4hkg - Revision history

OCA at 15:07, 20 September 2023

2023-09-20T15:07:43Z

←Older revision		Revision as of 15:07, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hkg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AB307-0294 Acinetobacter baumannii AB307-0294]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HKG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hkg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AB307-0294 Acinetobacter baumannii AB307-0294]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HKG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3002Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [https://pdbe.org/4hkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [https://www.ebi.ac.uk/pdbsum/4hkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [https://pdbe.org/4hkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [https://www.ebi.ac.uk/pdbsum/4hkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:22, 3 November 2022

2022-11-03T08:22:33Z

←Older revision		Revision as of 08:22, 3 November 2022
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	==Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway==		==Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway==
-	<StructureSection load='4hkg' size='340' side='right' caption='[[4hkg]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4hkg' size='340' side='right'caption='[[4hkg]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hkg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Acib3 Acib3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hkg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AB307-0294 Acinetobacter baumannii AB307-0294]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HKG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABBFA_003404 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=557600 ACIB3])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [https://pdbe.org/4hkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [https://www.ebi.ac.uk/pdbsum/4hkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [~~http~~://pdbe.org/4hkg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hkg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkg ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acib3]]~~	+	[[Category: Acinetobacter baumannii AB307-0294]]
-	~~[[Category: Allen, C L]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Gulick, A M]]~~	+	[[Category: Allen CL]]
-	~~[[Category: Non~~-~~ribosomal peptide synthetase~~]]	+	[[Category: Gulick AM]]
-	[[Category: ~~Nrp~~]]	+
-	[[Category: ~~Peptidyl carrier protein~~]]	+
-	[[Category: ~~Phosphopantetheine attachment site]]~~	+
-	~~[[Category: Phosphopantetheine binding protein~~]]	+

OCA at 08:45, 14 November 2018

2018-11-14T08:45:03Z

←Older revision		Revision as of 08:45, 14 November 2018
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [http://pdbe.org/4hkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [http://www.ebi.ac.uk/pdbsum/4hkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [http://pdbe.org/4hkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [http://www.ebi.ac.uk/pdbsum/4hkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkg ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Microorganisms produce a variety of natural products via secondary metabolic biosynthetic pathways. Two of these types of synthetic systems, the nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), use large modular enzymes containing multiple catalytic domains in a single protein. These multidomain enzymes use an integrated carrier protein domain to transport the growing, covalently bound natural product to the neighboring catalytic domains for each step in the synthesis. Interestingly, some PKS and NRPS clusters contain free-standing domains that interact intermolecularly with other proteins. Being expressed outside the architecture of a multi-domain protein, these so-called type II proteins present challenges to understand the precise role they play. Additional structures of individual and multi-domain components of the NRPS enzymes will therefore provide a better understanding of the features that govern the domain interactions in these interesting enzyme systems. The high-resolution crystal structure of a free-standing carrier protein from Acinetobacter baumannii that belongs to a larger NRPS-containing operon, encoded by the ABBFA_003406-ABBFA_003399 genes of A. baumannii strain AB307-0294, that has been implicated in A. baumannii motility, quorum sensing and biofilm formation, is presented here. Comparison with the closest structural homologs of other carrier proteins identifies the requirements for a conserved glycine residue and additional important sequence and structural requirements within the regions that interact with partner proteins.
		+
		+	Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein.,Allen CL, Gulick AM Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1718-25. doi:, 10.1107/S1399004714008311. Epub 2014 May 30. PMID:24914982<ref>PMID:24914982</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4hkg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:59, 11 August 2016

2016-08-11T16:59:00Z

←Older revision		Revision as of 16:59, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway==		==Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway==
	<StructureSection load='4hkg' size='340' side='right' caption='[[4hkg]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4hkg' size='340' side='right' caption='[[4hkg]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABBFA_003404 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=557600 ACIB3])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABBFA_003404 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=557600 ACIB3])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [http://www.ebi.ac.uk/pdbsum/4hkg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [http://pdbe.org/4hkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [http://www.ebi.ac.uk/pdbsum/4hkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkg ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 13:47, 4 January 2015

