4gmj - Revision history

OCA at 14:00, 8 November 2023

2023-11-08T14:00:11Z

←Older revision		Revision as of 14:00, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gmj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gmj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [https://pdbe.org/4gmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [https://www.ebi.ac.uk/pdbsum/4gmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [https://pdbe.org/4gmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [https://www.ebi.ac.uk/pdbsum/4gmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmj ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:05, 26 October 2022

2022-10-26T07:05:58Z

←Older revision		Revision as of 07:05, 26 October 2022
Line 1:		Line 1:

	==Structure of human NOT1 MIF4G domain co-crystallized with CAF1==		==Structure of human NOT1 MIF4G domain co-crystallized with CAF1==
-	<StructureSection load='4gmj' size='340' side='right' caption='[[4gmj]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4gmj' size='340' side='right'caption='[[4gmj]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gmj]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gmj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p51\|2p51]], [[2d5r\|2d5r]], [[4gml\|4gml]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [https://pdbe.org/4gmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [https://www.ebi.ac.uk/pdbsum/4gmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmj ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AD-005, CDC39, CNOT1, KIAA1007, NOT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CAF1, CNOT7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [~~http~~://pdbe.org/4gmj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gmj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/CNOT7_HUMAN CNOT7_HUMAN]] Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).	+	[https://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Izaurralde, E]]	+	[[Category: Large Structures]]
-	[[Category: Petit, P]]	+	[[Category: Izaurralde E]]
-	[[Category: Weichenrieder, O]]	+	[[Category: Petit P]]
-	[[Category: Wohlbold, L]]	+	[[Category: Weichenrieder O]]
-	~~[[Category: Ccr4-not]]~~	+	[[Category: Wohlbold L]]
-	~~[[Category: Deadenylase]]~~	+
-	~~[[Category: Mrna decay]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 21:40, 5 August 2016

2016-08-05T21:40:06Z

←Older revision		Revision as of 21:40, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of human NOT1 MIF4G domain co-crystallized with CAF1==		==Structure of human NOT1 MIF4G domain co-crystallized with CAF1==
	<StructureSection load='4gmj' size='340' side='right' caption='[[4gmj]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4gmj' size='340' side='right' caption='[[4gmj]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gmj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gmj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p51\|2p51]], [[2d5r\|2d5r]], [[4gml\|4gml]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p51\|2p51]], [[2d5r\|2d5r]], [[4gml\|4gml]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AD-005, CDC39, CNOT1, KIAA1007, NOT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), CAF1, CNOT7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AD-005, CDC39, CNOT1, KIAA1007, NOT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CAF1, CNOT7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [http://www.ebi.ac.uk/pdbsum/4gmj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [http://pdbe.org/4gmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [http://www.ebi.ac.uk/pdbsum/4gmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gmj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Izaurralde, E]]		[[Category: Izaurralde, E]]
	[[Category: Petit, P]]		[[Category: Petit, P]]

OCA at 22:08, 25 December 2014

2014-12-25T22:08:20Z

←Older revision		Revision as of 22:08, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [http://www.ebi.ac.uk/pdbsum/4gmj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [http://www.ebi.ac.uk/pdbsum/4gmj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/CNOT7_HUMAN CNOT7_HUMAN]] Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:23, 21 December 2014

2014-12-21T11:23:04Z

←Older revision		Revision as of 11:23, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gmj\| PDB=4gmj \| SCENE= }}~~	+	==Structure of human NOT1 MIF4G domain co-crystallized with CAF1==
-	===Structure of human NOT1 MIF4G domain co-crystallized with CAF1===	+	<StructureSection load='4gmj' size='340' side='right' caption='[[4gmj]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22977175}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gmj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p51\|2p51]], [[2d5r\|2d5r]], [[4gml\|4gml]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AD-005, CDC39, CNOT1, KIAA1007, NOT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CAF1, CNOT7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gmj RCSB], [http://www.ebi.ac.uk/pdbsum/4gmj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The CCR4-NOT complex plays a crucial role in post-transcriptional mRNA regulation in eukaryotic cells. It catalyzes the removal of mRNA poly(A) tails, thereby repressing translation and committing mRNAs to decay. The conserved core of the complex consists of a catalytic module comprising two deadenylases (CAF1/POP2 and CCR4a/b) and the NOT module, which contains at least NOT1, NOT2 and NOT3. NOT1 bridges the interaction between the two modules and therefore, acts as a scaffold protein for the assembly of the complex. Here, we present the crystal structures of the CAF1-binding domain of human NOT1 alone and in complex with CAF1. The NOT1 domain comprises five helical hairpins that adopt an MIF4G (middle portion of eIF4G) fold. This NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates. The conservation of critical structural and interface residues suggests that the NOT1 MIF4G domain adopts a similar fold and interacts with CAF1 in a similar manner in all eukaryotes. Our findings shed light on the assembly of the CCR4-NOT complex and provide the basis for dissecting the role of the NOT module in mRNA deadenylation.

