4hib - Revision history

OCA at 15:06, 20 September 2023

2023-09-20T15:06:37Z

←Older revision		Revision as of 15:06, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HIB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [https://pdbe.org/4hib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [https://www.ebi.ac.uk/pdbsum/4hib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [https://pdbe.org/4hib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [https://www.ebi.ac.uk/pdbsum/4hib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:21, 10 May 2023

2023-05-10T07:21:15Z

←Older revision		Revision as of 07:21, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4hib' size='340' side='right'caption='[[4hib]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4hib' size='340' side='right'caption='[[4hib]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HIB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HIB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4hkp\|4hkp]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS, OK/SW-cl.21 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [https://pdbe.org/4hib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [https://www.ebi.ac.uk/pdbsum/4hib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [https://pdbe.org/4hib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [https://www.ebi.ac.uk/pdbsum/4hib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>	+	[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Orotidine-5'-phosphate decarboxylase]]~~	+	[[Category: Kotra LP]]
-	[[Category: Kotra~~, L P~~]]	+	[[Category: Pai EF]]
-	[[Category: Pai~~, E F~~]]	+	[[Category: To TK]]
-	[[Category: To~~, T K]]~~	+
-	~~[[Category: Alpa-beta barrel]]~~	+
-	~~[[Category: Decarboxylase]]~~	+
-	~~[[Category: Lyase-lyase inhibitor complex]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 10:24, 4 August 2021

2021-08-04T10:24:40Z

←Older revision		Revision as of 10:24, 4 August 2021
Line 1:		Line 1:

	==Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH==		==Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH==
-	<StructureSection load='4hib' size='340' side='right' caption='[[4hib]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4hib' size='340' side='right'caption='[[4hib]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HIB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HIB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hkp\|4hkp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4hkp\|4hkp]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS, OK/SW-cl.21 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS, OK/SW-cl.21 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [~~http~~://pdbe.org/4hib PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hib PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [https://pdbe.org/4hib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [https://www.ebi.ac.uk/pdbsum/4hib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[~~http~~://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>	+	[[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]	+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
-	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]	+	*[[Uridine 5'-monophosphate synthase 3D structures\|Uridine 5'-monophosphate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Kotra, L P]]		[[Category: Kotra, L P]]

OCA at 11:20, 5 August 2016

2016-08-05T11:20:12Z

←Older revision		Revision as of 11:20, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH==		==Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH==
	<StructureSection load='4hib' size='340' side='right' caption='[[4hib]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4hib' size='340' side='right' caption='[[4hib]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HIB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HIB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hkp\|4hkp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hkp\|4hkp]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS, OK/SW-cl.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS, OK/SW-cl.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [http://www.ebi.ac.uk/pdbsum/4hib PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [http://pdbe.org/4hib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [http://www.ebi.ac.uk/pdbsum/4hib PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hib" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Kotra, L P]]		[[Category: Kotra, L P]]

OCA at 01:58, 25 December 2014

2014-12-25T01:58:24Z

←Older revision		Revision as of 01:58, 25 December 2014
Line 11:		Line 11:
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>		[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
-	== Function ==
-
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:52, 21 December 2014

2014-12-21T12:52:17Z

←Older revision		Revision as of 12:52, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hib\| PDB=4hib \| SCENE= }}~~	+	==Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH==
-	===Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH===	+	<StructureSection load='4hib' size='340' side='right' caption='[[4hib]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22991951}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HIB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hkp\|4hkp]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMPS, OK/SW-cl.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [http://www.ebi.ac.uk/pdbsum/4hib PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
		+	== Function ==

