4hqs - Revision history

OCA at 08:05, 9 November 2022

2022-11-09T08:05:15Z

←Older revision		Revision as of 08:05, 9 November 2022
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	==Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4==		==Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4==
-	<StructureSection load='4hqs' size='340' side='right' caption='[[4hqs]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='4hqs' size='340' side='right'caption='[[4hqs]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hqs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strpn Strpn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hqz\|4hqz]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqs OCA], [https://pdbe.org/4hqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hqs RCSB], [https://www.ebi.ac.uk/pdbsum/4hqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqs ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0659 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqs OCA], [~~http~~://pdbe.org/4hqs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hqs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hqs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqs ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H2UP26_STRPN A0A0H2UP26_STRPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Strpn~~]]	+	[[Category: Large Structures]]
-	[[Category: Abdullah~~, M R~~]]	+	[[Category: Streptococcus pneumoniae TIGR4]]
-	[[Category: Asmat~~, T M~~]]	+	[[Category: Abdullah MR]]
-	[[Category: Bartual~~, S G~~]]	+	[[Category: Asmat TM]]
-	[[Category: Hammerschmidt, S]]	+	[[Category: Bartual SG]]
-	[[Category: Hermoso~~, J A~~]]	+	[[Category: Hammerschmidt S]]
-	[[Category: Jensch, I]]	+	[[Category: Hermoso JA]]
-	[[Category: Petruschka, L]]	+	[[Category: Jensch I]]
-	[[Category: Pribyl, T]]	+	[[Category: Petruschka L]]
-	[[Category: Saleh, M]]	+	[[Category: Pribyl T]]
-	~~[[Category: Disulfide bridge]]~~	+	[[Category: Saleh M]]
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Thiorredoxin~~]]	+

OCA at 01:52, 5 August 2016

2016-08-05T01:52:50Z

←Older revision		Revision as of 01:52, 5 August 2016
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		+
	==Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4==		==Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4==
	<StructureSection load='4hqs' size='340' side='right' caption='[[4hqs]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='4hqs' size='340' side='right' caption='[[4hqs]], [[Resolution\|resolution]] 1.48Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hqz\|4hqz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hqz\|4hqz]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0659 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0659 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hqs RCSB], [http://www.ebi.ac.uk/pdbsum/4hqs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqs OCA], [http://pdbe.org/4hqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hqs RCSB], [http://www.ebi.ac.uk/pdbsum/4hqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hqs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:20, 21 December 2014

2014-12-21T18:20:48Z

←Older revision		Revision as of 18:20, 21 December 2014
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-	~~{{STRUCTURE_4hqs\| PDB=4hqs \| SCENE= }}~~	+	==Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4==
-	===Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4===	+	<StructureSection load='4hqs' size='340' side='right' caption='[[4hqs]], [[Resolution\|resolution]] 1.48Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24136784}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hqs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HQS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hqz\|4hqz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0659 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hqs RCSB], [http://www.ebi.ac.uk/pdbsum/4hqs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The respiratory pathogen Streptococcus pneumoniae has evolved efficient mechanisms to resist oxidative stress conditions and to displace other bacteria in the nasopharynx. Here we characterize at physiological, functional and structural levels two novel surface-exposed thioredoxin-family lipoproteins, Etrx1 and Etrx2. The impact of both Etrx proteins and their redox partner methionine sulfoxide reductase SpMsrAB2 on pneumococcal pathogenesis was assessed in mouse virulence studies and phagocytosis assays. The results demonstrate that loss of function of either both Etrx proteins or SpMsrAB2 dramatically attenuated pneumococcal virulence in the acute mouse pneumonia model and that Etrx proteins compensate each other. The deficiency of Etrx proteins or SpMsrAB2 further enhanced bacterial uptake by macrophages, and accelerated pneumococcal killing by H2 O2 or free methionine sulfoxides (MetSO). Moreover, the absence of both Etrx redox pathways provokes an accumulation of oxidized SpMsrAB2 in vivo. Taken together our results reveal insights into the role of two extracellular electron pathways required for reduction of SpMsrAB2 and surface-exposed MetSO. Identification of this system and its target proteins paves the way for the design of novel antimicrobials.

