4hpp - Revision history

OCA at 15:09, 20 September 2023

2023-09-20T15:09:37Z

←Older revision		Revision as of 15:09, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HPP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HPP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hpp OCA], [https://pdbe.org/4hpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hpp RCSB], [https://www.ebi.ac.uk/pdbsum/4hpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hpp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hpp OCA], [https://pdbe.org/4hpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hpp RCSB], [https://www.ebi.ac.uk/pdbsum/4hpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hpp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:31, 3 November 2022

2022-11-03T08:31:39Z

←Older revision		Revision as of 08:31, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of novel glutamine synthase homolog==		==Crystal structure of novel glutamine synthase homolog==
-	<StructureSection load='4hpp' size='340' side='right' caption='[[4hpp]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4hpp' size='340' side='right'caption='[[4hpp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hpp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HPP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HPP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA5508 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hpp OCA], [https://pdbe.org/4hpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hpp RCSB], [https://www.ebi.ac.uk/pdbsum/4hpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hpp ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--putrescine_ligase Glutamate--putrescine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.11 6.3.1.11] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hpp OCA], [~~http~~://pdbe.org/4hpp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hpp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hpp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hpp ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9HT65_PSEAE Q9HT65_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glutamate--putrescine ligase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Atanasova, V]]	+	[[Category: Atanasova V]]
-	[[Category: Dolezelova, Z]]	+	[[Category: Dolezelova Z]]
-	[[Category: Ladner~~, J E~~]]	+	[[Category: Ladner JE]]
-	[[Category: Parsons~~, J F]]~~	+	[[Category: Parsons JF]]
-	~~[[Category: Glutamate]]~~	+
-	~~[[Category: Glutamine synthase homolog]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Polyamine~~]]	+

OCA at 20:02, 15 December 2016

2016-12-15T20:02:28Z

←Older revision		Revision as of 20:02, 15 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of novel glutamine synthase homolog==		==Crystal structure of novel glutamine synthase homolog==
	<StructureSection load='4hpp' size='340' side='right' caption='[[4hpp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4hpp' size='340' side='right' caption='[[4hpp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hpp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HPP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hpp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HPP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA5508 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 ~~Pseudomonas aeruginosa PAO1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA5508 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--putrescine_ligase Glutamate--putrescine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.11 6.3.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--putrescine_ligase Glutamate--putrescine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.11 6.3.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hpp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hpp RCSB], [http://www.ebi.ac.uk/pdbsum/4hpp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hpp OCA], [http://pdbe.org/4hpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hpp RCSB], [http://www.ebi.ac.uk/pdbsum/4hpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hpp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hpp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Glutamate--putrescine ligase]]		[[Category: Glutamate--putrescine ligase]]
-	[[Category: ~~Pseudomonas aeruginosa pao1~~]]	+	[[Category: Pseae]]
	[[Category: Atanasova, V]]		[[Category: Atanasova, V]]
	[[Category: Dolezelova, Z]]		[[Category: Dolezelova, Z]]

OCA at 09:41, 10 December 2014

2014-12-10T09:41:03Z

←Older revision		Revision as of 09:41, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hpp.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of novel glutamine synthase homolog==
		+	<StructureSection load='4hpp' size='340' side='right' caption='[[4hpp]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hpp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HPP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA5508 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 Pseudomonas aeruginosa PAO1])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--putrescine_ligase Glutamate--putrescine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.11 6.3.1.11] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hpp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hpp RCSB], [http://www.ebi.ac.uk/pdbsum/4hpp PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of PA5508 from Pseudomonas aeruginosa, a glutamine synthetase (GS) homologue, has been determined at 2.5 A. Surprisingly, PA5508 forms single hexameric rings rather than the stacked double rings that are characteristic of GS. The C-terminal helical thong motif that links GS rings is present in PA5508; however, it is folded back toward the core of its own polypeptide, preventing it from interacting with a second ring. Interestingly, PA5508 displays a clear preference for aromatic amine substrates. Unique aspects of the structure illustrate how the enzyme is able to catalyze reactions involving bulky amines rather than ammonia.

-	~~{{STRUCTURE_4hpp\| PDB=4hpp \| SCENE= }}~~	+	Structure and Activity of PA5508, a Hexameric Glutamine Synthetase Homologue.,Ladner JE, Atanasova V, Dolezelova Z, Parsons JF Biochemistry. 2012 Dec 21;51(51):10121-3. doi: 10.1021/bi3014856. Epub 2012 Dec, 12. PMID:23234431<ref>PMID:23234431</ref>

-	~~===Crystal structure~~ of ~~novel glutamine synthase homolog===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23234431}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4hpp]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA].~~	+	</StructureSection>
	[[Category: Glutamate--putrescine ligase]]		[[Category: Glutamate--putrescine ligase]]
	[[Category: Pseudomonas aeruginosa pao1]]		[[Category: Pseudomonas aeruginosa pao1]]
-	[[Category: Atanasova, V.]]	+	[[Category: Atanasova, V]]
-	[[Category: Dolezelova, Z.]]	+	[[Category: Dolezelova, Z]]
-	[[Category: Ladner, J E.]]	+	[[Category: Ladner, J E]]
-	[[Category: Parsons, J F.]]	+	[[Category: Parsons, J F]]
	[[Category: Glutamate]]		[[Category: Glutamate]]
	[[Category: Glutamine synthase homolog]]		[[Category: Glutamine synthase homolog]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Polyamine]]		[[Category: Polyamine]]

OCA at 08:06, 2 January 2013

2013-01-02T08:06:22Z

←Older revision		Revision as of 08:06, 2 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hpp.jpg\|left\|200px]]

-	~~The entry~~ 4hpp ~~is ON HOLD~~	+	{{STRUCTURE_4hpp\| PDB=4hpp \| SCENE= }}

-	~~Authors: Ladner, J.E., Atanasova, V., Dolezelova, Z., Parsons, J.F.~~	+	===Crystal structure of novel glutamine synthase homolog===

-	~~Description: Crystal~~ structure ~~of novel glutamine~~ synthase homolog	+	{{ABSTRACT_PUBMED_23234431}}
		+
		+	==About this Structure==
		+	[[4hpp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPP OCA].
		+	[[Category: Glutamate--putrescine ligase]]
		+	[[Category: Pseudomonas aeruginosa pao1]]
		+	[[Category: Atanasova, V.]]
		+	[[Category: Dolezelova, Z.]]
		+	[[Category: Ladner, J E.]]
		+	[[Category: Parsons, J F.]]
		+	[[Category: Glutamate]]
		+	[[Category: Glutamine synthase homolog]]
		+	[[Category: Ligase]]
		+	[[Category: Polyamine]]

OCA: Protected "4hpp" [edit=sysop:move=sysop]

2012-10-31T08:43:43Z

Protected "4hpp" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:43, 31 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hpp is ON HOLD Authors: Ladner, J.E., Atanasova, V., Dolezelova, Z., Parsons, J.F. Description: Crystal structure of novel glutamine synthase homo...

2012-10-31T08:43:42Z

New page: '''Unreleased structure''' The entry 4hpp is ON HOLD Authors: Ladner, J.E., Atanasova, V., Dolezelova, Z., Parsons, J.F. Description: Crystal structure of novel glutamine synthase homo...

New page

'''Unreleased structure'''

The entry 4hpp is ON HOLD

Authors: Ladner, J.E., Atanasova, V., Dolezelova, Z., Parsons, J.F.

Description: Crystal structure of novel glutamine synthase homolog