4g9z - Revision history

OCA at 11:26, 1 March 2024

2024-03-01T11:26:21Z

←Older revision		Revision as of 11:26, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [https://pdbe.org/4g9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [https://www.ebi.ac.uk/pdbsum/4g9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [https://pdbe.org/4g9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [https://www.ebi.ac.uk/pdbsum/4g9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).		[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A hallmark of severe Lassa fever is the generalized immune suppression, the mechanism of which is poorly understood. Lassa virus (LASV) nucleoprotein (NP) is the only known 3-5 exoribonuclease that can suppress type I interferon (IFN) production possibly by degrading immune-stimulatory RNAs. How this unique enzymatic activity of LASV NP recognizes and processes RNA substrates is unknown. We provide an atomic view of a catalytically active exoribonuclease domain of LASV NP (LASV NP-C) in the process of degrading a 5 triphosphate double-stranded (ds) RNA substrate - a typical pathogen-associated molecular pattern (PAMP) molecule - to induce type I IFN production. Additionally, we provide for the first time a high-resolution crystal structure of an active exoribonuclease domain of Tacaribe arenavirus (TCRV) NP. Coupled with the in vitro enzymatic and cell-based interferon suppression assays, these structural analyses strongly support a unified model of an exoribonuclease-dependent IFN suppression mechanism shared by all known arenaviruses. New knowledge learned from these studies should aid the development of therapeutics against pathogenic arenaviruses that can infect hundreds of thousand individuals and kill thousands annually.
-
-	Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression.,Jiang X, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C J Biol Chem. 2013 Apr 24. PMID:23615902<ref>PMID:23615902</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4g9z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]		*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:44, 26 October 2022

2022-10-26T06:44:14Z

←Older revision		Revision as of 06:44, 26 October 2022
Line 1:		Line 1:

	==Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression==		==Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression==
-	<StructureSection load='4g9z' size='340' side='right' caption='[[4g9z]], [[Resolution\|resolution]] 2.03Å' scene=''>	+	<StructureSection load='4g9z' size='340' side='right'caption='[[4g9z]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lassj Lassj~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mwp\|3mwp]], [[3mx5\|3mx5]], [[3mx2\|3mx2]], [[3mwt\|3mwt]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [https://pdbe.org/4g9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [https://www.ebi.ac.uk/pdbsum/4g9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9z ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11622 LASSJ])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [~~http~~://pdbe.org/4g9z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4g9z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).	+	[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Nucleoprotein\|Nucleoprotein]]	+	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lassj~~]]	+	[[Category: Large Structures]]
-	[[Category: Dong, C]]	+	[[Category: Lassa virus Josiah]]
-	[[Category: Dong, H]]	+	[[Category: Dong C]]
-	[[Category: Huang, Q]]	+	[[Category: Dong H]]
-	[[Category: Jiang, X]]	+	[[Category: Huang Q]]
-	[[Category: Liang, Y]]	+	[[Category: Jiang X]]
-	[[Category: Ly, H]]	+	[[Category: Liang Y]]
-	~~[[Category: SSPF, Scottish Structural Proteomics Facility~~]]	+	[[Category: Ly H]]
-	[[Category: Wang, W]]	+	[[Category: Wang W]]
-	~~[[Category: 3'-5'-ribonuclease]]~~	+
-	~~[[Category: Nuclease]]~~	+
-	~~[[Category: Scottish structural proteomics facility]]~~	+
-	~~[[Category: Sspf]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Viral protein-rna complex~~]]	+

OCA at 13:21, 5 August 2016

2016-08-05T13:21:38Z

←Older revision		Revision as of 13:21, 5 August 2016
Line 1:		Line 1:
		+
	==Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression==		==Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression==
	<StructureSection load='4g9z' size='340' side='right' caption='[[4g9z]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='4g9z' size='340' side='right' caption='[[4g9z]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lassa_virus_josiah Lassa virus josiah~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassj Lassj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mwp\|3mwp]], [[3mx5\|3mx5]], [[3mx2\|3mx2]], [[3mwt\|3mwt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mwp\|3mwp]], [[3mx5\|3mx5]], [[3mx2\|3mx2]], [[3mwt\|3mwt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11622 ~~Lassa virus Josiah~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11622 LASSJ])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [http://www.ebi.ac.uk/pdbsum/4g9z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [http://pdbe.org/4g9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [http://www.ebi.ac.uk/pdbsum/4g9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4g9z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lassa virus josiah~~]]	+	[[Category: Lassj]]
	[[Category: Dong, C]]		[[Category: Dong, C]]
	[[Category: Dong, H]]		[[Category: Dong, H]]

OCA at 19:09, 25 December 2014

2014-12-25T19:09:58Z

←Older revision		Revision as of 19:09, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [http://www.ebi.ac.uk/pdbsum/4g9z PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [http://www.ebi.ac.uk/pdbsum/4g9z PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:05, 21 December 2014

