4h98 - Revision history

OCA at 15:01, 20 September 2023

2023-09-20T15:01:59Z

←Older revision		Revision as of 15:01, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H98 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H98 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [https://pdbe.org/4h98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [https://www.ebi.ac.uk/pdbsum/4h98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h98 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [https://pdbe.org/4h98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [https://www.ebi.ac.uk/pdbsum/4h98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h98 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:05, 3 November 2022

2022-11-03T08:05:39Z

←Older revision		Revision as of 08:05, 3 November 2022
Line 1:		Line 1:

	==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==		==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==
-	<StructureSection load='4h98' size='340' side='right' caption='[[4h98]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4h98' size='340' side='right'caption='[[4h98]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h98]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Canga Canga~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4H98 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H98 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3roa\|3roa]], [[3ro9\|3ro9]], [[3qly\|3qly]], [[3qlx\|3qlx]], [[3qlz\|3qlz]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [https://pdbe.org/4h98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [https://www.ebi.ac.uk/pdbsum/4h98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h98 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 CANGA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [~~http~~://pdbe.org/4h98 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4h98 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4h98 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6FPH0_CANGA Q6FPH0_CANGA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canga]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Dihydrofolate reductase~~]]	+	[[Category: Anderson AC]]
-	[[Category: Anderson~~, A C~~]]	+	[[Category: Paulsen JL]]
-	[[Category: Paulsen~~, J L]]~~	+
-	~~[[Category: Antifungal agent]]~~	+
-	~~[[Category: Candida glabrata]]~~	+
-	~~[[Category: Drug design]]~~	+
-	~~[[Category: Enzyme inhibitor]]~~	+
-	~~[[Category: Fungal protein]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~	+
-	~~[[Category: Tetrahydrofolate dehydrogenase~~]]	+

OCA at 13:25, 5 August 2016

2016-08-05T13:25:22Z

←Older revision		Revision as of 13:25, 5 August 2016
Line 1:		Line 1:
		+
	==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==		==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==
	<StructureSection load='4h98' size='340' side='right' caption='[[4h98]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4h98' size='340' side='right' caption='[[4h98]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 CANGA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 CANGA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [http://www.ebi.ac.uk/pdbsum/4h98 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [http://pdbe.org/4h98 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [http://www.ebi.ac.uk/pdbsum/4h98 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h98 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4h98" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:09, 21 December 2014

2014-12-21T11:09:12Z

←Older revision		Revision as of 11:09, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4h98\| PDB=4h98 \| SCENE= }}~~	+	==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==
-	===Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)===	+	<StructureSection load='4h98' size='340' side='right' caption='[[4h98]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23375226}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4h98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canga Canga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H98 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3roa\|3roa]], [[3ro9\|3ro9]], [[3qly\|3qly]], [[3qlx\|3qlx]], [[3qlz\|3qlz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 CANGA])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [http://www.ebi.ac.uk/pdbsum/4h98 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel strategy for targeting the pathogenic organisms Candida albicans and Candida glabrata focuses on the development of potent and selective antifolates effective against dihydrofolate reductase. Crystal structure analysis suggested that an essential loop at the active site (Thr 58-Phe 66) differs from the analogous residues in the human enzyme, potentially providing a mechanism for achieving selectivity. In order to probe the role of this loop, we employed chemical synthesis, crystal structure determination and molecular dynamics simulations. The results of these analyses show that the loop residues undergo ligand-induced conformational changes that are similar among the fungal and human species.

-	~~==About this Structure==~~	+	Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.,Paulsen JL, Viswanathan K, Wright DL, Anderson AC Bioorg Med Chem Lett. 2013 Mar 1;23(5):1279-84. doi: 10.1016/j.bmcl.2013.01.008. , Epub 2013 Jan 11. PMID:23375226<ref>PMID:23375226</ref>
-	~~[[4h98]] is a 2 chain structure with sequence~~ from ~~[http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Canga Canga]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4H98 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023375226</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Canga]]		[[Category: Canga]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
-	[[Category: Anderson, A C.]]	+	[[Category: Anderson, A C]]
-	[[Category: Paulsen, J L.]]	+	[[Category: Paulsen, J L]]
	[[Category: Antifungal agent]]		[[Category: Antifungal agent]]
	[[Category: Candida glabrata]]		[[Category: Candida glabrata]]

OCA at 12:15, 20 November 2013

2013-11-20T12:15:33Z

←Older revision		Revision as of 12:15, 20 November 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4h98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_glabrata_cbs_138 Candida glabrata cbs 138~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA].	+	[[4h98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canga Canga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA].
-	[[Category: ~~Candida glabrata cbs 138~~]]	+
		+	==See Also==
		+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023375226</ref><references group="xtra"/><references/>
		+	[[Category: Canga]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Anderson, A C.]]		[[Category: Anderson, A C.]]

OCA at 08:49, 27 March 2013

2013-03-27T08:49:19Z

←Older revision		Revision as of 08:49, 27 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4h98\| PDB=4h98 \| SCENE= }}
		+	===Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)===
		+	{{ABSTRACT_PUBMED_23375226}}

-	~~The entry~~ 4h98 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4h98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_glabrata_cbs_138 Candida glabrata cbs 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA].
-	~~Authors~~: ~~Paulsen, J~~.L., Anderson, A.C.	+	[[Category: Candida glabrata cbs 138]]
-		+	[[Category: Dihydrofolate reductase]]
-	~~Description~~: Candida glabrata ~~dihydrofolate reductase complexed with NADPH and 5-{3-~~[~~3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl~~]~~prop-1-yn-1~~-~~yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)~~	+	[[Category: Anderson, A C.]]
		+	[[Category: Paulsen, J L.]]
		+	[[Category: Antifungal agent]]
		+	[[Category: Candida glabrata]]
		+	[[Category: Drug design]]
		+	[[Category: Enzyme inhibitor]]
		+	[[Category: Fungal protein]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Tetrahydrofolate dehydrogenase]]

OCA at 07:08, 24 October 2012

2012-10-24T07:08:31Z

←Older revision		Revision as of 07:08, 24 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4h98 is ON HOLD	+	The entry 4h98 is ON HOLD until Paper Publication

	Authors: Paulsen, J.L., Anderson, A.C.		Authors: Paulsen, J.L., Anderson, A.C.

	Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)		Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)

OCA: Protected "4h98" [edit=sysop:move=sysop]

2012-10-03T05:50:17Z

Protected "4h98" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 3 October 2012

OCA: New page: '''Unreleased structure''' The entry 4h98 is ON HOLD Authors: Paulsen, J.L., Anderson, A.C. Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-...

2012-10-03T05:50:16Z

New page: '''Unreleased structure''' The entry 4h98 is ON HOLD Authors: Paulsen, J.L., Anderson, A.C. Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-...

New page

'''Unreleased structure'''

The entry 4h98 is ON HOLD

Authors: Paulsen, J.L., Anderson, A.C.

Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)