4f5w - Revision history

OCA at 08:50, 20 March 2024

2024-03-20T08:50:25Z

←Older revision		Revision as of 08:50, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4f5w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F5W FirstGlance]. <br>		<table><tr><td colspan='2'>[[4f5w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F5W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.201Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5w OCA], [https://pdbe.org/4f5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f5w RCSB], [https://www.ebi.ac.uk/pdbsum/4f5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f5w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5w OCA], [https://pdbe.org/4f5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f5w RCSB], [https://www.ebi.ac.uk/pdbsum/4f5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f5w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>		[https://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	STING functions as both an adaptor protein signaling cytoplasmic double-stranded DNA and a direct immunosensor of cyclic diguanylate monophosphate (c-di-GMP). The crystal structures of the C-terminal domain of human STING (STING(CTD)) and its complex with c-di-GMP reveal how STING recognizes c-di-GMP. In response to c-di-GMP binding, two surface loops, which serve as a gate and latch of the cleft formed by the dimeric STING(CTD), undergo rearrangements to interact with the ligand.
-
-	Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.,Shang G, Zhu D, Li N, Zhang J, Zhu C, Lu D, Liu C, Yu Q, Zhao Y, Xu S, Gu L Nat Struct Mol Biol. 2012 Jun 24;19(7):725-7. doi: 10.1038/nsmb.2332. PMID:22728660<ref>PMID:22728660</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4f5w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 04:36, 7 October 2022

2022-10-07T04:36:49Z

←Older revision		Revision as of 04:36, 7 October 2022
Line 1:		Line 1:

	==Crystal structure of ligand free human STING CTD==		==Crystal structure of ligand free human STING CTD==
-	<StructureSection load='4f5w' size='340' side='right' caption='[[4f5w]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4f5w' size='340' side='right'caption='[[4f5w]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4f5w]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4F5W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4f5w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F5W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f5y\|4f5y]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5w OCA], [https://pdbe.org/4f5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f5w RCSB], [https://www.ebi.ac.uk/pdbsum/4f5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f5w ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMEM173, ERIS, MITA, STING ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4f5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5w OCA], [~~http~~://pdbe.org/4f5w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4f5w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4f5w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4f5w ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>	+	[https://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Stimulator of interferon genes\|Stimulator of interferon genes]]	+	*[[Stimulator of interferon genes protein\|Stimulator of interferon genes protein]]
		+	*[[Stimulator of interferon genes protein 3D structures\|Stimulator of interferon genes protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Gu, L]]	+	[[Category: Large Structures]]
-	[[Category: Li, N]]	+	[[Category: Gu L]]
-	[[Category: Liu, C]]	+	[[Category: Li N]]
-	[[Category: Lu, D]]	+	[[Category: Liu C]]
-	[[Category: Shang, G]]	+	[[Category: Lu D]]
-	[[Category: Xu, S]]	+	[[Category: Shang G]]
-	[[Category: Yu, Q]]	+	[[Category: Xu S]]
-	[[Category: Zhang, J]]	+	[[Category: Yu Q]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhang J]]
-	[[Category: Zhu, C]]	+	[[Category: Zhao Y]]
-	[[Category: Zhu, D]]	+	[[Category: Zhu C]]
-	~~[[Category: Immune system]]~~	+	[[Category: Zhu D]]
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Innate immunity human sting~~]]	+

OCA at 11:40, 5 August 2016

2016-08-05T11:40:51Z

←Older revision		Revision as of 11:40, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of ligand free human STING CTD==		==Crystal structure of ligand free human STING CTD==
	<StructureSection load='4f5w' size='340' side='right' caption='[[4f5w]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4f5w' size='340' side='right' caption='[[4f5w]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4f5w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F5W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4f5w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F5W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f5y\|4f5y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f5y\|4f5y]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMEM173, ERIS, MITA, STING ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMEM173, ERIS, MITA, STING ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f5w RCSB], [http://www.ebi.ac.uk/pdbsum/4f5w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5w OCA], [http://pdbe.org/4f5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f5w RCSB], [http://www.ebi.ac.uk/pdbsum/4f5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f5w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4f5w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gu, L]]		[[Category: Gu, L]]
	[[Category: Li, N]]		[[Category: Li, N]]

OCA at 18:31, 25 December 2014

2014-12-25T18:31:32Z

←Older revision		Revision as of 18:31, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4f5w\| PDB~~=4f5w \| ~~SCENE~~= }}	+	==Crystal structure of ligand free human STING CTD==
-	===~~Crystal~~ structure of ligand ~~free human~~ STING ~~CTD~~===	+	<StructureSection load='4f5w' size='340' side='right' caption='[[4f5w]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22728660}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4f5w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F5W FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f5y\|4f5y]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMEM173, ERIS, MITA, STING ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f5w RCSB], [http://www.ebi.ac.uk/pdbsum/4f5w PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>		[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	STING functions as both an adaptor protein signaling cytoplasmic double-stranded DNA and a direct immunosensor of cyclic diguanylate monophosphate (c-di-GMP). The crystal structures of the C-terminal domain of human STING (STING(CTD)) and its complex with c-di-GMP reveal how STING recognizes c-di-GMP. In response to c-di-GMP binding, two surface loops, which serve as a gate and latch of the cleft formed by the dimeric STING(CTD), undergo rearrangements to interact with the ligand.
		+
		+	Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.,Shang G, Zhu D, Li N, Zhang J, Zhu C, Lu D, Liu C, Yu Q, Zhao Y, Xu S, Gu L Nat Struct Mol Biol. 2012 Jun 24;19(7):725-7. doi: 10.1038/nsmb.2332. PMID:22728660<ref>PMID:22728660</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4f5w]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:022728660</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Stimulator of interferon genes\|Stimulator of interferon genes]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gu, L.]]	+	[[Category: Gu, L]]
-	[[Category: Li, N.]]	+	[[Category: Li, N]]
-	[[Category: Liu, C.]]	+	[[Category: Liu, C]]
-	[[Category: Lu, D.]]	+	[[Category: Lu, D]]
-	[[Category: Shang, G.]]	+	[[Category: Shang, G]]
-	[[Category: Xu, S.]]	+	[[Category: Xu, S]]
-	[[Category: Yu, Q.]]	+	[[Category: Yu, Q]]
-	[[Category: Zhang, J.]]	+	[[Category: Zhang, J]]
-	[[Category: Zhao, Y.]]	+	[[Category: Zhao, Y]]
-	[[Category: Zhu, C.]]	+	[[Category: Zhu, C]]
-	[[Category: Zhu, D.]]	+	[[Category: Zhu, D]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Innate immunity]]		[[Category: Innate immunity]]
	[[Category: Innate immunity human sting]]		[[Category: Innate immunity human sting]]

OCA at 09:14, 4 September 2013

2013-09-04T09:14:09Z

←Older revision		Revision as of 09:14, 4 September 2013
Line 1:		Line 1:
-	[[Image:4f5w.jpg\|left\|200px]]
-
	{{STRUCTURE_4f5w\| PDB=4f5w \| SCENE= }}		{{STRUCTURE_4f5w\| PDB=4f5w \| SCENE= }}
-
	===Crystal structure of ligand free human STING CTD===		===Crystal structure of ligand free human STING CTD===
		+	{{ABSTRACT_PUBMED_22728660}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>

	==About this Structure==		==About this Structure==
	[[4f5w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA].		[[4f5w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022728660</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gu, L.]]		[[Category: Gu, L.]]

OCA at 05:59, 27 June 2012

2012-06-27T05:59:10Z

←Older revision		Revision as of 05:59, 27 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4f5w.jpg\|left\|200px]]

-	~~The entry~~ 4f5w ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4f5w\| PDB=4f5w \| SCENE= }}

-	~~Authors: Gu, L., Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S.~~	+	===Crystal structure of ligand free human STING CTD===

-	~~Description: Crystal~~ structure ~~of ligand free~~ human ~~STING CTD~~	+
		+	==About this Structure==
		+	[[4f5w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Gu, L.]]
		+	[[Category: Li, N.]]
		+	[[Category: Liu, C.]]
		+	[[Category: Lu, D.]]
		+	[[Category: Shang, G.]]
		+	[[Category: Xu, S.]]
		+	[[Category: Yu, Q.]]
		+	[[Category: Zhang, J.]]
		+	[[Category: Zhao, Y.]]
		+	[[Category: Zhu, C.]]
		+	[[Category: Zhu, D.]]
		+	[[Category: Immune system]]
		+	[[Category: Innate immunity]]
		+	[[Category: Innate immunity human sting]]

OCA at 05:31, 30 May 2012

2012-05-30T05:31:28Z

←Older revision		Revision as of 05:31, 30 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4f5w is ON HOLD	+	The entry 4f5w is ON HOLD until Paper Publication

	Authors: Gu, L., Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S.		Authors: Gu, L., Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S.

	Description: Crystal structure of ligand free human STING CTD		Description: Crystal structure of ligand free human STING CTD

OCA: Protected "4f5w" [edit=sysop:move=sysop]

2012-05-23T05:43:09Z

Protected "4f5w" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:43, 23 May 2012

OCA: New page: '''Unreleased structure''' The entry 4f5w is ON HOLD Authors: Gu, L., Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S. Description: Crystal str...

2012-05-23T05:43:08Z

New page: '''Unreleased structure''' The entry 4f5w is ON HOLD Authors: Gu, L., Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S. Description: Crystal str...

New page

'''Unreleased structure'''

The entry 4f5w is ON HOLD

Authors: Gu, L., Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S.

Description: Crystal structure of ligand free human STING CTD