4grz - Revision history

OCA at 15:54, 14 March 2024

2024-03-14T15:54:47Z

←Older revision		Revision as of 15:54, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4grz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4grz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3732Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [https://pdbe.org/4grz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [https://www.ebi.ac.uk/pdbsum/4grz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [https://pdbe.org/4grz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [https://www.ebi.ac.uk/pdbsum/4grz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>		[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	SHP-1 (PTPN6) is a member of the SHP sub-family of protein tyrosine phosphatases and plays a critical role in the regulation of the JAK/STAT signaling pathway. Previous studies suggested that SHP-1 contains a PTP1B-like second phosphotyrosine pocket that allows for binding of tandem phosphotyrosine residues, such as those found in the activation loop of JAK kinases. To discover the structural nature of the interaction between SHP-1 and the JAK family member, JAK1, we determined the 1.8A co-crystal structure of the SHP-1 catalytic domain and a JAK1-derived substrate peptide. This structure reveals electron density for only one bound phosphotyrosine residue. To investigate the role of the predicted second site pocket we determined the structures of SHP-1 in complex with phosphate and sulfate to 1.37A and 1.7A, respectively, and performed anomalous scattering experiments for a selenate-soaked crystal. These crystallographic data suggest that SHP-1 does not contain a PTP1B-like second site pocket. This conclusion is further supported by analysis of the relative dephosphorylation and binding affinities of mono- and tandem-phosphorylated peptide substrates. The crystal structures instead indicate that SHP-1 contains an extended C-terminal helix alpha2' incompatible with the predicted second phosphotyrosine binding site. This study suggests that SHP-1 defines a new category of PTP1B-like protein tyrosine phosphatases with a hindered second phosphotyrosine pocket.
-
-	Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.,Alicea-Velazquez NL, Jakoncic J, Boggon TJ J Struct Biol. 2013 Jan 4. pii: S1047-8477(12)00343-7. doi:, 10.1016/j.jsb.2012.12.009. PMID:23296072<ref>PMID:23296072</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4grz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:13, 26 October 2022

2022-10-26T07:13:40Z

←Older revision		Revision as of 07:13, 26 October 2022
Line 1:		Line 1:

	==Crystal structure of SHP1 catalytic domain with PO4==		==Crystal structure of SHP1 catalytic domain with PO4==
-	<StructureSection load='4grz' size='340' side='right' caption='[[4grz]], [[Resolution\|resolution]] 1.37Å' scene=''>	+	<StructureSection load='4grz' size='340' side='right'caption='[[4grz]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4grz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GRZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4grz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCP, PTP1C, PTPN6, SHP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [https://pdbe.org/4grz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [https://www.ebi.ac.uk/pdbsum/4grz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grz ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [~~http~~://pdbe.org/4grz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4grz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4grz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN]] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>	+	[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4grz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4grz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Protein-tyrosine-phosphatase~~]]	+	[[Category: Large Structures]]
-	[[Category: Alicea-Velazquez~~, N L~~]]	+	[[Category: Alicea-Velazquez NL]]
-	[[Category: Boggon~~, T J~~]]	+	[[Category: Boggon TJ]]
-	[[Category: Jakoncic, J]]	+	[[Category: Jakoncic J]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phosphatase domain~~]]	+

OCA at 08:32, 15 November 2017

2017-11-15T08:32:19Z

←Older revision		Revision as of 08:32, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4grz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4grz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:45, 5 August 2016

2016-08-05T21:45:35Z

←Older revision		Revision as of 21:45, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of SHP1 catalytic domain with PO4==		==Crystal structure of SHP1 catalytic domain with PO4==
	<StructureSection load='4grz' size='340' side='right' caption='[[4grz]], [[Resolution\|resolution]] 1.37Å' scene=''>		<StructureSection load='4grz' size='340' side='right' caption='[[4grz]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4grz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4grz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCP, PTP1C, PTPN6, SHP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCP, PTP1C, PTPN6, SHP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [http://www.ebi.ac.uk/pdbsum/4grz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [http://pdbe.org/4grz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [http://www.ebi.ac.uk/pdbsum/4grz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4grz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4grz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Alicea-Velazquez, N L]]		[[Category: Alicea-Velazquez, N L]]

OCA at 22:10, 25 December 2014

2014-12-25T22:10:40Z

←Older revision		Revision as of 22:10, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [http://www.ebi.ac.uk/pdbsum/4grz PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [http://www.ebi.ac.uk/pdbsum/4grz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN]] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:18, 10 December 2014

