4glp - Revision history

OCA at 06:37, 2 March 2023

2023-03-02T06:37:02Z

←Older revision		Revision as of 06:37, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4glp' size='340' side='right'caption='[[4glp]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='4glp' size='340' side='right'caption='[[4glp]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLP FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD14 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [https://pdbe.org/4glp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [https://www.ebi.ac.uk/pdbsum/4glp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4glp ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [https://pdbe.org/4glp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [https://www.ebi.ac.uk/pdbsum/4glp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4glp ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CD14_HUMAN CD14_HUMAN]] In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.<ref>PMID:23264655</ref>	+	[https://www.uniprot.org/uniprot/CD14_HUMAN CD14_HUMAN] In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.<ref>PMID:23264655</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kelley~~, S L~~]]	+	[[Category: Kelley SL]]
-	[[Category: Lukk, T]]	+	[[Category: Lukk T]]
-	[[Category: Nair~~, S K~~]]	+	[[Category: Nair SK]]
-	[[Category: Tapping~~, R I]]~~	+	[[Category: Tapping RI]]
-	~~[[Category: Alpha beta bent solenoid]]~~	+
-	~~[[Category: Cd14]]~~	+
-	~~[[Category: Endotoxin]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Leucine-rich repeat]]~~	+
-	~~[[Category: Lipopolysaccharide]]~~	+
-	~~[[Category: Lrr]]~~	+
-	~~[[Category: Pattern recognition]]~~	+
-	~~[[Category: Sepsis]]~~	+
-	~~[[Category: Serum~~]]	+

OCA at 09:21, 26 May 2021

2021-05-26T09:21:55Z

←Older revision		Revision as of 09:21, 26 May 2021
Line 1:		Line 1:

	==The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.==		==The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.==
-	<StructureSection load='4glp' size='340' side='right' caption='[[4glp]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<StructureSection load='4glp' size='340' side='right'caption='[[4glp]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GLP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLP FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD14 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD14 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [~~http~~://pdbe.org/4glp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4glp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4glp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [https://pdbe.org/4glp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [https://www.ebi.ac.uk/pdbsum/4glp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4glp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CD14_HUMAN CD14_HUMAN]] In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.<ref>PMID:23264655</ref>	+	[[https://www.uniprot.org/uniprot/CD14_HUMAN CD14_HUMAN]] In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.<ref>PMID:23264655</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kelley, S L]]		[[Category: Kelley, S L]]
	[[Category: Lukk, T]]		[[Category: Lukk, T]]

OCA at 09:23, 11 August 2016

2016-08-11T09:23:06Z

←Older revision		Revision as of 09:23, 11 August 2016
Line 1:		Line 1:
		+
	==The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.==		==The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.==
	<StructureSection load='4glp' size='340' side='right' caption='[[4glp]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='4glp' size='340' side='right' caption='[[4glp]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLP FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [http://www.ebi.ac.uk/pdbsum/4glp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [http://pdbe.org/4glp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [http://www.ebi.ac.uk/pdbsum/4glp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4glp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD14_HUMAN CD14_HUMAN]] In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.<ref>PMID:23264655</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4glp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kelley, S L]]		[[Category: Kelley, S L]]
	[[Category: Lukk, T]]		[[Category: Lukk, T]]

OCA at 12:51, 4 January 2015

2015-01-04T12:51:14Z

←Older revision		Revision as of 12:51, 4 January 2015
Line 1:		Line 1:
-	[[~~Image:~~4glp.~~png~~\|~~left\|200px~~]]	+	==The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.==
		+	<StructureSection load='4glp' size='340' side='right' caption='[[4glp]], [[Resolution\|resolution]] 4.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLP FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [http://www.ebi.ac.uk/pdbsum/4glp PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human monocyte differentiation Ag CD14 is a pattern recognition receptor that enhances innate immune responses to infection by sensitizing host cells to bacterial LPS (endotoxin), lipoproteins, lipoteichoic acid, and other acylated microbial products. CD14 physically delivers these lipidated microbial products to various TLR signaling complexes that subsequently induce intracellular proinflammatory signaling cascades upon ligand binding. The ensuing cellular responses are usually protective to the host but can also result in host fatality through sepsis. In this work, we have determined the x-ray crystal structure of human CD14. The structure reveals a bent solenoid typical of leucine-rich repeat proteins with an amino-terminal pocket that presumably binds acylated ligands including LPS. Comparison of human and mouse CD14 structures shows great similarity in overall protein fold. However, compared with mouse CD14, human CD14 contains an expanded pocket and alternative rim residues that are likely to be important for LPS binding and cell activation. The x-ray crystal structure of human CD14 presented in this article may foster additional ligand-bound structural studies, virtual docking studies, and drug design efforts to mitigate LPS-induced sepsis and other inflammatory diseases.

