4fbq - Revision history

OCA at 11:13, 1 March 2024

2024-03-01T11:13:34Z

←Older revision		Revision as of 11:13, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [https://pdbe.org/4fbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [https://www.ebi.ac.uk/pdbsum/4fbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [https://pdbe.org/4fbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [https://www.ebi.ac.uk/pdbsum/4fbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RAD32_SCHPO RAD32_SCHPO] Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51.[https://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>		[https://www.uniprot.org/uniprot/RAD32_SCHPO RAD32_SCHPO] Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51.[https://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Mre11-Rad50-Nbs1 (MRN) complex tethers, processes and signals DNA double-strand breaks, promoting genomic stability. To understand the functional architecture of MRN, we determined the crystal structures of the Schizosaccharomyces pombe Mre11 dimeric catalytic domain alone and in complex with a fragment of Nbs1. Two Nbs1 subunits stretch around the outside of the nuclease domains of Mre11, with one subunit additionally bridging and locking the Mre11 dimer via a highly conserved asymmetrical binding motif. Our results show that Mre11 forms a flexible dimer and suggest that Nbs1 not only is a checkpoint adaptor but also functionally influences Mre11-Rad50. Clinical mutations in Mre11 are located along the Nbs1-interaction sites and weaken the Mre11-Nbs1 interaction. However, they differentially affect DNA repair and telomere maintenance in Saccharomyces cerevisiae, potentially providing insight into their different human disease pathologies.
-
-	Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.,Schiller CB, Lammens K, Guerini I, Coordes B, Feldmann H, Schlauderer F, Mockel C, Schele A, Strasser K, Jackson SP, Hopfner KP Nat Struct Mol Biol. 2012 Jun 17;19(7):693-700. doi: 10.1038/nsmb.2323. PMID:22705791<ref>PMID:22705791</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4fbq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:46, 7 October 2022

2022-10-07T04:46:53Z

←Older revision		Revision as of 04:46, 7 October 2022
Line 3:		Line 3:
	<StructureSection load='4fbq' size='340' side='right'caption='[[4fbq]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4fbq' size='340' side='right'caption='[[4fbq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fission_yeast Fission yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fbk\|4fbk]], [[4fbw\|4fbw]], [[4fcx\|4fcx]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [https://pdbe.org/4fbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [https://www.ebi.ac.uk/pdbsum/4fbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [~~http~~://pdbe.org/4fbq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fbq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO]] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>	+	[https://www.uniprot.org/uniprot/RAD32_SCHPO RAD32_SCHPO] Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51.[https://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fission yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hopfner, K P]]~~	+	[[Category: Schizosaccharomyces pombe 972h-]]
-	~~[[Category: Lammens, K]]~~	+	[[Category: Hopfner KP]]
-	~~[[Category: Schiller, C B]]~~	+	[[Category: Lammens K]]
-	~~[[Category: Dna double~~-~~strand break repair~~]]	+	[[Category: Schiller CB]]
-	[[Category: ~~Hydrolase~~]]	+
-	[[Category: ~~Nuclease~~]]	+
-	[[Category: ~~Protein binding~~]]	+

OCA at 09:31, 5 February 2020

2020-02-05T09:31:49Z

←Older revision		Revision as of 09:31, 5 February 2020
Line 1:		Line 1:

	==Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site==		==Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site==
-	<StructureSection load='4fbq' size='340' side='right' caption='[[4fbq]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4fbq' size='340' side='right'caption='[[4fbq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Fission yeast]]		[[Category: Fission yeast]]
		+	[[Category: Large Structures]]
	[[Category: Hopfner, K P]]		[[Category: Hopfner, K P]]
	[[Category: Lammens, K]]		[[Category: Lammens, K]]

OCA at 17:18, 5 August 2016

2016-08-05T17:18:35Z

←Older revision		Revision as of 17:18, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site==		==Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site==
	<StructureSection load='4fbq' size='340' side='right' caption='[[4fbq]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4fbq' size='340' side='right' caption='[[4fbq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fbk\|4fbk]], [[4fbw\|4fbw]], [[4fcx\|4fcx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fbk\|4fbk]], [[4fbw\|4fbw]], [[4fcx\|4fcx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [http://www.ebi.ac.uk/pdbsum/4fbq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [http://pdbe.org/4fbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [http://www.ebi.ac.uk/pdbsum/4fbq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4fbq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Fission yeast]]
	[[Category: Hopfner, K P]]		[[Category: Hopfner, K P]]
	[[Category: Lammens, K]]		[[Category: Lammens, K]]

OCA at 20:34, 25 December 2014

2014-12-25T20:34:58Z

←Older revision		Revision as of 20:34, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fbk\|4fbk]], [[4fbw\|4fbw]], [[4fcx\|4fcx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fbk\|4fbk]], [[4fbw\|4fbw]], [[4fcx\|4fcx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [http://www.ebi.ac.uk/pdbsum/4fbq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [http://www.ebi.ac.uk/pdbsum/4fbq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO]] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Hopfner, K P.]]	+	[[Category: Hopfner, K P]]
-	[[Category: Lammens, K.]]	+	[[Category: Lammens, K]]
-	[[Category: Schiller, C B.]]	+	[[Category: Schiller, C B]]
	[[Category: Dna double-strand break repair]]		[[Category: Dna double-strand break repair]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nuclease]]		[[Category: Nuclease]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 07:34, 5 June 2014

