4gxb - Revision history

OCA at 08:51, 20 March 2024

2024-03-20T08:51:38Z

←Older revision		Revision as of 08:51, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GXB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxb OCA], [https://pdbe.org/4gxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gxb RCSB], [https://www.ebi.ac.uk/pdbsum/4gxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxb OCA], [https://pdbe.org/4gxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gxb RCSB], [https://www.ebi.ac.uk/pdbsum/4gxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref>		[https://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Transit of proteins through the endosomal organelle following endocytosis is critical for regulating the homeostasis of cell-surface proteins and controlling signal transduction pathways. However, the mechanisms that control these membrane-transport processes are poorly understood. The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged recently as key regulators of endosomal recycling and bind conserved Asn-Pro-Xaa-Tyr-sorting signals in transmembrane cargos via an atypical band, 4.1/ezrin/radixin/moesin (FERM) domain. Here we present the crystal structure of the SNX17 FERM domain bound to the sorting motif of the P-selectin adhesion protein, revealing both the architecture of the atypical FERM domain and the molecular basis for recognition of these essential sorting sequences. We further show that the PX-FERM proteins share a promiscuous ability to bind a wide array of putative cargo molecules, including receptor tyrosine kinases, and propose a model for their coordinated molecular interactions with membrane, cargo, and regulatory proteins.
-
-	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.,Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52. doi:, 10.1073/pnas.1216229110. Epub 2013 Feb 4. PMID:23382219<ref>PMID:23382219</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gxb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:24, 26 October 2022

2022-10-26T07:24:23Z

←Older revision		Revision as of 07:24, 26 October 2022
Line 1:		Line 1:

	==Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin==		==Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin==
-	<StructureSection load='4gxb' size='340' side='right' caption='[[4gxb]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4gxb' size='340' side='right'caption='[[4gxb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gxb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GXB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lui\|3lui]], [[3fog\|3fog]], [[1hes\|1hes]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxb OCA], [https://pdbe.org/4gxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gxb RCSB], [https://www.ebi.ac.uk/pdbsum/4gxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxb ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNX17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Selp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxb OCA], [~~http~~://pdbe.org/4gxb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gxb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gxb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN]] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref> [[http://www.uniprot.org/uniprot/LYAM3_MOUSE LYAM3_MOUSE]] Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.<ref>PMID:12370362</ref>	+	[https://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	==See Also==		==See Also==
	*[[Selectin\|Selectin]]		*[[Selectin\|Selectin]]
-	*[[Sorting nexin\|Sorting nexin]]	+	*[[Sorting nexin 3D structures\|Sorting nexin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: Bugarcic, A]]	+	[[Category: Mus musculus]]
-	[[Category: Collins~~, B M~~]]	+	[[Category: Bugarcic A]]
-	[[Category: Ghai, R]]	+	[[Category: Collins BM]]
-	[[Category: Li~~, S S~~]]	+	[[Category: Ghai R]]
-	[[Category: Liu, H]]	+	[[Category: Li SS]]
-	[[Category: Norwood~~, S J~~]]	+	[[Category: Liu H]]
-	[[Category: Teasdale~~, R D]]~~	+	[[Category: Norwood SJ]]
-	~~[[Category: Ferm domain]]~~	+	[[Category: Teasdale RD]]
-	~~[[Category: Protein transport-cell adhesion complex~~]]	+

OCA at 04:32, 5 August 2016

2016-08-05T04:32:32Z

←Older revision		Revision as of 04:32, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin==		==Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin==
	<StructureSection load='4gxb' size='340' side='right' caption='[[4gxb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4gxb' size='340' side='right' caption='[[4gxb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GXB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lui\|3lui]], [[3fog\|3fog]], [[1hes\|1hes]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lui\|3lui]], [[3fog\|3fog]], [[1hes\|1hes]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNX17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), Selp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNX17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Selp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gxb RCSB], [http://www.ebi.ac.uk/pdbsum/4gxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxb OCA], [http://pdbe.org/4gxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gxb RCSB], [http://www.ebi.ac.uk/pdbsum/4gxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN]] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref>	+	[[http://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN]] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref> [[http://www.uniprot.org/uniprot/LYAM3_MOUSE LYAM3_MOUSE]] Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.<ref>PMID:12370362</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gxb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Bugarcic, A]]		[[Category: Bugarcic, A]]
	[[Category: Collins, B M]]		[[Category: Collins, B M]]

OCA at 15:49, 25 December 2014

2014-12-25T15:49:56Z

←Older revision		Revision as of 15:49, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gxb~~\| ~~PDB~~=4gxb \| ~~SCENE~~= }}	+	==Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin==
-	===~~Structure~~ of the ~~SNX17~~ atypical FERM domain bound to the ~~NPxY~~ motif of P-selectin~~===~~	+	<StructureSection load='4gxb' size='340' side='right' caption='[[4gxb]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23382219}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GXB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lui\|3lui]], [[3fog\|3fog]], [[1hes\|1hes]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNX17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Selp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gxb RCSB], [http://www.ebi.ac.uk/pdbsum/4gxb PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN]] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transit of proteins through the endosomal organelle following endocytosis is critical for regulating the homeostasis of cell-surface proteins and controlling signal transduction pathways. However, the mechanisms that control these membrane-transport processes are poorly understood. The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged recently as key regulators of endosomal recycling and bind conserved Asn-Pro-Xaa-Tyr-sorting signals in transmembrane cargos via an atypical band, 4.1/ezrin/radixin/moesin (FERM) domain. Here we present the crystal structure of the SNX17 FERM domain bound to the sorting motif of the P-selectin adhesion protein, revealing both the architecture of the atypical FERM domain and the molecular basis for recognition of these essential sorting sequences. We further show that the PX-FERM proteins share a promiscuous ability to bind a wide array of putative cargo molecules, including receptor tyrosine kinases, and propose a model for their coordinated molecular interactions with membrane, cargo, and regulatory proteins.

