4ezc - Revision history

OCA at 11:07, 1 March 2024

2024-03-01T11:07:02Z

←Older revision		Revision as of 11:07, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ezc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ezc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.36Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [https://pdbe.org/4ezc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [https://www.ebi.ac.uk/pdbsum/4ezc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [https://pdbe.org/4ezc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [https://www.ebi.ac.uk/pdbsum/4ezc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/UT1_BOVIN UT1_BOVIN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.<ref>PMID:15845882</ref> <ref>PMID:22733730</ref>		[https://www.uniprot.org/uniprot/UT1_BOVIN UT1_BOVIN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.<ref>PMID:15845882</ref> <ref>PMID:22733730</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	As an adaptation to infrequent access to water, terrestrial mammals produce urine that is hyperosmotic to plasma. To prevent osmotic diuresis by the large quantity of urea generated by protein catabolism, the kidney epithelia contain facilitative urea transporters (UTs) that allow rapid equilibration between the urinary space and the hyperosmotic interstitium. Here we report the first X-ray crystal structure of a mammalian UT, UT-B, at a resolution of 2.36 A. UT-B is a homotrimer and each protomer contains a urea conduction pore with a narrow selectivity filter. Structural analyses and molecular dynamics simulations showed that the selectivity filter has two urea binding sites separated by an approximately 5.0 kcal/mol energy barrier. Functional studies showed that the rate of urea conduction in UT-B is increased by hypoosmotic stress, and that the site of osmoregulation coincides with the location of the energy barrier.
-
-	Structure and permeation mechanism of a mammalian urea transporter.,Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M Proc Natl Acad Sci U S A. 2012 Jun 25. PMID:22733730<ref>PMID:22733730</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4ezc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 04:24, 7 October 2022

2022-10-07T04:24:07Z

←Older revision		Revision as of 04:24, 7 October 2022
Line 1:		Line 1:

	==Crystal Structure of the UT-B Urea Transporter from Bos Taurus==		==Crystal Structure of the UT-B Urea Transporter from Bos Taurus==
-	<StructureSection load='4ezc' size='340' side='right' caption='[[4ezc]], [[Resolution\|resolution]] 2.36Å' scene=''>	+	<StructureSection load='4ezc' size='340' side='right'caption='[[4ezc]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ezc]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EZC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ezc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC14A1, UT-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [https://pdbe.org/4ezc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [https://www.ebi.ac.uk/pdbsum/4ezc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [~~http~~://pdbe.org/4ezc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ezc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/UT1_BOVIN UT1_BOVIN]] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.<ref>PMID:15845882</ref> <ref>PMID:22733730</ref>	+	[https://www.uniprot.org/uniprot/UT1_BOVIN UT1_BOVIN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.<ref>PMID:15845882</ref> <ref>PMID:22733730</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4ezc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ezc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Urea transporter\|Urea transporter]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
-	[[Category: ~~Cao, Y~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Levin, E J~~]]	+	[[Category: Cao Y]]
-	[[Category: ~~NYCOMPS, New York Consortium on Membrane Protein Structure~~]]	+	[[Category: Levin EJ]]
-	[[Category: Zhou, M]]	+	[[Category: Zhou M]]
-	~~[[Category: Channel]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: New york consortium on membrane protein structure]]~~	+
-	~~[[Category: Nycomp]]~~	+
-	~~[[Category: Permeation]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Slc14]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Urea transport~~]]	+

OCA at 08:11, 15 November 2017

2017-11-15T08:11:47Z

←Older revision		Revision as of 08:11, 15 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4ezc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ezc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Urea transporter\|Urea transporter]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:14, 5 August 2016

2016-08-05T18:14:54Z

←Older revision		Revision as of 18:14, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the UT-B Urea Transporter from Bos Taurus==		==Crystal Structure of the UT-B Urea Transporter from Bos Taurus==
	<StructureSection load='4ezc' size='340' side='right' caption='[[4ezc]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='4ezc' size='340' side='right' caption='[[4ezc]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ezc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ezc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC14A1, UT-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC14A1, UT-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [http://www.ebi.ac.uk/pdbsum/4ezc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [http://pdbe.org/4ezc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [http://www.ebi.ac.uk/pdbsum/4ezc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ezc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Cao, Y]]		[[Category: Cao, Y]]
	[[Category: Levin, E J]]		[[Category: Levin, E J]]

OCA at 20:53, 25 December 2014

2014-12-25T20:53:42Z

←Older revision		Revision as of 20:53, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [http://www.ebi.ac.uk/pdbsum/4ezc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [http://www.ebi.ac.uk/pdbsum/4ezc PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UT1_BOVIN UT1_BOVIN]] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.<ref>PMID:15845882</ref> <ref>PMID:22733730</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:18, 18 December 2014