-	==~~Disease~~==	+	<div style="background-color:#fffaf0;">
-	~~[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1~~ (~~ORAC1~~) ~~[MIM:[http://omim~~.~~org/entry/258900 258900]]~~. ~~A disorder~~ of ~~pyrimidine metabolism resulting in megaloblastic anemia~~ and ~~orotic acid crystalluria that is frequently associated with some degree~~ of ~~physical~~ and ~~mental retardation~~. ~~A minority~~ of ~~cases have additional features~~, ~~particularly congenital malformations~~ and ~~immune deficiencies~~.~~<ref>PMID:9042911</ref>~~	+	== Publication Abstract from PubMed ==
		+	Orotidine-5'-monophosphate decarboxylase (ODCase) is an interesting enzyme with an unusual catalytic activity and a potential drug target in Plasmodium falciparum, which causes malaria. ODCase has been shown to exhibit unusual and interesting interactions with a variety of nucleotide ligands. Cytidine-5'-monophosphate (CMP) is a poor ligand of ODCase, and CMP binds to the active site of ODCase with an unusual orientation and conformation. We designed N3- and N4-modified CMP derivatives as novel ligands to ODCase. These novel CMP derivatives and their corresponding nucleosides were evaluated against Plasmodium falciparum ODCase and parasitic cultures, respectively. These derivatives exhibited improved inhibition of the enzyme catalytic activity, displayed interesting binding conformations and unusual molecular rearrangements of the ligands. These findings with the modified CMP nucleotides underscored the potential of transformation of poor ligands to ODCase into novel inhibitors of this drug target.

-	~~==About this Structure==~~	+	Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist.,Purohit MK, Poduch E, Wei LW, Crandall IE, To T, Kain KC, Pai EF, Kotra LP J Med Chem. 2012 Nov 26;55(22):9988-97. doi: 10.1021/jm301176r. Epub 2012 Oct 18. PMID:22991951<ref>PMID:22991951</ref>
-	~~[[4hib]] is a 2 chain structure~~ with ~~sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4HIB OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]		*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
-	[[Category: Kotra, L P.]]	+	[[Category: Kotra, L P]]
-	[[Category: Pai, E F.]]	+	[[Category: Pai, E F]]
-	[[Category: To, T K.]]	+	[[Category: To, T K]]
	[[Category: Alpa-beta barrel]]		[[Category: Alpa-beta barrel]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
	[[Category: Lyase-lyase inhibitor complex]]		[[Category: Lyase-lyase inhibitor complex]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 21:12, 24 March 2013

2013-03-24T21:12:26Z

←Older revision		Revision as of 21:12, 24 March 2013
Line 1:		Line 1:
-	[[Image:4hib.png\|left\|200px]]
-
	{{STRUCTURE_4hib\| PDB=4hib \| SCENE= }}		{{STRUCTURE_4hib\| PDB=4hib \| SCENE= }}
-
	===Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH===		===Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH===
-
	{{ABSTRACT_PUBMED_22991951}}		{{ABSTRACT_PUBMED_22991951}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>

	==About this Structure==		==About this Structure==
	[[4hib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA].		[[4hib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA].
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
		+	*[[Uridine 5'-monophosphate synthase\|Uridine 5'-monophosphate synthase]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]

OCA at 10:37, 19 December 2012

2012-12-19T10:37:28Z

←Older revision		Revision as of 10:37, 19 December 2012
Line 1:		Line 1:
-	[[Image:4hib.~~jpg~~\|left\|200px]]	+	[[Image:4hib.png\|left\|200px]]

	{{STRUCTURE_4hib\| PDB=4hib \| SCENE= }}		{{STRUCTURE_4hib\| PDB=4hib \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH===		===Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH===

		+	{{ABSTRACT_PUBMED_22991951}}

	==About this Structure==		==About this Structure==

OCA at 06:59, 14 November 2012

2012-11-14T06:59:54Z

←Older revision		Revision as of 06:59, 14 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hib.jpg\|left\|200px]]

-	~~The entry~~ 4hib ~~is ON HOLD~~	+	{{STRUCTURE_4hib\| PDB=4hib \| SCENE= }}

-	~~Authors: To, T.K., Kotra, L.P., Pai, E.F.~~	+	===Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH===

-	~~Description: Crystal~~ structure ~~of human orotidine~~ 5'-~~monophosphate~~ decarboxylase ~~complexed with CMP~~-N4-OH	+
		+	==About this Structure==
		+	[[4hib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Orotidine-5'-phosphate decarboxylase]]
		+	[[Category: Kotra, L P.]]
		+	[[Category: Pai, E F.]]
		+	[[Category: To, T K.]]
		+	[[Category: Alpa-beta barrel]]
		+	[[Category: Decarboxylase]]
		+	[[Category: Lyase-lyase inhibitor complex]]
		+	[[Category: Tim barrel]]

OCA: Protected "4hib" [edit=sysop:move=sysop]

2012-10-17T06:38:44Z

Protected "4hib" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 17 October 2012