2014-12-21T11:05:33Z

←Older revision		Revision as of 11:05, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4g9z\| PDB=4g9z \| SCENE= }}~~	+	==Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression==
-	===Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression===	+	<StructureSection load='4g9z' size='340' side='right' caption='[[4g9z]], [[Resolution\|resolution]] 2.03Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23615902}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9Z FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mwp\|3mwp]], [[3mx5\|3mx5]], [[3mx2\|3mx2]], [[3mwt\|3mwt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11622 Lassa virus Josiah])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [http://www.ebi.ac.uk/pdbsum/4g9z PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A hallmark of severe Lassa fever is the generalized immune suppression, the mechanism of which is poorly understood. Lassa virus (LASV) nucleoprotein (NP) is the only known 3-5 exoribonuclease that can suppress type I interferon (IFN) production possibly by degrading immune-stimulatory RNAs. How this unique enzymatic activity of LASV NP recognizes and processes RNA substrates is unknown. We provide an atomic view of a catalytically active exoribonuclease domain of LASV NP (LASV NP-C) in the process of degrading a 5 triphosphate double-stranded (ds) RNA substrate - a typical pathogen-associated molecular pattern (PAMP) molecule - to induce type I IFN production. Additionally, we provide for the first time a high-resolution crystal structure of an active exoribonuclease domain of Tacaribe arenavirus (TCRV) NP. Coupled with the in vitro enzymatic and cell-based interferon suppression assays, these structural analyses strongly support a unified model of an exoribonuclease-dependent IFN suppression mechanism shared by all known arenaviruses. New knowledge learned from these studies should aid the development of therapeutics against pathogenic arenaviruses that can infect hundreds of thousand individuals and kill thousands annually.

-	~~==Function==~~	+	Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression.,Jiang X, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C J Biol Chem. 2013 Apr 24. PMID:23615902<ref>PMID:23615902</ref>
-	[[http://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of ~~protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering~~ with ~~beta interferon (IFN-beta) production~~. ~~Strongly inhibits the nuclear translocation of IRF3~~, ~~a protein involved in IFN activation pathway~~. ~~Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4g9z]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lassa_virus_josiah Lassa virus josiah]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023615902</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Nucleoprotein\|Nucleoprotein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lassa virus josiah]]		[[Category: Lassa virus josiah]]
-	[[Category: Dong, C.]]	+	[[Category: Dong, C]]
-	[[Category: Dong, H.]]	+	[[Category: Dong, H]]
-	[[Category: Huang, Q.]]	+	[[Category: Huang, Q]]
-	[[Category: Jiang, X.]]	+	[[Category: Jiang, X]]
-	[[Category: Liang, Y.]]	+	[[Category: Liang, Y]]
-	[[Category: Ly, H.]]	+	[[Category: Ly, H]]
-	[[Category: SSPF, Scottish Structural Proteomics Facility.]]	+	[[Category: SSPF, Scottish Structural Proteomics Facility]]
-	[[Category: Wang, W.]]	+	[[Category: Wang, W]]
	[[Category: 3'-5'-ribonuclease]]		[[Category: 3'-5'-ribonuclease]]
	[[Category: Nuclease]]		[[Category: Nuclease]]

OCA at 11:28, 24 July 2013

2013-07-24T11:28:54Z

←Older revision		Revision as of 11:28, 24 July 2013
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[4g9z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA].		[[4g9z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023615902</ref><references group="xtra"/><references/>
	[[Category: Lassa virus josiah]]		[[Category: Lassa virus josiah]]
	[[Category: Dong, C.]]		[[Category: Dong, C.]]

OCA at 06:15, 16 May 2013

2013-05-16T06:15:31Z

←Older revision		Revision as of 06:15, 16 May 2013
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	{{STRUCTURE_4g9z\| PDB=4g9z \| SCENE= }}		{{STRUCTURE_4g9z\| PDB=4g9z \| SCENE= }}
	===Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression===		===Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression===
		+	{{ABSTRACT_PUBMED_23615902}}

	==Function==		==Function==

OCA at 01:48, 4 April 2013

2013-04-04T01:48:14Z

←Older revision		Revision as of 01:48, 4 April 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4g9z\| PDB=4g9z \| SCENE= }}
		+	===Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression===

-	The ~~entry 4g9z~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).

-	~~Authors~~: ~~Jiang, X~~.~~, Huang, Q~~.~~, Wang, W~~., Dong, H., ~~Ly, H~~., Liang, Y., ~~Dong, C~~., Scottish Structural Proteomics Facility ~~(SSPF)~~	+	==About this Structure==
-		+	[[4g9z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA].
-	~~Description~~: ~~Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression~~	+	[[Category: Lassa virus josiah]]
		+	[[Category: Dong, C.]]
		+	[[Category: Dong, H.]]
		+	[[Category: Huang, Q.]]
		+	[[Category: Jiang, X.]]
		+	[[Category: Liang, Y.]]
		+	[[Category: Ly, H.]]
		+	[[Category: SSPF, Scottish Structural Proteomics Facility.]]
		+	[[Category: Wang, W.]]
		+	[[Category: 3'-5'-ribonuclease]]
		+	[[Category: Nuclease]]
		+	[[Category: Scottish structural proteomics facility]]
		+	[[Category: Sspf]]
		+	[[Category: Structural genomic]]
		+	[[Category: Viral protein-rna complex]]

OCA at 09:46, 13 March 2013

2013-03-13T09:46:06Z

←Older revision		Revision as of 09:46, 13 March 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g9z is ON HOLD ~~until sometime in the future~~	+	The entry 4g9z is ON HOLD

	Authors: Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C., Scottish Structural Proteomics Facility (SSPF)		Authors: Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C., Scottish Structural Proteomics Facility (SSPF)

	Description: Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression		Description: Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression

OCA at 04:51, 5 September 2012

2012-09-05T04:51:40Z

←Older revision		Revision as of 04:51, 5 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4g9z is ON HOLD	+	The entry 4g9z is ON HOLD until sometime in the future

	Authors: Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C., Scottish Structural Proteomics Facility (SSPF)		Authors: Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C., Scottish Structural Proteomics Facility (SSPF)

	Description: Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression		Description: Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression