4hbu - Revision history

OCA at 14:06, 8 November 2023

2023-11-08T14:06:51Z

←Older revision		Revision as of 14:06, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hbu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hbu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbu OCA], [https://pdbe.org/4hbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbu RCSB], [https://www.ebi.ac.uk/pdbsum/4hbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbu OCA], [https://pdbe.org/4hbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbu RCSB], [https://www.ebi.ac.uk/pdbsum/4hbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:09, 3 November 2022

2022-11-03T08:09:03Z

←Older revision		Revision as of 08:09, 3 November 2022
Line 3:		Line 3:
	<StructureSection load='4hbu' size='340' side='right'caption='[[4hbu]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4hbu' size='340' side='right'caption='[[4hbu]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hbu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HBU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hbu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gzb\|4gzb]], [[4hbt\|4hbt]], [[4hef\|4hef]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbu OCA], [https://pdbe.org/4hbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbu RCSB], [https://www.ebi.ac.uk/pdbsum/4hbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbu ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaUOE-1, bla, bla CTX-M-15, blaCTX-M-15, blaCTX-M15, CTX-M-15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbu OCA], [~~http~~://pdbe.org/4hbu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hbu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hbu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9EXV5_ECOLX Q9EXV5_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Beta-lactamase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benvenuti, M]]	+	[[Category: Benvenuti M]]
-	[[Category: Black~~, M T~~]]	+	[[Category: Black MT]]
-	[[Category: Bruneau~~, J M~~]]	+	[[Category: Bruneau JM]]
-	[[Category: Docquier~~, J D~~]]	+	[[Category: Docquier JD]]
-	[[Category: Mangani, S]]	+	[[Category: Mangani S]]
-	[[Category: Miossec, C]]	+	[[Category: Miossec C]]
-	[[Category: Rossolini~~, G M]]~~	+	[[Category: Rossolini GM]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Hydrolysis of beta-lactam~~]]	+

OCA at 08:32, 4 December 2019

2019-12-04T08:32:12Z

←Older revision		Revision as of 08:32, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)==		==Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)==
-	<StructureSection load='4hbu' size='340' side='right' caption='[[4hbu]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='4hbu' size='340' side='right'caption='[[4hbu]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hbu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hbu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBU FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Benvenuti, M]]		[[Category: Benvenuti, M]]
	[[Category: Black, M T]]		[[Category: Black, M T]]

OCA at 17:35, 9 March 2017

2017-03-09T17:35:19Z

←Older revision		Revision as of 17:35, 9 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)==		==Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)==
	<StructureSection load='4hbu' size='340' side='right' caption='[[4hbu]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4hbu' size='340' side='right' caption='[[4hbu]], [[Resolution\|resolution]] 1.10Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaUOE-1, bla, bla CTX-M-15, blaCTX-M-15, blaCTX-M15, CTX-M-15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaUOE-1, bla, bla CTX-M-15, blaCTX-M-15, blaCTX-M15, CTX-M-15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbu RCSB], [http://www.ebi.ac.uk/pdbsum/4hbu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbu OCA], [http://pdbe.org/4hbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hbu RCSB], [http://www.ebi.ac.uk/pdbsum/4hbu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hbu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:23, 4 January 2015

2015-01-04T13:23:03Z

←Older revision		Revision as of 13:23, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4hbu\| PDB=4hbu \| SCENE= }}~~	+	==Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)==
-	===Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)===	+	<StructureSection load='4hbu' size='340' side='right' caption='[[4hbu]], [[Resolution\|resolution]] 1.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23439634}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hbu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gzb\|4gzb]], [[4hbt\|4hbt]], [[4hef\|4hef]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaUOE-1, bla, bla CTX-M-15, blaCTX-M-15, blaCTX-M15, CTX-M-15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbu RCSB], [http://www.ebi.ac.uk/pdbsum/4hbu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although beta-lactams have been the most effective class of antibacterial agents used in clinical practice for the past half century, their effectiveness on Gram-negative bacteria has been eroded due to the emergence and spread of beta-lactamase enzymes that are not affected by currently marketed beta-lactam/beta-lactamase inhibitor combinations. Avibactam is a novel, covalent, non-beta-lactam beta-lactamase inhibitor presently in clinical development in combination with either ceftaroline or ceftazidime. In vitro studies show that avibactam may restore the broad-spectrum activity of cephalosporins against class A, class C and some class D beta-lactamases. Here we describe the structure of two clinically important beta-lactamase enzymes bound to avibactam, the class A CTX-M-15 extended-spectrum beta-lactamase and class C Pseudomonas aeruginosa AmpC beta-lactamase, which together provide insight into the binding modes for the respective enzyme classes. The structure reveals a similar binding mode in both enzymes and thus provides a rationale for the broad-spectrum inhibitory activity of avibactam. Identification of the key residues surrounding the binding pocket allows for a better understanding of the potency of this scaffold. Finally, avibactam has recently been shown to be a reversible inhibitor and the structure provides insights into the mechanism of avibactam recyclization. Analysis of the ultra-high resolution CTX-M-15 structure suggests how the deacylation mechanism favors recyclization over hydrolysis.