2014-06-05T07:34:51Z

←Older revision		Revision as of 07:34, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4fbq.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site==
		+	<StructureSection load='4fbq' size='340' side='right' caption='[[4fbq]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FBQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fbk\|4fbk]], [[4fbw\|4fbw]], [[4fcx\|4fcx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fbq RCSB], [http://www.ebi.ac.uk/pdbsum/4fbq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Mre11-Rad50-Nbs1 (MRN) complex tethers, processes and signals DNA double-strand breaks, promoting genomic stability. To understand the functional architecture of MRN, we determined the crystal structures of the Schizosaccharomyces pombe Mre11 dimeric catalytic domain alone and in complex with a fragment of Nbs1. Two Nbs1 subunits stretch around the outside of the nuclease domains of Mre11, with one subunit additionally bridging and locking the Mre11 dimer via a highly conserved asymmetrical binding motif. Our results show that Mre11 forms a flexible dimer and suggest that Nbs1 not only is a checkpoint adaptor but also functionally influences Mre11-Rad50. Clinical mutations in Mre11 are located along the Nbs1-interaction sites and weaken the Mre11-Nbs1 interaction. However, they differentially affect DNA repair and telomere maintenance in Saccharomyces cerevisiae, potentially providing insight into their different human disease pathologies.

-	~~{{STRUCTURE_4fbq\| PDB=4fbq \| SCENE= }}~~	+	Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.,Schiller CB, Lammens K, Guerini I, Coordes B, Feldmann H, Schlauderer F, Mockel C, Schele A, Strasser K, Jackson SP, Hopfner KP Nat Struct Mol Biol. 2012 Jun 17;19(7):693-700. doi: 10.1038/nsmb.2323. PMID:22705791<ref>PMID:22705791</ref>

-	~~===Crystal structure~~ of ~~a covalently fused Nbs1-Mre11 complex with two manganese ions per active site===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22705791}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4fbq]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022705791<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Hopfner, K P.]]		[[Category: Hopfner, K P.]]

OCA at 06:20, 25 July 2012

2012-07-25T06:20:23Z

←Older revision		Revision as of 06:20, 25 July 2012
Line 1:		Line 1:
-	[[Image:4fbq.~~jpg~~\|left\|200px]]	+	[[Image:4fbq.png\|left\|200px]]

	{{STRUCTURE_4fbq\| PDB=4fbq \| SCENE= }}		{{STRUCTURE_4fbq\| PDB=4fbq \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site===		===Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site===

		+	{{ABSTRACT_PUBMED_22705791}}

	==About this Structure==		==About this Structure==
	[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA].		[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022705791</ref><references group="xtra"/>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Hopfner, K P.]]		[[Category: Hopfner, K P.]]

OCA at 08:00, 20 June 2012

2012-06-20T08:00:29Z

←Older revision		Revision as of 08:00, 20 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4fbq.jpg\|left\|200px]]

-	~~The entry~~ 4fbq ~~is ON HOLD~~	+	{{STRUCTURE_4fbq\| PDB=4fbq \| SCENE= }}

-	~~Authors: Schiller, C.B., Lammens, K., Hopfner, K.P.~~	+	===Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site===

-	~~Description: Crystal structure of~~ a ~~covalently fused Nbs1-Mre11 complex~~ with ~~two manganese ions per active site~~	+
		+	==About this Structure==
		+	[[4fbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBQ OCA].
		+	[[Category: Schizosaccharomyces pombe]]
		+	[[Category: Hopfner, K P.]]
		+	[[Category: Lammens, K.]]
		+	[[Category: Schiller, C B.]]
		+	[[Category: Dna double-strand break repair]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nuclease]]
		+	[[Category: Protein binding]]

OCA: Protected "4fbq" [edit=sysop:move=sysop]

2012-05-30T05:34:56Z

Protected "4fbq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:34, 30 May 2012

OCA: New page: '''Unreleased structure''' The entry 4fbq is ON HOLD Authors: Schiller, C.B., Lammens, K., Hopfner, K.P. Description: Crystal structure of a covalently fused Nbs1-Mre11 complex with tw...

2012-05-30T05:34:56Z

New page: '''Unreleased structure''' The entry 4fbq is ON HOLD Authors: Schiller, C.B., Lammens, K., Hopfner, K.P. Description: Crystal structure of a covalently fused Nbs1-Mre11 complex with tw...

New page

'''Unreleased structure'''

The entry 4fbq is ON HOLD

Authors: Schiller, C.B., Lammens, K., Hopfner, K.P.

Description: Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site