4f4d - Revision history

OCA at 11:10, 1 March 2024

2024-03-01T11:10:25Z

←Older revision		Revision as of 11:10, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F4D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F4D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4d OCA], [https://pdbe.org/4f4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f4d RCSB], [https://www.ebi.ac.uk/pdbsum/4f4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4d OCA], [https://pdbe.org/4f4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f4d RCSB], [https://www.ebi.ac.uk/pdbsum/4f4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4d ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:34, 7 October 2022

2022-10-07T04:34:11Z

←Older revision		Revision as of 04:34, 7 October 2022
Line 3:		Line 3:
	<StructureSection load='4f4d' size='340' side='right'caption='[[4f4d]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4f4d' size='340' side='right'caption='[[4f4d]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4F4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F4D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f4g\|4f4g]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4d OCA], [https://pdbe.org/4f4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f4d RCSB], [https://www.ebi.ac.uk/pdbsum/4f4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4d ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FECH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4f4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4d OCA], [~~http~~://pdbe.org/4f4d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4f4d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4f4d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN]] Defects in FECH are the cause of erythropoietic protoporphyria (EPP) [MIM:[~~http~~://omim.org/entry/177000 177000]]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. EPP is a form of porphyria marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals.<ref>PMID:1755842</ref> <ref>PMID:1376018</ref> <ref>PMID:7910885</ref> <ref>PMID:8757534</ref> <ref>PMID:9585598</ref> <ref>PMID:9740232</ref> <ref>PMID:10942404</ref> <ref>PMID:11375302</ref> <ref>PMID:12063482</ref> <ref>PMID:12601550</ref> <ref>PMID:15286165</ref> <ref>PMID:17196862</ref>	+	[https://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN] Defects in FECH are the cause of erythropoietic protoporphyria (EPP) [MIM:[https://omim.org/entry/177000 177000]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. EPP is a form of porphyria marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals.<ref>PMID:1755842</ref> <ref>PMID:1376018</ref> <ref>PMID:7910885</ref> <ref>PMID:8757534</ref> <ref>PMID:9585598</ref> <ref>PMID:9740232</ref> <ref>PMID:10942404</ref> <ref>PMID:11375302</ref> <ref>PMID:12063482</ref> <ref>PMID:12601550</ref> <ref>PMID:15286165</ref> <ref>PMID:17196862</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN]] Catalyzes the ferrous insertion into protoporphyrin IX.	+	[https://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN] Catalyzes the ferrous insertion into protoporphyrin IX.

	==See Also==		==See Also==
Line 21:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ferrochelatase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dailey~~, H A~~]]	+	[[Category: Dailey HA]]
-	[[Category: Dailey~~, T E~~]]	+	[[Category: Dailey TE]]
-	[[Category: Lanzilotta~~, W N~~]]	+	[[Category: Lanzilotta WN]]
-	[[Category: Medlock~~, A E]]~~	+	[[Category: Medlock AE]]
-	~~[[Category: Heme biosynthesis]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 11:51, 17 July 2019

2019-07-17T11:51:44Z

←Older revision		Revision as of 11:51, 17 July 2019
Line 1:		Line 1:

	==F337R variant of human ferrochelatase==		==F337R variant of human ferrochelatase==
-	<StructureSection load='4f4d' size='340' side='right' caption='[[4f4d]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4f4d' size='340' side='right'caption='[[4f4d]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4D FirstGlance]. <br>
Line 16:		Line 16:

	==See Also==		==See Also==
-	*[[Ferrochelatase\|Ferrochelatase]]	+	*[[Ferrochelatase 3D structures\|Ferrochelatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 23:
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dailey, H A]]		[[Category: Dailey, H A]]
	[[Category: Dailey, T E]]		[[Category: Dailey, T E]]

OCA at 11:23, 4 August 2016

2016-08-04T11:23:33Z

←Older revision		Revision as of 11:23, 4 August 2016
Line 1:		Line 1:
		+
	==F337R variant of human ferrochelatase==		==F337R variant of human ferrochelatase==
	<StructureSection load='4f4d' size='340' side='right' caption='[[4f4d]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4f4d' size='340' side='right' caption='[[4f4d]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f4g\|4f4g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f4g\|4f4g]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FECH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FECH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f4d RCSB], [http://www.ebi.ac.uk/pdbsum/4f4d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4d OCA], [http://pdbe.org/4f4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f4d RCSB], [http://www.ebi.ac.uk/pdbsum/4f4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dailey, H A]]		[[Category: Dailey, H A]]
	[[Category: Dailey, T E]]		[[Category: Dailey, T E]]