-	~~==About this Structure==~~	+	Structural Insight into Potent Broad-spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases.,Lahiri SD, Mangani S, Durand-Reville T, Benvenuti M, De Luca F, Sanyal G, Docquier JD Antimicrob Agents Chemother. 2013 Feb 25. PMID:23439634<ref>PMID:23439634</ref>
-	~~[[4hbu]] is a 1 chain structure~~ with ~~sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4HBU OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023439634</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Benvenuti, M.]]	+	[[Category: Benvenuti, M]]
-	[[Category: Black, M T.]]	+	[[Category: Black, M T]]
-	[[Category: Bruneau, J M.]]	+	[[Category: Bruneau, J M]]
-	[[Category: Docquier, J D.]]	+	[[Category: Docquier, J D]]
-	[[Category: Mangani, S.]]	+	[[Category: Mangani, S]]
-	[[Category: Miossec, C.]]	+	[[Category: Miossec, C]]
-	[[Category: Rossolini, G M.]]	+	[[Category: Rossolini, G M]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Hydrolysis of beta-lactam]]		[[Category: Hydrolysis of beta-lactam]]

OCA at 09:54, 19 March 2014

2014-03-19T09:54:02Z

←Older revision		Revision as of 09:54, 19 March 2014
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4hbu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA].	+	[[4hbu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023439634</ref><references group="xtra"/><references/>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Escherichia coli]]
	[[Category: Benvenuti, M.]]		[[Category: Benvenuti, M.]]
	[[Category: Black, M T.]]		[[Category: Black, M T.]]

OCA at 22:44, 10 April 2013

2013-04-10T22:44:53Z

←Older revision		Revision as of 22:44, 10 April 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hbu\| PDB=4hbu \| SCENE= }}
		+	===Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)===
		+	{{ABSTRACT_PUBMED_23439634}}

-	~~The entry~~ 4hbu is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4hbu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBU OCA].
-	~~Authors~~: ~~Docquier, J~~.D., Benvenuti, M., Bruneau, J.M., ~~Rossolini, G.M~~., Miossec, C., ~~Black,~~ M.~~T., Mangani, S.~~	+	[[Category: Beta-lactamase]]
-		+	[[Category: Escherichia coli]]
-	~~Description~~: ~~Crystal structure of CTX~~-~~M-15 extended-spectrum~~ beta-~~lactamase in complex with avibactam (NXL104)~~	+	[[Category: Benvenuti, M.]]
		+	[[Category: Black, M T.]]
		+	[[Category: Bruneau, J M.]]
		+	[[Category: Docquier, J D.]]
		+	[[Category: Mangani, S.]]
		+	[[Category: Miossec, C.]]
		+	[[Category: Rossolini, G M.]]
		+	[[Category: Antibiotic resistance]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Hydrolysis of beta-lactam]]

OCA at 08:37, 31 October 2012

2012-10-31T08:37:48Z

←Older revision		Revision as of 08:37, 31 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hbu is ON HOLD	+	The entry 4hbu is ON HOLD until Paper Publication

	Authors: Docquier, J.D., Benvenuti, M., Bruneau, J.M., Rossolini, G.M., Miossec, C., Black, M.T., Mangani, S.		Authors: Docquier, J.D., Benvenuti, M., Bruneau, J.M., Rossolini, G.M., Miossec, C., Black, M.T., Mangani, S.

	Description: Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)		Description: Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)

OCA at 07:09, 24 October 2012

2012-10-24T07:09:10Z

←Older revision		Revision as of 07:09, 24 October 2012
Line 3:		Line 3:
	The entry 4hbu is ON HOLD		The entry 4hbu is ON HOLD

-	Authors: Docquier, J.D., Benvenuti, M., Bruneau, J.M., Rossolini, G. M. , Miossec, C., Black, M.T., Mangani, S.	+	Authors: Docquier, J.D., Benvenuti, M., Bruneau, J.M., Rossolini, G.M., Miossec, C., Black, M.T., Mangani, S.

	Description: Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)		Description: Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)

OCA: Protected "4hbu" [edit=sysop:move=sysop]

2012-10-10T06:58:51Z

Protected "4hbu" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 10 October 2012