4huz - Revision history

OCA at 15:11, 20 September 2023

2023-09-20T15:11:27Z

←Older revision		Revision as of 15:11, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4huz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingobium_chlorophenolicum Sphingobium chlorophenolicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4huz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingobium_chlorophenolicum Sphingobium chlorophenolicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4huz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huz OCA], [https://pdbe.org/4huz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4huz RCSB], [https://www.ebi.ac.uk/pdbsum/4huz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4huz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4huz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huz OCA], [https://pdbe.org/4huz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4huz RCSB], [https://www.ebi.ac.uk/pdbsum/4huz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4huz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:17, 9 November 2022

2022-11-09T08:17:35Z

←Older revision		Revision as of 08:17, 9 November 2022
Line 1:		Line 1:

	==2,6-Dichloro-p-hydroquinone 1,2-Dioxygenase==		==2,6-Dichloro-p-hydroquinone 1,2-Dioxygenase==
-	<StructureSection load='4huz' size='340' side='right' caption='[[4huz]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4huz' size='340' side='right'caption='[[4huz]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4huz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_33790 Atcc 33790~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HUZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4huz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingobium_chlorophenolicum Sphingobium chlorophenolicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46429 ATCC 33790])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4huz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huz OCA], [https://pdbe.org/4huz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4huz RCSB], [https://www.ebi.ac.uk/pdbsum/4huz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4huz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4huz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huz OCA], [~~http~~://pdbe.org/4huz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4huz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4huz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4huz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9ZBB0_SPHCR Q9ZBB0_SPHCR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 33790~~]]	+	[[Category: Large Structures]]
-	[[Category: Green~~, A R~~]]	+	[[Category: Sphingobium chlorophenolicum]]
-	[[Category: Hayes~~, R P~~]]	+	[[Category: Green AR]]
-	[[Category: Kang, C]]	+	[[Category: Hayes RP]]
-	[[Category: Lewis~~, K M~~]]	+	[[Category: Kang C]]
-	[[Category: Nissen~~, M S~~]]	+	[[Category: Lewis KM]]
-	[[Category: Xun, L]]	+	[[Category: Nissen MS]]
-	~~[[Category: Oxidoreductase~~]]	+	[[Category: Xun L]]

OCA at 09:19, 11 August 2016

2016-08-11T09:19:26Z

←Older revision		Revision as of 09:19, 11 August 2016
Line 1:		Line 1:
		+
	==2,6-Dichloro-p-hydroquinone 1,2-Dioxygenase==		==2,6-Dichloro-p-hydroquinone 1,2-Dioxygenase==
	<StructureSection load='4huz' size='340' side='right' caption='[[4huz]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4huz' size='340' side='right' caption='[[4huz]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4huz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sphingobium_chlorophenolicum Sphingobium chlorophenolicum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4huz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33790 Atcc 33790]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46429 ~~Sphingobium chlorophenolicum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46429 ATCC 33790])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4huz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4huz RCSB], [http://www.ebi.ac.uk/pdbsum/4huz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4huz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huz OCA], [http://pdbe.org/4huz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4huz RCSB], [http://www.ebi.ac.uk/pdbsum/4huz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4huz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4huz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sphingobium chlorophenolicum~~]]	+	[[Category: Atcc 33790]]
	[[Category: Green, A R]]		[[Category: Green, A R]]
	[[Category: Hayes, R P]]		[[Category: Hayes, R P]]

OCA at 12:45, 4 January 2015

2015-01-04T12:45:58Z

←Older revision		Revision as of 12:45, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4huz~~\| ~~PDB~~=4huz \| ~~SCENE~~= }}	+	==2,6-Dichloro-p-hydroquinone 1,2-Dioxygenase==
-	===2,6-~~Dichloro~~-p-hydroquinone 1,2-~~Dioxygenase===~~	+	<StructureSection load='4huz' size='340' side='right' caption='[[4huz]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23489289}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4huz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingobium_chlorophenolicum Sphingobium chlorophenolicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46429 Sphingobium chlorophenolicum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4huz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4huz RCSB], [http://www.ebi.ac.uk/pdbsum/4huz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PcpA (2,6-dichloro-p-hydroquinone 1,2-dioxygenase) from Sphingobium chlorophenolicum, a non-haem Fe(II) dioxygenase capable of cleaving the aromatic ring of p-hydroquinone and its substituted variants, is a member of the recently discovered p-hydroquinone 1,2-dioxygenases. Here we report the 2.6 A structure of PcpA, which consists of four betaalphabetabetabeta motifs, a hallmark of the vicinal oxygen chelate superfamily. The secondary co-ordination sphere of the Fe(II) centre forms an extensive hydrogen-bonding network with three solvent exposed residues, linking the catalytic Fe(II) to solvent. A tight hydrophobic pocket provides p-hydroquinones access to the Fe(II) centre. The p-hydroxyl group is essential for the substrate-binding, thus phenols and catechols, lacking a p-hydroxyl group, do not bind to PcpA. Site-directed mutagenesis and kinetic analysis confirm the critical catalytic role played by the highly conserved His10, Thr13, His226 and Arg259. Based on these results, we propose a general reaction mechanism for p-hydroquinone 1,2-dioxygenases.

-	~~==About this Structure==~~	+	Structural characterization of 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA) from Sphingobium chlorophenolicum, a new type of aromatic ring-cleavage enzyme.,Hayes RP, Green AR, Nissen MS, Lewis KM, Xun L, Kang C Mol Microbiol. 2013 Mar 14. doi: 10.1111/mmi.12204. PMID:23489289<ref>PMID:23489289</ref>
-	~~[[4huz]] is a~~ 1 ~~chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Sphingobium_chlorophenolicum~~ Sphingobium chlorophenolicum]. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4HUZ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023489289</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Sphingobium chlorophenolicum]]		[[Category: Sphingobium chlorophenolicum]]
-	[[Category: Green, A R.]]	+	[[Category: Green, A R]]
-	[[Category: Hayes, R P.]]	+	[[Category: Hayes, R P]]
-	[[Category: Kang, C.]]	+	[[Category: Kang, C]]
-	[[Category: Lewis, K M.]]	+	[[Category: Lewis, K M]]
-	[[Category: Nissen, M S.]]	+	[[Category: Nissen, M S]]
-	[[Category: Xun, L.]]	+	[[Category: Xun, L]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 14:30, 10 July 2013

2013-07-10T14:30:12Z

←Older revision		Revision as of 14:30, 10 July 2013
Line 5:		Line 5:
	==About this Structure==		==About this Structure==
	[[4huz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingobium_chlorophenolicum Sphingobium chlorophenolicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA].		[[4huz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingobium_chlorophenolicum Sphingobium chlorophenolicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023489289</ref><references group="xtra"/><references/>
	[[Category: Sphingobium chlorophenolicum]]		[[Category: Sphingobium chlorophenolicum]]
	[[Category: Green, A R.]]		[[Category: Green, A R.]]
Line 12:		Line 15:
	[[Category: Nissen, M S.]]		[[Category: Nissen, M S.]]
	[[Category: Xun, L.]]		[[Category: Xun, L.]]
-	[[Category: 2-dioxygenase]]
-	[[Category: 6-dichloro-p-hydroquinone 1]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 20:26, 17 April 2013

2013-04-17T20:26:36Z

←Older revision		Revision as of 20:26, 17 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4huz\| PDB=4huz \| SCENE= }}
		+	===2,6-Dichloro-p-hydroquinone 1,2-Dioxygenase===
		+	{{ABSTRACT_PUBMED_23489289}}

-	~~The entry~~ 4huz is ~~ON HOLD until Nov 05 2014~~	+	==About this Structure==
-		+	[[4huz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingobium_chlorophenolicum Sphingobium chlorophenolicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUZ OCA].
-	~~Authors~~: ~~Hayes, R~~.P.~~, Nissen, M~~.S., Green, A.R., Lewis, K.M., Xun, L.~~, Kang, C.~~	+	[[Category: Sphingobium chlorophenolicum]]
-		+	[[Category: Green, A R.]]
-	~~Description~~: 2,6-~~Dichloro~~-p-hydroquinone 1~~,2-Dioxygenase~~	+	[[Category: Hayes, R P.]]
		+	[[Category: Kang, C.]]
		+	[[Category: Lewis, K M.]]
		+	[[Category: Nissen, M S.]]
		+	[[Category: Xun, L.]]
		+	[[Category: 2-dioxygenase]]
		+	[[Category: 6-dichloro-p-hydroquinone 1]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "4huz" [edit=sysop:move=sysop]

2012-11-14T06:19:36Z

Protected "4huz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:19, 14 November 2012

OCA: New page: '''Unreleased structure''' The entry 4huz is ON HOLD until Nov 05 2014 Authors: Hayes, R.P., Nissen, M.S., Green, A.R., Lewis, K.M., Xun, L., Kang, C. Description: 2,6-Dichloro-p-hydro...

2012-11-14T06:19:35Z

New page: '''Unreleased structure''' The entry 4huz is ON HOLD until Nov 05 2014 Authors: Hayes, R.P., Nissen, M.S., Green, A.R., Lewis, K.M., Xun, L., Kang, C. Description: 2,6-Dichloro-p-hydro...

New page

'''Unreleased structure'''

The entry 4huz is ON HOLD until Nov 05 2014

Authors: Hayes, R.P., Nissen, M.S., Green, A.R., Lewis, K.M., Xun, L., Kang, C.

Description: 2,6-Dichloro-p-hydroquinone 1,2-Dioxygenase