2014-12-18T08:18:38Z

←Older revision		Revision as of 08:18, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ezc\| PDB=4ezc \| SCENE= }}~~	+	==Crystal Structure of the UT-B Urea Transporter from Bos Taurus==
-	===Crystal Structure of the UT-B Urea Transporter from Bos Taurus===	+	<StructureSection load='4ezc' size='340' side='right' caption='[[4ezc]], [[Resolution\|resolution]] 2.36Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22733730}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ezc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC14A1, UT-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ezc RCSB], [http://www.ebi.ac.uk/pdbsum/4ezc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	As an adaptation to infrequent access to water, terrestrial mammals produce urine that is hyperosmotic to plasma. To prevent osmotic diuresis by the large quantity of urea generated by protein catabolism, the kidney epithelia contain facilitative urea transporters (UTs) that allow rapid equilibration between the urinary space and the hyperosmotic interstitium. Here we report the first X-ray crystal structure of a mammalian UT, UT-B, at a resolution of 2.36 A. UT-B is a homotrimer and each protomer contains a urea conduction pore with a narrow selectivity filter. Structural analyses and molecular dynamics simulations showed that the selectivity filter has two urea binding sites separated by an approximately 5.0 kcal/mol energy barrier. Functional studies showed that the rate of urea conduction in UT-B is increased by hypoosmotic stress, and that the site of osmoregulation coincides with the location of the energy barrier.

-	~~==About this~~ Structure==	+	Structure and permeation mechanism of a mammalian urea transporter.,Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M Proc Natl Acad Sci U S A. 2012 Jun 25. PMID:22733730<ref>PMID:22733730</ref>
-	~~[[4ezc]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4EZC OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Urea transporter\|Urea transporter]]		*[[Urea transporter\|Urea transporter]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022733730<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Cao, Y.]]	+	[[Category: Cao, Y]]
-	[[Category: Levin, E J.]]	+	[[Category: Levin, E J]]
-	[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure.]]	+	[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure]]
-	[[Category: Zhou, M.]]	+	[[Category: Zhou, M]]
	[[Category: Channel]]		[[Category: Channel]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 09:06, 11 March 2013

2013-03-11T09:06:44Z

←Older revision		Revision as of 09:06, 11 March 2013
Line 1:		Line 1:
-	[[Image:4ezc.png\|left\|200px]]
-
	{{STRUCTURE_4ezc\| PDB=4ezc \| SCENE= }}		{{STRUCTURE_4ezc\| PDB=4ezc \| SCENE= }}
-
	===Crystal Structure of the UT-B Urea Transporter from Bos Taurus===		===Crystal Structure of the UT-B Urea Transporter from Bos Taurus===
-
	{{ABSTRACT_PUBMED_22733730}}		{{ABSTRACT_PUBMED_22733730}}

	==About this Structure==		==About this Structure==
	[[4ezc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA].		[[4ezc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA].
		+
		+	==See Also==
		+	*[[Urea transporter\|Urea transporter]]

	==Reference==		==Reference==

OCA at 06:56, 4 July 2012

2012-07-04T06:56:48Z

←Older revision		Revision as of 06:56, 4 July 2012
Line 1:		Line 1:
-	[[Image:4ezc.~~jpg~~\|left\|200px]]	+	[[Image:4ezc.png\|left\|200px]]

	{{STRUCTURE_4ezc\| PDB=4ezc \| SCENE= }}		{{STRUCTURE_4ezc\| PDB=4ezc \| SCENE= }}
Line 5:		Line 5:
	===Crystal Structure of the UT-B Urea Transporter from Bos Taurus===		===Crystal Structure of the UT-B Urea Transporter from Bos Taurus===

		+	{{ABSTRACT_PUBMED_22733730}}

	==About this Structure==		==About this Structure==
	[[4ezc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA].		[[4ezc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022733730</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Cao, Y.]]		[[Category: Cao, Y.]]

OCA at 05:58, 27 June 2012

2012-06-27T05:58:00Z

←Older revision		Revision as of 05:58, 27 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ezc.jpg\|left\|200px]]

-	~~The entry~~ 4ezc ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4ezc\| PDB=4ezc \| SCENE= }}

-	~~Authors: Cao, Y., Levin, E.J., Zhou, M., New York Consortium on Membrane Protein~~ Structure ~~(NYCOMPS)~~	+	===Crystal Structure of the UT-B Urea Transporter from Bos Taurus===

-	~~Description~~: ~~Crystal~~ Structure ~~of the UT~~-B Urea ~~Transporter from Bos Taurus~~	+
		+	==About this Structure==
		+	[[4ezc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZC OCA].
		+	[[Category: Bos taurus]]
		+	[[Category: Cao, Y.]]
		+	[[Category: Levin, E J.]]
		+	[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure.]]
		+	[[Category: Zhou, M.]]
		+	[[Category: Channel]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: New york consortium on membrane protein structure]]
		+	[[Category: Nycomp]]
		+	[[Category: Permeation]]
		+	[[Category: Psi-biology]]
		+	[[Category: Slc14]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transport protein]]
		+	[[Category: Urea transport]]

OCA at 07:18, 6 June 2012

2012-06-06T07:18:22Z

←Older revision		Revision as of 07:18, 6 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ezc is ON HOLD	+	The entry 4ezc is ON HOLD until Paper Publication

	Authors: Cao, Y., Levin, E.J., Zhou, M., New York Consortium on Membrane Protein Structure (NYCOMPS)		Authors: Cao, Y., Levin, E.J., Zhou, M., New York Consortium on Membrane Protein Structure (NYCOMPS)

	Description: Crystal Structure of the UT-B Urea Transporter from Bos Taurus		Description: Crystal Structure of the UT-B Urea Transporter from Bos Taurus