OCA at 11:13, 21 December 2014

2014-12-21T11:13:50Z

←Older revision		Revision as of 11:13, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4f4d~~\| ~~PDB~~=4f4d \| ~~SCENE~~= }}	+	==F337R variant of human ferrochelatase==
-	===~~F337R variant of human ferrochelatase~~===	+	<StructureSection load='4f4d' size='340' side='right' caption='[[4f4d]], [[Resolution\|resolution]] 1.80Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4D FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN]] Defects in FECH are the cause of erythropoietic protoporphyria (EPP) [MIM:[http://omim.org/entry/177000 177000]]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. EPP is a form of porphyria marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals.<ref>PMID:1755842</ref><ref>PMID:1376018</ref><ref>PMID:7910885</ref><ref>PMID:8757534</ref><ref>PMID:9585598</ref><ref>PMID:9740232</ref><ref>PMID:10942404</ref><ref>PMID:11375302</ref><ref>PMID:12063482</ref><ref>PMID:12601550</ref><ref>PMID:15286165</ref><ref>PMID:17196862</ref>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f4g\|4f4g]]</td></tr>
-	==Function==	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FECH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f4d RCSB], [http://www.ebi.ac.uk/pdbsum/4f4d PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN]] Defects in FECH are the cause of erythropoietic protoporphyria (EPP) [MIM:[http://omim.org/entry/177000 177000]]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. EPP is a form of porphyria marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals.<ref>PMID:1755842</ref> <ref>PMID:1376018</ref> <ref>PMID:7910885</ref> <ref>PMID:8757534</ref> <ref>PMID:9585598</ref> <ref>PMID:9740232</ref> <ref>PMID:10942404</ref> <ref>PMID:11375302</ref> <ref>PMID:12063482</ref> <ref>PMID:12601550</ref> <ref>PMID:15286165</ref> <ref>PMID:17196862</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN]] Catalyzes the ferrous insertion into protoporphyrin IX.		[[http://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN]] Catalyzes the ferrous insertion into protoporphyrin IX.
-
-	==About this Structure==
-	[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA].

	==See Also==		==See Also==
	*[[Ferrochelatase\|Ferrochelatase]]		*[[Ferrochelatase\|Ferrochelatase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dailey, H A.]]	+	[[Category: Dailey, H A]]
-	[[Category: Dailey, T E.]]	+	[[Category: Dailey, T E]]
-	[[Category: Lanzilotta, W N.]]	+	[[Category: Lanzilotta, W N]]
-	[[Category: Medlock, A E~~.]]~~	+	[[Category: Medlock, A E]]
-	~~[[Category: Ferrochelatase~~]]	+
	[[Category: Heme biosynthesis]]		[[Category: Heme biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 17:28, 24 March 2013

2013-03-24T17:28:26Z

←Older revision		Revision as of 17:28, 24 March 2013
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-	[[Image:4f4d.jpg\|left\|200px]]
-
	{{STRUCTURE_4f4d\| PDB=4f4d \| SCENE= }}		{{STRUCTURE_4f4d\| PDB=4f4d \| SCENE= }}
-
	===F337R variant of human ferrochelatase===		===F337R variant of human ferrochelatase===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN]] Defects in FECH are the cause of erythropoietic protoporphyria (EPP) [MIM:[http://omim.org/entry/177000 177000]]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. EPP is a form of porphyria marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals.<ref>PMID:1755842</ref><ref>PMID:1376018</ref><ref>PMID:7910885</ref><ref>PMID:8757534</ref><ref>PMID:9585598</ref><ref>PMID:9740232</ref><ref>PMID:10942404</ref><ref>PMID:11375302</ref><ref>PMID:12063482</ref><ref>PMID:12601550</ref><ref>PMID:15286165</ref><ref>PMID:17196862</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/HEMH_HUMAN HEMH_HUMAN]] Catalyzes the ferrous insertion into protoporphyrin IX.

	==About this Structure==		==About this Structure==
	[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA].		[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA].
		+
		+	==See Also==
		+	*[[Ferrochelatase\|Ferrochelatase]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Ferrochelatase]]		[[Category: Ferrochelatase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 05:21, 12 September 2012

2012-09-12T05:21:25Z

←Older revision		Revision as of 05:21, 12 September 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4f4d.jpg\|left\|200px]]

-	~~The entry~~ 4f4d ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4f4d\| PDB=4f4d \| SCENE= }}

-	~~Authors: Lanzilotta, W.N., Medlock, A.E., Dailey, T.E., Dailey, H.A.~~	+	===F337R variant of human ferrochelatase===

-	~~Description~~: ~~F337R variant of human ferrochelatase~~	+
		+	==About this Structure==
		+	[[4f4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4D OCA].
		+	[[Category: Ferrochelatase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Dailey, H A.]]
		+	[[Category: Dailey, T E.]]
		+	[[Category: Lanzilotta, W N.]]
		+	[[Category: Medlock, A E.]]
		+	[[Category: Ferrochelatase]]
		+	[[Category: Heme biosynthesis]]
		+	[[Category: Lyase]]

OCA at 07:22, 20 June 2012

2012-06-20T07:22:38Z

←Older revision		Revision as of 07:22, 20 June 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4f4d is ON HOLD	+	The entry 4f4d is ON HOLD until Paper Publication

	Authors: Lanzilotta, W.N., Medlock, A.E., Dailey, T.E., Dailey, H.A.		Authors: Lanzilotta, W.N., Medlock, A.E., Dailey, T.E., Dailey, H.A.

	Description: F337R variant of human ferrochelatase		Description: F337R variant of human ferrochelatase

OCA at 05:41, 23 May 2012

2012-05-23T05:41:47Z

←Older revision		Revision as of 05:41, 23 May 2012
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	Authors: Lanzilotta, W.N., Medlock, A.E., Dailey, T.E., Dailey, H.A.		Authors: Lanzilotta, W.N., Medlock, A.E., Dailey, T.E., Dailey, H.A.

-	Description: F337R ~~VARIANT OF HUMAN FERROCHELATASE~~	+	Description: F337R variant of human ferrochelatase

OCA: Protected "4f4d" [edit=sysop:move=sysop]

2012-05-16T08:56:16Z

Protected "4f4d" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:56, 16 May 2012