4hsb - Revision history

OCA at 11:44, 1 March 2024

2024-03-01T11:44:19Z

←Older revision		Revision as of 11:44, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hsb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hsb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HSB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsb OCA], [https://pdbe.org/4hsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hsb RCSB], [https://www.ebi.ac.uk/pdbsum/4hsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsb OCA], [https://pdbe.org/4hsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hsb RCSB], [https://www.ebi.ac.uk/pdbsum/4hsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>		[https://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Schizosaccharomyces pombe contains two paralogous proteins, Mag1 and Mag2, related to the helix-hairpin-helix (HhH) superfamily of alkylpurine DNA glycosylases from yeast and bacteria. Phylogenetic analysis of related proteins from four Schizosaccharomyces and other fungal species shows that the Mag1/Mag2 duplication is unique to the genus Schizosaccharomyces and most likely occurred in its ancestor. Mag1 excises N3- and N7-alkylguanines and 1,N(6)-ethenoadenine from DNA, whereas Mag2 has been reported to have no detectible alkylpurine base excision activity despite high sequence and active site similarity to Mag1. To understand this discrepancy we determined the crystal structure of Mag2 bound to abasic DNA and compared it to our previously determined Mag1-DNA structure. In contrast to Mag1, Mag2 does not flip the abasic moiety into the active site or stabilize the DNA strand 5' to the lesion, suggesting that it is incapable of forming a catalytically competent protein-DNA complex. Subtle differences in Mag1 and Mag2 interactions with the DNA duplex illustrate how Mag2 can stall at damage sites without fully engaging the lesion. We tested our structural predictions by mutational analysis of base excision and found a single amino acid responsible at least in part for Mag2's lack of activity. Substitution of Mag2 Asp56, which caps the helix at the base of the DNA intercalation loop, with the corresponding serine residue in Mag1 endows Mag2 with varepsilonA excision activity comparable to Mag1. This work provides novel insight into the chemical and physical determinants by which the HhH glycosylases engage DNA in a catalytically productive manner.
-
-	Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe.,Adhikary S, Cato MC, McGary KL, Rokas A, Eichman BF DNA Repair (Amst). 2012 Dec 27. pii: S1568-7864(12)00290-X. doi:, 10.1016/j.dnarep.2012.12.001. PMID:23273506<ref>PMID:23273506</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4hsb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:10, 9 November 2022

2022-11-09T08:10:02Z

←Older revision		Revision as of 08:10, 9 November 2022
Line 1:		Line 1:

	==S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA==		==S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA==
-	<StructureSection load='4hsb' size='340' side='right' caption='[[4hsb]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4hsb' size='340' side='right'caption='[[4hsb]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hsb]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fission_yeast Fission yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HSB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hsb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HSB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsb OCA], [https://pdbe.org/4hsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hsb RCSB], [https://www.ebi.ac.uk/pdbsum/4hsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsb ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[3s6i\|3s6i]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPBC23G7.11~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast]~~)~~</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsb OCA], [~~http~~://pdbe.org/4hsb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hsb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hsb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO]] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>	+	[https://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DNA-3-methyladenine glycosylase II~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Fission yeast~~]]	+	[[Category: Schizosaccharomyces pombe 972h-]]
-	[[Category: Adhikary, S]]	+	[[Category: Adhikary S]]
-	[[Category: Eichman~~, B F]]~~	+	[[Category: Eichman BF]]
-	~~[[Category: Helix-hairpin-helix]]~~	+
-	~~[[Category: Hydrolase-dna complex]]~~	+
-	~~[[Category: Non-specific dna-binding motif~~]]	+

OCA at 16:27, 4 August 2016

2016-08-04T16:27:07Z

←Older revision		Revision as of 16:27, 4 August 2016
Line 1:		Line 1:
		+
	==S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA==		==S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA==
	<StructureSection load='4hsb' size='340' side='right' caption='[[4hsb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4hsb' size='340' side='right' caption='[[4hsb]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPBC23G7.11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPBC23G7.11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hsb RCSB], [http://www.ebi.ac.uk/pdbsum/4hsb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsb OCA], [http://pdbe.org/4hsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hsb RCSB], [http://www.ebi.ac.uk/pdbsum/4hsb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hsb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:58, 25 December 2014

2014-12-25T10:58:58Z

←Older revision		Revision as of 10:58, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hsb\| PDB=4hsb \| SCENE= }}~~	+	==S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA==
-	===S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA===	+	<StructureSection load='4hsb' size='340' side='right' caption='[[4hsb]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23273506}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hsb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HSB FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s6i\|3s6i]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPBC23G7.11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hsb RCSB], [http://www.ebi.ac.uk/pdbsum/4hsb PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO]] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>		[[http://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO]] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Schizosaccharomyces pombe contains two paralogous proteins, Mag1 and Mag2, related to the helix-hairpin-helix (HhH) superfamily of alkylpurine DNA glycosylases from yeast and bacteria. Phylogenetic analysis of related proteins from four Schizosaccharomyces and other fungal species shows that the Mag1/Mag2 duplication is unique to the genus Schizosaccharomyces and most likely occurred in its ancestor. Mag1 excises N3- and N7-alkylguanines and 1,N(6)-ethenoadenine from DNA, whereas Mag2 has been reported to have no detectible alkylpurine base excision activity despite high sequence and active site similarity to Mag1. To understand this discrepancy we determined the crystal structure of Mag2 bound to abasic DNA and compared it to our previously determined Mag1-DNA structure. In contrast to Mag1, Mag2 does not flip the abasic moiety into the active site or stabilize the DNA strand 5' to the lesion, suggesting that it is incapable of forming a catalytically competent protein-DNA complex. Subtle differences in Mag1 and Mag2 interactions with the DNA duplex illustrate how Mag2 can stall at damage sites without fully engaging the lesion. We tested our structural predictions by mutational analysis of base excision and found a single amino acid responsible at least in part for Mag2's lack of activity. Substitution of Mag2 Asp56, which caps the helix at the base of the DNA intercalation loop, with the corresponding serine residue in Mag1 endows Mag2 with varepsilonA excision activity comparable to Mag1. This work provides novel insight into the chemical and physical determinants by which the HhH glycosylases engage DNA in a catalytically productive manner.

-	~~==About this Structure==~~	+	Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe.,Adhikary S, Cato MC, McGary KL, Rokas A, Eichman BF DNA Repair (Amst). 2012 Dec 27. pii: S1568-7864(12)00290-X. doi:, 10.1016/j.dnarep.2012.12.001. PMID:23273506<ref>PMID:23273506</ref>
-	~~[[4hsb]] is a 3 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Fission_yeast Fission yeast]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4HSB OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023273506</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: DNA-3-methyladenine glycosylase II]]		[[Category: DNA-3-methyladenine glycosylase II]]
	[[Category: Fission yeast]]		[[Category: Fission yeast]]
-	[[Category: Adhikary, S.]]	+	[[Category: Adhikary, S]]
-	[[Category: Eichman, B F.]]	+	[[Category: Eichman, B F]]
	[[Category: Helix-hairpin-helix]]		[[Category: Helix-hairpin-helix]]
	[[Category: Hydrolase-dna complex]]		[[Category: Hydrolase-dna complex]]
	[[Category: Non-specific dna-binding motif]]		[[Category: Non-specific dna-binding motif]]

OCA at 10:51, 1 January 2014

2014-01-01T10:51:50Z

←Older revision		Revision as of 10:51, 1 January 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4hsb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA].	+	[[4hsb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA].

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023273506</ref><references group="xtra"/><references/>
	[[Category: DNA-3-methyladenine glycosylase II]]		[[Category: DNA-3-methyladenine glycosylase II]]
-	[[Category: ~~Schizosaccharomyces pombe 972h-~~]]	+	[[Category: Fission yeast]]
	[[Category: Adhikary, S.]]		[[Category: Adhikary, S.]]
	[[Category: Eichman, B F.]]		[[Category: Eichman, B F.]]

OCA at 21:55, 10 April 2013

2013-04-10T21:55:47Z

←Older revision		Revision as of 21:55, 10 April 2013
Line 1:		Line 1:
-	[[Image:4hsb.jpg\|left\|200px]]
-
	{{STRUCTURE_4hsb\| PDB=4hsb \| SCENE= }}		{{STRUCTURE_4hsb\| PDB=4hsb \| SCENE= }}
-
	===S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA===		===S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA===
-
	{{ABSTRACT_PUBMED_23273506}}		{{ABSTRACT_PUBMED_23273506}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO]] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>

	==About this Structure==		==About this Structure==
	[[4hsb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA].		[[4hsb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: DNA-3-methyladenine glycosylase II]]		[[Category: DNA-3-methyladenine glycosylase II]]
	[[Category: Schizosaccharomyces pombe 972h-]]		[[Category: Schizosaccharomyces pombe 972h-]]

OCA at 11:39, 23 January 2013

2013-01-23T11:39:05Z

←Older revision		Revision as of 11:39, 23 January 2013
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-	~~'''Unreleased structure'''~~	+	[[Image:4hsb.jpg\|left\|200px]]

-	~~The entry~~ 4hsb ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4hsb\| PDB=4hsb \| SCENE= }}

-	~~Authors: Adhikary,~~ S.~~, Eichman, B.F.~~	+	===S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA===

-	~~Description~~: S. pombe 3-methyladenine ~~DNA~~ glycosylase-~~like protein Mag2 bound to damaged DNA~~	+	{{ABSTRACT_PUBMED_23273506}}
		+
		+	==About this Structure==
		+	[[4hsb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSB OCA].
		+	[[Category: DNA-3-methyladenine glycosylase II]]
		+	[[Category: Schizosaccharomyces pombe 972h-]]
		+	[[Category: Adhikary, S.]]
		+	[[Category: Eichman, B F.]]
		+	[[Category: Helix-hairpin-helix]]
		+	[[Category: Hydrolase-dna complex]]
		+	[[Category: Non-specific dna-binding motif]]

OCA: Protected "4hsb" [edit=sysop:move=sysop]

2012-11-08T13:26:14Z

Protected "4hsb" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:26, 8 November 2012

OCA: New page: '''Unreleased structure''' The entry 4hsb is ON HOLD until Paper Publication Authors: Adhikary, S., Eichman, B.F. Description: S. pombe 3-methyladenine DNA glycosylase-like protein Mag...

2012-11-08T13:26:13Z

New page: '''Unreleased structure''' The entry 4hsb is ON HOLD until Paper Publication Authors: Adhikary, S., Eichman, B.F. Description: S. pombe 3-methyladenine DNA glycosylase-like protein Mag...

New page

'''Unreleased structure'''

The entry 4hsb is ON HOLD until Paper Publication

Authors: Adhikary, S., Eichman, B.F.

Description: S. pombe 3-methyladenine DNA glycosylase-like protein Mag2 bound to damaged DNA