2015-01-04T13:47:00Z

←Older revision		Revision as of 13:47, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4hkg\| PDB=4hkg \| SCENE= }}~~	+	==Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway==
-	===Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway===	+	<StructureSection load='4hkg' size='340' side='right' caption='[[4hkg]], [[Resolution\|resolution]] 1.30Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[4hkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acib3 Acib3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HKG FirstGlance]. <br>
-	[[4hkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acib3 Acib3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA].	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABBFA_003404 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=557600 ACIB3])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hkg RCSB], [http://www.ebi.ac.uk/pdbsum/4hkg PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Acib3]]		[[Category: Acib3]]
-	[[Category: Allen, C L.]]	+	[[Category: Allen, C L]]
-	[[Category: Gulick, A M.]]	+	[[Category: Gulick, A M]]
	[[Category: Non-ribosomal peptide synthetase]]		[[Category: Non-ribosomal peptide synthetase]]
	[[Category: Nrp]]		[[Category: Nrp]]

OCA at 07:00, 15 January 2014

2014-01-15T07:00:50Z

←Older revision		Revision as of 07:00, 15 January 2014
Line 3:		Line 3:

	==About this Structure==		==About this Structure==
-	[[4hkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Acinetobacter_baumannii_ab307-0294 Acinetobacter baumannii ab307-0294~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA].	+	[[4hkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acib3 Acib3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA].
-	[[Category: ~~Acinetobacter baumannii ab307-0294~~]]	+	[[Category: Acib3]]
	[[Category: Allen, C L.]]		[[Category: Allen, C L.]]
	[[Category: Gulick, A M.]]		[[Category: Gulick, A M.]]
Line 10:		Line 10:
	[[Category: Nrp]]		[[Category: Nrp]]
	[[Category: Peptidyl carrier protein]]		[[Category: Peptidyl carrier protein]]
-	[[Category: Phosphoantetheine binding protein]]
	[[Category: Phosphopantetheine attachment site]]		[[Category: Phosphopantetheine attachment site]]
		+	[[Category: Phosphopantetheine binding protein]]

OCA at 09:49, 30 October 2013

2013-10-30T09:49:44Z

←Older revision		Revision as of 09:49, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4hkg\| PDB=4hkg \| SCENE= }}
		+	===Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway===

-	~~The entry~~ 4hkg is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4hkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii_ab307-0294 Acinetobacter baumannii ab307-0294]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKG OCA].
-	~~Authors~~: Allen, C.L., Gulick, A.M.	+	[[Category: Acinetobacter baumannii ab307-0294]]
-		+	[[Category: Allen, C L.]]
-	~~Description~~: ~~Crystal Structure of Free~~-~~Standing~~ Peptidyl ~~Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway~~	+	[[Category: Gulick, A M.]]
		+	[[Category: Non-ribosomal peptide synthetase]]
		+	[[Category: Nrp]]
		+	[[Category: Peptidyl carrier protein]]
		+	[[Category: Phosphoantetheine binding protein]]
		+	[[Category: Phosphopantetheine attachment site]]

OCA at 14:02, 28 November 2012

2012-11-28T14:02:32Z

←Older revision		Revision as of 14:02, 28 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hkg is ON HOLD	+	The entry 4hkg is ON HOLD until Paper Publication

	Authors: Allen, C.L., Gulick, A.M.		Authors: Allen, C.L., Gulick, A.M.

	Description: Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway		Description: Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway

OCA: Protected "4hkg" [edit=sysop:move=sysop]

2012-10-24T07:12:58Z

Protected "4hkg" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:12, 24 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hkg is ON HOLD Authors: Allen, C.L., Gulick, A.M. Description: Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Ac...

2012-10-24T07:12:57Z

New page: '''Unreleased structure''' The entry 4hkg is ON HOLD Authors: Allen, C.L., Gulick, A.M. Description: Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Ac...

New page

'''Unreleased structure'''

The entry 4hkg is ON HOLD

Authors: Allen, C.L., Gulick, A.M.

Description: Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway