4gqz - Revision history

OCA at 07:11, 26 October 2022

2022-10-26T07:11:34Z

←Older revision		Revision as of 07:11, 26 October 2022
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	==Crystal Structure of S.CueP==		==Crystal Structure of S.CueP==
-	<StructureSection load='4gqz' size='340' side='right' caption='[[4gqz]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4gqz' size='340' side='right'caption='[[4gqz]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gqz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Salty Salty~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gqz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqz OCA], [https://pdbe.org/4gqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqz RCSB], [https://www.ebi.ac.uk/pdbsum/4gqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqz ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STM3650 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqz OCA], [~~http~~://pdbe.org/4gqz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gqz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gqz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8ZL99_SALTY Q8ZL99_SALTY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Salty~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ha, N C~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: ~~Yoon, B Y~~]]	+	[[Category: Ha NC]]
-	[[Category: ~~Copper_resistance]]~~	+	[[Category: Yoon BY]]
-	~~[[Category: Cuep]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: V-shape dimer~~]]	+

OCA at 08:00, 11 August 2016

2016-08-11T08:00:52Z

←Older revision		Revision as of 08:00, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of S.CueP==		==Crystal Structure of S.CueP==
	<StructureSection load='4gqz' size='340' side='right' caption='[[4gqz]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4gqz' size='340' side='right' caption='[[4gqz]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gqz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gqz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STM3650 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 ~~Salmonella enterica subsp. enterica serovar Typhimurium str. LT2~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STM3650 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqz RCSB], [http://www.ebi.ac.uk/pdbsum/4gqz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqz OCA], [http://pdbe.org/4gqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gqz RCSB], [http://www.ebi.ac.uk/pdbsum/4gqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gqz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Salmonella enterica subsp. enterica serovar typhimurium str. lt2~~]]	+	[[Category: Salty]]
	[[Category: Ha, N C]]		[[Category: Ha, N C]]
	[[Category: Yoon, B Y]]		[[Category: Yoon, B Y]]

OCA at 13:21, 4 January 2015

2015-01-04T13:21:25Z

←Older revision		Revision as of 13:21, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4gqz~~\| ~~PDB~~=4gqz \| ~~SCENE~~= }}	+	==Crystal Structure of S.CueP==
-	===~~Crystal Structure of~~ S.~~CueP~~===	+	<StructureSection load='4gqz' size='340' side='right' caption='[[4gqz]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24100307}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gqz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STM3650 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqz RCSB], [http://www.ebi.ac.uk/pdbsum/4gqz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CueP was initially identified as a copper-resistance gene in Salmonella enterica serovar Typhimurium, which has evolved to survive in the phagosomes of macrophages. Recently, CueP was determined to be a periplasmic copper-binding protein and has been implicated in the transfer of copper ions to SodCII in the periplasm. In this study, the crystal structure of CueP has been determined, revealing a V-shaped dimeric structure. The conserved cysteine and histidine residues are clustered on the surface of one side of the C-terminal domain, suggesting that this cysteine- and histidine-rich region is related to the function of CueP. LC-MS/MS analysis established the presence of a disulfide bond between Cys96 and Cys176 under aerobic conditions. Subsequent biophysical analyses showed that the CueP protein binds copper and zinc, and the mutation of Cys104 to serine (C104S) dramatically reduced the binding affinity for copper and zinc, suggesting that the cysteine- and histidine-rich cluster is responsible for copper binding. This study provides a structural basis for the participation of CueP in the resistance of the intracellular pathogen Salmonella to copper.

-	~~==About this~~ Structure==	+	Structure of the periplasmic copper-binding protein CueP from Salmonella enterica serovar Typhimurium.,Yoon BY, Kim YH, Kim N, Yun BY, Kim JS, Lee JH, Cho HS, Lee K, Ha NC Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):1867-75. doi:, 10.1107/S090744491301531X. Epub 2013 Sep 20. PMID:24100307<ref>PMID:24100307</ref>
-	~~[[4gqz]] is a 4 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2~~ Salmonella ~~enterica subsp.~~ enterica serovar ~~typhimurium str~~. ~~lt2]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4GQZ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024100307</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
-	[[Category: Ha, N C.]]	+	[[Category: Ha, N C]]
-	[[Category: Yoon, B Y.]]	+	[[Category: Yoon, B Y]]
	[[Category: Copper_resistance]]		[[Category: Copper_resistance]]
	[[Category: Cuep]]		[[Category: Cuep]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]
	[[Category: V-shape dimer]]		[[Category: V-shape dimer]]

OCA at 05:16, 23 October 2013

2013-10-23T05:16:15Z

←Older revision		Revision as of 05:16, 23 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4gqz\| PDB=4gqz \| SCENE= }}		{{STRUCTURE_4gqz\| PDB=4gqz \| SCENE= }}
	===Crystal Structure of S.CueP===		===Crystal Structure of S.CueP===
		+	{{ABSTRACT_PUBMED_24100307}}

	==About this Structure==		==About this Structure==
	[[4gqz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQZ OCA].		[[4gqz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024100307</ref><references group="xtra"/><references/>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
	[[Category: Ha, N C.]]		[[Category: Ha, N C.]]

OCA at 07:59, 14 August 2013

2013-08-14T07:59:05Z

←Older revision		Revision as of 07:59, 14 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gqz\| PDB=4gqz \| SCENE= }}
		+	===Crystal Structure of S.CueP===

-	~~The entry~~ 4gqz is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4gqz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQZ OCA].
-	~~Authors~~: Ha, N.C., Yoon, B.Y.	+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
-		+	[[Category: Ha, N C.]]
-	~~Description~~: ~~Crystal Structure of S.CueP~~	+	[[Category: Yoon, B Y.]]
		+	[[Category: Copper_resistance]]
		+	[[Category: Cuep]]
		+	[[Category: Metal binding protein]]
		+	[[Category: V-shape dimer]]

OCA at 20:08, 26 September 2012

2012-09-26T20:08:11Z

←Older revision		Revision as of 20:08, 26 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gqz is ON HOLD	+	The entry 4gqz is ON HOLD until Paper Publication

	Authors: Ha, N.C., Yoon, B.Y.		Authors: Ha, N.C., Yoon, B.Y.

	Description: Crystal Structure of S.CueP		Description: Crystal Structure of S.CueP

OCA: Protected "4gqz" [edit=sysop:move=sysop]

2012-09-05T04:56:25Z

Protected "4gqz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:56, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gqz is ON HOLD Authors: Ha, N.C., Yoon, B.Y. Description: Crystal Structure of S.CueP

2012-09-05T04:56:24Z

New page: '''Unreleased structure''' The entry 4gqz is ON HOLD Authors: Ha, N.C., Yoon, B.Y. Description: Crystal Structure of S.CueP

New page

'''Unreleased structure'''

The entry 4gqz is ON HOLD

Authors: Ha, N.C., Yoon, B.Y.

Description: Crystal Structure of S.CueP