4h7x - Revision history

OCA at 11:35, 1 March 2024

2024-03-01T11:35:56Z

←Older revision		Revision as of 11:35, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7X FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [https://pdbe.org/4h7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [https://www.ebi.ac.uk/pdbsum/4h7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [https://pdbe.org/4h7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [https://www.ebi.ac.uk/pdbsum/4h7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>		[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The SAC (spindle assembly checkpoint) is a surveillance system that ensures the timely and accurate transmission of the genetic material to offspring. The process implies kinetochore targeting of the mitotic kinases Bub1 (budding uninhibited by benzamidine 1), BubR1 (Bub1 related) and Mps1 (monopolar spindle 1), which is mediated by the N-terminus of each kinase. In the present study we report the 1.8 A (1 A=0.1 nm) crystal structure of the TPR (tetratricopeptide repeat) domain in the N-terminal region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin), and determinants of dimerization. Moreover, we show that a stretch of amino acids at the very N-terminus of Mps1 is required for dimer formation, and that interfering with dimerization results in mislocalization and misregulation of kinase activity. The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking.
-
-	Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).,Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S, Bolanos-Garcia VM Biochem J. 2012 Dec 15;448(3):321-8. doi: 10.1042/BJ20121448. PMID:23067341<ref>PMID:23067341</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4h7x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:04, 3 November 2022

2022-11-03T08:04:17Z

←Older revision		Revision as of 08:04, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1==		==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1==
-	<StructureSection load='4h7x' size='340' side='right' caption='[[4h7x]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4h7x' size='340' side='right'caption='[[4h7x]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4H7X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4h7y\|4h7y]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [https://pdbe.org/4h7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [https://www.ebi.ac.uk/pdbsum/4h7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7x ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPS1, MPS1L1, NCBI Reference Sequence NM_003318.4, TTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [~~http~~://pdbe.org/4h7x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4h7x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>	+	[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Dual specificity protein kinase\|Dual specificity protein kinase]]	+	*[[Dual specificity protein kinase 3D structures\|Dual specificity protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dual-specificity kinase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Blundell~~, T L~~]]	+	[[Category: Blundell TL]]
-	[[Category: Bolanos-Garcia~~, V M~~]]	+	[[Category: Bolanos-Garcia VM]]
-	[[Category: Chirgadze~~, D Y]]~~	+	[[Category: Chirgadze DY]]
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Chromosome instability]]~~	+
-	~~[[Category: Mitotic checkpoint]]~~	+
-	~~[[Category: Mitotic checkpoint kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 21:00, 4 August 2016

2016-08-04T21:00:55Z

←Older revision		Revision as of 21:00, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1==		==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1==
	<StructureSection load='4h7x' size='340' side='right' caption='[[4h7x]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4h7x' size='340' side='right' caption='[[4h7x]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4h7y\|4h7y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4h7y\|4h7y]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPS1, MPS1L1, NCBI Reference Sequence NM_003318.4, TTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPS1, MPS1L1, NCBI Reference Sequence NM_003318.4, TTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [http://www.ebi.ac.uk/pdbsum/4h7x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [http://pdbe.org/4h7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [http://www.ebi.ac.uk/pdbsum/4h7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4h7x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]
	[[Category: Bolanos-Garcia, V M]]		[[Category: Bolanos-Garcia, V M]]

OCA at 19:37, 24 December 2014

2014-12-24T19:37:05Z

←Older revision		Revision as of 19:37, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [http://www.ebi.ac.uk/pdbsum/4h7x PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [http://www.ebi.ac.uk/pdbsum/4h7x PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:46, 10 December 2014

2014-12-10T09:46:32Z

←Older revision		Revision as of 09:46, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4h7x.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1==
		+	<StructureSection load='4h7x' size='340' side='right' caption='[[4h7x]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4h7y\|4h7y]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPS1, MPS1L1, NCBI Reference Sequence NM_003318.4, TTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [http://www.ebi.ac.uk/pdbsum/4h7x PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The SAC (spindle assembly checkpoint) is a surveillance system that ensures the timely and accurate transmission of the genetic material to offspring. The process implies kinetochore targeting of the mitotic kinases Bub1 (budding uninhibited by benzamidine 1), BubR1 (Bub1 related) and Mps1 (monopolar spindle 1), which is mediated by the N-terminus of each kinase. In the present study we report the 1.8 A (1 A=0.1 nm) crystal structure of the TPR (tetratricopeptide repeat) domain in the N-terminal region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin), and determinants of dimerization. Moreover, we show that a stretch of amino acids at the very N-terminus of Mps1 is required for dimer formation, and that interfering with dimerization results in mislocalization and misregulation of kinase activity. The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking.

