4hh9 - Revision history

OCA at 15:05, 20 September 2023

2023-09-20T15:05:39Z

←Older revision		Revision as of 15:05, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [https://pdbe.org/4hh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [https://www.ebi.ac.uk/pdbsum/4hh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hh9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [https://pdbe.org/4hh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [https://www.ebi.ac.uk/pdbsum/4hh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hh9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:17, 3 November 2022

2022-11-03T08:17:16Z

←Older revision		Revision as of 08:17, 3 November 2022
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	<StructureSection load='4hh9' size='340' side='right'caption='[[4hh9]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4hh9' size='340' side='right'caption='[[4hh9]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hha\|4hha]], [[4hie\|4hie]], [[4hih\|4hih]], [[4hii\|4hii]], [[4hij\|4hij]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [https://pdbe.org/4hh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [https://www.ebi.ac.uk/pdbsum/4hh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hh9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [~~http~~://pdbe.org/4hh9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hh9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hh9 ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bryson, S]]	+	[[Category: Bryson S]]
-	[[Category: Damgupta, S]]	+	[[Category: Damgupta S]]
-	[[Category: Pai~~, E F~~]]	+	[[Category: Pai EF]]
-	[[Category: Pfoh, R]]	+	[[Category: Pfoh R]]
-	[[Category: Risnes, L]]	+	[[Category: Risnes L]]
-	[[Category: Schrader~~, J W~~]]	+	[[Category: Schrader JW]]
-	[[Category: Thomson~~, C A]]~~	+	[[Category: Thomson CA]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 09:39, 5 February 2020

2020-02-05T09:39:01Z

←Older revision		Revision as of 09:39, 5 February 2020
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	==Anti-Human Cytomegalovirus (HCMV) Fab KE5==		==Anti-Human Cytomegalovirus (HCMV) Fab KE5==
-	<StructureSection load='4hh9' size='340' side='right' caption='[[4hh9]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4hh9' size='340' side='right'caption='[[4hh9]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Bryson, S]]		[[Category: Bryson, S]]
	[[Category: Damgupta, S]]		[[Category: Damgupta, S]]

OCA at 07:20, 13 December 2017

2017-12-13T07:20:12Z

←Older revision		Revision as of 07:20, 13 December 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [http://pdbe.org/4hh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hh9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [http://pdbe.org/4hh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hh9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human Ab response to certain pathogens is oligoclonal, with preferred IgV genes being used more frequently than others. A pair of such preferred genes, IGVK3-11 and IGVH3-30, contributes to the generation of protective Abs directed against the 23F serotype of the pneumonococcal capsular polysaccharide of Streptococcus pneumoniae and against the AD-2S1 peptide of the gB membrane protein of human CMV. Structural analyses of Fab fragments of mAbs 023.102 and pn132p2C05 in complex with portions of the 23F polysaccharide revealed five germline-encoded residues in contact with the key component, l-rhamnose. In the case of the AD-2S1 peptide, the KE5 Fab fragment complex identified nine germline-encoded contact residues. Two of these germline-encoded residues, Arg91L and Trp94L, contact both the l-rhamnose and the AD-2S1 peptide. Comparison of the respective paratopes that bind to carbohydrate and protein reveals that stochastic diversity in both CDR3 loops alone almost exclusively accounts for their divergent specificity. Combined evolutionary pressure by human CMV and the 23F serotype of S. pneumoniae acted on the IGVK3-11 and IGVH3-30 genes as demonstrated by the multiple germline-encoded amino acids that contact both l-rhamnose and AD-2S1 peptide.
		+
		+	Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation.,Bryson S, Thomson CA, Risnes LF, Dasgupta S, Smith K, Schrader JW, Pai EF J Immunol. 2016 Jun 1;196(11):4723-30. doi: 10.4049/jimmunol.1402890. Epub 2016, Apr 29. PMID:27183571<ref>PMID:27183571</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4hh9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:50, 5 August 2016

