4gwn - Revision history

OCA at 14:02, 8 November 2023

2023-11-08T14:02:39Z

←Older revision		Revision as of 14:02, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GWN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GWN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [https://pdbe.org/4gwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [https://www.ebi.ac.uk/pdbsum/4gwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gwn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [https://pdbe.org/4gwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [https://www.ebi.ac.uk/pdbsum/4gwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gwn ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:23, 26 October 2022

2022-10-26T07:23:31Z

←Older revision		Revision as of 07:23, 26 October 2022
Line 1:		Line 1:

	==Crystal structure of human mature meprin beta==		==Crystal structure of human mature meprin beta==
-	<StructureSection load='4gwn' size='340' side='right' caption='[[4gwn]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4gwn' size='340' side='right'caption='[[4gwn]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GWN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gwm\|4gwm]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [https://pdbe.org/4gwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [https://www.ebi.ac.uk/pdbsum/4gwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gwn ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MEP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Meprin_B Meprin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.63 3.4.24.63] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [~~http~~://pdbe.org/4gwn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gwn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gwn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MEP1B_HUMAN MEP1B_HUMAN]] Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.<ref>PMID:21693781</ref>	+	[https://www.uniprot.org/uniprot/MEP1B_HUMAN MEP1B_HUMAN] Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.<ref>PMID:21693781</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Meprin B~~]]	+	[[Category: Large Structures]]
-	[[Category: Arolas~~, J L~~]]	+	[[Category: Arolas JL]]
-	[[Category: Becker-Pauly, C]]	+	[[Category: Becker-Pauly C]]
-	[[Category: Bode, W]]	+	[[Category: Bode W]]
-	[[Category: Broder, C]]	+	[[Category: Broder C]]
-	[[Category: Gomis-Ruth~~, F X~~]]	+	[[Category: Gomis-Ruth FX]]
-	[[Category: Guevara, T]]	+	[[Category: Guevara T]]
-	[[Category: Jefferson, T]]	+	[[Category: Jefferson T]]
-	[[Category: Sterchi~~, E E~~]]	+	[[Category: Sterchi EE]]
-	[[Category: Stocker, W]]	+	[[Category: Stocker W]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Multidomain structure~~]]	+

OCA at 08:33, 15 November 2017

2017-11-15T08:33:51Z

←Older revision		Revision as of 08:33, 15 November 2017
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GWN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GWN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=~~GOL~~:~~GLYCEROL~~'>~~GOL~~</scene>, <scene name='pdbligand=NA:~~SODIUM+ION~~'>NA</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~FUC~~:~~ALPHA-L-FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gwm\|4gwm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gwm\|4gwm]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MEP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MEP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

OCA at 09:12, 4 August 2016

2016-08-04T09:12:40Z

←Older revision		Revision as of 09:12, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human mature meprin beta==		==Crystal structure of human mature meprin beta==
	<StructureSection load='4gwn' size='340' side='right' caption='[[4gwn]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4gwn' size='340' side='right' caption='[[4gwn]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GWN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gwm\|4gwm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gwm\|4gwm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MEP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MEP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Meprin_B Meprin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.63 3.4.24.63] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Meprin_B Meprin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.63 3.4.24.63] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [http://www.ebi.ac.uk/pdbsum/4gwn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [http://pdbe.org/4gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [http://www.ebi.ac.uk/pdbsum/4gwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gwn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Meprin B]]		[[Category: Meprin B]]
	[[Category: Arolas, J L]]		[[Category: Arolas, J L]]

OCA at 07:42, 25 December 2014

2014-12-25T07:42:10Z

←Older revision		Revision as of 07:42, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [http://www.ebi.ac.uk/pdbsum/4gwn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [http://www.ebi.ac.uk/pdbsum/4gwn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MEP1B_HUMAN MEP1B_HUMAN]] Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.<ref>PMID:21693781</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:15, 10 December 2014

