4hk0 - Revision history

OCA at 08:21, 3 November 2022

2022-11-03T08:21:47Z

←Older revision		Revision as of 08:21, 3 November 2022
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	<StructureSection load='4hk0' size='340' side='right'caption='[[4hk0]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4hk0' size='340' side='right'caption='[[4hk0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hk0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HK0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hk0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HK0 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hk3\|4hk3]], [[4hkb\|4hkb]], [[4hkx\|4hkx]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk0 OCA], [https://pdbe.org/4hk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hk0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hk0 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk0 OCA], [~~http~~://pdbe.org/4hk0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hk0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hk0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hk0 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8N355_HUMAN Q8N355_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harrison~~, S C~~]]	+	[[Category: Harrison SC]]
-	[[Category: Schmidt~~, A G]]~~	+	[[Category: Schmidt AG]]
-	~~[[Category: Fab fragment]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 09:24, 5 February 2020

2020-02-05T09:24:57Z

←Older revision		Revision as of 09:24, 5 February 2020
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	==UCA Fab (unbound) from CH65-CH67 Lineage==		==UCA Fab (unbound) from CH65-CH67 Lineage==
-	<StructureSection load='4hk0' size='340' side='right' caption='[[4hk0]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4hk0' size='340' side='right'caption='[[4hk0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hk0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HK0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hk0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HK0 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]
	[[Category: Schmidt, A G]]		[[Category: Schmidt, A G]]
	[[Category: Fab fragment]]		[[Category: Fab fragment]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 19:53, 15 December 2016

2016-12-15T19:53:51Z

←Older revision		Revision as of 19:53, 15 December 2016
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		+
	==UCA Fab (unbound) from CH65-CH67 Lineage==		==UCA Fab (unbound) from CH65-CH67 Lineage==
	<StructureSection load='4hk0' size='340' side='right' caption='[[4hk0]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4hk0' size='340' side='right' caption='[[4hk0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hk0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HK0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hk0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HK0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hk3\|4hk3]], [[4hkb\|4hkb]], [[4hkx\|4hkx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hk3\|4hk3]], [[4hkb\|4hkb]], [[4hkx\|4hkx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hk0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk0 OCA], [http://pdbe.org/4hk0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hk0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hk0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hk0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]
	[[Category: Schmidt, A G]]		[[Category: Schmidt, A G]]
	[[Category: Fab fragment]]		[[Category: Fab fragment]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 09:20, 10 December 2014

2014-12-10T09:20:30Z

←Older revision		Revision as of 09:20, 10 December 2014
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-	[[~~Image:~~4hk0.~~png~~\|~~left~~\|~~200px~~]]	+	==UCA Fab (unbound) from CH65-CH67 Lineage==
		+	<StructureSection load='4hk0' size='340' side='right' caption='[[4hk0]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hk0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HK0 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hk3\|4hk3]], [[4hkb\|4hkb]], [[4hkx\|4hkx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hk0 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Affinity maturation refines a naive B-cell response by selecting mutations in antibody variable domains that enhance antigen binding. We describe a B-cell lineage expressing broadly neutralizing influenza virus antibodies derived from a subject immunized with the 2007 trivalent vaccine. The lineage comprises three mature antibodies, the unmutated common ancestor, and a common intermediate. Their heavy-chain complementarity determining region inserts into the conserved receptor-binding pocket of influenza HA. We show by analysis of structures, binding kinetics and long time-scale molecular dynamics simulations that antibody evolution in this lineage has rigidified the initially flexible heavy-chain complementarity determining region by two nearly independent pathways and that this preconfiguration accounts for most of the affinity gain. The results advance our understanding of strategies for developing more broadly effective influenza vaccines.

-	~~{{STRUCTURE_4hk0\| PDB=4hk0 \| SCENE= }}~~	+	Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.,Schmidt AG, Xu H, Khan AR, O'Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, Haynes BF, Liao HX, Shaw DE, Harrison SC Proc Natl Acad Sci U S A. 2012 Nov 21. PMID:23175789<ref>PMID:23175789</ref>

-	~~===UCA Fab (unbound) from CH65-CH67 Lineage===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23175789}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4hk0]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Harrison, S C.]]	+	[[Category: Harrison, S C]]
-	[[Category: Schmidt, A G.]]	+	[[Category: Schmidt, A G]]
	[[Category: Fab fragment]]		[[Category: Fab fragment]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 09:57, 5 December 2012

2012-12-05T09:57:15Z

←Older revision		Revision as of 09:57, 5 December 2012
Line 1:		Line 1:
-	[[Image:4hk0.~~jpg~~\|left\|200px]]	+	[[Image:4hk0.png\|left\|200px]]

	{{STRUCTURE_4hk0\| PDB=4hk0 \| SCENE= }}		{{STRUCTURE_4hk0\| PDB=4hk0 \| SCENE= }}
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	===UCA Fab (unbound) from CH65-CH67 Lineage===		===UCA Fab (unbound) from CH65-CH67 Lineage===

		+	{{ABSTRACT_PUBMED_23175789}}

	==About this Structure==		==About this Structure==

OCA at 09:49, 21 November 2012

2012-11-21T09:49:04Z

←Older revision		Revision as of 09:49, 21 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hk0.jpg\|left\|200px]]

-	~~The entry~~ 4hk0 ~~is ON HOLD~~	+	{{STRUCTURE_4hk0\| PDB=4hk0 \| SCENE= }}

-	~~Authors: Schmidt, A.G., Harrison, S.C.~~	+	===UCA Fab (unbound) from CH65-CH67 Lineage===

-	~~Description~~: ~~UCA Fab (unbound)~~ from ~~CH65~~-~~CH67 Lineage~~	+
		+	==About this Structure==
		+	[[4hk0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK0 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Harrison, S C.]]
		+	[[Category: Schmidt, A G.]]
		+	[[Category: Fab fragment]]
		+	[[Category: Immune system]]

OCA: Protected "4hk0" [edit=sysop:move=sysop]

2012-10-24T07:12:29Z

Protected "4hk0" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:12, 24 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hk0 is ON HOLD Authors: Schmidt, A.G., Harrison, S.C. Description: UCA Fab (unbound) from CH65-CH67 Lineage

2012-10-24T07:12:28Z

New page: '''Unreleased structure''' The entry 4hk0 is ON HOLD Authors: Schmidt, A.G., Harrison, S.C. Description: UCA Fab (unbound) from CH65-CH67 Lineage

New page

'''Unreleased structure'''

The entry 4hk0 is ON HOLD

Authors: Schmidt, A.G., Harrison, S.C.

Description: UCA Fab (unbound) from CH65-CH67 Lineage