4g6a - Revision history

OCA at 15:39, 14 March 2024

2024-03-14T15:39:45Z

←Older revision		Revision as of 15:39, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G6A FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G6A FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [https://pdbe.org/4g6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [https://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.501Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [https://pdbe.org/4g6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [https://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q9YK84_9HEPC Q9YK84_9HEPC]		[https://www.uniprot.org/uniprot/Q9YK84_9HEPC Q9YK84_9HEPC]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	We have determined the crystal structure of broadly neutralizing antibody (bnAb) AP33 bound to a peptide corresponding to hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412-423. Comparison with bnAb HCV1 bound to the same epitope reveals a different angle of approach to the antigen by bnAb AP33, and slight variation in its beta-hairpin conformation of the epitope. These structures establish two different modes of binding to E2 that antibodies adopt to neutralize diverse HCV.
-
-	Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412-423 in complex with antibody AP33.,Kong L, Giang E, Nieusma T, Robbins JB, Deller MC, Stanfield RL, Wilson IA, Law M J Virol. 2012 Sep 12. PMID:22973046<ref>PMID:22973046</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g6a" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:26, 19 October 2022

2022-10-19T20:26:30Z

←Older revision		Revision as of 20:26, 19 October 2022
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	<StructureSection load='4g6a' size='340' side='right'caption='[[4g6a]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4g6a' size='340' side='right'caption='[[4g6a]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G6A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G6A FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [~~http~~://pdbe.org/4g6a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [https://pdbe.org/4g6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [https://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9YK84_9HEPC Q9YK84_9HEPC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Hepacivirus C]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kong, L]]	+	[[Category: Kong L]]
-	[[Category: Law, M]]	+	[[Category: Law M]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold~~]]	+

OCA at 08:18, 27 March 2019

2019-03-27T08:18:23Z

←Older revision		Revision as of 08:18, 27 March 2019
Line 1:		Line 1:

	==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33==		==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33==
-	<StructureSection load='4g6a' size='340' side='right' caption='[[4g6a]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4g6a' size='340' side='right'caption='[[4g6a]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6A FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6A FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kong, L]]		[[Category: Kong, L]]
	[[Category: Law, M]]		[[Category: Law, M]]

OCA at 21:19, 11 August 2016

2016-08-11T21:19:13Z

←Older revision		Revision as of 21:19, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33==		==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33==
	<StructureSection load='4g6a' size='340' side='right' caption='[[4g6a]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4g6a' size='340' side='right' caption='[[4g6a]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6A FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [http://www.ebi.ac.uk/pdbsum/4g6a PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [http://pdbe.org/4g6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [http://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g6a" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kong, L]]		[[Category: Kong, L]]
	[[Category: Law, M]]		[[Category: Law, M]]

OCA at 14:26, 4 January 2015

2015-01-04T14:26:39Z

←Older revision		Revision as of 14:26, 4 January 2015
Line 1:		Line 1:
-	[[~~Image~~:4g6a.~~png\|left\|200px~~]]	+	==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33==
		+	<StructureSection load='4g6a' size='340' side='right' caption='[[4g6a]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6A FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [http://www.ebi.ac.uk/pdbsum/4g6a PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have determined the crystal structure of broadly neutralizing antibody (bnAb) AP33 bound to a peptide corresponding to hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412-423. Comparison with bnAb HCV1 bound to the same epitope reveals a different angle of approach to the antigen by bnAb AP33, and slight variation in its beta-hairpin conformation of the epitope. These structures establish two different modes of binding to E2 that antibodies adopt to neutralize diverse HCV.

-	~~{{STRUCTURE_4g6a\| PDB=4g6a \| SCENE= }}~~	+	Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412-423 in complex with antibody AP33.,Kong L, Giang E, Nieusma T, Robbins JB, Deller MC, Stanfield RL, Wilson IA, Law M J Virol. 2012 Sep 12. PMID:22973046<ref>PMID:22973046</ref>

-	~~===Structure~~ of the ~~Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22973046}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4g6a]] is a 6 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kong, L.]]	+	[[Category: Kong, L]]
-	[[Category: Law, M.]]	+	[[Category: Law, M]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 10:36, 14 November 2012

2012-11-14T10:36:34Z

←Older revision		Revision as of 10:36, 14 November 2012
Line 5:		Line 5:
	===Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33===		===Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33===

		+	{{ABSTRACT_PUBMED_22973046}}

	==About this Structure==		==About this Structure==

OCA at 07:15, 14 November 2012

2012-11-14T07:15:29Z

←Older revision		Revision as of 07:15, 14 November 2012
Line 1:		Line 1:
-	[[Image:4g6a.~~jpg~~\|left\|200px]]	+	[[Image:4g6a.png\|left\|200px]]

	{{STRUCTURE_4g6a\| PDB=4g6a \| SCENE= }}		{{STRUCTURE_4g6a\| PDB=4g6a \| SCENE= }}
Line 5:		Line 5:
	===Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33===		===Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33===

-	{{ABSTRACT_PUBMED_22973046}}

	==About this Structure==		==About this Structure==

OCA at 20:36, 26 September 2012

2012-09-26T20:36:06Z

←Older revision		Revision as of 20:36, 26 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4g6a.jpg\|left\|200px]]

-	~~The entry~~ 4g6a ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4g6a\| PDB=4g6a \| SCENE= }}

-	~~Authors: Kong, L., Wilson, I.A., Law, M.~~	+	===Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33===

-	~~Description~~: ~~Antibody~~-~~Peptide Complex~~	+	{{ABSTRACT_PUBMED_22973046}}
		+
		+	==About this Structure==
		+	[[4g6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Kong, L.]]
		+	[[Category: Law, M.]]
		+	[[Category: Wilson, I A.]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold]]

OCA at 04:57, 8 August 2012

2012-08-08T04:57:59Z

←Older revision		Revision as of 04:57, 8 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g6a is ON HOLD	+	The entry 4g6a is ON HOLD until Paper Publication

	Authors: Kong, L., Wilson, I.A., Law, M.		Authors: Kong, L., Wilson, I.A., Law, M.

	Description: Antibody-Peptide Complex		Description: Antibody-Peptide Complex

OCA: Protected "4g6a" [edit=sysop:move=sysop]

2012-07-25T06:53:57Z

Protected "4g6a" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:53, 25 July 2012