4g2y - Revision history

OCA at 08:50, 20 March 2024

2024-03-20T08:50:51Z

←Older revision		Revision as of 08:50, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g2y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g2y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI5:2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE'>NI5</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI5:2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE'>NI5</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [https://pdbe.org/4g2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [https://www.ebi.ac.uk/pdbsum/4g2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [https://pdbe.org/4g2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [https://www.ebi.ac.uk/pdbsum/4g2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.		[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cyclic nucleotide phosphodiesterase type 5 (PDE5) is a prime drug target for treating the diseases associated with a lower level of the cyclic guanosine monophosphate (cGMP), which is a specific substrate for PDE5 hydrolysis. Here we report a series of novel PDE5 inhibitors with the new scaffold of the monocyclic pyrimidin-4(3H)-one ring developed using the structure-based discovery strategy. In total, 37 derivatives of the pyrimidin-4(3H)-ones, were designed, synthesized, and evaluated for their inhibitory activities to PDE5, resulting in 25 compounds with IC50 ranging from 1 to 100 nM and 11 compounds with IC50 ranging from 1 to 10 nM. Compound 5, 5,6-diethyl-2-[2-n-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H) -one, the most potent compound, has an excellent IC50 (1.6 nM) in vitro and a good efficacy in a rat model of erection. It thus provides a potential candidate for the further development into a new drug targeting PDE5.
-
-	Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.,Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov, 19. PMID:23137303<ref>PMID:23137303</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g2y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]		*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:22, 19 October 2022

2022-10-19T20:22:13Z

←Older revision		Revision as of 20:22, 19 October 2022
Line 1:		Line 1:

	==Crystal structure of PDE5A complexed with its inhibitor==		==Crystal structure of PDE5A complexed with its inhibitor==
-	<StructureSection load='4g2y' size='340' side='right' caption='[[4g2y]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4g2y' size='340' side='right'caption='[[4g2y]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g2y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g2y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI5:2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE'>NI5</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI5:2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE'>NI5</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g2w\|4g2w]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [https://pdbe.org/4g2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [https://www.ebi.ac.uk/pdbsum/4g2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2y ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5, PDE5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [~~http~~://pdbe.org/4g2y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g2y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2y ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.	+	[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Chen, T T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ren, J~~]]	+	[[Category: Chen TT]]
-	[[Category: ~~Xu, Y C~~]]	+	[[Category: Ren J]]
-	[[Category: ~~Hydrolase-hydrolase inhibitor complex]]~~	+	[[Category: Xu YC]]
-	~~[[Category: Phosphodiesterase~~]]	+

OCA at 09:42, 5 August 2016

2016-08-05T09:42:15Z

←Older revision		Revision as of 09:42, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of PDE5A complexed with its inhibitor==		==Crystal structure of PDE5A complexed with its inhibitor==
	<StructureSection load='4g2y' size='340' side='right' caption='[[4g2y]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4g2y' size='340' side='right' caption='[[4g2y]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g2y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g2y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI5:2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE'>NI5</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI5:2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE'>NI5</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g2w\|4g2w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g2w\|4g2w]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5, PDE5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5, PDE5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [http://www.ebi.ac.uk/pdbsum/4g2y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [http://pdbe.org/4g2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [http://www.ebi.ac.uk/pdbsum/4g2y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g2y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, T T]]		[[Category: Chen, T T]]
	[[Category: Ren, J]]		[[Category: Ren, J]]

OCA at 17:45, 25 December 2014

2014-12-25T17:45:16Z

←Older revision		Revision as of 17:45, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [http://www.ebi.ac.uk/pdbsum/4g2y PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [http://www.ebi.ac.uk/pdbsum/4g2y PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:10, 21 December 2014

2014-12-21T11:10:14Z

←Older revision		Revision as of 11:10, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4g2y\| PDB=4g2y \| SCENE= }}~~	+	==Crystal structure of PDE5A complexed with its inhibitor==
-	===Crystal structure of PDE5A complexed with its inhibitor===	+	<StructureSection load='4g2y' size='340' side='right' caption='[[4g2y]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23137303}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g2y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2Y FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI5:2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE'>NI5</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g2w\|4g2w]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5, PDE5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [http://www.ebi.ac.uk/pdbsum/4g2y PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclic nucleotide phosphodiesterase type 5 (PDE5) is a prime drug target for treating the diseases associated with a lower level of the cyclic guanosine monophosphate (cGMP), which is a specific substrate for PDE5 hydrolysis. Here we report a series of novel PDE5 inhibitors with the new scaffold of the monocyclic pyrimidin-4(3H)-one ring developed using the structure-based discovery strategy. In total, 37 derivatives of the pyrimidin-4(3H)-ones, were designed, synthesized, and evaluated for their inhibitory activities to PDE5, resulting in 25 compounds with IC50 ranging from 1 to 100 nM and 11 compounds with IC50 ranging from 1 to 10 nM. Compound 5, 5,6-diethyl-2-[2-n-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H) -one, the most potent compound, has an excellent IC50 (1.6 nM) in vitro and a good efficacy in a rat model of erection. It thus provides a potential candidate for the further development into a new drug targeting PDE5.

-	~~==Function==~~	+	Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.,Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov, 19. PMID:23137303<ref>PMID:23137303</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides~~. ~~This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4g2y]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023137303</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Phosphodiesterase\|Phosphodiesterase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, T T.]]	+	[[Category: Chen, T T]]
-	[[Category: Ren, J.]]	+	[[Category: Ren, J]]
-	[[Category: Xu, Y C.]]	+	[[Category: Xu, Y C]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Phosphodiesterase]]		[[Category: Phosphodiesterase]]

OCA at 10:12, 30 June 2013

2013-06-30T10:12:58Z

←Older revision		Revision as of 10:12, 30 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4g2y\| PDB=4g2y \| SCENE= }}
		+	===Crystal structure of PDE5A complexed with its inhibitor===
		+	{{ABSTRACT_PUBMED_23137303}}

-	~~The entry 4g2y is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.

-	~~Authors~~: ~~Xu,Y~~.C.~~, Ren,J~~.~~, Li,L~~.~~, Chen,T~~.T.	+	==About this Structure==
		+	[[4g2y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA].

-	~~Description~~: ~~Crystal structure of PDE5A complexed with its~~ inhibitor	+	==Reference==
		+	<ref group="xtra">PMID:023137303</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, T T.]]
		+	[[Category: Ren, J.]]
		+	[[Category: Xu, Y C.]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Phosphodiesterase]]

OCA at 05:42, 3 October 2012

2012-10-03T05:42:35Z

←Older revision		Revision as of 05:42, 3 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g2y is ON HOLD	+	The entry 4g2y is ON HOLD until Paper Publication

	Authors: Xu,Y.C., Ren,J., Li,L., Chen,T.T.		Authors: Xu,Y.C., Ren,J., Li,L., Chen,T.T.

	Description: Crystal structure of PDE5A complexed with its inhibitor		Description: Crystal structure of PDE5A complexed with its inhibitor

OCA at 05:28, 1 August 2012

2012-08-01T05:28:23Z

←Older revision		Revision as of 05:28, 1 August 2012
Line 5:		Line 5:
	Authors: Xu,Y.C., Ren,J., Li,L., Chen,T.T.		Authors: Xu,Y.C., Ren,J., Li,L., Chen,T.T.

-	Description: ~~CRYSTAL STRUCTURE OF~~ PDE5A ~~COMPLEXED WITH ITS INHIBITOR~~	+	Description: Crystal structure of PDE5A complexed with its inhibitor

OCA: Protected "4g2y" [edit=sysop:move=sysop]

2012-07-18T05:09:27Z

Protected "4g2y" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:09, 18 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g2y is ON HOLD Authors: Xu,Y.C., Ren,J., Li,L., Chen,T.T. Description: CRYSTAL STRUCTURE OF PDE5A COMPLEXED WITH ITS INHIBITOR

2012-07-18T05:09:26Z

New page: '''Unreleased structure''' The entry 4g2y is ON HOLD Authors: Xu,Y.C., Ren,J., Li,L., Chen,T.T. Description: CRYSTAL STRUCTURE OF PDE5A COMPLEXED WITH ITS INHIBITOR

New page

'''Unreleased structure'''

The entry 4g2y is ON HOLD

Authors: Xu,Y.C., Ren,J., Li,L., Chen,T.T.

Description: CRYSTAL STRUCTURE OF PDE5A COMPLEXED WITH ITS INHIBITOR