2016-08-05T14:50:58Z

←Older revision		Revision as of 14:50, 5 August 2016
Line 1:		Line 1:
		+
	==Anti-Human Cytomegalovirus (HCMV) Fab KE5==		==Anti-Human Cytomegalovirus (HCMV) Fab KE5==
	<StructureSection load='4hh9' size='340' side='right' caption='[[4hh9]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4hh9' size='340' side='right' caption='[[4hh9]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hha\|4hha]], [[4hie\|4hie]], [[4hih\|4hih]], [[4hii\|4hii]], [[4hij\|4hij]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hha\|4hha]], [[4hie\|4hie]], [[4hih\|4hih]], [[4hii\|4hii]], [[4hij\|4hij]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hh9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [http://pdbe.org/4hh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hh9 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 12:39, 21 December 2014

2014-12-21T12:39:42Z

←Older revision		Revision as of 12:39, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hh9\| PDB=4hh9 \| SCENE= }}~~	+	==Anti-Human Cytomegalovirus (HCMV) Fab KE5==
-	===Anti-Human Cytomegalovirus (HCMV) Fab KE5===	+	<StructureSection load='4hh9' size='340' side='right' caption='[[4hh9]], [[Resolution\|resolution]] 1.70Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[4hh9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HH9 FirstGlance]. <br>
-	[[4hh9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA].	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hha\|4hha]], [[4hie\|4hie]], [[4hih\|4hih]], [[4hii\|4hii]], [[4hij\|4hij]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hh9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hh9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hh9 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bryson, S.]]	+	[[Category: Bryson, S]]
-	[[Category: Damgupta, S.]]	+	[[Category: Damgupta, S]]
-	[[Category: Pai, E F.]]	+	[[Category: Pai, E F]]
-	[[Category: Pfoh, R.]]	+	[[Category: Pfoh, R]]
-	[[Category: Risnes, L.]]	+	[[Category: Risnes, L]]
-	[[Category: Schrader, J W.]]	+	[[Category: Schrader, J W]]
-	[[Category: Thomson, C A.]]	+	[[Category: Thomson, C A]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Fab]]		[[Category: Fab]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 06:51, 23 October 2013

2013-10-23T06:51:54Z

←Older revision		Revision as of 06:51, 23 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4hh9\| PDB=4hh9 \| SCENE= }}
		+	===Anti-Human Cytomegalovirus (HCMV) Fab KE5===

-	~~The entry~~ 4hh9 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4hh9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HH9 OCA].
-	~~Authors~~: Bryson, S.~~, Risnes, L.,~~ Damgupta, S., ~~Thomson, C~~.~~A.,~~ Pfoh, R., Schrader, J.W., ~~Pai, E.F~~.	+	[[Category: Homo sapiens]]
-		+	[[Category: Bryson, S.]]
-	~~Description~~: ~~Anti-Human Cytomegalovirus (HCMV)~~ Fab ~~KE5~~	+	[[Category: Damgupta, S.]]
		+	[[Category: Pai, E F.]]
		+	[[Category: Pfoh, R.]]
		+	[[Category: Risnes, L.]]
		+	[[Category: Schrader, J W.]]
		+	[[Category: Thomson, C A.]]
		+	[[Category: Antibody]]
		+	[[Category: Fab]]
		+	[[Category: Immune system]]

OCA at 08:09, 27 March 2013

2013-03-27T08:09:57Z

←Older revision		Revision as of 08:09, 27 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hh9 is ON HOLD	+	The entry 4hh9 is ON HOLD until Paper Publication

	Authors: Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Pfoh, R., Schrader, J.W., Pai, E.F.		Authors: Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Pfoh, R., Schrader, J.W., Pai, E.F.

	Description: Anti-Human Cytomegalovirus (HCMV) Fab KE5		Description: Anti-Human Cytomegalovirus (HCMV) Fab KE5

OCA at 07:10, 24 October 2012

2012-10-24T07:10:43Z

←Older revision		Revision as of 07:10, 24 October 2012
Line 3:		Line 3:
	The entry 4hh9 is ON HOLD		The entry 4hh9 is ON HOLD

-	Authors: Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Pfoh, R., Schrader, J.W., Pai, E. F.	+	Authors: Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Pfoh, R., Schrader, J.W., Pai, E.F.

	Description: Anti-Human Cytomegalovirus (HCMV) Fab KE5		Description: Anti-Human Cytomegalovirus (HCMV) Fab KE5

OCA: Protected "4hh9" [edit=sysop:move=sysop]

2012-10-17T06:37:43Z

Protected "4hh9" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:37, 17 October 2012