4gmn - Revision history

OCA at 11:32, 1 March 2024

2024-03-01T11:32:44Z

←Older revision		Revision as of 11:32, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gmn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gmn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmn OCA], [https://pdbe.org/4gmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmn RCSB], [https://www.ebi.ac.uk/pdbsum/4gmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmn OCA], [https://pdbe.org/4gmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmn RCSB], [https://www.ebi.ac.uk/pdbsum/4gmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/G0SEG2_CHATD G0SEG2_CHATD]		[https://www.uniprot.org/uniprot/G0SEG2_CHATD G0SEG2_CHATD]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Ribosomal proteins are synthesized in the cytoplasm, before nuclear import and assembly with ribosomal RNA (rRNA). Little is known about coordination of nucleocytoplasmic transport with ribosome assembly. Here, we identify a transport adaptor, symportin 1 (Syo1), that facilitates synchronized coimport of the two 5S-rRNA binding proteins Rpl5 and Rpl11. In vitro studies revealed that Syo1 concomitantly binds Rpl5-Rpl11 and furthermore recruits the import receptor Kap104. The Syo1-Rpl5-Rpl11 import complex is released from Kap104 by RanGTP and can be directly transferred onto the 5S rRNA. Syo1 can shuttle back to the cytoplasm by interaction with phenylalanine-glycine nucleoporins. X-ray crystallography uncovered how the alpha-solenoid symportin accommodates the Rpl5 amino terminus, normally bound to 5S rRNA, in an extended groove. Symportin-mediated coimport of Rpl5-Rpl11 could ensure coordinated and stoichiometric incorporation of these proteins into pre-60S ribosomes.
-
-	Synchronizing nuclear import of ribosomal proteins with ribosome assembly.,Kressler D, Bange G, Ogawa Y, Stjepanovic G, Bradatsch B, Pratte D, Amlacher S, Strauss D, Yoneda Y, Katahira J, Sinning I, Hurt E Science. 2012 Nov 2;338(6107):666-71. doi: 10.1126/science.1226960. PMID:23118189<ref>PMID:23118189</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gmn" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:06, 26 October 2022

2022-10-26T07:06:09Z

←Older revision		Revision as of 07:06, 26 October 2022
Line 1:		Line 1:

	==Structural basis of Rpl5 recognition by Syo1==		==Structural basis of Rpl5 recognition by Syo1==
-	<StructureSection load='4gmn' size='340' side='right' caption='[[4gmn]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='4gmn' size='340' side='right'caption='[[4gmn]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gmn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chatd Chatd~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GMN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gmn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMN FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0063640, Rpl5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), CTHT_0033460, Syo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmn OCA], [https://pdbe.org/4gmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmn RCSB], [https://www.ebi.ac.uk/pdbsum/4gmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmn OCA], [~~http~~://pdbe.org/4gmn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gmn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gmn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmn ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G0SEG2_CHATD G0SEG2_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chatd~~]]	+	[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
-	[[Category: ~~Bange, G~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Sinning, I~~]]	+	[[Category: Bange G]]
-	[[Category: ~~Arm]]~~	+	[[Category: Sinning I]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Heat]]~~	+
-	~~[[Category: Kap104]]~~	+
-	~~[[Category: Linear motif]]~~	+
-	~~[[Category: Nuclear transport]]~~	+
-	~~[[Category: Ribosome assembly]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rpl11]]~~	+
-	~~[[Category: Solenoid~~]]	+

OCA at 20:07, 15 December 2016

2016-12-15T20:07:48Z

←Older revision		Revision as of 20:07, 15 December 2016
Line 1:		Line 1:
-	[[Image:4gmn.png\|left\|200px]]

-	~~{{STRUCTURE_4gmn~~\| ~~PDB~~=4gmn \| ~~SCENE~~= }}	+	==Structural basis of Rpl5 recognition by Syo1==
		+	<StructureSection load='4gmn' size='340' side='right' caption='[[4gmn]], [[Resolution\|resolution]] 2.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GMN FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0063640, Rpl5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), CTHT_0033460, Syo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmn OCA], [http://pdbe.org/4gmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gmn RCSB], [http://www.ebi.ac.uk/pdbsum/4gmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmn ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ribosomal proteins are synthesized in the cytoplasm, before nuclear import and assembly with ribosomal RNA (rRNA). Little is known about coordination of nucleocytoplasmic transport with ribosome assembly. Here, we identify a transport adaptor, symportin 1 (Syo1), that facilitates synchronized coimport of the two 5S-rRNA binding proteins Rpl5 and Rpl11. In vitro studies revealed that Syo1 concomitantly binds Rpl5-Rpl11 and furthermore recruits the import receptor Kap104. The Syo1-Rpl5-Rpl11 import complex is released from Kap104 by RanGTP and can be directly transferred onto the 5S rRNA. Syo1 can shuttle back to the cytoplasm by interaction with phenylalanine-glycine nucleoporins. X-ray crystallography uncovered how the alpha-solenoid symportin accommodates the Rpl5 amino terminus, normally bound to 5S rRNA, in an extended groove. Symportin-mediated coimport of Rpl5-Rpl11 could ensure coordinated and stoichiometric incorporation of these proteins into pre-60S ribosomes.

