4fn9 - Revision history

OCA at 15:29, 14 March 2024

2024-03-14T15:29:41Z

←Older revision		Revision as of 15:29, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FN9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FN9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fn9 OCA], [https://pdbe.org/4fn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fn9 RCSB], [https://www.ebi.ac.uk/pdbsum/4fn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fn9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fn9 OCA], [https://pdbe.org/4fn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fn9 RCSB], [https://www.ebi.ac.uk/pdbsum/4fn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fn9 ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Most proteins are regulated by physical interactions with other molecules; some are highly specific, but others interact with many partners. Despite much speculation, we know little about how and why specificity/promiscuity evolves in natural proteins. It is widely assumed that specific proteins evolved from more promiscuous ancient forms and that most proteins' specificity has been tuned to an optimal state by selection. Here we use ancestral protein reconstruction to trace the evolutionary history of ligand recognition in the steroid hormone receptors (SRs), a family of hormone-regulated animal transcription factors. We resurrected the deepest ancestral proteins in the SR family and characterized the structure-activity relationships by which they distinguished among ligands. We found that that the most ancient split in SR evolution involved a discrete switch from an ancient receptor for aromatized estrogens-including xenobiotics-to a derived receptor that recognized non-aromatized progestagens and corticosteroids. The family's history, viewed in relation to the evolution of their ligands, suggests that SRs evolved according to a principle of minimal specificity: at each point in time, receptors evolved ligand recognition criteria that were just specific enough to parse the set of endogenous substances to which they were exposed. By studying the atomic structures of resurrected SR proteins, we found that their promiscuity evolved because the ancestral binding cavity was larger than the primary ligand and contained excess hydrogen bonding capacity, allowing adventitious recognition of larger molecules with additional functional groups. Our findings provide an historical explanation for the sensitivity of modern SRs to natural and synthetic ligands-including endocrine-disrupting drugs and pollutants-and show that knowledge of history can contribute to ligand prediction. They suggest that SR promiscuity may reflect the limited power of selection within real biological systems to discriminate between perfect and "good enough."
-
-	Evolution of minimal specificity and promiscuity in steroid hormone receptors.,Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW PLoS Genet. 2012 Nov;8(11):e1003072. doi: 10.1371/journal.pgen.1003072. Epub 2012, Nov 15. PMID:23166518<ref>PMID:23166518</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4fn9" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:00, 19 October 2022

2022-10-19T20:00:38Z

←Older revision		Revision as of 20:00, 19 October 2022
Line 3:		Line 3:
	<StructureSection load='4fn9' size='340' side='right'caption='[[4fn9]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4fn9' size='340' side='right'caption='[[4fn9]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4FN9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FN9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fne\|4fne]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fn9 OCA], [https://pdbe.org/4fn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fn9 RCSB], [https://www.ebi.ac.uk/pdbsum/4fn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fn9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fn9 OCA], [~~http~~://pdbe.org/4fn9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4fn9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4fn9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4fn9 ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Colucci~~, J K~~]]	+	[[Category: Colucci JK]]
-	[[Category: Ortlund~~, E A~~]]	+	[[Category: Ortlund EA]]
-	[[Category: Thornton~~, J W]]~~	+	[[Category: Thornton JW]]
-	~~[[Category: Ancestral]]~~	+
-	~~[[Category: Cytosolic]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Nuclear]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Progesterone receptor]]~~	+
-	~~[[Category: Steroid receptor]]~~	+
-	~~[[Category: Steroid-binding protein~~]]	+

OCA at 07:33, 27 March 2019

2019-03-27T07:33:45Z

←Older revision		Revision as of 07:33, 27 March 2019
Line 1:		Line 1:

	==X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex==		==X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex==
-	<StructureSection load='4fn9' size='340' side='right' caption='[[4fn9]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4fn9' size='340' side='right'caption='[[4fn9]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FN9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FN9 FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Colucci, J K]]		[[Category: Colucci, J K]]
	[[Category: Ortlund, E A]]		[[Category: Ortlund, E A]]

OCA at 19:58, 15 December 2016

2016-12-15T19:58:46Z

←Older revision		Revision as of 19:58, 15 December 2016
Line 1:		Line 1:
		+
	==X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex==		==X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex==
	<StructureSection load='4fn9' size='340' side='right' caption='[[4fn9]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4fn9' size='340' side='right' caption='[[4fn9]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fne\|4fne]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fne\|4fne]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fn9 RCSB], [http://www.ebi.ac.uk/pdbsum/4fn9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fn9 OCA], [http://pdbe.org/4fn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fn9 RCSB], [http://www.ebi.ac.uk/pdbsum/4fn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fn9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4fn9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:39, 15 February 2015

2015-02-15T07:39:40Z

←Older revision		Revision as of 07:39, 15 February 2015
Line 1:		Line 1:
-	[[~~Image:~~4fn9.~~jpg~~\|~~left~~\|~~200px~~]]	+	==X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex==
		+	<StructureSection load='4fn9' size='340' side='right' caption='[[4fn9]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FN9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fne\|4fne]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fn9 RCSB], [http://www.ebi.ac.uk/pdbsum/4fn9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Most proteins are regulated by physical interactions with other molecules; some are highly specific, but others interact with many partners. Despite much speculation, we know little about how and why specificity/promiscuity evolves in natural proteins. It is widely assumed that specific proteins evolved from more promiscuous ancient forms and that most proteins' specificity has been tuned to an optimal state by selection. Here we use ancestral protein reconstruction to trace the evolutionary history of ligand recognition in the steroid hormone receptors (SRs), a family of hormone-regulated animal transcription factors. We resurrected the deepest ancestral proteins in the SR family and characterized the structure-activity relationships by which they distinguished among ligands. We found that that the most ancient split in SR evolution involved a discrete switch from an ancient receptor for aromatized estrogens-including xenobiotics-to a derived receptor that recognized non-aromatized progestagens and corticosteroids. The family's history, viewed in relation to the evolution of their ligands, suggests that SRs evolved according to a principle of minimal specificity: at each point in time, receptors evolved ligand recognition criteria that were just specific enough to parse the set of endogenous substances to which they were exposed. By studying the atomic structures of resurrected SR proteins, we found that their promiscuity evolved because the ancestral binding cavity was larger than the primary ligand and contained excess hydrogen bonding capacity, allowing adventitious recognition of larger molecules with additional functional groups. Our findings provide an historical explanation for the sensitivity of modern SRs to natural and synthetic ligands-including endocrine-disrupting drugs and pollutants-and show that knowledge of history can contribute to ligand prediction. They suggest that SR promiscuity may reflect the limited power of selection within real biological systems to discriminate between perfect and "good enough."

-	~~{{STRUCTURE_4fn9\| PDB=4fn9 \| SCENE= }}~~	+	Evolution of minimal specificity and promiscuity in steroid hormone receptors.,Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW PLoS Genet. 2012 Nov;8(11):e1003072. doi: 10.1371/journal.pgen.1003072. Epub 2012, Nov 15. PMID:23166518<ref>PMID:23166518</ref>

-	~~===X-ray Crystal structure~~ of the ~~Ancestral 3-keto steroid receptor - Progesterone complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23166518}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA].~~	+	</StructureSection>
-	[[Category: Colucci, J K.]]	+	[[Category: Colucci, J K]]
-	[[Category: Ortlund, E A.]]	+	[[Category: Ortlund, E A]]
-	[[Category: Thornton, J W.]]	+	[[Category: Thornton, J W]]
	[[Category: Ancestral]]		[[Category: Ancestral]]
	[[Category: Cytosolic]]		[[Category: Cytosolic]]

OCA at 09:22, 2 January 2013

2013-01-02T09:22:18Z

←Older revision		Revision as of 09:22, 2 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4fn9.jpg\|left\|200px]]

-	~~The entry~~ 4fn9 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4fn9\| PDB=4fn9 \| SCENE= }}

-	~~Authors: Colucci, J.K., Ortlund, E.A., Thornton, J.W.~~	+	===X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex===

-	~~Description~~: X-~~ray Crystal structure of the~~ Ancestral ~~3-keto steroid~~ receptor -Progesterone ~~complex~~	+	{{ABSTRACT_PUBMED_23166518}}
		+
		+	==About this Structure==
		+	[[4fn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FN9 OCA].
		+	[[Category: Colucci, J K.]]
		+	[[Category: Ortlund, E A.]]
		+	[[Category: Thornton, J W.]]
		+	[[Category: Ancestral]]
		+	[[Category: Cytosolic]]
		+	[[Category: Hormone]]
		+	[[Category: Nuclear]]
		+	[[Category: Nuclear receptor]]
		+	[[Category: Progesterone receptor]]
		+	[[Category: Steroid receptor]]
		+	[[Category: Steroid-binding protein]]

OCA at 06:46, 25 July 2012

2012-07-25T06:46:01Z

←Older revision		Revision as of 06:46, 25 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4fn9 is ON HOLD	+	The entry 4fn9 is ON HOLD until Paper Publication

	Authors: Colucci, J.K., Ortlund, E.A., Thornton, J.W.		Authors: Colucci, J.K., Ortlund, E.A., Thornton, J.W.

	Description: X-ray Crystal structure of the Ancestral 3-keto steroid receptor -Progesterone complex		Description: X-ray Crystal structure of the Ancestral 3-keto steroid receptor -Progesterone complex

OCA: Protected "4fn9" [edit=sysop:move=sysop]

2012-06-27T05:27:39Z

Protected "4fn9" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 27 June 2012

OCA: New page: '''Unreleased structure''' The entry 4fn9 is ON HOLD Authors: Colucci, J.K., Ortlund, E.A., Thornton, J.W. Description: X-ray Crystal structure of the Ancestral 3-keto steroid receptor...

2012-06-27T05:27:36Z

New page: '''Unreleased structure''' The entry 4fn9 is ON HOLD Authors: Colucci, J.K., Ortlund, E.A., Thornton, J.W. Description: X-ray Crystal structure of the Ancestral 3-keto steroid receptor...

New page

'''Unreleased structure'''

The entry 4fn9 is ON HOLD

Authors: Colucci, J.K., Ortlund, E.A., Thornton, J.W.

Description: X-ray Crystal structure of the Ancestral 3-keto steroid receptor -Progesterone complex