4gsd - Revision history

OCA at 06:48, 3 April 2024

2024-04-03T06:48:22Z

←Older revision		Revision as of 06:48, 3 April 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsd OCA], [https://pdbe.org/4gsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsd RCSB], [https://www.ebi.ac.uk/pdbsum/4gsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsd ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.251Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsd OCA], [https://pdbe.org/4gsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsd RCSB], [https://www.ebi.ac.uk/pdbsum/4gsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsd ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Recent studies described the experimental adaptation of influenza H5 HAs that confers respiratory droplet transmission (rdt) to influenza virus in ferrets. Acquisition of the ability to transmit via aerosol may lead to the development of a highly pathogenic pandemic H5 virus. Vaccines are predicted to play an important role in H5N1 control should the virus become readily transmissible between humans. We obtained PBMCs from patients who received an A/Vietnam/1203/2004 H5N1 subunit vaccine. Human hybridomas were then generated and characterized. We identified antibodies that bound the HA head domain and recognized both WT and rdt H5 HAs. We used a combination of structural techniques to define a mechanism of antibody recognition of an H5 HA receptor-binding site that neutralized H5N1 influenza viruses and pseudoviruses carrying the HA rdt variants that have mutations near the receptor-binding site. Incorporation or retention of this critical antigenic site should be considered in the design of novel H5 HA immunogens to protect against mammalian-adapted H5N1 mutants.
-
-	Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses.,Thornburg NJ, Nannemann DP, Blum DL, Belser JA, Tumpey TM, Deshpande S, Fritz GA, Sapparapu G, Krause JC, Lee JH, Ward AB, Lee DE, Li S, Winarski KL, Spiller BW, Meiler J, Crowe JE Jr J Clin Invest. 2013 Oct 1;123(10):4405-4409. doi: 10.1172/JCI69377. Epub 2013 Sep, 3. PMID:23999429<ref>PMID:23999429</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gsd" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:14, 26 October 2022

2022-10-26T07:14:53Z

←Older revision		Revision as of 07:14, 26 October 2022
Line 3:		Line 3:
	<StructureSection load='4gsd' size='340' side='right'caption='[[4gsd]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4gsd' size='340' side='right'caption='[[4gsd]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GSD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsd OCA], [~~http~~://pdbe.org/4gsd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gsd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gsd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsd ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsd OCA], [https://pdbe.org/4gsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsd RCSB], [https://www.ebi.ac.uk/pdbsum/4gsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Spiller~~, B W~~]]	+	[[Category: Spiller BW]]
-	[[Category: Winarski~~, K L]]~~	+	[[Category: Winarski KL]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Influenza h5 hemagglutanin~~]]	+

OCA at 09:22, 5 February 2020

2020-02-05T09:22:36Z

←Older revision		Revision as of 09:22, 5 February 2020
Line 1:		Line 1:

	==H5.3 Fab Structure==		==H5.3 Fab Structure==
-	<StructureSection load='4gsd' size='340' side='right' caption='[[4gsd]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4gsd' size='340' side='right'caption='[[4gsd]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSD FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Spiller, B W]]		[[Category: Spiller, B W]]
	[[Category: Winarski, K L]]		[[Category: Winarski, K L]]

OCA at 16:52, 11 August 2016

2016-08-11T16:52:50Z

←Older revision		Revision as of 16:52, 11 August 2016
Line 1:		Line 1:
		+
	==H5.3 Fab Structure==		==H5.3 Fab Structure==
	<StructureSection load='4gsd' size='340' side='right' caption='[[4gsd]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4gsd' size='340' side='right' caption='[[4gsd]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gsd RCSB], [http://www.ebi.ac.uk/pdbsum/4gsd PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsd OCA], [http://pdbe.org/4gsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gsd RCSB], [http://www.ebi.ac.uk/pdbsum/4gsd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gsd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Spiller, B W]]		[[Category: Spiller, B W]]
	[[Category: Winarski, K L]]		[[Category: Winarski, K L]]