2014-12-10T09:15:52Z

←Older revision		Revision as of 09:15, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4gwn.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of human mature meprin beta==
		+	<StructureSection load='4gwn' size='340' side='right' caption='[[4gwn]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gwn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GWN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gwm\|4gwm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MEP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Meprin_B Meprin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.63 3.4.24.63] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gwn RCSB], [http://www.ebi.ac.uk/pdbsum/4gwn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ectodomain shedding at the cell surface is a major mechanism to regulate the extracellular and circulatory concentration or the activities of signaling proteins at the plasma membrane. Human meprin beta is a 145-kDa disulfide-linked homodimeric multidomain type-I membrane metallopeptidase that sheds membrane-bound cytokines and growth factors, thereby contributing to inflammatory diseases, angiogenesis, and tumor progression. In addition, it cleaves amyloid precursor protein (APP) at the beta-secretase site, giving rise to amyloidogenic peptides. We have solved the X-ray crystal structure of a major fragment of the meprin beta ectoprotein, the first of a multidomain oligomeric transmembrane sheddase, and of its zymogen. The meprin beta dimer displays a compact shape, whose catalytic domain undergoes major rearrangement upon activation, and reveals an exosite and a sugar-rich channel, both of which possibly engage in substrate binding. A plausible structure-derived working mechanism suggests that substrates such as APP are shed close to the plasma membrane surface following an "N-like" chain trace.

-	~~{{STRUCTURE_4gwn\| PDB=4gwn \| SCENE= }}~~	+	Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane.,Arolas JL, Broder C, Jefferson T, Guevara T, Sterchi EE, Bode W, Stocker W, Becker-Pauly C, Gomis-Ruth FX Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16131-6. doi:, 10.1073/pnas.1211076109. Epub 2012 Sep 17. PMID:22988105<ref>PMID:22988105</ref>

-	~~===Crystal structure~~ of ~~human mature meprin beta===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22988105}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4gwn]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Meprin B]]		[[Category: Meprin B]]
-	[[Category: Arolas, J L.]]	+	[[Category: Arolas, J L]]
-	[[Category: Becker-Pauly, C.]]	+	[[Category: Becker-Pauly, C]]
-	[[Category: Bode, W.]]	+	[[Category: Bode, W]]
-	[[Category: Broder, C.]]	+	[[Category: Broder, C]]
-	[[Category: Gomis-Ruth, F X.]]	+	[[Category: Gomis-Ruth, F X]]
-	[[Category: Guevara, T.]]	+	[[Category: Guevara, T]]
-	[[Category: Jefferson, T.]]	+	[[Category: Jefferson, T]]
-	[[Category: Sterchi, E E.]]	+	[[Category: Sterchi, E E]]
-	[[Category: Stocker, W.]]	+	[[Category: Stocker, W]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Multidomain structure]]		[[Category: Multidomain structure]]

OCA at 09:03, 31 October 2012

2012-10-31T09:03:14Z

←Older revision		Revision as of 09:03, 31 October 2012
Line 1:		Line 1:
-	[[Image:4gwn.~~jpg~~\|left\|200px]]	+	[[Image:4gwn.png\|left\|200px]]

	{{STRUCTURE_4gwn\| PDB=4gwn \| SCENE= }}		{{STRUCTURE_4gwn\| PDB=4gwn \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of human mature meprin beta===		===Crystal structure of human mature meprin beta===

		+	{{ABSTRACT_PUBMED_22988105}}

	==About this Structure==		==About this Structure==

OCA at 07:24, 19 September 2012

2012-09-19T07:24:48Z

←Older revision		Revision as of 07:24, 19 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gwn.jpg\|left\|200px]]

-	~~The entry~~ 4gwn ~~is ON HOLD~~	+	{{STRUCTURE_4gwn\| PDB=4gwn \| SCENE= }}

-	~~Authors: Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F.X.~~	+	===Crystal structure of human mature meprin beta===

-	~~Description~~: ~~Crystal~~ structure ~~of human mature meprin beta~~	+
		+	==About this Structure==
		+	[[4gwn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWN OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Meprin B]]
		+	[[Category: Arolas, J L.]]
		+	[[Category: Becker-Pauly, C.]]
		+	[[Category: Bode, W.]]
		+	[[Category: Broder, C.]]
		+	[[Category: Gomis-Ruth, F X.]]
		+	[[Category: Guevara, T.]]
		+	[[Category: Jefferson, T.]]
		+	[[Category: Sterchi, E E.]]
		+	[[Category: Stocker, W.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Multidomain structure]]

OCA: Protected "4gwn" [edit=sysop:move=sysop]

2012-09-12T04:54:48Z

Protected "4gwn" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:54, 12 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gwn is ON HOLD Authors: Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F...

2012-09-12T04:54:47Z

New page: '''Unreleased structure''' The entry 4gwn is ON HOLD Authors: Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F...

New page

'''Unreleased structure'''

The entry 4gwn is ON HOLD

Authors: Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F.X.

Description: Crystal structure of human mature meprin beta