-	~~==About this Structure==~~	+	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.,Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52. doi:, 10.1073/pnas.1216229110. Epub 2013 Feb 4. PMID:23382219<ref>PMID:23382219</ref>
-	~~[[4gxb]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http~~:~~//en~~.~~wikipedia~~.~~org/wiki~~/~~Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4GXB OCA~~].	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+
		+	==See Also==
		+	*[[Selectin\|Selectin]]
		+	*[[Sorting nexin\|Sorting nexin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bugarcic, A.]]	+	[[Category: Bugarcic, A]]
-	[[Category: Collins, B M.]]	+	[[Category: Collins, B M]]
-	[[Category: Ghai, R.]]	+	[[Category: Ghai, R]]
-	[[Category: Li, S S.]]	+	[[Category: Li, S S]]
-	[[Category: Liu, H.]]	+	[[Category: Liu, H]]
-	[[Category: Norwood, S J.]]	+	[[Category: Norwood, S J]]
-	[[Category: Teasdale, R D.]]	+	[[Category: Teasdale, R D]]
	[[Category: Ferm domain]]		[[Category: Ferm domain]]
	[[Category: Protein transport-cell adhesion complex]]		[[Category: Protein transport-cell adhesion complex]]

OCA at 10:25, 13 March 2013

2013-03-13T10:25:30Z

←Older revision		Revision as of 10:25, 13 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gxb\| PDB=4gxb \| SCENE= }}
		+	===Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin===
		+	{{ABSTRACT_PUBMED_23382219}}

-	~~The entry~~ 4gxb is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4gxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXB OCA].
-	~~Authors~~: ~~Ghai~~, R., ~~Bugarcic~~, A., Liu, H., Norwood, S.J.~~, Li, S.,~~ Teasdale, R.D.~~, Collins, B.M.~~	+	[[Category: Homo sapiens]]
-		+	[[Category: Mus musculus]]
-	~~Description~~: ~~Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P~~-~~selectin~~	+	[[Category: Bugarcic, A.]]
		+	[[Category: Collins, B M.]]
		+	[[Category: Ghai, R.]]
		+	[[Category: Li, S S.]]
		+	[[Category: Liu, H.]]
		+	[[Category: Norwood, S J.]]
		+	[[Category: Teasdale, R D.]]
		+	[[Category: Ferm domain]]
		+	[[Category: Protein transport-cell adhesion complex]]

OCA at 10:57, 19 December 2012

2012-12-19T10:57:31Z

←Older revision		Revision as of 10:57, 19 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gxb is ON HOLD	+	The entry 4gxb is ON HOLD until Paper Publication

	Authors: Ghai, R., Bugarcic, A., Liu, H., Norwood, S.J., Li, S., Teasdale, R.D., Collins, B.M.		Authors: Ghai, R., Bugarcic, A., Liu, H., Norwood, S.J., Li, S., Teasdale, R.D., Collins, B.M.

	Description: Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin		Description: Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin

OCA at 06:55, 19 September 2012

2012-09-19T06:55:26Z

←Older revision		Revision as of 06:55, 19 September 2012
Line 3:		Line 3:
	The entry 4gxb is ON HOLD		The entry 4gxb is ON HOLD

-	Authors: Ghai, R, Bugarcic, A, Liu, H, Norwood, S.J., Li, S, Teasdale, R.D., Collins, B.M.	+	Authors: Ghai, R., Bugarcic, A., Liu, H., Norwood, S.J., Li, S., Teasdale, R.D., Collins, B.M.

	Description: Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin		Description: Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin

OCA: Protected "4gxb" [edit=sysop:move=sysop]

2012-09-12T04:55:30Z

Protected "4gxb" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 12 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gxb is ON HOLD Authors: Ghai, R, Bugarcic, A, Liu, H, Norwood, S.J., Li, S, Teasdale, R.D., Collins, B.M. Description: Structure of the SNX17 atyp...

2012-09-12T04:55:29Z

New page: '''Unreleased structure''' The entry 4gxb is ON HOLD Authors: Ghai, R, Bugarcic, A, Liu, H, Norwood, S.J., Li, S, Teasdale, R.D., Collins, B.M. Description: Structure of the SNX17 atyp...

New page

'''Unreleased structure'''

The entry 4gxb is ON HOLD

Authors: Ghai, R, Bugarcic, A, Liu, H, Norwood, S.J., Li, S, Teasdale, R.D., Collins, B.M.

Description: Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin