4hls - Revision history

OCA at 15:08, 20 September 2023

2023-09-20T15:08:09Z

←Older revision		Revision as of 15:08, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hls]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hls]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hls OCA], [https://pdbe.org/4hls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hls RCSB], [https://www.ebi.ac.uk/pdbsum/4hls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hls ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hls OCA], [https://pdbe.org/4hls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hls RCSB], [https://www.ebi.ac.uk/pdbsum/4hls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hls ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:25, 3 November 2022

2022-11-03T08:25:20Z

←Older revision		Revision as of 08:25, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of mutant rabbit PRP 121-230 (S170N)==		==Crystal structure of mutant rabbit PRP 121-230 (S170N)==
-	<StructureSection load='4hls' size='340' side='right' caption='[[4hls]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='4hls' size='340' side='right'caption='[[4hls]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hls]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~European_rabbit European rabbit~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HLS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hls]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hmm\|4hmm]], [[4hmr\|4hmr]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hls OCA], [https://pdbe.org/4hls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hls RCSB], [https://www.ebi.ac.uk/pdbsum/4hls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hls ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP, PRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hls OCA], [~~http~~://pdbe.org/4hls PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hls RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hls PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hls ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.	+	[https://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).	+	[https://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Prion\|Prion]]	+	*[[Prion 3D structures\|Prion 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~European rabbit~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Chakrabartty, A~~]]	+	[[Category: Oryctolagus cuniculus]]
-	[[Category: ~~Pai, E F~~]]	+	[[Category: Chakrabartty A]]
-	[[Category: ~~Sweeting, B~~]]	+	[[Category: Pai EF]]
-	[[Category: ~~Membrane]]~~	+	[[Category: Sweeting B]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Prion]]~~	+
-	~~[[Category: Prp~~]]	+

OCA at 14:36, 5 August 2016

2016-08-05T14:36:40Z

←Older revision		Revision as of 14:36, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of mutant rabbit PRP 121-230 (S170N)==		==Crystal structure of mutant rabbit PRP 121-230 (S170N)==
	<StructureSection load='4hls' size='340' side='right' caption='[[4hls]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4hls' size='340' side='right' caption='[[4hls]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hls]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Oryctolagus_cuniculus Oryctolagus cuniculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hls]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hmm\|4hmm]], [[4hmr\|4hmr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hmm\|4hmm]], [[4hmr\|4hmr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP, PRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 ~~Oryctolagus cuniculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP, PRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hls OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hls RCSB], [http://www.ebi.ac.uk/pdbsum/4hls PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hls OCA], [http://pdbe.org/4hls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hls RCSB], [http://www.ebi.ac.uk/pdbsum/4hls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hls ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hls" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Oryctolagus cuniculus~~]]	+	[[Category: European rabbit]]
	[[Category: Chakrabartty, A]]		[[Category: Chakrabartty, A]]
	[[Category: Pai, E F]]		[[Category: Pai, E F]]

OCA at 12:22, 21 December 2014

2014-12-21T12:22:35Z

←Older revision		Revision as of 12:22, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hls\| PDB=4hls \| SCENE= }}~~	+	==Crystal structure of mutant rabbit PRP 121-230 (S170N)==
-	===Crystal structure of mutant rabbit PRP 121-230 (S170N)===	+	<StructureSection load='4hls' size='340' side='right' caption='[[4hls]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23675452}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hls]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLS FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hmm\|4hmm]], [[4hmr\|4hmr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRNP, PRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hls OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hls RCSB], [http://www.ebi.ac.uk/pdbsum/4hls PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.		[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Susceptibility of a particular species to prion disease is affected by small differences in the sequence of PrP and correlates with the propensity of its PrP to assume the beta-state. A helix-cap motif in the beta2-alpha2-loop of native alpha-helical rabbit PrP, a resistant species, contains sequence differences that influence intra- and interspecies transmission. To determine the effect the helix-cap motif on beta-state refolding propensity, we mutated S170N, S174N, and S170N/S174N of the rabbit PrP helix-cap to resemble that of hamster PrP and conversely, N170S, N174S, and N170S/N174S of hamster PrP to resemble the helix-cap of rabbit PrP. High-resolution crystal structures (1.45-1.6 A) revealed that these mutations ablate hydrogen-bonding interactions within the helix-cap motif in rabbit PrP(C). They also alter the beta-state-misfolding propensity of PrP; the serine mutations in hamster PrP decrease the propensity up to 35%, whereas the asparagine mutations in rabbit PrP increase it up to 42%. Rapid dilution of rabbit and hamster into beta-state buffer conditions causes quick conversion to beta-state monomers. Kinetic monitoring using size-exclusion chromatography showed that the monomer population decreases exponentially mirrored by an increase in an octameric species. The monomer-octamer transition rates are faster for hamster than for rabbit PrP. The N170S/N174S mutant of hamster PrP has a smaller octamer component at the endpoint compared to the wild-type, whereas the kinetics of octamer formation in mutant and wild-type rabbit PrP are comparable. These findings demonstrate that the sequence of the beta2-alpha2 helix-cap affects refolding to the beta-state and subsequently, may influence susceptibility to prion disease.