-	~~===Structural basis~~ of ~~Rpl5 recognition by Syo1===~~	+	Synchronizing nuclear import of ribosomal proteins with ribosome assembly.,Kressler D, Bange G, Ogawa Y, Stjepanovic G, Bradatsch B, Pratte D, Amlacher S, Strauss D, Yoneda Y, Katahira J, Sinning I, Hurt E Science. 2012 Nov 2;338(6107):666-71. doi: 10.1126/science.1226960. PMID:23118189<ref>PMID:23118189</ref>

-		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~==About this Structure==~~	+	</div>
-	~~[[4gmn]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Chaetomium_thermophilum_var~~.~~_thermophilum_dsm_1495 Chaetomium thermophilum var. thermophilum dsm 1495]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca~~-~~bin~~/~~ocashort?id~~=~~4GMN OCA].~~	+	<div class="pdbe-citations 4gmn" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Chaetomium thermophilum var. thermophilum dsm 1495~~]]	+	== References ==
-	[[Category: Bange, G.]]	+	<references/>
-	[[Category: Sinning, I.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Chatd]]
		+	[[Category: Bange, G]]
		+	[[Category: Sinning, I]]
	[[Category: Arm]]		[[Category: Arm]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 06:48, 14 November 2012

2012-11-14T06:48:37Z

←Older revision		Revision as of 06:48, 14 November 2012
Line 1:		Line 1:
-	[[Image:4gmn.~~jpg~~\|left\|200px]]	+	[[Image:4gmn.png\|left\|200px]]

	{{STRUCTURE_4gmn\| PDB=4gmn \| SCENE= }}		{{STRUCTURE_4gmn\| PDB=4gmn \| SCENE= }}

OCA at 09:25, 31 October 2012

2012-10-31T09:25:34Z

←Older revision		Revision as of 09:25, 31 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gmn.jpg\|left\|200px]]

-	~~The entry~~ 4gmn ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gmn\| PDB=4gmn \| SCENE= }}

-	~~Authors: Bange, G., Sinning, I.~~	+	===Structural basis of Rpl5 recognition by Syo1===

-	~~Description~~: ~~Structural basis of Rpl5 recognition by Syo1~~	+
		+	==About this Structure==
		+	[[4gmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_dsm_1495 Chaetomium thermophilum var. thermophilum dsm 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMN OCA].
		+	[[Category: Chaetomium thermophilum var. thermophilum dsm 1495]]
		+	[[Category: Bange, G.]]
		+	[[Category: Sinning, I.]]
		+	[[Category: Arm]]
		+	[[Category: Chaperone]]
		+	[[Category: Heat]]
		+	[[Category: Kap104]]
		+	[[Category: Linear motif]]
		+	[[Category: Nuclear transport]]
		+	[[Category: Ribosome assembly]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rpl11]]
		+	[[Category: Solenoid]]

OCA at 04:47, 29 August 2012

2012-08-29T04:47:37Z

←Older revision		Revision as of 04:47, 29 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gmn is ON HOLD	+	The entry 4gmn is ON HOLD until Paper Publication

	Authors: Bange, G., Sinning, I.		Authors: Bange, G., Sinning, I.

	Description: Structural basis of Rpl5 recognition by Syo1		Description: Structural basis of Rpl5 recognition by Syo1

OCA: Protected "4gmn" [edit=sysop:move=sysop]

2012-08-22T05:38:00Z

Protected "4gmn" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:38, 22 August 2012

OCA: New page: '''Unreleased structure''' The entry 4gmn is ON HOLD Authors: Bange, G., Sinning, I. Description: Structural basis of Rpl5 recognition by Syo1

2012-08-22T05:38:00Z

New page: '''Unreleased structure''' The entry 4gmn is ON HOLD Authors: Bange, G., Sinning, I. Description: Structural basis of Rpl5 recognition by Syo1

New page

'''Unreleased structure'''

The entry 4gmn is ON HOLD

Authors: Bange, G., Sinning, I.

Description: Structural basis of Rpl5 recognition by Syo1