-	~~{{STRUCTURE_4glp\| PDB=4glp \| SCENE= }}~~	+	The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket.,Kelley SL, Lukk T, Nair SK, Tapping RI J Immunol. 2012 Dec 21. PMID:23264655<ref>PMID:23264655</ref>

-	~~===The crystal structure~~ of ~~soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23264655}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4glp]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kelley, S L.]]	+	[[Category: Kelley, S L]]
-	[[Category: Lukk, T.]]	+	[[Category: Lukk, T]]
-	[[Category: Nair, S K.]]	+	[[Category: Nair, S K]]
-	[[Category: Tapping, R I.]]	+	[[Category: Tapping, R I]]
	[[Category: Alpha beta bent solenoid]]		[[Category: Alpha beta bent solenoid]]
	[[Category: Cd14]]		[[Category: Cd14]]

OCA at 08:59, 16 January 2013

2013-01-16T08:59:51Z

←Older revision		Revision as of 08:59, 16 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4glp.png\|left\|200px]]

-	~~The entry~~ 4glp ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4glp\| PDB=4glp \| SCENE= }}

-	~~Authors: Kelley, S.L., Lukk, T., Nair, S.K., Tapping, R.I~~.	+	===The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.===

-	~~Description: The crystal structure of soluble human CD14 reveals~~ a ~~bent solenoid~~ with ~~a hydrophobic amino~~-~~terminal pocket~~.	+	{{ABSTRACT_PUBMED_23264655}}
		+
		+	==About this Structure==
		+	[[4glp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Kelley, S L.]]
		+	[[Category: Lukk, T.]]
		+	[[Category: Nair, S K.]]
		+	[[Category: Tapping, R I.]]
		+	[[Category: Alpha beta bent solenoid]]
		+	[[Category: Cd14]]
		+	[[Category: Endotoxin]]
		+	[[Category: Immune system]]
		+	[[Category: Leucine-rich repeat]]
		+	[[Category: Lipopolysaccharide]]
		+	[[Category: Lrr]]
		+	[[Category: Pattern recognition]]
		+	[[Category: Sepsis]]
		+	[[Category: Serum]]

OCA at 09:00, 21 November 2012

2012-11-21T09:00:58Z

←Older revision		Revision as of 09:00, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4glp is ON HOLD	+	The entry 4glp is ON HOLD until Paper Publication

	Authors: Kelley, S.L., Lukk, T., Nair, S.K., Tapping, R.I.		Authors: Kelley, S.L., Lukk, T., Nair, S.K., Tapping, R.I.

	Description: The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.		Description: The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.

OCA at 06:52, 19 September 2012

2012-09-19T06:52:45Z

←Older revision		Revision as of 06:52, 19 September 2012
Line 3:		Line 3:
	The entry 4glp is ON HOLD		The entry 4glp is ON HOLD

-	Authors: Kelley, S. L., Lukk, T., Nair, S. K., Tapping, R. I.	+	Authors: Kelley, S.L., Lukk, T., Nair, S.K., Tapping, R.I.

	Description: The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.		Description: The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.

OCA: Protected "4glp" [edit=sysop:move=sysop]

2012-08-22T05:37:03Z

Protected "4glp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 22 August 2012

OCA: New page: '''Unreleased structure''' The entry 4glp is ON HOLD Authors: Kelley, S. L., Lukk, T., Nair, S. K., Tapping, R. I. Description: The crystal structure of soluble human CD14 reveals a be...

2012-08-22T05:37:03Z

New page: '''Unreleased structure''' The entry 4glp is ON HOLD Authors: Kelley, S. L., Lukk, T., Nair, S. K., Tapping, R. I. Description: The crystal structure of soluble human CD14 reveals a be...

New page

'''Unreleased structure'''

The entry 4glp is ON HOLD

Authors: Kelley, S. L., Lukk, T., Nair, S. K., Tapping, R. I.

Description: The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.