4f3i - Revision history

OCA at 15:15, 14 March 2024

2024-03-14T15:15:22Z

←Older revision		Revision as of 15:15, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4f3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F3I FirstGlance]. <br>		<table><tr><td colspan='2'>[[4f3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F3I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3i OCA], [https://pdbe.org/4f3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f3i RCSB], [https://www.ebi.ac.uk/pdbsum/4f3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f3i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3i OCA], [https://pdbe.org/4f3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f3i RCSB], [https://www.ebi.ac.uk/pdbsum/4f3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f3i ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	NF-kappaB-mediated inflammation is the major pathology in chronic kidney diseases, including HIV-associated nephropathy (HIVAN) that ultimately progresses to end stage renal disease. HIV infection in the kidney induces NF-kappaB activation, leading to the production of proinflammatory chemokines, cytokines, and adhesion molecules. In this study, we explored selective inhibition of NF-kappaB transcriptional activity by small molecule blocking NF-kappaB binding to the transcriptional cofactor BRD4, which is required for the assembly of the productive transcriptional complex comprising positive transcription elongation factor b and RNA polymerase II. We showed that our BET (Bromodomain and Extra-Terminal domain)-specific bromodomain inhibitor MS417, designed to block BRD4 binding to the acetylated NF-kappaB, effectively attenuates NF-kappaB transcriptional activation of proinflammatory genes in kidney cells treated with TNFalpha or infected by HIV. MS417 ameliorates inflammation and kidney injury in HIV-1 transgenic mice, an animal model for HIVAN. Our study suggests that BET bromodomain inhibition, targeting at the proinflammatory activity of NF-kappaB, represents a new therapeutic approach for treating NF-kappaB-mediated inflammation and kidney injury in HIVAN.
-
-	Down-regulation of NF-kappaB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.,Zhang G, Liu R, Zhong Y, Plotnikov AN, Zhang W, Zeng L, Rusinova E, Gerona-Nevarro G, Moshkina N, Joshua J, Chuang PY, Ohlmeyer M, He JC, Zhou MM J Biol Chem. 2012 Aug 17;287(34):28840-51. Epub 2012 May 29. PMID:22645123<ref>PMID:22645123</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4f3i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 04:31, 7 October 2022

2022-10-07T04:31:49Z

←Older revision		Revision as of 04:31, 7 October 2022
Line 1:		Line 1:

	==Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor==		==Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor==
-	<StructureSection load='4f3i' size='340' side='right' caption='[[4f3i]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='4f3i' size='340' side='right'caption='[[4f3i]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4f3i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4F3I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4f3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F3I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3i OCA], [https://pdbe.org/4f3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f3i RCSB], [https://www.ebi.ac.uk/pdbsum/4f3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f3i ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3i OCA], [~~http~~://pdbe.org/4f3i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4f3i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4f3i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4f3i ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4f3i" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4f3i" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Joshua, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Plotnikov, A N~~]]	+	[[Category: Joshua J]]
-	[[Category: ~~Zhou, M M~~]]	+	[[Category: Plotnikov AN]]
-	[[Category: ~~Acetyl~~-~~lysine binding]]~~	+	[[Category: Zhou M-M]]
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Protein-inhibitor complex]]~~	+
-	~~[[Category: Signaling protein-inhibitor complex~~]]	+

OCA at 06:35, 7 February 2018

2018-02-07T06:35:48Z

←Older revision		Revision as of 06:35, 7 February 2018
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4f3i" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4f3i" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:10, 4 August 2016

2016-08-04T21:10:11Z

←Older revision		Revision as of 21:10, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor==		==Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor==
	<StructureSection load='4f3i' size='340' side='right' caption='[[4f3i]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4f3i' size='340' side='right' caption='[[4f3i]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4f3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F3I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4f3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F3I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f3i RCSB], [http://www.ebi.ac.uk/pdbsum/4f3i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3i OCA], [http://pdbe.org/4f3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f3i RCSB], [http://www.ebi.ac.uk/pdbsum/4f3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f3i ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4f3i" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Joshua, J]]		[[Category: Joshua, J]]
	[[Category: Plotnikov, A N]]		[[Category: Plotnikov, A N]]

OCA at 10:40, 21 December 2014

2014-12-21T10:40:19Z

←Older revision		Revision as of 10:40, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4f3i\| PDB=4f3i \| SCENE= }}~~	+	==Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor==
-	===Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor===	+	<StructureSection load='4f3i' size='340' side='right' caption='[[4f3i]], [[Resolution\|resolution]] 1.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22645123}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4f3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F3I FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f3i RCSB], [http://www.ebi.ac.uk/pdbsum/4f3i PDBsum]</span></td></tr>
-	==Function==	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	NF-kappaB-mediated inflammation is the major pathology in chronic kidney diseases, including HIV-associated nephropathy (HIVAN) that ultimately progresses to end stage renal disease. HIV infection in the kidney induces NF-kappaB activation, leading to the production of proinflammatory chemokines, cytokines, and adhesion molecules. In this study, we explored selective inhibition of NF-kappaB transcriptional activity by small molecule blocking NF-kappaB binding to the transcriptional cofactor BRD4, which is required for the assembly of the productive transcriptional complex comprising positive transcription elongation factor b and RNA polymerase II. We showed that our BET (Bromodomain and Extra-Terminal domain)-specific bromodomain inhibitor MS417, designed to block BRD4 binding to the acetylated NF-kappaB, effectively attenuates NF-kappaB transcriptional activation of proinflammatory genes in kidney cells treated with TNFalpha or infected by HIV. MS417 ameliorates inflammation and kidney injury in HIV-1 transgenic mice, an animal model for HIVAN. Our study suggests that BET bromodomain inhibition, targeting at the proinflammatory activity of NF-kappaB, represents a new therapeutic approach for treating NF-kappaB-mediated inflammation and kidney injury in HIVAN.

-	~~==About this Structure==~~	+	Down-regulation of NF-kappaB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.,Zhang G, Liu R, Zhong Y, Plotnikov AN, Zhang W, Zeng L, Rusinova E, Gerona-Nevarro G, Moshkina N, Joshua J, Chuang PY, Ohlmeyer M, He JC, Zhou MM J Biol Chem. 2012 Aug 17;287(34):28840-51. Epub 2012 May 29. PMID:22645123<ref>PMID:22645123</ref>
-	~~[[4f3i]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4F3I OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Joshua, J.]]	+	[[Category: Joshua, J]]
-	[[Category: Plotnikov, A N.]]	+	[[Category: Plotnikov, A N]]
-	[[Category: Zhou, M M.]]	+	[[Category: Zhou, M M]]
	[[Category: Acetyl-lysine binding]]		[[Category: Acetyl-lysine binding]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Protein-inhibitor complex]]		[[Category: Protein-inhibitor complex]]
	[[Category: Signaling protein-inhibitor complex]]		[[Category: Signaling protein-inhibitor complex]]

OCA at 03:09, 25 March 2013

2013-03-25T03:09:09Z

←Older revision		Revision as of 03:09, 25 March 2013
Line 1:		Line 1:
-	[[Image:4f3i.jpg\|left\|200px]]
-
	{{STRUCTURE_4f3i\| PDB=4f3i \| SCENE= }}		{{STRUCTURE_4f3i\| PDB=4f3i \| SCENE= }}
-
	===Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor===		===Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor===
-
	{{ABSTRACT_PUBMED_22645123}}		{{ABSTRACT_PUBMED_22645123}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

	==About this Structure==		==About this Structure==
	[[4f3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA].		[[4f3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Joshua, J.]]		[[Category: Joshua, J.]]

OCA at 05:11, 12 September 2012

2012-09-12T05:11:00Z

←Older revision		Revision as of 05:11, 12 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4f3i.jpg\|left\|200px]]

-	~~The entry~~ 4f3i ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4f3i\| PDB=4f3i \| SCENE= }}

-	~~Authors: Joshua, J., Zhou, M.-M., Plotnikov, A.N.~~	+	===Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor===

-	~~Description: Crystal~~ structure ~~of the first bromodomain of human BRD4 in complex~~ with ~~MS417~~ inhibitor	+	{{ABSTRACT_PUBMED_22645123}}
		+
		+	==About this Structure==
		+	[[4f3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3I OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Joshua, J.]]
		+	[[Category: Plotnikov, A N.]]
		+	[[Category: Zhou, M M.]]
		+	[[Category: Acetyl-lysine binding]]
		+	[[Category: Nucleus]]
		+	[[Category: Protein-inhibitor complex]]
		+	[[Category: Signaling protein-inhibitor complex]]

OCA at 05:46, 13 June 2012

2012-06-13T05:46:29Z

←Older revision		Revision as of 05:46, 13 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4f3i is ON HOLD	+	The entry 4f3i is ON HOLD until Paper Publication

	Authors: Joshua, J., Zhou, M.-M., Plotnikov, A.N.		Authors: Joshua, J., Zhou, M.-M., Plotnikov, A.N.

	Description: Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor		Description: Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor

OCA at 05:41, 23 May 2012

2012-05-23T05:41:36Z

←Older revision		Revision as of 05:41, 23 May 2012
Line 5:		Line 5:
	Authors: Joshua, J., Zhou, M.-M., Plotnikov, A.N.		Authors: Joshua, J., Zhou, M.-M., Plotnikov, A.N.

-	Description: ~~CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN~~ BRD4 ~~IN COMPLEX WITH~~ MS417 ~~INHIBITOR~~	+	Description: Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor

OCA: Protected "4f3i" [edit=sysop:move=sysop]

2012-05-16T08:55:25Z

Protected "4f3i" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:55, 16 May 2012