OCA at 10:53, 25 January 2015

2015-01-25T10:53:09Z

←Older revision		Revision as of 10:53, 25 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4gsd\| PDB~~=4gsd \| ~~SCENE~~= }}	+	==H5.3 Fab Structure==
-	===H5.~~3 Fab Structure~~===	+	<StructureSection load='4gsd' size='340' side='right' caption='[[4gsd]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23999429}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSD FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gsd RCSB], [http://www.ebi.ac.uk/pdbsum/4gsd PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recent studies described the experimental adaptation of influenza H5 HAs that confers respiratory droplet transmission (rdt) to influenza virus in ferrets. Acquisition of the ability to transmit via aerosol may lead to the development of a highly pathogenic pandemic H5 virus. Vaccines are predicted to play an important role in H5N1 control should the virus become readily transmissible between humans. We obtained PBMCs from patients who received an A/Vietnam/1203/2004 H5N1 subunit vaccine. Human hybridomas were then generated and characterized. We identified antibodies that bound the HA head domain and recognized both WT and rdt H5 HAs. We used a combination of structural techniques to define a mechanism of antibody recognition of an H5 HA receptor-binding site that neutralized H5N1 influenza viruses and pseudoviruses carrying the HA rdt variants that have mutations near the receptor-binding site. Incorporation or retention of this critical antigenic site should be considered in the design of novel H5 HA immunogens to protect against mammalian-adapted H5N1 mutants.

-	~~==About this Structure==~~	+	Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses.,Thornburg NJ, Nannemann DP, Blum DL, Belser JA, Tumpey TM, Deshpande S, Fritz GA, Sapparapu G, Krause JC, Lee JH, Ward AB, Lee DE, Li S, Winarski KL, Spiller BW, Meiler J, Crowe JE Jr J Clin Invest. 2013 Oct 1;123(10):4405-4409. doi: 10.1172/JCI69377. Epub 2013 Sep, 3. PMID:23999429<ref>PMID:23999429</ref>
-	~~[[4gsd]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4GSD OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023999429</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Spiller, B W]]		[[Category: Spiller, B W]]
-	[[Category: Winarski, K L.]]	+	[[Category: Winarski, K L]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Immune response]]		[[Category: Immune response]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Influenza h5 hemagglutanin]]		[[Category: Influenza h5 hemagglutanin]]

OCA at 05:03, 10 October 2013

2013-10-10T05:03:04Z

←Older revision		Revision as of 05:03, 10 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4gsd\| PDB=4gsd \| SCENE= }}		{{STRUCTURE_4gsd\| PDB=4gsd \| SCENE= }}
	===H5.3 Fab Structure===		===H5.3 Fab Structure===
		+	{{ABSTRACT_PUBMED_23999429}}

	==About this Structure==		==About this Structure==
	[[4gsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA].		[[4gsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023999429</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Spiller, B W]]		[[Category: Spiller, B W]]

OCA at 08:33, 21 August 2013

2013-08-21T08:33:44Z

←Older revision		Revision as of 08:33, 21 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gsd\| PDB=4gsd \| SCENE= }}
		+	===H5.3 Fab Structure===

-	~~The entry~~ 4gsd is ~~ON HOLD until Jan 21 2015~~	+	==About this Structure==
-		+	[[4gsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSD OCA].
-	~~Authors~~: Spiller, B.W, Winarski, K.L.	+	[[Category: Homo sapiens]]
-		+	[[Category: Spiller, B W]]
-	~~Description~~: ~~H5.3 Fab Structure~~	+	[[Category: Winarski, K L.]]
		+	[[Category: Antibody]]
		+	[[Category: Immune response]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza h5 hemagglutanin]]

OCA at 14:48, 10 July 2013

2013-07-10T14:48:53Z

←Older revision		Revision as of 14:48, 10 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gsd is ON HOLD until ~~Paper Publication~~	+	The entry 4gsd is ON HOLD until Jan 21 2015

	Authors: Spiller, B.W, Winarski, K.L.		Authors: Spiller, B.W, Winarski, K.L.

	Description: H5.3 Fab Structure		Description: H5.3 Fab Structure

OCA at 08:35, 31 October 2012

2012-10-31T08:35:28Z

←Older revision		Revision as of 08:35, 31 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gsd is ON HOLD	+	The entry 4gsd is ON HOLD until Paper Publication

	Authors: Spiller, B.W, Winarski, K.L.		Authors: Spiller, B.W, Winarski, K.L.

	Description: H5.3 Fab Structure		Description: H5.3 Fab Structure

OCA: Protected "4gsd" [edit=sysop:move=sysop]

2012-09-05T04:57:44Z

Protected "4gsd" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 5 September 2012