-	~~==About this Structure==~~	+	Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence.,Saleh M, Bartual SG, Abdullah MR, Jensch I, Asmat TM, Petruschka L, Pribyl T, Gellert M, Lillig CH, Antelmann H, Hermoso JA, Hammerschmidt S EMBO Mol Med. 2013 Oct 18. doi: 10.1002/emmm.201202435. PMID:24136784<ref>PMID:24136784</ref>
-	~~[[4hqs]] is a 1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4HQS OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024136784</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Abdullah, M R.]]	+	== References ==
-	[[Category: Asmat, T M.]]	+	<references/>
-	[[Category: Bartual, S G.]]	+	__TOC__
-	[[Category: Hammerschmidt, S.]]	+	</StructureSection>
-	[[Category: Hermoso, J A.]]	+	[[Category: Strpn]]
-	[[Category: Jensch, I.]]	+	[[Category: Abdullah, M R]]
-	[[Category: Petruschka, L.]]	+	[[Category: Asmat, T M]]
-	[[Category: Pribyl, T.]]	+	[[Category: Bartual, S G]]
-	[[Category: Saleh, M.]]	+	[[Category: Hammerschmidt, S]]
		+	[[Category: Hermoso, J A]]
		+	[[Category: Jensch, I]]
		+	[[Category: Petruschka, L]]
		+	[[Category: Pribyl, T]]
		+	[[Category: Saleh, M]]
	[[Category: Disulfide bridge]]		[[Category: Disulfide bridge]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]

OCA at 10:20, 25 December 2013

2013-12-25T10:20:16Z

←Older revision		Revision as of 10:20, 25 December 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hqs\| PDB=4hqs \| SCENE= }}
		+	===Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4===
		+	{{ABSTRACT_PUBMED_24136784}}

-	~~The entry~~ 4hqs is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4hqs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQS OCA].

-	~~Authors~~: ~~Bartual~~, ~~S.G~~., ~~Saleh,~~ M., ~~Abdullah~~, M., Jensch, I.~~, Asmat, M.T.,~~ Petruschka, L., Pribyl, T., ~~Hermoso, J.A., Hammerschmidt, S~~.	+	==Reference==
-		+	<ref group="xtra">PMID:024136784</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4~~	+	[[Category: Abdullah, M R.]]
		+	[[Category: Asmat, T M.]]
		+	[[Category: Bartual, S G.]]
		+	[[Category: Hammerschmidt, S.]]
		+	[[Category: Hermoso, J A.]]
		+	[[Category: Jensch, I.]]
		+	[[Category: Petruschka, L.]]
		+	[[Category: Pribyl, T.]]
		+	[[Category: Saleh, M.]]
		+	[[Category: Disulfide bridge]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Membrane]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Thiorredoxin]]

OCA at 09:06, 21 November 2012

2012-11-21T09:06:13Z

←Older revision		Revision as of 09:06, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hqs is ON HOLD	+	The entry 4hqs is ON HOLD until Paper Publication

-	Authors: Bartual, S.G., ~~Shalek~~, M., Abdullah, M., Jensch, I., Asmat, M.T., Petruschka, L., Pribyl, T., Hermoso, J.A., Hammerschmidt, S.	+	Authors: Bartual, S.G., Saleh, M., Abdullah, M., Jensch, I., Asmat, M.T., Petruschka, L., Pribyl, T., Hermoso, J.A., Hammerschmidt, S.

	Description: Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4		Description: Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4

OCA at 13:24, 8 November 2012

2012-11-08T13:24:38Z

←Older revision		Revision as of 13:24, 8 November 2012
Line 3:		Line 3:
	The entry 4hqs is ON HOLD		The entry 4hqs is ON HOLD

-	Authors: Bartual, S.G., Shalek, M., Abdullah, M., Jensch, I., Asmat, M.T., Petruschka, L., Pribyl, T., Hermoso, J.A. , Hammerschmidt, S.	+	Authors: Bartual, S.G., Shalek, M., Abdullah, M., Jensch, I., Asmat, M.T., Petruschka, L., Pribyl, T., Hermoso, J.A., Hammerschmidt, S.

	Description: Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4		Description: Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4

OCA: Protected "4hqs" [edit=sysop:move=sysop]

2012-10-31T08:44:53Z

Protected "4hqs" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:44, 31 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hqs is ON HOLD Authors: Bartual, S.G., Shalek, M., Abdullah, M., Jensch, I., Asmat, M.T., Petruschka, L., Pribyl, T., Hermoso, J.A. , Hammerschmidt...

2012-10-31T08:44:52Z

New page: '''Unreleased structure''' The entry 4hqs is ON HOLD Authors: Bartual, S.G., Shalek, M., Abdullah, M., Jensch, I., Asmat, M.T., Petruschka, L., Pribyl, T., Hermoso, J.A. , Hammerschmidt...

New page

'''Unreleased structure'''

The entry 4hqs is ON HOLD

Authors: Bartual, S.G., Shalek, M., Abdullah, M., Jensch, I., Asmat, M.T., Petruschka, L., Pribyl, T., Hermoso, J.A. , Hammerschmidt, S.

Description: Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_0659 (Etrx1) from Streptococcus pneumoniae strain TIGR4