4hwk - Revision history

OCA at 15:11, 20 September 2023

2023-09-20T15:11:59Z

←Older revision		Revision as of 15:11, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hwk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hwk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SFY:4-AMINO-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE'>SFY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SFY:4-AMINO-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE'>SFY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwk OCA], [https://pdbe.org/4hwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwk RCSB], [https://www.ebi.ac.uk/pdbsum/4hwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwk OCA], [https://pdbe.org/4hwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwk RCSB], [https://www.ebi.ac.uk/pdbsum/4hwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:20, 9 November 2022

2022-11-09T08:20:10Z

←Older revision		Revision as of 08:20, 9 November 2022
Line 1:		Line 1:

	==Crystal structure of human sepiapterin reductase in complex with sulfapyridine==		==Crystal structure of human sepiapterin reductase in complex with sulfapyridine==
-	<StructureSection load='4hwk' size='340' side='right' caption='[[4hwk]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4hwk' size='340' side='right'caption='[[4hwk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hwk]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HWK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hwk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SFY:4-AMINO-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE'>SFY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SFY:4-AMINO-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE'>SFY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwk OCA], [https://pdbe.org/4hwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwk RCSB], [https://www.ebi.ac.uk/pdbsum/4hwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwk ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sepiapterin_reductase_(L-erythro-7,8-dihydrobiopterin_forming) Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.153 1.1.1.153] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwk OCA], [~~http~~://pdbe.org/4hwk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hwk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hwk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:[~~http~~://omim.org/entry/612716 612716]]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.<ref>PMID:11443547</ref> <ref>PMID:16650784</ref> <ref>PMID:17159114</ref>	+	[https://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN] Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:[https://omim.org/entry/612716 612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.<ref>PMID:11443547</ref> <ref>PMID:16650784</ref> <ref>PMID:17159114</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.	+	[https://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN] Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Johnsson, K~~]]	+	[[Category: Large Structures]]
-	[[Category: Pedersen, M ~~Groenlund~~]]	+	[[Category: Groenlund Pedersen M]]
-	[[Category: ~~Pojer, F~~]]	+	[[Category: Johnsson K]]
-	[[Category: ~~Oxidoreductase-antibiotic complex]]~~	+	[[Category: Pojer F]]
-	~~[[Category: Reductase~~]]	+

OCA at 18:12, 4 August 2016

2016-08-04T18:12:10Z

←Older revision		Revision as of 18:12, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human sepiapterin reductase in complex with sulfapyridine==		==Crystal structure of human sepiapterin reductase in complex with sulfapyridine==
	<StructureSection load='4hwk' size='340' side='right' caption='[[4hwk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4hwk' size='340' side='right' caption='[[4hwk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hwk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hwk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SFY:4-AMINO-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE'>SFY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SFY:4-AMINO-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE'>SFY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sepiapterin_reductase_(L-erythro-7,8-dihydrobiopterin_forming) Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.153 1.1.1.153] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sepiapterin_reductase_(L-erythro-7,8-dihydrobiopterin_forming) Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.153 1.1.1.153] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwk RCSB], [http://www.ebi.ac.uk/pdbsum/4hwk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwk OCA], [http://pdbe.org/4hwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hwk RCSB], [http://www.ebi.ac.uk/pdbsum/4hwk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hwk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Johnsson, K]]		[[Category: Johnsson, K]]
	[[Category: Pedersen, M Groenlund]]		[[Category: Pedersen, M Groenlund]]

OCA at 12:23, 21 December 2014

2014-12-21T12:23:30Z

←Older revision		Revision as of 12:23, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hwk\| PDB=4hwk \| SCENE= }}~~	+	==Crystal structure of human sepiapterin reductase in complex with sulfapyridine==
-	===Crystal structure of human sepiapterin reductase in complex with sulfapyridine===	+	<StructureSection load='4hwk' size='340' side='right' caption='[[4hwk]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23704574}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hwk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWK FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SFY:4-AMINO-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE'>SFY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sepiapterin_reductase_(L-erythro-7,8-dihydrobiopterin_forming) Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.153 1.1.1.153] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwk RCSB], [http://www.ebi.ac.uk/pdbsum/4hwk PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:[http://omim.org/entry/612716 612716]]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.<ref>PMID:11443547</ref> <ref>PMID:16650784</ref> <ref>PMID:17159114</ref>		[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:[http://omim.org/entry/612716 612716]]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.<ref>PMID:11443547</ref> <ref>PMID:16650784</ref> <ref>PMID:17159114</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.		[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The introduction of sulfa drugs for the chemotherapy of bacterial infections in 1935 revolutionized medicine. Although their mechanism of action is understood, the molecular bases for most of their side effects remain obscure. Here, we report that sulfamethoxazole and other sulfa drugs interfere with tetrahydrobiopterin biosynthesis through inhibition of sepiapterin reductase. Crystal structures of sepiapterin reductase with bound sulfa drugs reveal how structurally diverse sulfa drugs achieve specific inhibition of the enzyme. The effect of sulfa drugs on tetrahydrobiopterin-dependent neurotransmitter biosynthesis in cell-based assays provides a rationale for some of their central nervous system-related side effects, particularly in high-dose sulfamethoxazole therapy of Pneumocystis pneumonia. Our findings reveal an unexpected aspect of the pharmacology of sulfa drugs and might translate into their improved medical use.

-	~~==About this Structure==~~	+	Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.,Haruki H, Pedersen MG, Gorska KI, Pojer F, Johnsson K Science. 2013 May 24;340(6135):987-91. doi: 10.1126/science.1232972. PMID:23704574<ref>PMID:23704574</ref>
-	~~[[4hwk]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4HWK OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023704574</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Johnsson, K.]]	+	[[Category: Johnsson, K]]
-	[[Category: Pedersen, M Groenlund.]]	+	[[Category: Pedersen, M Groenlund]]
-	[[Category: Pojer, F.]]	+	[[Category: Pojer, F]]
	[[Category: Oxidoreductase-antibiotic complex]]		[[Category: Oxidoreductase-antibiotic complex]]
	[[Category: Reductase]]		[[Category: Reductase]]

OCA at 15:29, 19 June 2013

2013-06-19T15:29:22Z

←Older revision		Revision as of 15:29, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hwk\| PDB=4hwk \| SCENE= }}
		+	===Crystal structure of human sepiapterin reductase in complex with sulfapyridine===
		+	{{ABSTRACT_PUBMED_23704574}}

-	~~The~~ entry ~~4hwk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:[http://omim.org/entry/612716 612716]]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.<ref>PMID:11443547</ref> <ref>PMID:16650784</ref> <ref>PMID:17159114</ref>

-	~~Authors~~: ~~Groenlund Pedersen, M~~., ~~Pojer, F.~~, ~~Johnsson~~, K.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

-	~~Description: Crystal~~ structure ~~of human sepiapterin reductase in complex~~ with ~~sulfapyridine~~	+	==About this Structure==
		+	[[4hwk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023704574</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Johnsson, K.]]
		+	[[Category: Pedersen, M Groenlund.]]
		+	[[Category: Pojer, F.]]
		+	[[Category: Oxidoreductase-antibiotic complex]]
		+	[[Category: Reductase]]

OCA at 11:57, 30 January 2013

2013-01-30T11:57:17Z

←Older revision		Revision as of 11:57, 30 January 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hwk is ON HOLD	+	The entry 4hwk is ON HOLD until Paper Publication

	Authors: Groenlund Pedersen, M., Pojer, F., Johnsson, K.		Authors: Groenlund Pedersen, M., Pojer, F., Johnsson, K.

	Description: Crystal structure of human sepiapterin reductase in complex with sulfapyridine		Description: Crystal structure of human sepiapterin reductase in complex with sulfapyridine

OCA: Protected "4hwk" [edit=sysop:move=sysop]

2012-11-14T06:21:12Z

Protected "4hwk" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:21, 14 November 2012

OCA: New page: '''Unreleased structure''' The entry 4hwk is ON HOLD Authors: Groenlund Pedersen, M., Pojer, F., Johnsson, K. Description: Crystal structure of human sepiapterin reductase in complex w...

2012-11-14T06:21:11Z

New page: '''Unreleased structure''' The entry 4hwk is ON HOLD Authors: Groenlund Pedersen, M., Pojer, F., Johnsson, K. Description: Crystal structure of human sepiapterin reductase in complex w...

New page

'''Unreleased structure'''

The entry 4hwk is ON HOLD

Authors: Groenlund Pedersen, M., Pojer, F., Johnsson, K.

Description: Crystal structure of human sepiapterin reductase in complex with sulfapyridine