2014-12-10T09:18:13Z

←Older revision		Revision as of 09:18, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4grz.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of SHP1 catalytic domain with PO4==
		+	<StructureSection load='4grz' size='340' side='right' caption='[[4grz]], [[Resolution\|resolution]] 1.37Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4grz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCP, PTP1C, PTPN6, SHP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4grz RCSB], [http://www.ebi.ac.uk/pdbsum/4grz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SHP-1 (PTPN6) is a member of the SHP sub-family of protein tyrosine phosphatases and plays a critical role in the regulation of the JAK/STAT signaling pathway. Previous studies suggested that SHP-1 contains a PTP1B-like second phosphotyrosine pocket that allows for binding of tandem phosphotyrosine residues, such as those found in the activation loop of JAK kinases. To discover the structural nature of the interaction between SHP-1 and the JAK family member, JAK1, we determined the 1.8A co-crystal structure of the SHP-1 catalytic domain and a JAK1-derived substrate peptide. This structure reveals electron density for only one bound phosphotyrosine residue. To investigate the role of the predicted second site pocket we determined the structures of SHP-1 in complex with phosphate and sulfate to 1.37A and 1.7A, respectively, and performed anomalous scattering experiments for a selenate-soaked crystal. These crystallographic data suggest that SHP-1 does not contain a PTP1B-like second site pocket. This conclusion is further supported by analysis of the relative dephosphorylation and binding affinities of mono- and tandem-phosphorylated peptide substrates. The crystal structures instead indicate that SHP-1 contains an extended C-terminal helix alpha2' incompatible with the predicted second phosphotyrosine binding site. This study suggests that SHP-1 defines a new category of PTP1B-like protein tyrosine phosphatases with a hindered second phosphotyrosine pocket.

-	~~{{STRUCTURE_4grz\| PDB=4grz \| SCENE= }}~~	+	Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.,Alicea-Velazquez NL, Jakoncic J, Boggon TJ J Struct Biol. 2013 Jan 4. pii: S1047-8477(12)00343-7. doi:, 10.1016/j.jsb.2012.12.009. PMID:23296072<ref>PMID:23296072</ref>

-	~~===Crystal structure~~ of ~~SHP1 catalytic domain with PO4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23296072}}~~	+	==See Also==
-		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4grz~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: Alicea-Velazquez, N L.]]	+	[[Category: Alicea-Velazquez, N L]]
-	[[Category: Boggon, T J.]]	+	[[Category: Boggon, T J]]
-	[[Category: Jakoncic, J.]]	+	[[Category: Jakoncic, J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phosphatase domain]]		[[Category: Phosphatase domain]]

OCA at 11:36, 23 January 2013

2013-01-23T11:36:27Z

←Older revision		Revision as of 11:36, 23 January 2013
Line 1:		Line 1:
-	[[Image:4grz.~~jpg~~\|left\|200px]]	+	[[Image:4grz.png\|left\|200px]]

	{{STRUCTURE_4grz\| PDB=4grz \| SCENE= }}		{{STRUCTURE_4grz\| PDB=4grz \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of SHP1 catalytic domain with PO4===		===Crystal structure of SHP1 catalytic domain with PO4===

		+	{{ABSTRACT_PUBMED_23296072}}

	==About this Structure==		==About this Structure==

OCA at 11:36, 19 December 2012

2012-12-19T11:36:37Z

←Older revision		Revision as of 11:36, 19 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4grz.jpg\|left\|200px]]

-	~~The entry~~ 4grz ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4grz\| PDB=4grz \| SCENE= }}

-	~~Authors: Alicea-Velazquez, N.L., Jakoncic, J., Boggon, T.J.~~	+	===Crystal structure of SHP1 catalytic domain with PO4===

-	~~Description~~: Protein X-~~PO4~~	+
		+	==About this Structure==
		+	[[4grz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRZ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: Alicea-Velazquez, N L.]]
		+	[[Category: Boggon, T J.]]
		+	[[Category: Jakoncic, J.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phosphatase domain]]

OCA at 06:53, 10 October 2012

2012-10-10T06:53:23Z

←Older revision		Revision as of 06:53, 10 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4grz is ON HOLD	+	The entry 4grz is ON HOLD until Paper Publication

	Authors: Alicea-Velazquez, N.L., Jakoncic, J., Boggon, T.J.		Authors: Alicea-Velazquez, N.L., Jakoncic, J., Boggon, T.J.

	Description: Protein X-PO4		Description: Protein X-PO4

OCA: Protected "4grz" [edit=sysop:move=sysop]

2012-09-05T04:57:21Z

Protected "4grz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 5 September 2012