-	~~{{STRUCTURE_4h7x\| PDB=4h7x \| SCENE= }}~~	+	Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).,Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S, Bolanos-Garcia VM Biochem J. 2012 Dec 15;448(3):321-8. doi: 10.1042/BJ20121448. PMID:23067341<ref>PMID:23067341</ref>

-	~~===Crystal structure~~ of the ~~tetratricopeptide repeat (TPR) motif~~ of ~~human dual specificity protein kinase Mps1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23067341}}~~	+	==See Also==
-		+	*[[Dual specificity protein kinase\|Dual specificity protein kinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4h7x~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blundell, T L.]]	+	[[Category: Blundell, T L]]
-	[[Category: Bolanos-Garcia, V M.]]	+	[[Category: Bolanos-Garcia, V M]]
-	[[Category: Chirgadze, D Y.]]	+	[[Category: Chirgadze, D Y]]
	[[Category: Cancer]]		[[Category: Cancer]]
	[[Category: Chromosome instability]]		[[Category: Chromosome instability]]

OCA at 21:14, 12 December 2012

2012-12-12T21:14:50Z

←Older revision		Revision as of 21:14, 12 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4h7x.jpg\|left\|200px]]

-	~~The entry~~ 4h7x ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4h7x\| PDB=4h7x \| SCENE= }}

-	~~Authors: Bolanos-Garcia, V.M., Chirgadze, D.Y., Blundell, T.L.~~	+	===Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1===

-	~~Description: Crystal~~ structure ~~of the tetratricopeptide repeat (TPR) motif of human dual~~ specificity ~~protein~~ kinase ~~Mps1~~	+	{{ABSTRACT_PUBMED_23067341}}
		+
		+	==About this Structure==
		+	[[4h7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA].
		+	[[Category: Dual-specificity kinase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Blundell, T L.]]
		+	[[Category: Bolanos-Garcia, V M.]]
		+	[[Category: Chirgadze, D Y.]]
		+	[[Category: Cancer]]
		+	[[Category: Chromosome instability]]
		+	[[Category: Mitotic checkpoint]]
		+	[[Category: Mitotic checkpoint kinase]]
		+	[[Category: Transferase]]

OCA at 06:33, 17 October 2012

2012-10-17T06:33:39Z

←Older revision		Revision as of 06:33, 17 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4h7x is ON HOLD	+	The entry 4h7x is ON HOLD until Paper Publication

	Authors: Bolanos-Garcia, V.M., Chirgadze, D.Y., Blundell, T.L.		Authors: Bolanos-Garcia, V.M., Chirgadze, D.Y., Blundell, T.L.

-	Description: Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual kinase Mps1	+	Description: Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1

OCA: Protected "4h7x" [edit=sysop:move=sysop]

2012-10-03T05:48:56Z

Protected "4h7x" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:48, 3 October 2012

OCA: New page: '''Unreleased structure''' The entry 4h7x is ON HOLD Authors: Bolanos-Garcia, V.M., Chirgadze, D.Y., Blundell, T.L. Description: Crystal structure of the tetratricopeptide repeat (TPR)...

2012-10-03T05:48:55Z

New page: '''Unreleased structure''' The entry 4h7x is ON HOLD Authors: Bolanos-Garcia, V.M., Chirgadze, D.Y., Blundell, T.L. Description: Crystal structure of the tetratricopeptide repeat (TPR)...

New page

'''Unreleased structure'''

The entry 4h7x is ON HOLD

Authors: Bolanos-Garcia, V.M., Chirgadze, D.Y., Blundell, T.L.

Description: Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual kinase Mps1