal Structure of Mouse Catenin beta-59 in 5.6M urea===

-	~~The entry 4eva~~ is ~~ON HOLD until Apr 26 2014~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE]] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).

-	~~Authors~~: Wang, C., Zhang, G.Y.	+	==About this Structure==
-		+	[[4eva]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVA OCA].
-	~~Description~~: ~~Crystal Structure of~~ Mouse ~~Catenin~~ beta~~-59 in 5.6M urea~~	+	[[Category: Mus musculus]]
		+	[[Category: Wang, C.]]
		+	[[Category: Zhang, G Y.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Mouse beta catenin]]
		+	[[Category: Urea]]

OCA at 08:51, 9 May 2012

2012-05-09T08:51:07Z

←Older revision		Revision as of 08:51, 9 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4eva is ON HOLD	+	The entry 4eva is ON HOLD until Apr 26 2014

	Authors: Wang, C., Zhang, G.Y.		Authors: Wang, C., Zhang, G.Y.

	Description: Crystal Structure of Mouse Catenin beta-59 in 5.6M urea		Description: Crystal Structure of Mouse Catenin beta-59 in 5.6M urea

OCA: Protected "4eva" [edit=sysop:move=sysop]

2012-05-02T19:00:46Z

Protected "4eva" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:00, 2 May 2012

OCA: New page: '''Unreleased structure''' The entry 4eva is ON HOLD Authors: Wang, C., Zhang, G.Y. Description: Crystal Structure of Mouse Catenin beta-59 in 5.6M urea

2012-05-02T19:00:45Z

New page: '''Unreleased structure''' The entry 4eva is ON HOLD Authors: Wang, C., Zhang, G.Y. Description: Crystal Structure of Mouse Catenin beta-59 in 5.6M urea

New page

'''Unreleased structure'''

The entry 4eva is ON HOLD

Authors: Wang, C., Zhang, G.Y.

Description: Crystal Structure of Mouse Catenin beta-59 in 5.6M urea