-	~~==Function==~~	+	The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.,Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O Nucleic Acids Res. 2012 Nov;40(21):11058-72. doi: 10.1093/nar/gks883. Epub 2012, Sep 12. PMID:22977175<ref>PMID:22977175</ref>
-	~~[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to~~ the CCR4-NOT ~~complex that functions as general transcription regulation~~ complex. ~~Acts as a transcriptional repressor~~. ~~Represses the ligand~~-~~dependent transcriptional activation by nuclear receptors~~.~~<ref>~~PMID:~~10637334</ref>~~ <ref>PMID:~~16778766~~</ref> [[http://www.uniprot.org/uniprot/CNOT7_HUMAN CNOT7_HUMAN]] Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4gmj]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Izaurralde, E.]]	+	[[Category: Izaurralde, E]]
-	[[Category: Petit, P.]]	+	[[Category: Petit, P]]
-	[[Category: Weichenrieder, O.]]	+	[[Category: Weichenrieder, O]]
-	[[Category: Wohlbold, L.]]	+	[[Category: Wohlbold, L]]
	[[Category: Ccr4-not]]		[[Category: Ccr4-not]]
	[[Category: Deadenylase]]		[[Category: Deadenylase]]

OCA at 21:45, 10 April 2013

2013-04-10T21:45:25Z

←Older revision		Revision as of 21:45, 10 April 2013
Line 1:		Line 1:
-	[[Image:4gmj.jpg\|left\|200px]]
-
	{{STRUCTURE_4gmj\| PDB=4gmj \| SCENE= }}		{{STRUCTURE_4gmj\| PDB=4gmj \| SCENE= }}
-
	===Structure of human NOT1 MIF4G domain co-crystallized with CAF1===		===Structure of human NOT1 MIF4G domain co-crystallized with CAF1===
		+	{{ABSTRACT_PUBMED_22977175}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/CNOT7_HUMAN CNOT7_HUMAN]] Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).

	==About this Structure==		==About this Structure==
	[[4gmj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA].		[[4gmj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Izaurralde, E]]	+	[[Category: Izaurralde, E.]]
-	[[Category: Petit, P]]	+	[[Category: Petit, P.]]
-	[[Category: Weichenrieder, O]]	+	[[Category: Weichenrieder, O.]]
-	[[Category: Wohlbold, L]]	+	[[Category: Wohlbold, L.]]
	[[Category: Ccr4-not]]		[[Category: Ccr4-not]]
	[[Category: Deadenylase]]		[[Category: Deadenylase]]

OCA at 06:28, 3 October 2012

2012-10-03T06:28:27Z

←Older revision		Revision as of 06:28, 3 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gmj.jpg\|left\|200px]]

-	~~The entry~~ 4gmj ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gmj\| PDB=4gmj \| SCENE= }}

-	~~Authors: Petit, P, Weichenrieder, O, Wohlbold, L, Izaurralde, E~~	+	===Structure of human NOT1 MIF4G domain co-crystallized with CAF1===

-	~~Description:~~ Structure ~~of human NOT1 MIF4G domain co-crystallized~~ with ~~CAF1~~	+
		+	==About this Structure==
		+	[[4gmj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Izaurralde, E]]
		+	[[Category: Petit, P]]
		+	[[Category: Weichenrieder, O]]
		+	[[Category: Wohlbold, L]]
		+	[[Category: Ccr4-not]]
		+	[[Category: Deadenylase]]
		+	[[Category: Mrna decay]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Transcription]]

OCA at 06:53, 19 September 2012

2012-09-19T06:53:00Z

←Older revision		Revision as of 06:53, 19 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gmj is ON HOLD	+	The entry 4gmj is ON HOLD until Paper Publication

	Authors: Petit, P, Weichenrieder, O, Wohlbold, L, Izaurralde, E		Authors: Petit, P, Weichenrieder, O, Wohlbold, L, Izaurralde, E

	Description: Structure of human NOT1 MIF4G domain co-crystallized with CAF1		Description: Structure of human NOT1 MIF4G domain co-crystallized with CAF1

OCA at 04:54, 5 September 2012

2012-09-05T04:54:43Z

←Older revision		Revision as of 04:54, 5 September 2012
Line 3:		Line 3:
	The entry 4gmj is ON HOLD		The entry 4gmj is ON HOLD

-	Authors: ~~PETIT~~, P, ~~WEICHENRIEDER~~, O, ~~WOHLBOLD~~, L, ~~IZAURRALDE~~, E	+	Authors: Petit, P, Weichenrieder, O, Wohlbold, L, Izaurralde, E

	Description: Structure of human NOT1 MIF4G domain co-crystallized with CAF1		Description: Structure of human NOT1 MIF4G domain co-crystallized with CAF1

OCA: Protected "4gmj" [edit=sysop:move=sysop]

2012-08-22T05:37:54Z

Protected "4gmj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 22 August 2012