4g42 - Revision history

OCA at 20:23, 19 October 2022

2022-10-19T20:23:36Z

←Older revision		Revision as of 20:23, 19 October 2022
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	<StructureSection load='4g42' size='340' side='right'caption='[[4g42]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='4g42' size='340' side='right'caption='[[4g42]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g42]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g42]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G42 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e0r\|4e0r]], [[4g43\|4g43]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g42 OCA], [https://pdbe.org/4g42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g42 RCSB], [https://www.ebi.ac.uk/pdbsum/4g42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g42 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g42 OCA], [~~http~~://pdbe.org/4g42 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g42 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g42 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g42 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~B2MG_CHICK B2MG_CHICK~~]~~] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.~~	+	[https://www.uniprot.org/uniprot/O46790_CHICK O46790_CHICK]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Gao, F]]	+	[[Category: Gao F]]
-	[[Category: Gao~~, G F~~]]	+	[[Category: Gao GF]]
-	[[Category: Kaufman, J]]	+	[[Category: Kaufman J]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Qi, J]]	+	[[Category: Qi J]]
-	[[Category: Xia, C]]	+	[[Category: Xia C]]
-	[[Category: Zhang, J]]	+	[[Category: Zhang J]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mhc i complex]]~~	+
-	~~[[Category: Narrow binding groove~~]]	+

OCA at 07:50, 27 March 2019

2019-03-27T07:50:19Z

←Older revision		Revision as of 07:50, 27 March 2019
Line 1:		Line 1:

	==Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D==		==Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D==
-	<StructureSection load='4g42' size='340' side='right' caption='[[4g42]], [[Resolution\|resolution]] 2.29Å' scene=''>	+	<StructureSection load='4g42' size='340' side='right'caption='[[4g42]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g42]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G42 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g42]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G42 FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Gao, F]]		[[Category: Gao, F]]

OCA at 17:30, 5 August 2016

2016-08-05T17:30:57Z

←Older revision		Revision as of 17:30, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D==		==Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D==
	<StructureSection load='4g42' size='340' side='right' caption='[[4g42]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='4g42' size='340' side='right' caption='[[4g42]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g42]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g42]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G42 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e0r\|4e0r]], [[4g43\|4g43]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e0r\|4e0r]], [[4g43\|4g43]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g42 RCSB], [http://www.ebi.ac.uk/pdbsum/4g42 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g42 OCA], [http://pdbe.org/4g42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g42 RCSB], [http://www.ebi.ac.uk/pdbsum/4g42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g42 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g42" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Gao, F]]		[[Category: Gao, F]]

OCA at 20:39, 25 December 2014

2014-12-25T20:39:24Z

←Older revision		Revision as of 20:39, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g42 RCSB], [http://www.ebi.ac.uk/pdbsum/4g42 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g42 RCSB], [http://www.ebi.ac.uk/pdbsum/4g42 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B2MG_CHICK B2MG_CHICK]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:07, 9 December 2014

2014-12-09T17:07:40Z

←Older revision		Revision as of 17:07, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4g42.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D==
		+	<StructureSection load='4g42' size='340' side='right' caption='[[4g42]], [[Resolution\|resolution]] 2.29Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g42]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G42 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4e0r\|4e0r]], [[4g43\|4g43]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g42 RCSB], [http://www.ebi.ac.uk/pdbsum/4g42 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The MHC has genetic associations with many diseases, often due to differences in presentation of antigenic peptides by polymorphic MHC molecules to T lymphocytes of the immune system. In chickens, only a single classical class I molecule in each MHC haplotype is expressed well due to coevolution with the polymorphic TAPs which means that resistance and susceptibility to infectious pathogens are particularly easy to observe. Previously, structures of chicken MHC class I molecule BF22101 from B21 haplotype showed an unusually large peptide-binding groove that accommodates a broad spectrum of peptides to present as epitopes to CTLs, explaining the MHC-determined resistance of B21 chickens to Marek's disease. In this study, we report the crystal structure of BF20401 from the B4 (also known as B13) haplotype, showing a highly positively charged surface hitherto unobserved in other MHC molecules, as well as a remarkably narrow groove due to the allele-specific residues with bulky side chains. Together, these properties limit the number of epitope peptides that can bind this class I molecule. However, peptide-binding assays show that in vitro, BF20401 can bind a wider variety of peptides than are found on the surface of B4 cells. Thus, a combination of the specificities of the polymorphic TAP and the MHC results in a very limited set of BF20401 peptides with negatively charged anchors to be presented to T lymphocytes.