-	~~==Function==~~	+	N-Terminal Helix-Cap in alpha-Helix 2 Modulates beta-State Misfolding in Rabbit and Hamster Prion Proteins.,Sweeting B, Brown E, Khan MQ, Chakrabartty A, Pai EF PLoS One. 2013 May 10;8(5):e63047. doi: 10.1371/journal.pone.0063047. Print 2013. PMID:23675452<ref>PMID:23675452</ref>
-	~~[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] May play a role~~ in ~~neuronal development~~ and ~~synaptic plasticity~~. ~~May be required for neuronal myelin sheath maintenance~~. May ~~play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis~~ (~~in vitro~~). ~~Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts~~. ~~Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hls]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023675452</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Prion\|Prion]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Chakrabartty, A.]]	+	[[Category: Chakrabartty, A]]
-	[[Category: Pai, E F.]]	+	[[Category: Pai, E F]]
-	[[Category: Sweeting, B.]]	+	[[Category: Sweeting, B]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Prion]]		[[Category: Prion]]
	[[Category: Prp]]		[[Category: Prp]]

OCA at 15:26, 19 June 2013

2013-06-19T15:26:07Z

←Older revision		Revision as of 15:26, 19 June 2013
Line 1:		Line 1:
	{{STRUCTURE_4hls\| PDB=4hls \| SCENE= }}		{{STRUCTURE_4hls\| PDB=4hls \| SCENE= }}
	===Crystal structure of mutant rabbit PRP 121-230 (S170N)===		===Crystal structure of mutant rabbit PRP 121-230 (S170N)===
		+	{{ABSTRACT_PUBMED_23675452}}

	==Disease==		==Disease==
Line 10:		Line 11:
	==About this Structure==		==About this Structure==
	[[4hls]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA].		[[4hls]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023675452</ref><references group="xtra"/><references/>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Chakrabartty, A.]]		[[Category: Chakrabartty, A.]]

OCA at 07:31, 16 May 2013

2013-05-16T07:31:21Z

←Older revision		Revision as of 07:31, 16 May 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hls\| PDB=4hls \| SCENE= }}
		+	===Crystal structure of mutant rabbit PRP 121-230 (S170N)===

-	~~The entry 4hls is ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

-	~~Authors~~: ~~Sweeting, B~~.~~, Chakrabartty, A~~.~~, Pai, E~~.F.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

-	~~Description: Crystal~~ structure ~~of mutant rabbit PRP 121~~-~~230 (S170N)~~	+	==About this Structure==
		+	[[4hls]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLS OCA].
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Chakrabartty, A.]]
		+	[[Category: Pai, E F.]]
		+	[[Category: Sweeting, B.]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Prion]]
		+	[[Category: Prp]]

OCA at 08:40, 31 October 2012

2012-10-31T08:40:45Z

←Older revision		Revision as of 08:40, 31 October 2012
Line 5:		Line 5:
	Authors: Sweeting, B., Chakrabartty, A., Pai, E.F.		Authors: Sweeting, B., Chakrabartty, A., Pai, E.F.

-	Description: ~~CRYSTAL STRUCTURE OF MUTANT RABBIT~~ PRP 121-230 (S170N)	+	Description: Crystal structure of mutant rabbit PRP 121-230 (S170N)

OCA: Protected "4hls" [edit=sysop:move=sysop]

2012-10-24T07:14:24Z

Protected "4hls" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:14, 24 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hls is ON HOLD Authors: Sweeting, B., Chakrabartty, A., Pai, E.F. Description: CRYSTAL STRUCTURE OF MUTANT RABBIT PRP 121-230 (S170N)

2012-10-24T07:14:23Z

New page: '''Unreleased structure''' The entry 4hls is ON HOLD Authors: Sweeting, B., Chakrabartty, A., Pai, E.F. Description: CRYSTAL STRUCTURE OF MUTANT RABBIT PRP 121-230 (S170N)

New page

'''Unreleased structure'''

The entry 4hls is ON HOLD

Authors: Sweeting, B., Chakrabartty, A., Pai, E.F.

Description: CRYSTAL STRUCTURE OF MUTANT RABBIT PRP 121-230 (S170N)