-	~~{{STRUCTURE_4g42\| PDB=4g42 \| SCENE= }}~~	+	Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens.,Zhang J, Chen Y, Qi J, Gao F, Liu Y, Liu J, Zhou X, Kaufman J, Xia C, Gao GF J Immunol. 2012 Nov 1;189(9):4478-87. doi: 10.4049/jimmunol.1200885. Epub 2012, Oct 5. PMID:23041567<ref>PMID:23041567</ref>

-	~~===Structure~~ of the ~~Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23041567}}~~	+	==See Also==
-		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4g42~~]] ~~is a 6 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Gao, F.]]	+	[[Category: Gao, F]]
-	[[Category: Gao, G F.]]	+	[[Category: Gao, G F]]
-	[[Category: Kaufman, J.]]	+	[[Category: Kaufman, J]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Qi, J.]]	+	[[Category: Qi, J]]
-	[[Category: Xia, C.]]	+	[[Category: Xia, C]]
-	[[Category: Zhang, J.]]	+	[[Category: Zhang, J]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Mhc i complex]]		[[Category: Mhc i complex]]
	[[Category: Narrow binding groove]]		[[Category: Narrow binding groove]]

OCA at 09:40, 21 November 2012

2012-11-21T09:40:34Z

←Older revision		Revision as of 09:40, 21 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g42.jpg\|left\|200px]]

-	~~The entry~~ 4g42 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4g42\| PDB=4g42 \| SCENE= }}

-	~~Authors: Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, J., Kaufman, J., Xia, C., Gao, G.F.~~	+	===Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D===

-	~~Description:~~ Structure ~~of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D~~	+	{{ABSTRACT_PUBMED_23041567}}
		+
		+	==About this Structure==
		+	[[4g42]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G42 OCA].
		+	[[Category: Gallus gallus]]
		+	[[Category: Chen, Y.]]
		+	[[Category: Gao, F.]]
		+	[[Category: Gao, G F.]]
		+	[[Category: Kaufman, J.]]
		+	[[Category: Liu, J.]]
		+	[[Category: Qi, J.]]
		+	[[Category: Xia, C.]]
		+	[[Category: Zhang, J.]]
		+	[[Category: Immune system]]
		+	[[Category: Mhc i complex]]
		+	[[Category: Narrow binding groove]]

OCA at 06:50, 10 October 2012

2012-10-10T06:50:38Z

←Older revision		Revision as of 06:50, 10 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g42 is ON HOLD	+	The entry 4g42 is ON HOLD until Paper Publication

	Authors: Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, J., Kaufman, J., Xia, C., Gao, G.F.		Authors: Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, J., Kaufman, J., Xia, C., Gao, G.F.

	Description: Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D		Description: Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D

OCA: Protected "4g42" [edit=sysop:move=sysop]

2012-07-25T06:51:40Z

Protected "4g42" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:51, 25 July 2012

OCA: New page: '''Unreleased structure''' The entry 4g42 is ON HOLD Authors: Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, J., Kaufman, J., Xia, C., Gao, G.F. Description: Structure of the Chicken MHC C...

2012-07-25T06:51:39Z

New page: '''Unreleased structure''' The entry 4g42 is ON HOLD Authors: Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, J., Kaufman, J., Xia, C., Gao, G.F. Description: Structure of the Chicken MHC C...

New page

'''Unreleased structure'''

The entry 4g42 is ON HOLD

Authors: Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, J., Kaufman, J., Xia, C., Gao, G.F.

Description: Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D